plesnila - Search Results

Year	Number of Results
1992	1
1996	2
1997	8
1998	3
1999	3
2000	7
2001	4
2002	7
2003	6
2004	5
2005	8
2006	16
2007	9
2008	11
2009	10
2010	11
2011	11
2012	12
2013	11
2014	10
2015	14
2016	9
2017	9
2018	3
2019	6
2020	15
2021	25
2022	10
2023	15
2024	15
2025	8

1

Anionic Cyanine Membrane Probes for Live Cells and In Vivo Fluorescence Imaging.

Danylchuk DI, Khalin I, Suseela YV, Filser S, Plesnila N, Klymchenko AS. Danylchuk DI, et al. Anal Chem. 2025 Apr 11. doi: 10.1021/acs.analchem.4c05795. Online ahead of print. Anal Chem. 2025. PMID: 40217570

2

Nanocarrier Drug Release and Blood-Brain Barrier Penetration at Post-Stroke Microthrombi Monitored by Real-Time Förster Resonance Energy Transfer.

Khalin I, Adarsh N, Schifferer M, Wehn A, Boide-Trujillo VJ, Mamrak U, Shrouder J, Misgeld T, Filser S, Klymchenko AS, Plesnila N. Khalin I, et al. ACS Nano. 2025 Apr 3. doi: 10.1021/acsnano.4c17011. Online ahead of print. ACS Nano. 2025. PMID: 40180319

3

An improved method for sampling and quantitative protein analytics of cerebrospinal fluid of individual mice.

Lourbopoulos A, Müller SA, Jocher G, Wick M, Plesnila N, Lichtenthaler SF. Lourbopoulos A, et al. Mol Cell Proteomics. 2025 Mar 27:100958. doi: 10.1016/j.mcpro.2025.100958. Online ahead of print. Mol Cell Proteomics. 2025. PMID: 40157722 Free article.

4

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies.

Georgopoulos M, Pavlopoulos A, Zerva N, Kokkonakis A, Mourouzis I, Plesnila N, Pantos C, Lourbopoulos A. Georgopoulos M, et al. J Vis Exp. 2025 Feb 7;(216). doi: 10.3791/66847. J Vis Exp. 2025. PMID: 39995185

5

Mild TBI Changes Brain and Plasma Neurosteroid Levels in Mice.

Umeasalugo KE, Khalin I, Seker B, Liere P, Pianos A, Sanchez-Garcia M, Schumacher M, Koerte IK, Plesnila N. Umeasalugo KE, et al. Neurotrauma Rep. 2025 Jan 20;6(1):39-52. doi: 10.1089/neur.2024.0151. eCollection 2025. Neurotrauma Rep. 2025. PMID: 39990706 Free PMC article.

6

P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.

Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, Mitra M, Martin AF, Menéndez-Méndez A, Wang Y, Strogulski NR, Sun MJ, Melia C, Conte G, Plaza-García S, Khalin I, Teng X, Plesnila N, Klebl B, Dinkel K, Hamacher M, Bhattacharya A, Ceusters M, Palmer J, Loane DJ, Llop J, Henshall DC, Engel T. Alves M, et al. Theranostics. 2025 Jan 27;15(4):1399-1419. doi: 10.7150/thno.97254. eCollection 2025. Theranostics. 2025. PMID: 39886340 Free PMC article.

7

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.

Luo J, Molbay M, Chen Y, Horvath I, Kadletz K, Kick B, Zhao S, Al-Maskari R, Singh I, Ali M, Bhatia HS, Minde DP, Negwer M, Hoeher L, Calandra GM, Groschup B, Su J, Kimna C, Rong Z, Galensowske N, Todorov MI, Jeridi D, Ohn TL, Roth S, Simats A, Singh V, Khalin I, Pan C, Arús BA, Bruns OT, Zeidler R, Liesz A, Protzer U, Plesnila N, Ussar S, Hellal F, Paetzold J, Elsner M, Dietz H, Erturk A. Luo J, et al. Nat Biotechnol. 2025 Jan 14. doi: 10.1038/s41587-024-02528-1. Online ahead of print. Nat Biotechnol. 2025. PMID: 39809933

8

Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.

Rong Z, Mai H, Ebert G, Kapoor S, Puelles VG, Czogalla J, Hu S, Su J, Prtvar D, Singh I, Schädler J, Delbridge C, Steinke H, Frenzel H, Schmidt K, Braun C, Bruch G, Ruf V, Ali M, Sühs KW, Nemati M, Hopfner F, Ulukaya S, Jeridi D, Mistretta D, Caliskan ÖS, Wettengel JM, Cherif F, Kolabas ZI, Molbay M, Horvath I, Zhao S, Krahmer N, Yildirim AÖ, Ussar S, Herms J, Huber TB, Tahirovic S, Schwarzmaier SM, Plesnila N, Höglinger G, Ondruschka B, Bechmann I, Protzer U, Elsner M, Bhatia HS, Hellal F, Ertürk A. Rong Z, et al. Cell Host Microbe. 2024 Dec 11;32(12):2112-2130.e10. doi: 10.1016/j.chom.2024.11.007. Epub 2024 Nov 29. Cell Host Microbe. 2024. PMID: 39615487 Free article.

9

Reliable infarction of the middle cerebral artery territory in C57BL/6 mice using pterygopalatine artery ligation and filament optimization - The PURE-MCAo model.

Yoshimura S, Dorok M, Mamrak U, Wehn A, Krestel E, Khalin I, Plesnila N. Yoshimura S, et al. J Cereb Blood Flow Metab. 2025 May;45(5):871-884. doi: 10.1177/0271678X241281841. Epub 2024 Oct 7. J Cereb Blood Flow Metab. 2025. PMID: 39370987 Free PMC article.

10

Variables Predicting Experimental Stroke Outcome: How Well Do We Know Our Models?

Endres M, Plesnila N, Boltze J. Endres M, et al. Circ Res. 2024 Aug 16;135(5):593-595. doi: 10.1161/CIRCRESAHA.124.325129. Epub 2024 Aug 15. Circ Res. 2024. PMID: 39146396 No abstract available.

11

Combining array tomography with electron tomography provides insights into leakiness of the blood-brain barrier in mouse cortex.

Kislinger G, Fabig G, Wehn A, Rodriguez L, Jiang H, Niemann C, Klymchenko AS, Plesnila N, Misgeld T, Müller-Reichert T, Khalin I, Schifferer M. Kislinger G, et al. Elife. 2024 Aug 5;12:RP90565. doi: 10.7554/eLife.90565. Elife. 2024. PMID: 39102289 Free PMC article.

12

Innate immune memory after brain injury drives inflammatory cardiac dysfunction.

Simats A, Zhang S, Messerer D, Chong F, Beşkardeş S, Chivukula AS, Cao J, Besson-Girard S, Montellano FA, Morbach C, Carofiglio O, Ricci A, Roth S, Llovera G, Singh R, Chen Y, Filser S, Plesnila N, Braun C, Spitzer H, Gokce O, Dichgans M, Heuschmann PU, Hatakeyama K, Beltrán E, Clauss S, Bonev B, Schulz C, Liesz A. Simats A, et al. Cell. 2024 Aug 22;187(17):4637-4655.e26. doi: 10.1016/j.cell.2024.06.028. Epub 2024 Jul 22. Cell. 2024. PMID: 39043180 Free article.

13

Panel stacking is a threat to consensus statement validity.

Kepp KP, Aavitsland P, Ballin M, Balloux F, Baral S, Bardosh K, Bauchner H, Bendavid E, Bhopal R, Blumstein DT, Boffetta P, Bourgeois F, Brufsky A, Collignon PJ, Cripps S, Cristea IA, Curtis N, Djulbegovic B, Faude O, Flacco ME, Guyatt GH, Hajishengallis G, Hemkens LG, Hoffmann T, Joffe AR, Klassen TP, Koletsi D, Kontoyiannis DP, Kuhl E, La Vecchia C, Lallukka T, Lambris J, Levitt M, Makridakis S, Maltezou HC, Manzoli L, Marusic A, Mavragani C, Moher D, Mol BW, Muka T, Naudet F, Noble PW, Nordström A, Nordström P, Pandis N, Papatheodorou S, Patel CJ, Petersen I, Pilz S, Plesnila N, Ponsonby AL, Rivas MA, Saltelli A, Schabus M, Schippers MC, Schünemann H, Solmi M, Stang A, Streeck H, Sturmberg JP, Thabane L, Thombs BD, Tsakris A, Wood SN, Ioannidis JPA. Kepp KP, et al. J Clin Epidemiol. 2024 Sep;173:111428. doi: 10.1016/j.jclinepi.2024.111428. Epub 2024 Jun 17. J Clin Epidemiol. 2024. PMID: 38897481 Free PMC article.

14

Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo.

Groschup B, Calandra GM, Raitmayr C, Shrouder J, Llovera G, Zaki AG, Burgstaller S, Bischof H, Eroglu E, Liesz A, Malli R, Filser S, Plesnila N. Groschup B, et al. Sci Rep. 2024 Jun 14;14(1):13753. doi: 10.1038/s41598-024-62993-1. Sci Rep. 2024. PMID: 38877089 Free PMC article.

15

Bradykinin 2 Receptors Mediate Long-Term Neurocognitive Deficits After Experimental Traumatic Brain Injury.

Wehn AC, Khalin I, Hu S, Harapan BN, Mao X, Cheng S, Plesnila N, Terpolilli NA. Wehn AC, et al. J Neurotrauma. 2024 Nov;41(21-22):2442-2454. doi: 10.1089/neu.2024.0042. Epub 2024 Jun 27. J Neurotrauma. 2024. PMID: 38818807

16

To see or not to see: In vivo nanocarrier detection methods in the brain and their challenges.

Wehn AC, Krestel E, Harapan BN, Klymchenko A, Plesnila N, Khalin I. Wehn AC, et al. J Control Release. 2024 Jul;371:216-236. doi: 10.1016/j.jconrel.2024.05.044. Epub 2024 May 31. J Control Release. 2024. PMID: 38810705 Free article. Review.

17

Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial.

Beck J, Fung C, Strbian D, Bütikofer L, Z'Graggen WJ, Lang MF, Beyeler S, Gralla J, Ringel F, Schaller K, Plesnila N, Arnold M, Hacke W, Jüni P, Mendelow AD, Stapf C, Al-Shahi Salman R, Bressan J, Lerch S, Hakim A, Martinez-Majander N, Piippo-Karjalainen A, Vajkoczy P, Wolf S, Schubert GA, Höllig A, Veldeman M, Roelz R, Gruber A, Rauch P, Mielke D, Rohde V, Kerz T, Uhl E, Thanasi E, Huttner HB, Kallmünzer B, Jaap Kappelle L, Deinsberger W, Roth C, Lemmens R, Leppert J, Sanmillan JL, Coutinho JM, Hackenberg KAM, Reimann G, Mazighi M, Bassetti CLA, Mattle HP, Raabe A, Fischer U; SWITCH study investigators. Beck J, et al. Lancet. 2024 Jun 1;403(10442):2395-2404. doi: 10.1016/S0140-6736(24)00702-5. Epub 2024 May 15. Lancet. 2024. PMID: 38761811 Free article. Clinical Trial.

