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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1971 1
1973 2
1975 4
1976 3
1977 3
1979 2
1980 8
1981 1
1982 12
1983 6
1984 5
1985 2
1986 7
1987 9
1988 7
1989 5
1990 24
1991 10
1992 14
1993 10
1994 29
1995 22
1996 25
1997 23
1998 24
1999 24
2000 19
2001 19
2002 24
2003 25
2004 31
2005 31
2006 34
2007 38
2008 20
2009 34
2010 26
2011 37
2012 38
2013 23
2014 28
2015 24
2016 37
2017 31
2018 25
2019 19
2020 32
2021 21
2022 14
2023 14
2024 11
2025 16
2026 6

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875 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Pharmacotherapy and immunotherapy of allergic rhinitis induced by house dust mite, grass, and birch pollen allergens: a meta-analysis of randomized clinical trials.
Marko M, Pawliczak R. Marko M, et al. Expert Rev Respir Med. 2023 Jul-Dec;17(7):607-621. doi: 10.1080/17476348.2023.2241364. Epub 2023 Jul 28. Expert Rev Respir Med. 2023. PMID: 37489655 Review.
The authors focused on the division into selected AR's triggers: house dust mites (HDMs), grass pollen, and birch pollen. METHODS: For each drug and allergen class, a meta-analysis of the efficacy and adverse events (AEs) was performed. ...The best total effi …
The authors focused on the division into selected AR's triggers: house dust mites (HDMs), grass pollen, and birch pollen. METH …
Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response.
Golebski K, Layhadi JA, Sahiner U, Steveling-Klein EH, Lenormand MM, Li RCY, Bal SM, Heesters BA, Vilà-Nadal G, Hunewald O, Montamat G, HeFeng FQ, Ollert M, Fedina O, Lao-Araya M, Vijverberg SJH, Maitland-van der Zee AH, van Drunen CM, Fokkens WJ, Durham SR, Spits H, Shamji MH. Golebski K, et al. Immunity. 2021 Feb 9;54(2):291-307.e7. doi: 10.1016/j.immuni.2020.12.013. Epub 2021 Jan 14. Immunity. 2021. PMID: 33450188 Free article. Clinical Trial.
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to the sensitizing allergen is unclear. ...Altogether, our findings underscore the contribution of IL-10(+) ILC2s in the disease-modifying effect by allergen immunotherapy …
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to the sensitizing allergen is unclear …
Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?
Annesi-Maesano I, Cecchi L, Biagioni B, Chung KF, Clot B, Collaud Coen M, D'Amato G, Damialis A, Dominguez-Ortega J, Galàn C, Gilles S, Holgate S, Jeebhay M, Kazadzis S, Papadopoulos NG, Quirce S, Sastre J, Tummon F, Traidl-Hoffmann C, Walusiak-Skorupa J, Alonso-Coello P, Canelo-Aybar C, Cantero-Fortiz Y, Rigau D, Salazar J, Verdugo-Paiva F, Jutel M, Akdis CA, Agache I. Annesi-Maesano I, et al. Allergy. 2023 Aug;78(8):2121-2147. doi: 10.1111/all.15724. Epub 2023 Apr 10. Allergy. 2023. PMID: 36961370 Review.
Rare data show that among subjects under 18 years of age, an exposure to grass pollen lagged up to 3 days may lower lung function. Further research considering effect modifiers of pollen sensitization, hay fever, asthma, air pollution, green spaces, and pre-existing …
Rare data show that among subjects under 18 years of age, an exposure to grass pollen lagged up to 3 days may lower lung function. Fu …
Efficacy and safety of sublingual versus subcutaneous immunotherapy in children with allergic rhinitis: a systematic review and meta-analysis.
Yang J, Lei S. Yang J, et al. Front Immunol. 2023 Dec 15;14:1274241. doi: 10.3389/fimmu.2023.1274241. eCollection 2023. Front Immunol. 2023. PMID: 38162647 Free PMC article.

Subgroup analysis was further conducted in terms of study design [randomized controlled trials (RCTs), cohort studies], allergen [house dust mites (HDMs), grass pollen], treatment duration ( 24, 12-23 or < 12 months), allergen immunotherapy (AIT) modality

