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Plecanatide for Treatment of Chronic Constipation and Irritable Bowel Syndrome.
Love BL. Love BL. Am J Med. 2019 May;132(5):572-575. doi: 10.1016/j.amjmed.2018.11.027. Epub 2018 Dec 11. Am J Med. 2019. PMID: 30550753 Review.
Chronic idiopathic constipation and irritable bowel syndrome with constipation are commonly encountered in ambulatory patients, but limited options exist for patients with persistent or severe symptoms following treatment with nonprescription products. ...The …
Chronic idiopathic constipation and irritable bowel syndrome with constipation are commonly encountered in ambulatory p …
Plecanatide for the treatment of constipation-predominant irritable bowel syndrome.
Miner PB. Miner PB. Expert Rev Gastroenterol Hepatol. 2020 Feb;14(2):71-84. doi: 10.1080/17474124.2020.1722101. Epub 2020 Feb 5. Expert Rev Gastroenterol Hepatol. 2020. PMID: 31985305 Review.
Introduction: As an analogue of uroguanylin plecanatide binds to the Guanylate Cyclase-C receptor activating fluid and ion secretion in the small intestine with the same pH-dependent binding kinetics as the natural ligand. Plecanatide has been FDA approved as safe a …
Introduction: As an analogue of uroguanylin plecanatide binds to the Guanylate Cyclase-C receptor activating fluid and ion secretion …
AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation.
Chang L, Sultan S, Lembo A, Verne GN, Smalley W, Heidelbaugh JJ. Chang L, et al. Gastroenterology. 2022 Jul;163(1):118-136. doi: 10.1053/j.gastro.2022.04.016. Gastroenterology. 2022. PMID: 35738724
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction associated with significant disease burden. ...The panel made a strong recommendation for linaclotide (high certainty) and conditional recommendations for tena …
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction associated with sig …
Efficacy and safety of plecanatide in treating constipation predominant irritable bowel syndrome.
Miner PB Jr. Miner PB Jr. Expert Opin Pharmacother. 2018 Feb;19(2):177-183. doi: 10.1080/14656566.2018.1427733. Epub 2018 Jan 29. Expert Opin Pharmacother. 2018. PMID: 29376436 Review.
Areas covered: Herein, all published research regarding the development of and clinical experience with plecanatide is reviewed. Clinical study results in patients with Chronic Idiopathic Constipation (CIC) and Irritable Bowel Syndrome with Constipatio …
Areas covered: Herein, all published research regarding the development of and clinical experience with plecanatide is reviewed. Clin …
Plecanatide Improves Symptoms of Irritable Bowel Syndrome with Constipation: Results of an Integrated Efficacy and Safety Analysis of Two Phase 3 Trials.
Brenner DM, Dorn SD, Fogel RP, Christie J, Laitman AP, Rosenberg J. Brenner DM, et al. Int J Gen Med. 2023 Aug 25;16:3769-3777. doi: 10.2147/IJGM.S400431. eCollection 2023. Int J Gen Med. 2023. PMID: 37649852 Free PMC article.
PURPOSE: Patients with irritable bowel syndrome with constipation (IBS-C) experience abdominal pain with altered bowel movements. Plecanatide is indicated as IBS-C treatment in adults. This integrated analysis further characterizes plecanatid …
PURPOSE: Patients with irritable bowel syndrome with constipation (IBS-C) experience abdominal pain with altered bow …
Constipation-predominant irritable bowel syndrome treatment options Linaclotide, Lubiprostone, Plecanatide, and Tenapanor: analysis of the FDA Adverse Event Reporting System (FAERS) database.
Andrews MB, Adler DG. Andrews MB, et al. Expert Opin Drug Saf. 2025 Jun 13:1-8. doi: 10.1080/14740338.2025.2519833. Online ahead of print. Expert Opin Drug Saf. 2025. PMID: 40503810
BACKGROUND: FDA approved treatments for constipation-predominant irritable bowel syndrome (IBS-C) include secretagogues (Linaclotide, Lubiprostone, and Plecanatide) and a retainagogue (Tenapanor). ...RESULTS: Linaclotide was most associated with diarrh …
BACKGROUND: FDA approved treatments for constipation-predominant irritable bowel syndrome (IBS-C) include secretagogues …
Irritable Bowel Syndrome: What Treatments Really Work.
Alammar N, Stein E. Alammar N, et al. Med Clin North Am. 2019 Jan;103(1):137-152. doi: 10.1016/j.mcna.2018.08.006. Med Clin North Am. 2019. PMID: 30466670 Review.
Irritable bowel syndrome (IBS) is present in patients with symptoms of chronic abdominal pain and altered bowel habits but no identifiable organic etiology. ...Newer treatments for IBS-D, such as eluxadoline, and IBS-C, with linaclotide, lubiprostone, …
Irritable bowel syndrome (IBS) is present in patients with symptoms of chronic abdominal pain and altered bowel …
Plecanatide Improves Abdominal Bloating and Bowel Symptoms of Irritable Bowel Syndrome with Constipation.
Brenner DM, Sharma A, Rao SSC, Laitman AP, Heimanson Z, Allen C, Sayuk GS. Brenner DM, et al. Dig Dis Sci. 2024 May;69(5):1731-1738. doi: 10.1007/s10620-024-08330-y. Epub 2024 Apr 9. Dig Dis Sci. 2024. PMID: 38594429 Free PMC article. Clinical Trial.
BACKGROUND: Bloating is a bothersome symptom in irritable bowel syndrome with constipation (IBS-C). AIM: To evaluate plecanatide efficacy in patients with IBS-C stratified by bloating intensity. ...CONCLUSION: Plecanatide treatment improved IBS- …
BACKGROUND: Bloating is a bothersome symptom in irritable bowel syndrome with constipation (IBS-C). AIM: To evaluate …
Focus on Pharmacotherapy for Irritable Bowel Syndrome with Constipation.
Liu JJ, Brenner DM. Liu JJ, et al. Gastroenterol Clin North Am. 2021 Sep;50(3):639-653. doi: 10.1016/j.gtc.2021.04.004. Gastroenterol Clin North Am. 2021. PMID: 34304792 Review.
Irritable bowel syndrome with constipation is a common disorder that significantly impairs quality of life. There are now multiple classes of therapeutics that have been shown via rigorous clinical testing to improve the abdominal and bowel symptoms at …
Irritable bowel syndrome with constipation is a common disorder that significantly impairs quality of life. There are n …
Drugs for Irritable Bowel Syndrome.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2020 Mar 23;62(1594):25-32. Med Lett Drugs Ther. 2020. PMID: 32324172 No abstract available.
68 results