18

Swiss trial of decompressive craniectomy versus best medical treatment of spontaneous supratentorial intracerebral haemorrhage (SWITCH): an international, multicentre, randomised-controlled, two-arm, assessor-blinded trial.

Fischer U, Fung C, Beyeler S, Bütikofer L, Z'Graggen W, Ringel F, Gralla J, Schaller K, Plesnila N, Strbian D, Arnold M, Hacke W, Jüni P, Mendelow AD, Stapf C, Al-Shahi Salman R, Bressan J, Lerch S, Bassetti CLA, Mattle HP, Raabe A, Beck J. Fischer U, et al. Eur Stroke J. 2024 Sep;9(3):781-788. doi: 10.1177/23969873241231047. Epub 2024 Feb 12. Eur Stroke J. 2024. PMID: 38347736 Free PMC article.

19

Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo.

Shrouder JJ, Calandra GM, Filser S, Varga DP, Besson-Girard S, Mamrak U, Dorok M, Bulut-Impraim B, Seker FB, Gesierich B, Laredo F, Wehn AC, Khalin I, Bayer P, Liesz A, Gokce O, Plesnila N. Shrouder JJ, et al. Brain. 2024 Mar 1;147(3):1057-1074. doi: 10.1093/brain/awad401. Brain. 2024. PMID: 38153327

20

Focal Cerebral Ischemia Induces Global Subacute Changes in the Number of Neuroblasts and Neurons and the Angiogenic Factor Density in Mice.

Pilipenko V, Dzirkale Z, Rozkalne R, Upite J, Hellal F, Plesnila N, Jansone B. Pilipenko V, et al. Medicina (Kaunas). 2023 Dec 14;59(12):2168. doi: 10.3390/medicina59122168. Medicina (Kaunas). 2023. PMID: 38138271 Free PMC article.

21

Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke.

Sienel RI, Mamrak U, Biller J, Roth S, Zellner A, Parakaw T, Khambata RS, Liesz A, Haffner C, Ahluwalia A, Seker BF, Plesnila N. Sienel RI, et al. J Neuroinflammation. 2023 Dec 15;20(1):301. doi: 10.1186/s12974-023-02988-3. J Neuroinflammation. 2023. PMID: 38102677 Free PMC article.

22

Treatment with Cerebrolysin Prolongs Lifespan in a Mouse Model of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.

Kastberger B, Winter S, Brandstätter H, Biller J, Wagner W, Plesnila N. Kastberger B, et al. Adv Biol (Weinh). 2024 Feb;8(2):e2300439. doi: 10.1002/adbi.202300439. Epub 2023 Dec 7. Adv Biol (Weinh). 2024. PMID: 38062874

23

Structural changes of CA1 pyramidal neurons after stroke in the contralesional hippocampus.

Merino-Serrais P, Plaza-Alonso S, Hellal F, Valero-Freitag S, Kastanauskaite A, Plesnila N, DeFelipe J. Merino-Serrais P, et al. Brain Pathol. 2024 May;34(3):e13222. doi: 10.1111/bpa.13222. Epub 2023 Nov 27. Brain Pathol. 2024. PMID: 38012061 Free PMC article.

24

BK channels sustain neuronal Ca²⁺ oscillations to support hippocampal long-term potentiation and memory formation.

Pham T, Hussein T, Calis D, Bischof H, Skrabak D, Cruz Santos M, Maier S, Spähn D, Kalina D, Simonsig S, Ehinger R, Groschup B, Knipper M, Plesnila N, Ruth P, Lukowski R, Matt L. Pham T, et al. Cell Mol Life Sci. 2023 Nov 21;80(12):369. doi: 10.1007/s00018-023-05016-y. Cell Mol Life Sci. 2023. PMID: 37989805 Free PMC article.

25

Characterization of Vasogenic and Cytotoxic Brain Edema Formation After Experimental Traumatic Brain Injury by Free Water Diffusion Magnetic Resonance Imaging.

Hu S, Exner C, Sienel RI, When AC, Seker FB, Boldoczki FM, Guo Y, Duering M, Pasternak O, Plesnila N, Schwarzmaier SM. Hu S, et al. J Neurotrauma. 2024 Feb;41(3-4):393-406. doi: 10.1089/neu.2023.0222. Epub 2023 Dec 13. J Neurotrauma. 2024. PMID: 37776177 Free PMC article.

26

Nimodipine Reduces Microvasospasms After Experimental Subarachnoid Hemorrhage.

Schwarting J, Harapan BN, Lin X, Plesnila N, Terpolilli NA. Schwarting J, et al. Stroke. 2023 Oct;54(10):2666-2670. doi: 10.1161/STROKEAHA.123.043976. Epub 2023 Sep 7. Stroke. 2023. PMID: 37675614

27

Distinct molecular profiles of skull bone marrow in health and neurological disorders.

Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnörich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Díaz-Marugán L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schädler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Höglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kümpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ, Erturk A. Kolabas ZI, et al. Cell. 2023 Aug 17;186(17):3706-3725.e29. doi: 10.1016/j.cell.2023.07.009. Epub 2023 Aug 9. Cell. 2023. PMID: 37562402 Free PMC article.

28

Pericytes Are Not Associated With Reduced Capillary Perfusion After Experimental Subarachnoid Hemorrhage.

Schwarting J, Nehrkorn K, Harapan BN, Balbi M, Terpolilli NA, Plesnila N. Schwarting J, et al. Stroke. 2023 Aug;54(8):2172-2177. doi: 10.1161/STROKEAHA.123.042936. Epub 2023 Jun 29. Stroke. 2023. PMID: 37381898

29

Perivascular Macrophages Mediate Microvasospasms After Experimental Subarachnoid Hemorrhage.

Lin X, Khalin I, Harapan BN, Terpolilli NA, Schwarting J, Plesnila N. Lin X, et al. Stroke. 2023 Aug;54(8):2126-2134. doi: 10.1161/STROKEAHA.122.042290. Epub 2023 Jun 16. Stroke. 2023. PMID: 37325921

30

Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation.

Galea I, Bandyopadhyay S, Bulters D, Humar R, Hugelshofer M, Schaer DJ; SAH Delphi Group. Galea I, et al. Stroke. 2023 Jul;54(7):1930-1942. doi: 10.1161/STROKEAHA.123.040205. Epub 2023 May 26. Stroke. 2023. PMID: 37232189 Free PMC article. Review.

31

Correction: Dying transplanted neural stem cells mediate survival bystander effects in the injured brain.

Han W, Meißner EM, Neunteibl S, Günther M, Kahnt J, Dolga A, Xie C, Plesnila N, Zhu C, Blomgren K, Culmsee C. Han W, et al. Cell Death Dis. 2023 Mar 20;14(3):203. doi: 10.1038/s41419-023-05730-2. Cell Death Dis. 2023. PMID: 36941267 Free PMC article. No abstract available.

32

Dying transplanted neural stem cells mediate survival bystander effects in the injured brain.

Han W, Meißner EM, Neunteibl S, Günther M, Kahnt J, Dolga A, Xie C, Plesnila N, Zhu C, Blomgren K, Culmsee C. Han W, et al. Cell Death Dis. 2023 Mar 1;14(3):173. doi: 10.1038/s41419-023-05698-z. Cell Death Dis. 2023. PMID: 36854658 Free PMC article.

33

Hemispheric analysis of mitochondrial Complex I and II activity in the mouse model of ischemia-reperfusion-induced injury.

Bahire KL, Maļuhins R, Bello F, Freitag SV, Jeļisejevs I, Gile R, Upīte J, Plesnila N, Jansone B. Bahire KL, et al. Mitochondrion. 2023 Mar;69:147-158. doi: 10.1016/j.mito.2023.02.005. Epub 2023 Feb 9. Mitochondrion. 2023. PMID: 36764500

34

Size-Selective Transfer of Lipid Nanoparticle-Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury.

Khalin I, Adarsh N, Schifferer M, Wehn A, Groschup B, Misgeld T, Klymchenko A, Plesnila N. Khalin I, et al. Small. 2022 May;18(18):e2200302. doi: 10.1002/smll.202200302. Epub 2022 Apr 5. Small. 2022. PMID: 35384294

35

Microanatomical study of pyramidal neurons in the contralesional somatosensory cortex after experimental ischemic stroke.

Merino-Serrais P, Plaza-Alonso S, Hellal F, Valero-Freitag S, Kastanauskaite A, Muñoz A, Plesnila N, DeFelipe J. Merino-Serrais P, et al. Cereb Cortex. 2023 Feb 7;33(4):1074-1089. doi: 10.1093/cercor/bhac121. Cereb Cortex. 2023. PMID: 35353195 Free PMC article.

36

Pharmacologically targeting inflammation and improving cerebrospinal fluid circulation improves outcome after subarachnoid haemorrhage.

Zille M, Plesnila N, Boltze J. Zille M, et al. EBioMedicine. 2022 Mar;77:103937. doi: 10.1016/j.ebiom.2022.103937. Epub 2022 Mar 13. EBioMedicine. 2022. PMID: 35290830 Free PMC article. No abstract available.

37

Inhaled Nitric Oxide Treatment for Aneurysmal SAH Patients With Delayed Cerebral Ischemia.

Fung C, Z'Graggen WJ, Jakob SM, Gralla J, Haenggi M, Rothen HU, Mordasini P, Lensch M, Söll N, Terpolilli N, Feiler S, Oertel MF, Raabe A, Plesnila N, Takala J, Beck J. Fung C, et al. Front Neurol. 2022 Feb 18;13:817072. doi: 10.3389/fneur.2022.817072. eCollection 2022. Front Neurol. 2022. PMID: 35250821 Free PMC article.

38

Ca_V2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury.

Terpolilli NA, Dolp R, Waehner K, Schwarzmaier SM, Rumbler E, Todorov B, Ferrari MD, van den Maagdenberg AMJM, Plesnila N. Terpolilli NA, et al. Elife. 2022 Mar 3;11:e74923. doi: 10.7554/eLife.74923. Elife. 2022. PMID: 35238776 Free PMC article.

39

Are We Looking Into an Iron Age for Subarachnoid Hemorrhage?

Plesnila N. Plesnila N. Stroke. 2022 May;53(5):1643-1644. doi: 10.1161/STROKEAHA.121.037670. Epub 2022 Feb 24. Stroke. 2022. PMID: 35196872 No abstract available.

40

Perfusion pressure determines vascular integrity and histomorphological quality following perfusion fixation of the brain.

Schwarzmaier SM, Knarr MRO, Hu S, Ertürk A, Hellal F, Plesnila N. Schwarzmaier SM, et al. J Neurosci Methods. 2022 Apr 15;372:109493. doi: 10.1016/j.jneumeth.2022.109493. Epub 2022 Feb 10. J Neurosci Methods. 2022. PMID: 35151669

41

Adhesion of Leukocytes to Cerebral Venules Precedes Neuronal Cell Death and Is Sufficient to Trigger Tissue Damage After Cerebral Ischemia.