…
Subgroup analysis was further conducted in terms of study design [randomized controlled trials (RCTs), cohort studies], allergen [hou …
The SQ tree sublingual immunotherapy tablet is effective and well tolerated in children-A pivotal phase III trial.
Gappa M, Gagnon R, Horak F, Cichocka-Jarosz E, Dalgaard T, Hargreaves K, Mikler J, Emeryk A, Hansen KS, Pfaar O. Gappa M, et al. Allergy. 2025 Mar;80(3):795-806. doi: 10.1111/all.16363. Epub 2024 Nov 4. Allergy. 2025. PMID: 39495086 Free PMC article. Clinical Trial.
BACKGROUND: Allergic rhinitis and/or conjunctivitis (AR/C) induced by tree pollen is common and negatively impacts quality of life in children and adolescents. This phase III trial investigated the efficacy and safety of the SQ tree SLIT-tablet in a paediatric population ( …
BACKGROUND: Allergic rhinitis and/or conjunctivitis (AR/C) induced by tree pollen is common and negatively impacts quality of life in …
Immunotherapy with grass pollen major allergens.
Osterballe O. Osterballe O. Allergy. 1982 Aug;37(6):379-88. doi: 10.1111/j.1398-9995.1982.tb02316.x. Allergy. 1982. PMID: 7137533 Clinical Trial.
Perennial hyposensitization with a partially purified timothy extract resulted in a statistically significantly higher degree of clinical protection than treatment with the two timothy major allergens (Nos. 19 and 25) and protected better from the second--than during the f …
Perennial hyposensitization with a partially purified timothy extract resulted in a statistically significantly higher degree of clinical pr …
Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy.
Altman MC, Segnitz RM, Larson D, Jayavelu ND, Smith MT, Patel S, Scadding GW, Qin T, Sanda S, Steveling E, Eifan AO, Penagos M, Jacobson MR, Parkin RV, Shamji MH, Togias A, Durham SR. Altman MC, et al. J Allergy Clin Immunol. 2023 Nov;152(5):1247-1260. doi: 10.1016/j.jaci.2023.06.025. Epub 2023 Jul 15. J Allergy Clin Immunol. 2023. PMID: 37460024 Free PMC article. Clinical Trial.
BACKGROUND: Allergen immunotherapy (AIT) is a well-established disease-modifying therapy for allergic rhinitis, yet the fundamental mechanisms underlying its clinical effect remain inadequately understood. ...METHODS: We used longitudinal transcriptomic profiling of nasal …
BACKGROUND: Allergen immunotherapy (AIT) is a well-established disease-modifying therapy for allergic rhinitis, yet the fundamental m …
Pollen used to produce allergen extracts.
Codina R, Lockey RF. Codina R, et al. Ann Allergy Asthma Immunol. 2017 Feb;118(2):148-153. doi: 10.1016/j.anai.2016.02.005. Epub 2016 Mar 16. Ann Allergy Asthma Immunol. 2017. PMID: 26993170
RESULTS: Both genetic and environmental factors affect the allergenic composition of pollen because it is a biologically active pharmaceutical ingredient obtained from nature. ...The regulations associated with pollen used to manufacture allergen extra …
RESULTS: Both genetic and environmental factors affect the allergenic composition of pollen because it is a biologically activ …
Grass pollen allergoids conjugated with mannan for subcutaneous and sublingual immunotherapy: a dose-finding study.
Ojeda P, Barjau MC, Subiza J, Moreno A, Ojeda I, Solano E, Alonso A, Caballero R, Del Pozo S, Gómez-Perosanz M, Sánchez-Trincado JL, Benito-Villalvilla C, Angelina A, Soria I, Reche PA, Palomares O, Subiza JL, Casanovas M. Ojeda P, et al. Front Immunol. 2024 Jun 26;15:1431351. doi: 10.3389/fimmu.2024.1431351. eCollection 2024. Front Immunol. 2024. PMID: 38989287 Free PMC article. Clinical Trial.
BACKGROUND: Polymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic cells. In this study, we aimed to determine the optimal dose of mannan-allergoid conjugates derived from grass pollen (Phleum pratense …
BACKGROUND: Polymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic ce …
Short-course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy.
Mösges R, Raskopf E, Klimek L, Pfaar O, Zielen S, Xenofontos E, Decker L, Neuhof C, Rybachuk A, Acikel C, Sahin H, Allekotte S, Del Pozo Collado S, Subiza JL, Casanovas M, Cuevas M. Mösges R, et al. Allergy. 2025 Mar;80(3):817-826. doi: 10.1111/all.16387. Epub 2024 Nov 9. Allergy. 2025. PMID: 39520181 Free PMC article. Clinical Trial.
Here, we assessed the clinical impact of the mannan-conjugated birch pollen polymerized allergoid T502 in birch pollen-induced allergic rhinoconjunctivitis. ...Efficacy was assessed by comparing the combined symptom and medication score (CSMS) between placebo and T5 …
Here, we assessed the clinical impact of the mannan-conjugated birch pollen polymerized allergoid T502 in birch pollen-induced …
875 results