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Showing results for polydatin
Your search for polidatin retrieved no results
Mechanisms of polydatin against spinal cord ischemia-reperfusion injury based on network pharmacology, molecular docking and molecular dynamics simulation.
Sun Z, Wang Y, Pang X, Wang X, Zeng H. Sun Z, et al. Bioorg Chem. 2023 Nov;140:106840. doi: 10.1016/j.bioorg.2023.106840. Epub 2023 Sep 8. Bioorg Chem. 2023. PMID: 37683540
Molecular dynamics simulations revealed good binding abilities between polydatin and MAPK3. CONCLUSIONS: Polydatin exerts its effects on spinal cord ischemia-reperfusion injury through multiple targets and pathways. MAPK3 may be a key target of polydatin in s …
Molecular dynamics simulations revealed good binding abilities between polydatin and MAPK3. CONCLUSIONS: Polydatin exerts its …
Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.
Karami A, Fakhri S, Kooshki L, Khan H. Karami A, et al. Molecules. 2022 Oct 1;27(19):6474. doi: 10.3390/molecules27196474. Molecules. 2022. PMID: 36235012 Free PMC article. Review.
Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. ...In the present study, the therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin are reviewed to prov …
Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. ...In the present stu …
Polydatin for treating atherosclerotic diseases: A functional and mechanistic overview.
Wu M, Li X, Wang S, Yang S, Zhao R, Xing Y, Liu L. Wu M, et al. Biomed Pharmacother. 2020 Aug;128:110308. doi: 10.1016/j.biopha.2020.110308. Epub 2020 May 29. Biomed Pharmacother. 2020. PMID: 32480216 Free article. Review.
Polydatin treats atherosclerosis mainly from three aspects: anti-inflammatory, regulating lipid metabolism and anti-oxidative stress. This article will review the pharmacological mechanism of polydatin in anti-atherosclerosis, the biological characteristics of Polyg …
Polydatin treats atherosclerosis mainly from three aspects: anti-inflammatory, regulating lipid metabolism and anti-oxidative stress. …
Polydatin: A Critical Promising Natural Agent for Liver Protection via Antioxidative Stress.
Tang D, Zhang Q, Duan H, Ye X, Liu J, Peng W, Wu C. Tang D, et al. Oxid Med Cell Longev. 2022 Feb 10;2022:9218738. doi: 10.1155/2022/9218738. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35186191 Free PMC article. Review.
Polydatin, one of the natural active small molecules, was commonly applied in protecting and treating liver disorders in preclinical studies. ...In addition, polydatin acts as a free radical scavenger against reactive oxygen species (ROS) by its phenolic and ethylen …
Polydatin, one of the natural active small molecules, was commonly applied in protecting and treating liver disorders in preclinical …
Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies.
Schimith LE, Dos Santos MG, Arbo BD, André-Miral C, Muccillo-Baisch AL, Hort MA. Schimith LE, et al. Phytother Res. 2022 Jul;36(7):2852-2877. doi: 10.1002/ptr.7497. Epub 2022 May 25. Phytother Res. 2022. PMID: 35614539
Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities, including neuroprotective properties, exerting preventive and/or therapeutic effects in central nervous system (CNS) disorders. ...Overall …
Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities …
The protective mechanisms of polydatin in cerebral ischemia.
Tang KS, Tan JS. Tang KS, et al. Eur J Pharmacol. 2019 Jan 5;842:133-138. doi: 10.1016/j.ejphar.2018.10.039. Epub 2018 Oct 30. Eur J Pharmacol. 2019. PMID: 30385347 Review.
Thus, there is a need to explore for new compounds that can halt or reverse the deterioration of neurons in the stroke patients' brain. Polydatin, a precursor of resveratrol, is a natural stilbene commonly found in food. This review article describes how different paramete …
Thus, there is a need to explore for new compounds that can halt or reverse the deterioration of neurons in the stroke patients' brain. P …
Protective Effects of Polydatin Against Dementia-Related Disorders.
Tang KS. Tang KS. Curr Neuropharmacol. 2021;19(2):127-135. doi: 10.2174/1570159X18666200611144825. Curr Neuropharmacol. 2021. PMID: 32525774 Free PMC article. Review.
Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer's disease, vas …
Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. …
Polydatin accelerates osteoporotic bone repair by inducing the osteogenesis-angiogenesis coupling of bone marrow mesenchymal stem cells via the PI3K/AKT/GSK-3beta/beta-catenin pathway.
Zhou C, Hu G, Li Y, Zheng S. Zhou C, et al. Int J Surg. 2025 Jan 1;111(1):411-425. doi: 10.1097/JS9.0000000000002075. Int J Surg. 2025. PMID: 39248296 Free PMC article.
BACKGROUND: Polydatin (POL), a natural stilbenoid, has multiple pharmacological activities. However, its effect on osteoporotic bone defects has not yet been examined. ...
BACKGROUND: Polydatin (POL), a natural stilbenoid, has multiple pharmacological activities. However, its effect on osteoporotic bone …
Polydatin Alleviated Ischemia-Reperfusion Induced Kidney Injury by Inhibiting SETD2-Mediated Ferroptosis.
He M, Tang S, Wang L, Hu X, Yao X, Wu H. He M, et al. Phytother Res. 2025 Nov;39(11):5391-5408. doi: 10.1002/ptr.70088. Epub 2025 Oct 13. Phytother Res. 2025. PMID: 41083610
SETD2 knockout mice were utilized to validate Polydatin's protective mechanism. Polydatin significantly improved renal function, reducing SCr, BUN, and injury biomarkers (NGAL, KIM-1). ...SETD2 overexpression negated Polydatin's benefits, while knockout enhan …
SETD2 knockout mice were utilized to validate Polydatin's protective mechanism. Polydatin significantly improved renal functio …
Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications.
Yasmin F, Tang KS. Yasmin F, et al. Biosci Rep. 2025 May 30;45(5):303-323. doi: 10.1042/BSR20241307. Biosci Rep. 2025. PMID: 40958722 Free PMC article. Review.
Evidence indicates that polydatin effectively improves insulin sensitivity, lowers blood glucose levels, and exhibits antioxidant properties. ...Additionally, polydatin restores endothelial function in vascular complications associated with diabetes. ...
Evidence indicates that polydatin effectively improves insulin sensitivity, lowers blood glucose levels, and exhibits antioxidant pro …
899 results