Sienel RI, Kataoka H, Kim SW, Seker FB, Plesnila N. Sienel RI, et al. Front Neurol. 2022 Jan 24;12:807658. doi: 10.3389/fneur.2021.807658. eCollection 2021. Front Neurol. 2022. PMID: 35140676 Free PMC article.

42

Dynamic tracing using ultra-bright labeling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers in vivo.

Khalin I, Severi C, Heimburger D, Wehn A, Hellal F, Reisch A, Klymchenko AS, Plesnila N. Khalin I, et al. Nanomedicine. 2022 Feb;40:102511. doi: 10.1016/j.nano.2021.102511. Epub 2021 Dec 13. Nanomedicine. 2022. PMID: 34915181

43

A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium-Mediated Excitotoxicity.

Chovsepian A, Berchtold D, Winek K, Mamrak U, Ramírez Álvarez I, Dening Y, Golubczyk D, Weitbrecht L, Dames C, Aillery M, Fernandez-Sanz C, Gajewski Z, Dieterich M, Janowski M, Falkai P, Walczak P, Plesnila N, Meisel A, Pan-Montojo F. Chovsepian A, et al. Adv Sci (Weinh). 2022 Feb;9(4):e2103265. doi: 10.1002/advs.202103265. Epub 2021 Dec 14. Adv Sci (Weinh). 2022. PMID: 34904402 Free PMC article.

44

Neurovascular Reactivity in the Aging Mouse Brain Assessed by Laser Speckle Contrast Imaging and 2-Photon Microscopy: Quantification by an Investigator-Independent Analysis Tool.

Seker FB, Fan Z, Gesierich B, Gaubert M, Sienel RI, Plesnila N. Seker FB, et al. Front Neurol. 2021 Nov 11;12:745770. doi: 10.3389/fneur.2021.745770. eCollection 2021. Front Neurol. 2021. PMID: 34858312 Free PMC article.

45

Immobilization of Recombinant Fluorescent Biosensors Permits Imaging of Extracellular Ion Signals.

Burgstaller S, Bischof H, Rauter T, Schmidt T, Schindl R, Patz S, Groschup B, Filser S, van den Boom L, Sasse P, Lukowski R, Plesnila N, Graier WF, Malli R. Burgstaller S, et al. ACS Sens. 2021 Nov 26;6(11):3994-4000. doi: 10.1021/acssensors.1c01369. Epub 2021 Nov 9. ACS Sens. 2021. PMID: 34752056 Free PMC article.

46

Scavenging Free Iron Reduces Arteriolar Microvasospasms After Experimental Subarachnoid Hemorrhage.

Liu H, Schwarting J, Terpolilli NA, Nehrkorn K, Plesnila N. Liu H, et al. Stroke. 2021 Dec;52(12):4033-4042. doi: 10.1161/STROKEAHA.120.033472. Epub 2021 Nov 9. Stroke. 2021. PMID: 34749506

47

The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.

Tüshaus J, Müller SA, Shrouder J, Arends M, Simons M, Plesnila N, Blobel CP, Lichtenthaler SF. Tüshaus J, et al. FASEB J. 2021 Nov;35(11):e21962. doi: 10.1096/fj.202100936R. FASEB J. 2021. PMID: 34613632 Free PMC article.

48

The Need for New Biomarkers to Assist with Stroke Prevention and Prediction of Post-Stroke Therapy Based on Plasma-Derived Extracellular Vesicles.

Driga MP, Catalin B, Olaru DG, Slowik A, Plesnila N, Hermann DM, Popa-Wagner A. Driga MP, et al. Biomedicines. 2021 Sep 15;9(9):1226. doi: 10.3390/biomedicines9091226. Biomedicines. 2021. PMID: 34572411 Free PMC article. Review.

49

Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.

Auffenberg E, Hedrich UB, Barbieri R, Miely D, Groschup B, Wuttke TV, Vogel N, Lührs P, Zanardi I, Bertelli S, Spielmann N, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Pusch M, Dichgans M, Lerche H, Gavazzo P, Plesnila N, Freilinger T. Auffenberg E, et al. J Clin Invest. 2021 Nov 1;131(21):e142202. doi: 10.1172/JCI142202. J Clin Invest. 2021. PMID: 34546973 Free PMC article.

50

Role of Pial Microvasospasms and Leukocyte Plugging for Parenchymal Perfusion after Subarachnoid Hemorrhage Assessed by In Vivo Multi-Photon Microscopy.

Schwarting J, Nehrkorn K, Liu H, Plesnila N, Terpolilli NA. Schwarting J, et al. Int J Mol Sci. 2021 Aug 6;22(16):8444. doi: 10.3390/ijms22168444. Int J Mol Sci. 2021. PMID: 34445151 Free PMC article.

51

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury.

Wehn AC, Khalin I, Duering M, Hellal F, Culmsee C, Vandenabeele P, Plesnila N, Terpolilli NA. Wehn AC, et al. Acta Neuropathol Commun. 2021 Aug 17;9(1):138. doi: 10.1186/s40478-021-01236-0. Acta Neuropathol Commun. 2021. PMID: 34404478 Free PMC article.

52

Influence of Organic Solvents on Secondary Brain Damage after Experimental Traumatic Brain Injury.

Walter J, Schwarting J, Plesnila N, Terpolilli NA. Walter J, et al. Neurotrauma Rep. 2020 Nov 6;1(1):148-156. doi: 10.1089/neur.2020.0029. eCollection 2020. Neurotrauma Rep. 2020. PMID: 34223539 Free PMC article.

53

Stroke and stroke prevention in sickle cell anemia in developed and selected developing countries.

Bhattacharya P, Sarmah D, Dave KR, Goswami A, Watanabe M, Wang X, Kalia K, Plesnila N, Yavagal DR, Alvarez O. Bhattacharya P, et al. J Neurol Sci. 2021 Aug 15;427:117510. doi: 10.1016/j.jns.2021.117510. Epub 2021 May 26. J Neurol Sci. 2021. PMID: 34077859 Review.

54

Building the Evidence Base for Treatment of Chronic Subdural Hematoma.

Marklund N, Plesnila N, Brody DL. Marklund N, et al. J Neurotrauma. 2021 Jun 1;38(11):1465-1466. doi: 10.1089/neu.2021.29107.editorial. J Neurotrauma. 2021. PMID: 34060923 No abstract available.

55

Erratum: Potassium ions promote hexokinase-II dependent glycolysis.

Bischof H, Burgstaller S, Springer A, Matt L, Rauter T, Bachkönig OA, Schmidt T, Groschner K, Schindl R, Madl T, Plesnila N, Lukowski R, Graier WF, Malli R. Bischof H, et al. iScience. 2021 May 4;24(5):102468. doi: 10.1016/j.isci.2021.102468. eCollection 2021 May 21. iScience. 2021. PMID: 34013175 Free PMC article.

56

Potassium ions promote hexokinase-II dependent glycolysis.

Bischof H, Burgstaller S, Springer A, Matt L, Rauter T, Bachkönig OA, Schmidt T, Groschner K, Schindl R, Madl T, Plesnila N, Lukowski R, Graier WF, Malli R. Bischof H, et al. iScience. 2021 Mar 22;24(4):102346. doi: 10.1016/j.isci.2021.102346. eCollection 2021 Apr 23. iScience. 2021. PMID: 33870140 Free PMC article.

57

Translational neuroimaging in mild traumatic brain injury.

Wiegand TLT, Sollmann N, Bonke EM, Umeasalugo KE, Sobolewski KR, Plesnila N, Shenton ME, Lin AP, Koerte IK. Wiegand TLT, et al. J Neurosci Res. 2022 May;100(5):1201-1217. doi: 10.1002/jnr.24840. Epub 2021 Mar 31. J Neurosci Res. 2022. PMID: 33789358 Review.

58

Acid-Ion Sensing Channel 1a Deletion Reduces Chronic Brain Damage and Neurological Deficits after Experimental Traumatic Brain Injury.

Cheng S, Mao X, Lin X, Wehn A, Hu S, Mamrak U, Khalin I, Wostrack M, Ringel F, Plesnila N, Terpolilli NA. Cheng S, et al. J Neurotrauma. 2021 Jun 1;38(11):1572-1584. doi: 10.1089/neu.2020.7568. Epub 2021 May 6. J Neurotrauma. 2021. PMID: 33779289

59

AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates PI3K-p70S6K signalling.

Pfeiffer S, Tomašcová A, Mamrak U, Haunsberger SJ, Connolly NMC, Resler A, Düssmann H, Weisová P, Jirström E, D'Orsi B, Chen G, Cremona M, Hennessy BT, Plesnila N, Prehn JHM. Pfeiffer S, et al. J Neurochem. 2021 Nov;159(4):710-728. doi: 10.1111/jnc.15347. Epub 2021 Mar 18. J Neurochem. 2021. PMID: 33694332 Free article.

60

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.

Boltze J, Aronowski JA, Badaut J, Buckwalter MS, Caleo M, Chopp M, Dave KR, Didwischus N, Dijkhuizen RM, Doeppner TR, Dreier JP, Fouad K, Gelderblom M, Gertz K, Golubczyk D, Gregson BA, Hamel E, Hanley DF, Härtig W, Hummel FC, Ikhsan M, Janowski M, Jolkkonen J, Karuppagounder SS, Keep RF, Koerte IK, Kokaia Z, Li P, Liu F, Lizasoain I, Ludewig P, Metz GAS, Montagne A, Obenaus A, Palumbo A, Pearl M, Perez-Pinzon M, Planas AM, Plesnila N, Raval AP, Rueger MA, Sansing LH, Sohrabji F, Stagg CJ, Stetler RA, Stowe AM, Sun D, Taguchi A, Tanter M, Vay SU, Vemuganti R, Vivien D, Walczak P, Wang J, Xiong Y, Zille M. Boltze J, et al. Front Aging Neurosci. 2021 Jan 28;13:623751. doi: 10.3389/fnagi.2021.623751. eCollection 2021. Front Aging Neurosci. 2021. PMID: 33584250 Free PMC article.

61

Circadian effects on stroke outcome - Did we not wake up in time for neuroprotection?

Boltze J, Didwischus N, Merrow M, Dallmann R, Plesnila N. Boltze J, et al. J Cereb Blood Flow Metab. 2021 Mar;41(3):684-686. doi: 10.1177/0271678X20978711. Epub 2020 Dec 18. J Cereb Blood Flow Metab. 2021. PMID: 33337257 Free PMC article.

62

Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice.

Lenz IJ, Plesnila N, Terpolilli NA. Lenz IJ, et al. J Cereb Blood Flow Metab. 2021 Jul;41(7):1669-1681. doi: 10.1177/0271678X20973787. Epub 2020 Nov 30. J Cereb Blood Flow Metab. 2021. PMID: 33256507 Free PMC article.

