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Japanese Cedar (Cryptomeria japonica) pollen allergen induces elevation of intracellular calcium in human keratinocytes and impairs epidermal barrier function of human skin ex vivo.
Kumamoto J, Tsutsumi M, Goto M, Nagayama M, Denda M. Kumamoto J, et al. Arch Dermatol Res. 2016 Jan;308(1):49-54. doi: 10.1007/s00403-015-1602-y. Epub 2015 Oct 26. Arch Dermatol Res. 2016. PMID: 26498292
Cry j1 is the major peptide allergen of Japanese cedar (Sugi), Cryptomeria japonica. Since some allergens disrupt epidermal permeability barrier homeostasis, we hypothesized that Cry j1 might have a similar effect. ...Cry j1 significantly impaired the barrier …
Cry j1 is the major peptide allergen of Japanese cedar (Sugi), Cryptomeria japonica. Since some allergens disrupt epidermal permeabil …
Dual function of novel pollen coat (surface) proteins: IgE-binding capacity and proteolytic activity disrupting the airway epithelial barrier.
Bashir ME, Ward JM, Cummings M, Karrar EE, Root M, Mohamed AB, Naclerio RM, Preuss D. Bashir ME, et al. PLoS One. 2013;8(1):e53337. doi: 10.1371/journal.pone.0053337. Epub 2013 Jan 7. PLoS One. 2013. PMID: 23308195 Free PMC article.
These proteins represent a class of novel dual-function proteins residing on the coat of the pollen grain that have IgE-binding capacity and proteolytic activity, which disrupts the integrity of the airway epithelial barrier. The identification of pollen …
These proteins represent a class of novel dual-function proteins residing on the coat of the pollen grain that have IgE-bindin …
Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.
Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S. Shimura S, et al. J Invest Dermatol. 2016 Jul;136(7):1408-1417. doi: 10.1016/j.jid.2016.02.810. Epub 2016 Mar 14. J Invest Dermatol. 2016. PMID: 26987428 Free article.
Allergen sources such as mites, insects, fungi, and pollen contain proteases. Airway exposure to proteases induces allergic airway inflammation and IgE/IgG1 responses via IL-33-dependent mechanisms in mice. ...These results suggest that allergen source-derive …
Allergen sources such as mites, insects, fungi, and pollen contain proteases. Airway exposure to proteases induces alle …
Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases.
Takai T, Ikeda S. Takai T, et al. Allergol Int. 2011 Mar;60(1):25-35. doi: 10.2332/allergolint.10-RAI-0273. Epub 2011 Dec 25. Allergol Int. 2011. PMID: 21173566 Free article. Review.
Environmental proteases can cause barrier breakdown in the skin, not only in the epithelium, and stimulate various types of cells through IgE-independent mechanisms. Endogenous protease inhibitors control the functions of environmental and endog …
Environmental proteases can cause barrier breakdown in the skin, not only in the epithelium, and stimulate various type …
Tranexamic acid blocks the thrombin-mediated delay of epidermal permeability barrier recovery induced by the cedar pollen allergen, Cry j1.
Nakanishi S, Kumamoto J, Denda M. Nakanishi S, et al. Sci Rep. 2018 Oct 23;8(1):15610. doi: 10.1038/s41598-018-33898-7. Sci Rep. 2018. PMID: 30353092 Free PMC article.
We previously demonstrated that Cry j1, the major pollen allergen of Cryptomeria japonica (Japanese cedar), transiently increases protease activity and intracellular Ca(2+) concentration in cultured human keratinocytes, and delays recovery after stratum corneum b …
We previously demonstrated that Cry j1, the major pollen allergen of Cryptomeria japonica (Japanese cedar), transiently increases …
Analysis of Results of Specific IgE in 100 Atopic Dermatitis Patients with the Use of Multiplex Examination ALEX2-Allergy Explorer.
Čelakovská J, Bukač J, Cermákova E, Vaňková R, Skalská H, Krejsek J, Andrýs C. Čelakovská J, et al. Int J Mol Sci. 2021 May 17;22(10):5286. doi: 10.3390/ijms22105286. Int J Mol Sci. 2021. PMID: 34067936 Free PMC article.
The severity of AD is in significant relation to the sensitization to molecular components of storage mites (Gly d 2, Lep d 2-NPC2 family), lipocalins (Can f 1, Can f 2, Can f 4, and Can f 6), arginine kinase (Asp f 6, Bla g 9, Der p 20, Pen m 2), uteroglobin (Fel d 1, Ory c 3), …
The severity of AD is in significant relation to the sensitization to molecular components of storage mites (Gly d 2, Lep d 2-NPC2 family), …