63

Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model.

Ramírez-Fernández A, Urbina-Treviño L, Conte G, Alves M, Rissiek B, Durner A, Scalbert N, Zhang J, Magnus T, Koch-Nolte F, Plesnila N, Deussing JM, Engel T, Kopp R, Nicke A. Ramírez-Fernández A, et al. Sci Rep. 2020 Nov 16;10(1):19876. doi: 10.1038/s41598-020-76428-0. Sci Rep. 2020. PMID: 33199725 Free PMC article.

64

Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span.

Rauen K, Späni CB, Tartaglia MC, Ferretti MT, Reichelt L, Probst P, Schäpers B, Müller F, Jahn K, Plesnila N. Rauen K, et al. Geroscience. 2021 Feb;43(1):263-278. doi: 10.1007/s11357-020-00273-2. Epub 2020 Oct 17. Geroscience. 2021. PMID: 33070278 Free PMC article.

65

Access to data from clinical trials in the COVID-19 crisis: open, flexible, and time-sensitive.

Ewers M, Ioannidis JPA, Plesnila N. Ewers M, et al. J Clin Epidemiol. 2021 Feb;130:143-146. doi: 10.1016/j.jclinepi.2020.10.008. Epub 2020 Oct 14. J Clin Epidemiol. 2021. PMID: 33068714 Free PMC article. No abstract available.

66

Longitudinal Characterization of Blood-Brain Barrier Permeability after Experimental Traumatic Brain Injury by In Vivo 2-Photon Microscopy.

Hu Y, Seker B, Exner C, Zhang J, Plesnila N, Schwarzmaier SM. Hu Y, et al. J Neurotrauma. 2021 Feb 15;38(4):399-410. doi: 10.1089/neu.2020.7271. Epub 2020 Oct 30. J Neurotrauma. 2021. PMID: 33012249

67

Contusion Rodent Model of Traumatic Brain Injury: Controlled Cortical Impact.

Fournier ML, Clément T, Aussudre J, Plesnila N, Obenaus A, Badaut J. Fournier ML, et al. Methods Mol Biol. 2021;2193:49-65. doi: 10.1007/978-1-0716-0845-6_6. Methods Mol Biol. 2021. PMID: 32808258

68

Decompressive Craniectomy Is Associated With Good Quality of Life Up to 10 Years After Rehabilitation From Traumatic Brain Injury.

Rauen K, Reichelt L, Probst P, Schäpers B, Müller F, Jahn K, Plesnila N. Rauen K, et al. Crit Care Med. 2020 Aug;48(8):1157-1164. doi: 10.1097/CCM.0000000000004387. Crit Care Med. 2020. PMID: 32697486

69

Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain.

Khalin I, Heimburger D, Melnychuk N, Collot M, Groschup B, Hellal F, Reisch A, Plesnila N, Klymchenko AS. Khalin I, et al. ACS Nano. 2020 Aug 25;14(8):9755-9770. doi: 10.1021/acsnano.0c01505. Epub 2020 Jul 28. ACS Nano. 2020. PMID: 32680421

70

Quality of life up to 10 years after traumatic brain injury: a cross-sectional analysis.

Rauen K, Reichelt L, Probst P, Schäpers B, Müller F, Jahn K, Plesnila N. Rauen K, et al. Health Qual Life Outcomes. 2020 Jun 4;18(1):166. doi: 10.1186/s12955-020-01391-3. Health Qual Life Outcomes. 2020. PMID: 32498679 Free PMC article.

71

Systematic Review and Meta-analysis of Methodological Quality in In Vivo Animal Studies of Subarachnoid Hemorrhage.

Grüter BE, Croci D, Schöpf S, Nevzati E, d'Allonzo D, Lattmann J, Roth T, Bircher B, Muroi C, Dutilh G, Widmer HR, Plesnila N, Fandino J, Marbacher S. Grüter BE, et al. Transl Stroke Res. 2020 Dec;11(6):1175-1184. doi: 10.1007/s12975-020-00801-4. Epub 2020 Mar 15. Transl Stroke Res. 2020. PMID: 32172515 Free article.

72

Progressive Histopathological Damage Occurring Up to One Year after Experimental Traumatic Brain Injury Is Associated with Cognitive Decline and Depression-Like Behavior.

Mao X, Terpolilli NA, Wehn A, Cheng S, Hellal F, Liu B, Seker B, Plesnila N. Mao X, et al. J Neurotrauma. 2020 Jun 1;37(11):1331-1341. doi: 10.1089/neu.2019.6510. Epub 2020 Feb 5. J Neurotrauma. 2020. PMID: 31847690

73

Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect.

Panahpour H, Terpolilli NA, Schaffert D, Culmsee C, Plesnila N. Panahpour H, et al. Front Neurol. 2019 Sep 4;10:942. doi: 10.3389/fneur.2019.00942. eCollection 2019. Front Neurol. 2019. PMID: 31551909 Free PMC article.

74

Vasopressin V_1a Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury.

Rauen K, Pop V, Trabold R, Badaut J, Plesnila N. Rauen K, et al. J Neurotrauma. 2020 Feb 15;37(4):665-674. doi: 10.1089/neu.2019.6653. Epub 2019 Dec 4. J Neurotrauma. 2020. PMID: 31547764 Free PMC article.

75

Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice.

Zvejniece L, Stelfa G, Vavers E, Kupats E, Kuka J, Svalbe B, Zvejniece B, Albert-Weissenberger C, Sirén AL, Plesnila N, Dambrova M. Zvejniece L, et al. J Neurotrauma. 2020 Jan 15;37(2):295-304. doi: 10.1089/neu.2019.6524. Epub 2019 Nov 8. J Neurotrauma. 2020. PMID: 31441378 Free PMC article.

76

Long-term impairment of neurovascular coupling following experimental subarachnoid hemorrhage.

Balbi M, Vega MJ, Lourbopoulos A, Terpolilli NA, Plesnila N. Balbi M, et al. J Cereb Blood Flow Metab. 2020 Jun;40(6):1193-1202. doi: 10.1177/0271678X19863021. Epub 2019 Jul 11. J Cereb Blood Flow Metab. 2020. PMID: 31296132 Free PMC article.

77

Plasminogen activator inhibitor-1 augments damage by impairing fibrinolysis after traumatic brain injury.

Griemert EV, Schwarzmaier SM, Hummel R, Gölz C, Yang D, Neuhaus W, Burek M, Förster CY, Petkovic I, Trabold R, Plesnila N, Engelhard K, Schäfer MK, Thal SC. Griemert EV, et al. Ann Neurol. 2019 May;85(5):667-680. doi: 10.1002/ana.25458. Epub 2019 Mar 30. Ann Neurol. 2019. PMID: 30843275 Free PMC article.

78

Capillary flow disturbances after experimental subarachnoid hemorrhage: A contributor to delayed cerebral ischemia?

Anzabi M, Angleys H, Aamand R, Ardalan M, Mouridsen K, Rasmussen PM, Sørensen JCH, Plesnila N, Østergaard L, Iversen NK. Anzabi M, et al. Microcirculation. 2019 Apr;26(3):e12516. doi: 10.1111/micc.12516. Epub 2019 Mar 7. Microcirculation. 2019. PMID: 30431201

79

Cross-talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury.

Frik J, Merl-Pham J, Plesnila N, Mattugini N, Kjell J, Kraska J, Gómez RM, Hauck SM, Sirko S, Götz M. Frik J, et al. EMBO Rep. 2018 May;19(5):e45294. doi: 10.15252/embr.201745294. Epub 2018 Apr 9. EMBO Rep. 2018. PMID: 29632244 Free PMC article.

80

Microvasospasms After Experimental Subarachnoid Hemorrhage Do Not Depend on Endothelin A Receptors.

Liu H, Dienel A, Schöller K, Schwarzmaier SM, Nehrkorn K, Plesnila N, Terpolilli NA. Liu H, et al. Stroke. 2018 Mar;49(3):693-699. doi: 10.1161/STROKEAHA.117.020028. Epub 2018 Feb 8. Stroke. 2018. PMID: 29438081

81

Cylindromatosis mediates neuronal cell death in vitro and in vivo.

Ganjam GK, Terpolilli NA, Diemert S, Eisenbach I, Hoffmann L, Reuther C, Herden C, Roth J, Plesnila N, Culmsee C. Ganjam GK, et al. Cell Death Differ. 2018 Aug;25(8):1394-1407. doi: 10.1038/s41418-017-0046-7. Epub 2018 Jan 19. Cell Death Differ. 2018. PMID: 29352268 Free PMC article.

82

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo.

Bischof H, Rehberg M, Stryeck S, Artinger K, Eroglu E, Waldeck-Weiermair M, Gottschalk B, Rost R, Deak AT, Niedrist T, Vujic N, Lindermuth H, Prassl R, Pelzmann B, Groschner K, Kratky D, Eller K, Rosenkranz AR, Madl T, Plesnila N, Graier WF, Malli R. Bischof H, et al. Nat Commun. 2017 Nov 10;8(1):1422. doi: 10.1038/s41467-017-01615-z. Nat Commun. 2017. PMID: 29127288 Free PMC article.

83

Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4^-/- Mice.

Krieg SM, Voigt F, Knuefermann P, Kirschning CJ, Plesnila N, Ringel F. Krieg SM, et al. Front Neurol. 2017 Aug 30;8:455. doi: 10.3389/fneur.2017.00455. eCollection 2017. Front Neurol. 2017. PMID: 28912751 Free PMC article.

84

The choroid plexus is a key cerebral invasion route for T cells after stroke.

Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I, Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A. Llovera G, et al. Acta Neuropathol. 2017 Dec;134(6):851-868. doi: 10.1007/s00401-017-1758-y. Epub 2017 Jul 31. Acta Neuropathol. 2017. PMID: 28762187 Free article.

85

RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke.

Tiedt S, Prestel M, Malik R, Schieferdecker N, Duering M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, Dorn F, Krohn K, Teupser D, Liesz A, Plesnila N, Holdt LM, Dichgans M. Tiedt S, et al. Circ Res. 2017 Sep 29;121(8):970-980. doi: 10.1161/CIRCRESAHA.117.311572. Epub 2017 Jul 19. Circ Res. 2017. PMID: 28724745

86

Inversion of neurovascular coupling after subarachnoid hemorrhage in vivo.

Balbi M, Koide M, Wellman GC, Plesnila N. Balbi M, et al. J Cereb Blood Flow Metab. 2017 Nov;37(11):3625-3634. doi: 10.1177/0271678X16686595. Epub 2017 Jan 23. J Cereb Blood Flow Metab. 2017. PMID: 28112024 Free PMC article.

87

Recent progress in translational research on neurovascular and neurodegenerative disorders.

Demuth HU, Dijkhuizen RM, Farr TD, Gelderblom M, Horsburgh K, Iadecola C, Mcleod DD, Michalski D, Murphy TH, Orbe J, Otte WM, Petzold GC, Plesnila N, Reiser G, Reymann KG, Rueger MA, Saur D, Savitz SI, Schilling S, Spratt NJ, Turner RJ, Vemuganti R, Vivien D, Yepes M, Zille M, Boltze J; ISN&N meeting contributors. Demuth HU, et al. Restor Neurol Neurosci. 2017;35(1):87-103. doi: 10.3233/RNN-160690. Restor Neurol Neurosci. 2017. PMID: 28059802 Free PMC article. Review.

88

Time-Dependent Effects of Arginine-Vasopressin V1 Receptor Inhibition on Secondary Brain Damage after Traumatic Brain Injury.

Krieg SM, Trabold R, Plesnila N. Krieg SM, et al. J Neurotrauma. 2017 Apr 1;34(7):1329-1336. doi: 10.1089/neu.2016.4514. Epub 2016 Dec 6. J Neurotrauma. 2017. PMID: 27762660

89

Shrinkage-mediated imaging of entire organs and organisms using uDISCO.

Pan C, Cai R, Quacquarelli FP, Ghasemigharagoz A, Lourbopoulos A, Matryba P, Plesnila N, Dichgans M, Hellal F, Ertürk A. Pan C, et al. Nat Methods. 2016 Oct;13(10):859-67. doi: 10.1038/nmeth.3964. Epub 2016 Aug 22. Nat Methods. 2016. PMID: 27548807

90

Inadequate food and water intake determine mortality following stroke in mice.

Lourbopoulos A, Mamrak U, Roth S, Balbi M, Shrouder J, Liesz A, Hellal F, Plesnila N. Lourbopoulos A, et al. J Cereb Blood Flow Metab. 2017 Jun;37(6):2084-2097. doi: 10.1177/0271678X16660986. Epub 2016 Jan 1. J Cereb Blood Flow Metab. 2017. PMID: 27449604 Free PMC article.

91

Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines.

Boltze J, Wagner DC, Henninger N, Plesnila N, Ayata C. Boltze J, et al. Transl Stroke Res. 2016 Aug;7(4):241-7. doi: 10.1007/s12975-016-0474-6. Epub 2016 Jun 14. Transl Stroke Res. 2016. PMID: 27297402 Free PMC article.

92

Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons.

Osterstock G, Mitutsova V, Barre A, Granier M, Fontanaud P, Chazalon M, Carmignac D, Robinson IC, Low MJ, Plesnila N, Hodson DJ, Mollard P, Méry PF. Osterstock G, et al. Sci Rep. 2016 Apr 13;6:24394. doi: 10.1038/srep24394. Sci Rep. 2016. PMID: 27072430 Free PMC article.

93

The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI.

Schwarzmaier SM, de Chaumont C, Balbi M, Terpolilli NA, Kleinschnitz C, Gruber A, Plesnila N. Schwarzmaier SM, et al. J Neurotrauma. 2016 Sep 1;33(17):1634-44. doi: 10.1089/neu.2015.4173. Epub 2016 Feb 17. J Neurotrauma. 2016. PMID: 26886854 Free PMC article.

94

Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo.

Balbi M, Koide M, Schwarzmaier SM, Wellman GC, Plesnila N. Balbi M, et al. J Cereb Blood Flow Metab. 2017 Jan;37(1):178-187. doi: 10.1177/0271678X15621253. Epub 2015 Dec 16. J Cereb Blood Flow Metab. 2017. PMID: 26676226 Free PMC article.

95

Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms.

Terpolilli NA, Feiler S, Dienel A, Müller F, Heumos N, Friedrich B, Stover J, Thal S, Schöller K, Plesnila N. Terpolilli NA, et al. J Cereb Blood Flow Metab. 2016 Dec;36(12):2096-2107. doi: 10.1177/0271678X15605848. Epub 2015 Nov 2. J Cereb Blood Flow Metab. 2016. PMID: 26661144 Free PMC article.

96

The immune system in traumatic brain injury.

Plesnila N. Plesnila N. Curr Opin Pharmacol. 2016 Feb;26:110-7. doi: 10.1016/j.coph.2015.10.008. Epub 2015 Nov 21. Curr Opin Pharmacol. 2016. PMID: 26613129 Review.

97

Temporal Profile of MicroRNA Expression in Contused Cortex after Traumatic Brain Injury in Mice.

Meissner L, Gallozzi M, Balbi M, Schwarzmaier S, Tiedt S, Terpolilli NA, Plesnila N. Meissner L, et al. J Neurotrauma. 2016 Apr 15;33(8):713-20. doi: 10.1089/neu.2015.4077. Epub 2015 Dec 23. J Neurotrauma. 2016. PMID: 26426744

98

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Ghosh M, Balbi M, Hellal F, Dichgans M, Lindauer U, Plesnila N. Ghosh M, et al. Ann Neurol. 2015 Dec;78(6):887-900. doi: 10.1002/ana.24512. Epub 2015 Oct 7. Ann Neurol. 2015. PMID: 26312599

99

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A. Llovera G, et al. Sci Transl Med. 2015 Aug 5;7(299):299ra121. doi: 10.1126/scitranslmed.aaa9853. Sci Transl Med. 2015. PMID: 26246166

100

Are We Barking Up the Wrong Vessels? Cerebral Microcirculation After Subarachnoid Hemorrhage.

Terpolilli NA, Brem C, Bühler D, Plesnila N. Terpolilli NA, et al. Stroke. 2015 Oct;46(10):3014-9. doi: 10.1161/STROKEAHA.115.006353. Epub 2015 Jul 7. Stroke. 2015. PMID: 26152299 Review. No abstract available.

101

Dysfunction of mouse cerebral arteries during early aging.

Balbi M, Ghosh M, Longden TA, Jativa Vega M, Gesierich B, Hellal F, Lourbopoulos A, Nelson MT, Plesnila N. Balbi M, et al. J Cereb Blood Flow Metab. 2015 Sep;35(9):1445-53. doi: 10.1038/jcbfm.2015.107. Epub 2015 Jun 10. J Cereb Blood Flow Metab. 2015. PMID: 26058694 Free PMC article.

102

Applying the retro-enantio approach to obtain a peptide capable of overcoming the blood-brain barrier.

Prades R, Oller-Salvia B, Schwarzmaier SM, Selva J, Moros M, Balbi M, Grazú V, de La Fuente JM, Egea G, Plesnila N, Teixidó M, Giralt E. Prades R, et al. Angew Chem Int Ed Engl. 2015 Mar 23;54(13):3967-72. doi: 10.1002/anie.201411408. Epub 2015 Feb 4. Angew Chem Int Ed Engl. 2015. PMID: 25650865

103

Bax regulates neuronal Ca2+ homeostasis.

D'Orsi B, Kilbride SM, Chen G, Perez Alvarez S, Bonner HP, Pfeiffer S, Plesnila N, Engel T, Henshall DC, Düssmann H, Prehn JH. D'Orsi B, et al. J Neurosci. 2015 Jan 28;35(4):1706-22. doi: 10.1523/JNEUROSCI.2453-14.2015. J Neurosci. 2015. PMID: 25632145 Free PMC article.

104

Effect of decompressive craniectomy on outcome following subarachnoid hemorrhage in mice.

Bühler D, Azghandi S, Schüller K, Plesnila N. Bühler D, et al. Stroke. 2015 Mar;46(3):819-26. doi: 10.1161/STROKEAHA.114.007703. Epub 2015 Jan 15. Stroke. 2015. PMID: 25593134

105

Identification of the Vascular Source of Vasogenic Brain Edema following Traumatic Brain Injury Using In Vivo 2-Photon Microscopy in Mice.

Schwarzmaier SM, Gallozzi M, Plesnila N. Schwarzmaier SM, et al. J Neurotrauma. 2015 Jul 1;32(13):990-1000. doi: 10.1089/neu.2014.3775. Epub 2015 Apr 15. J Neurotrauma. 2015. PMID: 25585052

106

Contributions of the immune system to the pathophysiology of traumatic brain injury - evidence by intravital microscopy.

Schwarzmaier SM, Plesnila N. Schwarzmaier SM, et al. Front Cell Neurosci. 2014 Nov 4;8:358. doi: 10.3389/fncel.2014.00358. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25408636 Free PMC article. Review.

107

Endothelial nitric oxide synthase mediates arteriolar vasodilatation after traumatic brain injury in mice.

Schwarzmaier SM, Terpolilli NA, Dienel A, Gallozzi M, Schinzel R, Tegtmeier F, Plesnila N. Schwarzmaier SM, et al. J Neurotrauma. 2015 May 15;32(10):731-8. doi: 10.1089/neu.2014.3650. Epub 2015 Feb 25. J Neurotrauma. 2015. PMID: 25363688

108

The neuroprotective effect of 17β-estradiol is independent of its antioxidative properties.

Gröger M, Plesnila N. Gröger M, et al. Brain Res. 2014 Nov 17;1589:61-7. doi: 10.1016/j.brainres.2014.08.029. Epub 2014 Aug 20. Brain Res. 2014. PMID: 25148707

109

Modeling stroke in mice: permanent coagulation of the distal middle cerebral artery.

Llovera G, Roth S, Plesnila N, Veltkamp R, Liesz A. Llovera G, et al. J Vis Exp. 2014 Jul 31;(89):e51729. doi: 10.3791/51729. J Vis Exp. 2014. PMID: 25145316 Free PMC article.

110

Protocol for the induction of subarachnoid hemorrhage in mice by perforation of the Circle of Willis with an endovascular filament.

Bühler D, Schüller K, Plesnila N. Bühler D, et al. Transl Stroke Res. 2014 Dec;5(6):653-9. doi: 10.1007/s12975-014-0366-6. Epub 2014 Aug 16. Transl Stroke Res. 2014. PMID: 25123204 Free PMC article.

111

Effect of small molecule vasopressin V1a and V2 receptor antagonists on brain edema formation and secondary brain damage following traumatic brain injury in mice.

Krieg SM, Sonanini S, Plesnila N, Trabold R. Krieg SM, et al. J Neurotrauma. 2015 Feb 15;32(4):221-7. doi: 10.1089/neu.2013.3274. Epub 2014 Dec 16. J Neurotrauma. 2015. PMID: 25111427 Free PMC article.

112

CO2 has no therapeutic effect on early microvasospasm after experimental subarachnoid hemorrhage.

Friedrich B, Michalik R, Oniszczuk A, Abubaker K, Kozniewska E, Plesnila N. Friedrich B, et al. J Cereb Blood Flow Metab. 2014 Aug;34(8):e1-6. doi: 10.1038/jcbfm.2014.96. Epub 2014 May 28. J Cereb Blood Flow Metab. 2014. PMID: 24865999 Free PMC article.

113

Sustained alterations of hypothalamic tanycytes during posttraumatic hypopituitarism in male mice.

Osterstock G, El Yandouzi T, Romanò N, Carmignac D, Langlet F, Coutry N, Guillou A, Schaeffer M, Chauvet N, Vanacker C, Galibert E, Dehouck B, Robinson IC, Prévot V, Mollard P, Plesnila N, Méry PF. Osterstock G, et al. Endocrinology. 2014 May;155(5):1887-98. doi: 10.1210/en.2013-1336. Epub 2014 Mar 6. Endocrinology. 2014. PMID: 24601879

114

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.

Dolga AM, de Andrade A, Meissner L, Knaus HG, Höllerhage M, Christophersen P, Zischka H, Plesnila N, Höglinger GU, Culmsee C. Dolga AM, et al. Cell Death Dis. 2014 Jan 16;5(1):e999. doi: 10.1038/cddis.2013.530. Cell Death Dis. 2014. PMID: 24434522 Free PMC article.

115

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress.

Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C. Doti N, et al. Cell Death Dis. 2014 Jan 16;5(1):e993. doi: 10.1038/cddis.2013.518. Cell Death Dis. 2014. PMID: 24434516 Free PMC article.

116

Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines.

Boltze J, Ayata C, Wagner DC, Plesnila N. Boltze J, et al. Stroke. 2014 Feb;45(2):357. doi: 10.1161/STROKEAHA.113.004148. Epub 2014 Jan 9. Stroke. 2014. PMID: 24407954 Free PMC article. No abstract available.

117

Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury.

Zhu C, Sun Y, Gao J, Wang X, Plesnila N, Blomgren K. Zhu C, et al. Transl Stroke Res. 2013 Apr;4(2):201-7. doi: 10.1007/s12975-012-0217-2. Epub 2012 Oct 20. Transl Stroke Res. 2013. PMID: 24323275

118

A murine model of subarachnoid hemorrhage.

Schüller K, Bühler D, Plesnila N. Schüller K, et al. J Vis Exp. 2013 Nov 21;(81):e50845. doi: 10.3791/50845. J Vis Exp. 2013. PMID: 24300521 Free PMC article.

119

A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies.

Schmitt S, Saathoff F, Meissner L, Schropp EM, Lichtmannegger J, Schulz S, Eberhagen C, Borchard S, Aichler M, Adamski J, Plesnila N, Rothenfusser S, Kroemer G, Zischka H. Schmitt S, et al. Anal Biochem. 2013 Dec 1;443(1):66-74. doi: 10.1016/j.ab.2013.08.007. Epub 2013 Aug 19. Anal Biochem. 2013. PMID: 23969012

120

The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo.

McFadden TM, Duffy GP, Allen AB, Stevens HY, Schwarzmaier SM, Plesnila N, Murphy JM, Barry FP, Guldberg RE, O'Brien FJ. McFadden TM, et al. Acta Biomater. 2013 Dec;9(12):9303-16. doi: 10.1016/j.actbio.2013.08.014. Epub 2013 Aug 17. Acta Biomater. 2013. PMID: 23958783

121

Pathophysiological Role of Global Cerebral Ischemia following Subarachnoid Hemorrhage: The Current Experimental Evidence.

Plesnila N. Plesnila N. Stroke Res Treat. 2013;2013:651958. doi: 10.1155/2013/651958. Epub 2013 Jun 12. Stroke Res Treat. 2013. PMID: 23844316 Free PMC article.

122

Bradykinin in blood and cerebrospinal fluid after acute cerebral lesions: correlations with cerebral edema and intracranial pressure.

Kunz M, Nussberger J, Holtmannspötter M, Bitterling H, Plesnila N, Zausinger S. Kunz M, et al. J Neurotrauma. 2013 Oct 1;30(19):1638-44. doi: 10.1089/neu.2012.2774. J Neurotrauma. 2013. PMID: 23638655

123

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].

Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M. Sirko S, et al. Cell Stem Cell. 2013 Apr 4;12(4):426-39. doi: 10.1016/j.stem.2013.01.019. Cell Stem Cell. 2013. PMID: 23561443 Free article.

124

In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice.

Schwarzmaier SM, Zimmermann R, McGarry NB, Trabold R, Kim SW, Plesnila N. Schwarzmaier SM, et al. J Neuroinflammation. 2013 Feb 28;10:32. doi: 10.1186/1742-2094-10-32. J Neuroinflammation. 2013. PMID: 23448240 Free PMC article.

125

Arginine vasopressin V1a receptor-deficient mice have reduced brain edema and secondary brain damage following traumatic brain injury.

Rauen K, Trabold R, Brem C, Terpolilli NA, Plesnila N. Rauen K, et al. J Neurotrauma. 2013 Aug 15;30(16):1442-8. doi: 10.1089/neu.2012.2807. Epub 2013 Jul 20. J Neurotrauma. 2013. PMID: 23441636

126

Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.

Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C. Dolga AM, et al. J Biol Chem. 2013 Apr 12;288(15):10792-804. doi: 10.1074/jbc.M113.453522. Epub 2013 Feb 19. J Biol Chem. 2013. PMID: 23430260 Free PMC article.

127

Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice.

Terpolilli NA, Kim SW, Thal SC, Kuebler WM, Plesnila N. Terpolilli NA, et al. J Cereb Blood Flow Metab. 2013 Feb;33(2):311-8. doi: 10.1038/jcbfm.2012.176. Epub 2012 Nov 28. J Cereb Blood Flow Metab. 2013. PMID: 23188422 Free PMC article.

128

[Experimental therapy approaches for ischemic stroke].

Kleinschnitz C, Plesnila N. Kleinschnitz C, et al. Nervenarzt. 2012 Oct;83(10):1275-81. doi: 10.1007/s00115-012-3536-3. Nervenarzt. 2012. PMID: 23015194 Review. German.

129

Connexin 36 promotes cortical spreading depolarization and ischemic brain damage.

Bargiotas P, Muhammad S, Rahman M, Jakob N, Trabold R, Fuchs E, Schilling L, Plesnila N, Monyer H, Schwaninger M. Bargiotas P, et al. Brain Res. 2012 Oct 15;1479:80-5. doi: 10.1016/j.brainres.2012.08.046. Epub 2012 Aug 31. Brain Res. 2012. PMID: 22960118

130

Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function.

Neye N, Enigk F, Shiva S, Habazettl H, Plesnila N, Kuppe H, Gladwin MT, Kuebler WM. Neye N, et al. Intensive Care Med. 2012 Aug;38(8):1381-91. doi: 10.1007/s00134-012-2605-1. Epub 2012 Jun 1. Intensive Care Med. 2012. PMID: 22653370

131

Impact of anesthesia on pathophysiology and mortality following subarachnoid hemorrhage in rats.

Hockel K, Trabold R, Schöller K, Török E, Plesnila N. Hockel K, et al. Exp Transl Stroke Med. 2012 Mar 13;4(1):5. doi: 10.1186/2040-7378-4-5. Exp Transl Stroke Med. 2012. PMID: 22414527 Free PMC article.

132

Inhibition of Drp1 provides neuroprotection in vitro and in vivo.

Grohm J, Kim SW, Mamrak U, Tobaben S, Cassidy-Stone A, Nunnari J, Plesnila N, Culmsee C. Grohm J, et al. Cell Death Differ. 2012 Sep;19(9):1446-58. doi: 10.1038/cdd.2012.18. Epub 2012 Mar 2. Cell Death Differ. 2012. PMID: 22388349 Free PMC article.

133

Paving the road to translation.

Plesnila N. Plesnila N. Cerebrovasc Dis. 2012;33(4):340. doi: 10.1159/000336857. Epub 2012 Feb 16. Cerebrovasc Dis. 2012. PMID: 22343133 Free article. No abstract available.

134

Nitric oxide: considerations for the treatment of ischemic stroke.

Terpolilli NA, Moskowitz MA, Plesnila N. Terpolilli NA, et al. J Cereb Blood Flow Metab. 2012 Jul;32(7):1332-46. doi: 10.1038/jcbfm.2012.12. Epub 2012 Feb 15. J Cereb Blood Flow Metab. 2012. PMID: 22333622 Free PMC article. Review.

135

Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles.

Terpolilli NA, Kim SW, Thal SC, Kataoka H, Zeisig V, Nitzsche B, Klaesner B, Zhu C, Schwarzmaier S, Meissner L, Mamrak U, Engel DC, Drzezga A, Patel RP, Blomgren K, Barthel H, Boltze J, Kuebler WM, Plesnila N. Terpolilli NA, et al. Circ Res. 2012 Mar 2;110(5):727-38. doi: 10.1161/CIRCRESAHA.111.253419. Epub 2011 Dec 29. Circ Res. 2012. PMID: 22207711

136

Experimental subarachnoid hemorrhage causes early and long-lasting microarterial constriction and microthrombosis: an in-vivo microscopy study.

Friedrich B, Müller F, Feiler S, Schöller K, Plesnila N. Friedrich B, et al. J Cereb Blood Flow Metab. 2012 Mar;32(3):447-55. doi: 10.1038/jcbfm.2011.154. Epub 2011 Dec 7. J Cereb Blood Flow Metab. 2012. PMID: 22146194 Free PMC article.

137

Vasopressin V(1a) receptors mediate posthemorrhagic systemic hypertension thereby determining rebleeding rate and outcome after experimental subarachnoid hemorrhage.

Hockel K, Schöller K, Trabold R, Nussberger J, Plesnila N. Hockel K, et al. Stroke. 2012 Jan;43(1):227-32. doi: 10.1161/STROKEAHA.111.626168. Epub 2011 Oct 13. Stroke. 2012. PMID: 21998059

138

Contribution of matrix metalloproteinase-9 to cerebral edema and functional outcome following experimental subarachnoid hemorrhage.

Feiler S, Plesnila N, Thal SC, Zausinger S, Schöller K. Feiler S, et al. Cerebrovasc Dis. 2011;32(3):289-95. doi: 10.1159/000328248. Epub 2011 Sep 9. Cerebrovasc Dis. 2011. PMID: 21912109

139

Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice.

Thal SE, Zhu C, Thal SC, Blomgren K, Plesnila N. Thal SE, et al. Neurosci Lett. 2011 Jul 15;499(1):1-3. doi: 10.1016/j.neulet.2011.05.016. Epub 2011 May 14. Neurosci Lett. 2011. PMID: 21616126

140

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus HG, D'Orsi B, Prehn JH, Eisel UL, Plant T, Plesnila N, Culmsee C. Dolga AM, et al. Cell Death Dis. 2011 Apr 21;2(4):e147. doi: 10.1038/cddis.2011.30. Cell Death Dis. 2011. PMID: 21509037 Free PMC article.

141

In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury.

Engel T, Plesnila N, Prehn JH, Henshall DC. Engel T, et al. J Cereb Blood Flow Metab. 2011 May;31(5):1196-210. doi: 10.1038/jcbfm.2011.26. Epub 2011 Mar 2. J Cereb Blood Flow Metab. 2011. PMID: 21364604 Free PMC article. Review.

142

Fluid resuscitation after traumatic brain injury with hypovolemic shock: still a bloody business?

Plesnila N. Plesnila N. Crit Care Med. 2011 Mar;39(3):592-3. doi: 10.1097/CCM.0b013e31820a4f50. Crit Care Med. 2011. PMID: 21330861 No abstract available.

143

Contribution of bradykinin receptors to the development of secondary brain damage after experimental subarachnoid hemorrhage.

Schöller K, Feiler S, Anetsberger S, Kim SW, Plesnila N. Schöller K, et al. Neurosurgery. 2011 Apr;68(4):1118-23. doi: 10.1227/NEU.0b013e31820a0024. Neurosurgery. 2011. PMID: 21242838

144

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

Massie A, Schallier A, Kim SW, Fernando R, Kobayashi S, Beck H, De Bundel D, Vermoesen K, Bannai S, Smolders I, Conrad M, Plesnila N, Sato H, Michotte Y. Massie A, et al. FASEB J. 2011 Apr;25(4):1359-69. doi: 10.1096/fj.10-177212. Epub 2010 Dec 29. FASEB J. 2011. PMID: 21191088

145

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons.

Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C. Tobaben S, et al. Cell Death Differ. 2011 Feb;18(2):282-92. doi: 10.1038/cdd.2010.92. Epub 2010 Aug 6. Cell Death Differ. 2011. PMID: 20689558 Free PMC article.

146

Characterization of a 3-vessel occlusion model for the induction of complete global cerebral ischemia in mice.

Thal SC, Thal SE, Plesnila N. Thal SC, et al. J Neurosci Methods. 2010 Oct 15;192(2):219-27. doi: 10.1016/j.jneumeth.2010.07.032. Epub 2010 Aug 3. J Neurosci Methods. 2010. PMID: 20688105

147

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor.

Engel T, Caballero-Caballero A, Schindler CK, Plesnila N, Strasser A, Prehn JH, Henshall DC. Engel T, et al. J Neurochem. 2010 Oct;115(1):92-101. doi: 10.1111/j.1471-4159.2010.06909.x. Epub 2010 Jul 30. J Neurochem. 2010. PMID: 20646170 Free article.

148

Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring.

Feiler S, Friedrich B, Schöller K, Thal SC, Plesnila N. Feiler S, et al. J Neurosci Methods. 2010 Jul 15;190(2):164-70. doi: 10.1016/j.jneumeth.2010.05.005. Epub 2010 May 10. J Neurosci Methods. 2010. PMID: 20457182

149

High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice.

van den Maagdenberg AM, Pizzorusso T, Kaja S, Terpolilli N, Shapovalova M, Hoebeek FE, Barrett CF, Gherardini L, van de Ven RC, Todorov B, Broos LA, Tottene A, Gao Z, Fodor M, De Zeeuw CI, Frants RR, Plesnila N, Plomp JJ, Pietrobon D, Ferrari MD. van den Maagdenberg AM, et al. Ann Neurol. 2010 Jan;67(1):85-98. doi: 10.1002/ana.21815. Ann Neurol. 2010. PMID: 20186955

150

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death.

Grohm J, Plesnila N, Culmsee C. Grohm J, et al. Brain Behav Immun. 2010 Jul;24(5):831-8. doi: 10.1016/j.bbi.2009.11.015. Epub 2009 Dec 2. Brain Behav Immun. 2010. PMID: 19961923

151

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo.

Cardoso AL, Costa P, de Almeida LP, Simões S, Plesnila N, Culmsee C, Wagner E, de Lima MC. Cardoso AL, et al. J Control Release. 2010 Mar 19;142(3):392-403. doi: 10.1016/j.jconrel.2009.11.004. Epub 2009 Nov 11. J Control Release. 2010. PMID: 19913061

152

Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice.

Schwarzmaier SM, Kim SW, Trabold R, Plesnila N. Schwarzmaier SM, et al. J Neurotrauma. 2010 Jan;27(1):121-30. doi: 10.1089/neu.2009.1114. J Neurotrauma. 2010. PMID: 19803784

153

The role of bradykinin B(1) and B(2) receptors for secondary brain damage after traumatic brain injury in mice.

Trabold R, Erös C, Zweckberger K, Relton J, Beck H, Nussberger J, Müller-Esterl W, Bader M, Whalley E, Plesnila N. Trabold R, et al. J Cereb Blood Flow Metab. 2010 Jan;30(1):130-9. doi: 10.1038/jcbfm.2009.196. Epub 2009 Sep 23. J Cereb Blood Flow Metab. 2010. PMID: 19773800 Free PMC article.

154

Level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig depend on the stimulus frequency.

Olzowy B, von Gleichenstein G, Canis M, Plesnila N, Strieth S, Deppe C, Mees K. Olzowy B, et al. Eur Arch Otorhinolaryngol. 2010 Mar;267(3):351-5. doi: 10.1007/s00405-009-1052-2. Epub 2009 Jul 21. Eur Arch Otorhinolaryngol. 2010. PMID: 19629511

155

Mild hypothermia (33 degrees C) reduces intracranial hypertension and improves functional outcome after subarachnoid hemorrhage in rats.

Török E, Klopotowski M, Trabold R, Thal SC, Plesnila N, Schöller K. Török E, et al. Neurosurgery. 2009 Aug;65(2):352-9; discussion 359. doi: 10.1227/01.NEU.0000345632.09882.FF. Neurosurgery. 2009. PMID: 19625915

156

The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice.

Terpolilli NA, Zweckberger K, Trabold R, Schilling L, Schinzel R, Tegtmeier F, Plesnila N. Terpolilli NA, et al. J Neurotrauma. 2009 Nov;26(11):1963-75. doi: 10.1089/neu.2008.0853. J Neurotrauma. 2009. PMID: 19514849

157

Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome.

Thal SC, Sporer S, Schmid-Elsaesser R, Plesnila N, Zausinger S. Thal SC, et al. Crit Care Med. 2009 Jul;37(7):2228-34. doi: 10.1097/CCM.0b013e3181a068fc. Crit Care Med. 2009. PMID: 19487935

158

Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury.

Zweckberger K, Plesnila N. Zweckberger K, et al. Neurosci Lett. 2009 Apr 24;454(2):115-7. doi: 10.1016/j.neulet.2009.02.014. Epub 2009 Feb 11. Neurosci Lett. 2009. PMID: 19429066

159

Brain edema formation and neurological impairment after subarachnoid hemorrhage in rats. Laboratory investigation.

Thal SC, Sporer S, Klopotowski M, Thal SE, Woitzik J, Schmid-Elsaesser R, Plesnila N, Zausinger S. Thal SC, et al. J Neurosurg. 2009 Nov;111(5):988-94. doi: 10.3171/2009.3.JNS08412. J Neurosurg. 2009. PMID: 19425896

160

Effects of transient focal cerebral ischemia in mice deficient in puma.

Kuroki K, Virard I, Concannon CG, Engel T, Woods I, Taki W, Plesnila N, Henshall DC, Prehn JH. Kuroki K, et al. Neurosci Lett. 2009 Feb 27;451(3):237-40. doi: 10.1016/j.neulet.2009.01.019. Epub 2009 Jan 13. Neurosci Lett. 2009. PMID: 19159665

161

Role of vasopressin V(1a) and V2 receptors for the development of secondary brain damage after traumatic brain injury in mice.

Trabold R, Krieg S, Schöller K, Plesnila N. Trabold R, et al. J Neurotrauma. 2008 Dec;25(12):1459-65. doi: 10.1089/neu.2008.0597. J Neurotrauma. 2008. PMID: 19118456

162

Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury.

Slemmer JE, Zhu C, Landshamer S, Trabold R, Grohm J, Ardeshiri A, Wagner E, Sweeney MI, Blomgren K, Culmsee C, Weber JT, Plesnila N. Slemmer JE, et al. Am J Pathol. 2008 Dec;173(6):1795-805. doi: 10.2353/ajpath.2008.080168. Epub 2008 Nov 6. Am J Pathol. 2008. PMID: 18988795 Free PMC article.

163

Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS.

Cardoso AL, Simões S, de Almeida LP, Plesnila N, Pedroso de Lima MC, Wagner E, Culmsee C. Cardoso AL, et al. J Control Release. 2008 Dec 8;132(2):113-23. doi: 10.1016/j.jconrel.2008.08.014. Epub 2008 Sep 2. J Control Release. 2008. PMID: 18796321

164

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M. Seiler A, et al. Cell Metab. 2008 Sep;8(3):237-48. doi: 10.1016/j.cmet.2008.07.005. Cell Metab. 2008. PMID: 18762024 Free article.

165

Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells.

Ringel F, Plesnila N. Ringel F, et al. Neurosci Lett. 2008 Sep 19;442(3):219-23. doi: 10.1016/j.neulet.2008.07.017. Epub 2008 Jul 11. Neurosci Lett. 2008. PMID: 18638521

166

Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.

Engel DC, Mies G, Terpolilli NA, Trabold R, Loch A, De Zeeuw CI, Weber JT, Maas AI, Plesnila N. Engel DC, et al. J Neurotrauma. 2008 Jul;25(7):739-53. doi: 10.1089/neu.2007.0480. J Neurotrauma. 2008. PMID: 18627253

167

Classification of traumatic brain injury for targeted therapies.

Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT; Workshop Scientific Team and Advisory Panel Members. Saatman KE, et al. J Neurotrauma. 2008 Jul;25(7):719-38. doi: 10.1089/neu.2008.0586. J Neurotrauma. 2008. PMID: 18627252 Free PMC article.

168

Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke.

Beck H, Semisch M, Culmsee C, Plesnila N, Hatzopoulos AK. Beck H, et al. Am J Pathol. 2008 Jul;173(1):77-92. doi: 10.2353/ajpath.2008.070648. Epub 2008 Jun 13. Am J Pathol. 2008. PMID: 18556777 Free PMC article.

169

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death.

Landshamer S, Hoehn M, Barth N, Duvezin-Caubet S, Schwake G, Tobaben S, Kazhdan I, Becattini B, Zahler S, Vollmar A, Pellecchia M, Reichert A, Plesnila N, Wagner E, Culmsee C. Landshamer S, et al. Cell Death Differ. 2008 Oct;15(10):1553-63. doi: 10.1038/cdd.2008.78. Epub 2008 Jun 6. Cell Death Differ. 2008. PMID: 18535584 Free PMC article.

170

Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice.

von Baumgarten L, Trabold R, Thal S, Back T, Plesnila N. von Baumgarten L, et al. J Cereb Blood Flow Metab. 2008 Jul;28(7):1353-60. doi: 10.1038/jcbfm.2008.30. Epub 2008 Apr 16. J Cereb Blood Flow Metab. 2008. PMID: 18414497

171

Complex level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig.

Olzowy B, von Gleichenstein G, Canis M, Plesnila N, Mees K. Olzowy B, et al. Eur Arch Otorhinolaryngol. 2008 Nov;265(11):1329-33. doi: 10.1007/s00405-008-0663-3. Epub 2008 Apr 4. Eur Arch Otorhinolaryngol. 2008. PMID: 18389267

172

Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia.

Culmsee C, Junker V, Thal S, Kremers W, Maier S, Schneider HJ, Plesnila N, Krieglstein J. Culmsee C, et al. Eur J Pharmacol. 2007 Dec 1;575(1-3):57-65. doi: 10.1016/j.ejphar.2007.07.066. Epub 2007 Aug 3. Eur J Pharmacol. 2007. PMID: 17869242

173

Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity.

Slemmer JE, Haasdijk ED, Engel DC, Plesnila N, Weber JT. Slemmer JE, et al. Eur J Neurosci. 2007 Aug;26(3):649-56. doi: 10.1111/j.1460-9568.2007.05708.x. Eur J Neurosci. 2007. PMID: 17686042

174

Decompression craniectomy after traumatic brain injury: recent experimental results.

Plesnila N. Plesnila N. Prog Brain Res. 2007;161:393-400. doi: 10.1016/S0079-6123(06)61028-5. Prog Brain Res. 2007. PMID: 17618993 Review.

175

Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.

Plesnila N, von Baumgarten L, Retiounskaia M, Engel D, Ardeshiri A, Zimmermann R, Hoffmann F, Landshamer S, Wagner E, Culmsee C. Plesnila N, et al. Cell Death Differ. 2007 Aug;14(8):1529-41. doi: 10.1038/sj.cdd.4402159. Epub 2007 Apr 27. Cell Death Differ. 2007. PMID: 17464322

176

Characterization of microvascular basal lamina damage and blood-brain barrier dysfunction following subarachnoid hemorrhage in rats.

Schöller K, Trinkl A, Klopotowski M, Thal SC, Plesnila N, Trabold R, Hamann GF, Schmid-Elsaesser R, Zausinger S. Schöller K, et al. Brain Res. 2007 Apr 20;1142:237-46. doi: 10.1016/j.brainres.2007.01.034. Epub 2007 Jan 17. Brain Res. 2007. PMID: 17303089

177

Effect of oxidative stress on glial cell volume.

Ringel F, Bieringer F, Baethmann A, Plesnila N. Ringel F, et al. J Neurotrauma. 2006 Nov;23(11):1693-704. doi: 10.1089/neu.2006.23.1693. J Neurotrauma. 2006. PMID: 17115914

178

Targeting Bid to prevent programmed cell death in neurons.

Culmsee C, Plesnila N. Culmsee C, et al. Biochem Soc Trans. 2006 Dec;34(Pt 6):1334-40. doi: 10.1042/BST0341334. Biochem Soc Trans. 2006. PMID: 17073814 Review.

179

Distraction vs remodeling surgery for craniosynostosis.

Kim SW, Shim KW, Plesnila N, Kim YO, Choi JU, Kim DS. Kim SW, et al. Childs Nerv Syst. 2007 Feb;23(2):201-6. doi: 10.1007/s00381-006-0209-1. Epub 2006 Oct 13. Childs Nerv Syst. 2007. PMID: 17053939 Clinical Trial.

180

Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons.

Isele NB, Lee HS, Landshamer S, Straube A, Padovan CS, Plesnila N, Culmsee C. Isele NB, et al. Neurochem Int. 2007 Jan;50(1):243-50. doi: 10.1016/j.neuint.2006.08.007. Epub 2006 Oct 16. Neurochem Int. 2007. PMID: 17050038

181

Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

Zhu C, Wang X, Huang Z, Qiu L, Xu F, Vahsen N, Nilsson M, Eriksson PS, Hagberg H, Culmsee C, Plesnila N, Kroemer G, Blomgren K. Zhu C, et al. Cell Death Differ. 2007 Apr;14(4):775-84. doi: 10.1038/sj.cdd.4402053. Epub 2006 Oct 13. Cell Death Differ. 2007. PMID: 17039248

182

Special aspects of severe head injury: recent developments.

Baethmann A, Eriskat J, Stoffel M, Chapuis D, Wirth A, Plesnila N. Baethmann A, et al. Curr Opin Anaesthesiol. 1998 Apr;11(2):193-200. doi: 10.1097/00001503-199804000-00013. Curr Opin Anaesthesiol. 1998. PMID: 17013219

183

Non-invasive intraoperative monitoring of blood pressure and arterial pCO2 during surgical anesthesia in mice.

Thal SC, Plesnila N. Thal SC, et al. J Neurosci Methods. 2007 Jan 30;159(2):261-7. doi: 10.1016/j.jneumeth.2006.07.016. Epub 2006 Sep 1. J Neurosci Methods. 2007. PMID: 16945419

184

Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.

Becattini B, Culmsee C, Leone M, Zhai D, Zhang X, Crowell KJ, Rega MF, Landshamer S, Reed JC, Plesnila N, Pellecchia M. Becattini B, et al. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12602-6. doi: 10.1073/pnas.0603460103. Epub 2006 Aug 4. Proc Natl Acad Sci U S A. 2006. PMID: 16891420 Free PMC article.

185

Effect of early and delayed decompressive craniectomy on secondary brain damage after controlled cortical impact in mice.

Zweckberger K, Erös C, Zimmermann R, Kim SW, Engel D, Plesnila N. Zweckberger K, et al. J Neurotrauma. 2006 Jul;23(7):1083-93. doi: 10.1089/neu.2006.23.1083. J Neurotrauma. 2006. PMID: 16866621

186

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.

Le Corre S, Klafki HW, Plesnila N, Hübinger G, Obermeier A, Sahagún H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, Roder HM. Le Corre S, et al. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9673-8. doi: 10.1073/pnas.0602913103. Epub 2006 Jun 12. Proc Natl Acad Sci U S A. 2006. PMID: 16769887 Free PMC article.

187

Therapeutic window of bradykinin B2 receptor inhibition after focal cerebral ischemia in rats.

Kläsner B, Lumenta DB, Pruneau D, Zausinger S, Plesnila N. Kläsner B, et al. Neurochem Int. 2006 Oct;49(5):442-7. doi: 10.1016/j.neuint.2006.02.010. Epub 2006 Apr 19. Neurochem Int. 2006. PMID: 16624448

188

Influence of the duration of ischemia and reperfusion on infarct volume and microvascular damage in mice.

Vosko MR, Burggraf D, Liebetrau M, Wunderlich N, Jäger G, Gröger M, Plesnila N, Hamann GF. Vosko MR, et al. Neurol Res. 2006 Mar;28(2):200-5. doi: 10.1179/016164105X48789. Neurol Res. 2006. PMID: 16551441

189

Lactacidosis-induced glial cell swelling depends on extracellular Ca2+.

Ringel F, Baethmann A, Plesnila N. Ringel F, et al. Neurosci Lett. 2006 May 8;398(3):306-9. doi: 10.1016/j.neulet.2006.01.012. Epub 2006 Feb 15. Neurosci Lett. 2006. PMID: 16469448

190

Simultaneous bilateral laser Doppler fluxmetry and electrophysiological recording during middle cerebral artery occlusion in rats.

Hungerhuber E, Zausinger S, Westermaier T, Plesnila N, Schmid-Elsaesser R. Hungerhuber E, et al. J Neurosci Methods. 2006 Jun 30;154(1-2):109-15. doi: 10.1016/j.jneumeth.2005.12.004. Epub 2006 Jan 24. J Neurosci Methods. 2006. PMID: 16439028

191

Arterial hypotension triggers perifocal depolarizations and aggravates secondary damage in focal brain injury.

Trabold R, Schueler OG, Eriskat J, Plesnila N, Baethmann AJ, Back T. Trabold R, et al. Brain Res. 2006 Feb 3;1071(1):237-44. doi: 10.1016/j.brainres.2005.11.095. Epub 2006 Jan 17. Brain Res. 2006. PMID: 16412395

192

Neuroprotective effects of a postischemic treatment with a bradykinin B2 receptor antagonist in a rat model of temporary focal cerebral ischemia.

Lumenta DB, Plesnila N, Kläsner B, Baethmann A, Pruneau D, Schmid-Elsaesser R, Zausinger S. Lumenta DB, et al. Brain Res. 2006 Jan 19;1069(1):227-34. doi: 10.1016/j.brainres.2005.11.043. Epub 2005 Dec 27. Brain Res. 2006. PMID: 16378603

193

Hypertonic fluid resuscitation from subarachnoid hemorrhage in rats: a comparison between small volume resuscitation and mannitol.

Bermueller C, Thal SC, Plesnila N, Schmid-Elsaesser R, Kreimeier U, Zausinger S. Bermueller C, et al. J Neurol Sci. 2006 Feb 15;241(1-2):73-82. doi: 10.1016/j.jns.2005.10.016. Epub 2005 Dec 15. J Neurol Sci. 2006. PMID: 16343544

194

Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.

Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M, Blomgren K, Plesnila N. Culmsee C, et al. J Neurosci. 2005 Nov 2;25(44):10262-72. doi: 10.1523/JNEUROSCI.2818-05.2005. J Neurosci. 2005. PMID: 16267234 Free PMC article.

195

Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb.

Massberg S, Schürzinger K, Lorenz M, Konrad I, Schulz C, Plesnila N, Kennerknecht E, Rudelius M, Sauer S, Braun S, Kremmer E, Emambokus NR, Frampton J, Gawaz M. Massberg S, et al. Circulation. 2005 Aug 23;112(8):1180-8. doi: 10.1161/CIRCULATIONAHA.105.539221. Epub 2005 Aug 15. Circulation. 2005. PMID: 16103235

196

Cluster analysis: a useful tool for the analysis of cerebral laser-Doppler scanning data.

Friedrich DH, Baethmann A, Plesnila N. Friedrich DH, et al. J Neurosci Methods. 2005 Jul 15;146(1):91-7. doi: 10.1016/j.jneumeth.2005.01.016. Epub 2005 Feb 19. J Neurosci Methods. 2005. PMID: 15935225

197

Motoneuron survival after C7 nerve root avulsion and replantation in the adult rabbit: effects of local ciliary neurotrophic factor and brain-derived neurotrophic factor application.

Lang EM, Asan E, Plesnila N, Hofmann GO, Sendtner M. Lang EM, et al. Plast Reconstr Surg. 2005 Jun;115(7):2042-50. doi: 10.1097/01.prs.0000163328.51271.dd. Plast Reconstr Surg. 2005. PMID: 15923853

198

Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice.

Gröger M, Lebesgue D, Pruneau D, Relton J, Kim SW, Nussberger J, Plesnila N. Gröger M, et al. J Cereb Blood Flow Metab. 2005 Aug;25(8):978-89. doi: 10.1038/sj.jcbfm.9600096. J Cereb Blood Flow Metab. 2005. PMID: 15815587

199

Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia.

Vakili A, Kataoka H, Plesnila N. Vakili A, et al. J Cereb Blood Flow Metab. 2005 Aug;25(8):1012-9. doi: 10.1038/sj.jcbfm.9600097. J Cereb Blood Flow Metab. 2005. PMID: 15744246

200

Role of mitochondrial proteins for neuronal cell death after focal cerebral ischemia.

Plesnila N. Plesnila N. Acta Neurochir Suppl. 2004;89:15-9. doi: 10.1007/978-3-7091-0603-7_3. Acta Neurochir Suppl. 2004. PMID: 15335097 Review.

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