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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 2
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1981 6
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1983 8
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1987 9
1988 8
1989 8
1990 7
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1992 6
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1994 5
1995 8
1996 11
1997 1
1998 10
1999 4
2000 8
2001 5
2002 9
2003 5
2004 3
2005 7
2006 5
2007 5
2008 9
2009 3
2010 5
2011 10
2012 6
2013 1
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294 results

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Page 1
Polyclonal hypergammaglobulinaemia: assessment, clinical interpretation, and management.
Zhao EJ, Cheng CV, Mattman A, Chen LYC. Zhao EJ, et al. Lancet Haematol. 2021 May;8(5):e365-e375. doi: 10.1016/S2352-3026(21)00056-9. Lancet Haematol. 2021. PMID: 33894171 Review.
This Review outlines a practical approach to assessing and managing polyclonal hypergammaglobulinaemia in adults. Polyclonal hypergammaglobulinaemia is most commonly caused by liver disease, immune dysregulation, or inflammation, but can also pr …
This Review outlines a practical approach to assessing and managing polyclonal hypergammaglobulinaemia in adults. Polyclona …
IgG4-related disease for the hematologist.
Chen LYC. Chen LYC. Hematology Am Soc Hematol Educ Program. 2024 Dec 6;2024(1):594-603. doi: 10.1182/hematology.2024000584. Hematology Am Soc Hematol Educ Program. 2024. PMID: 39644037 Free PMC article. Review.
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated disease with many important manifestations in hematopoietic and lymphoid tissue. ...The disease can present with predominantly proliferative features, such as swollen lacrimal and salivary glands, orbital ps …
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated disease with many important manifestations in hematopoietic and lym …
Expert Perspective: Diagnosis and Treatment of Castleman Disease.
Chen LYC, Zhang L, Fajgenbaum DC. Chen LYC, et al. Arthritis Rheumatol. 2026 Jan;78(1):12-25. doi: 10.1002/art.43269. Epub 2025 Aug 29. Arthritis Rheumatol. 2026. PMID: 40457814 Free PMC article. Review.
Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune-mediated conditions. MCD can be associated with excessive cytokine production due to a plasma cell neoplasm (MCD-polyneuropathy, organomegaly, endocrinopathy, monoclonal paraprotein, skin …
Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune-mediated conditions. MCD can be associated with …
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs.
Plagemann PG, Rowland RR, Cafruny WA. Plagemann PG, et al. Viral Immunol. 2005;18(1):138-47. doi: 10.1089/vim.2005.18.138. Viral Immunol. 2005. PMID: 15802958
The immune complexes bound to uncoated ELISA plates with a much lower affinity than Abs to plates coated with peptides containing the appropriate epitopes. ...Overall the PRRSV-induced hypergammaglobulinemia and generation of ELISA plate-binding immune comple …
The immune complexes bound to uncoated ELISA plates with a much lower affinity than Abs to plates coated with peptides containing the …
Castleman disease.
Saeed-Abdul-Rahman I, Al-Amri AM. Saeed-Abdul-Rahman I, et al. Korean J Hematol. 2012 Sep;47(3):163-77. doi: 10.5045/kjh.2012.47.3.163. Epub 2012 Sep 25. Korean J Hematol. 2012. PMID: 23071471 Free PMC article.
The pathogenesis is unknown, but the bulk of evidence points toward faulty immune regulation, resulting in excessive B-lymphocyte and plasma-cell proliferation in lymphatic tissue. ...The hyaline-vascular cases usually are largely asymptomatic, whereas the less common plas …
The pathogenesis is unknown, but the bulk of evidence points toward faulty immune regulation, resulting in excessive B-lymphocyte and …
Lysosomal Storage Disorders and Malignancy.
Pastores GM, Hughes DA. Pastores GM, et al. Diseases. 2017 Feb 27;5(1):8. doi: 10.3390/diseases5010008. Diseases. 2017. PMID: 28933361 Free PMC article. Review.
Studies have indicated an increased frequency of polyclonal and monoclonal gammopathy among patients with GD. It has been shown that two major sphingolipids that accumulate in GD, namely, beta-glucosylceramide 22:0 (betaGL1-22) and glucosylsphingosine (LGL1), can be recogn …
Studies have indicated an increased frequency of polyclonal and monoclonal gammopathy among patients with GD. It has been shown that …
The Deadly Dance of B Cells with Trypanosomatids.
Silva-Barrios S, Charpentier T, Stäger S. Silva-Barrios S, et al. Trends Parasitol. 2018 Feb;34(2):155-171. doi: 10.1016/j.pt.2017.10.001. Epub 2017 Oct 28. Trends Parasitol. 2018. PMID: 29089182 Review.
However, some chronic infectious diseases actively induce immune deregulations that often lead to defective, if not deleterious, humoral immune responses. In this review we summarize how Leishmania and Trypanosoma spp. directly manipulate B cell responses to induce …
However, some chronic infectious diseases actively induce immune deregulations that often lead to defective, if not deleterious, humo …
[Angioimmunoblastic T-cell lymphoma].
Lachenal F. Lachenal F. Presse Med. 2007 Nov;36(11 Pt 2):1655-62. doi: 10.1016/j.lpm.2007.06.001. Epub 2007 Jun 22. Presse Med. 2007. PMID: 17587541 Review. French.
Patients present with generalized lymphadenopathy and systemic symptoms; half also have hepatomegaly, splenomegaly and a rash. Polyclonal hypergammaglobulinemia, elevated lactate dehydrogenase, and anemia are the main laboratory abnormalities. ...Genetic analysis th …
Patients present with generalized lymphadenopathy and systemic symptoms; half also have hepatomegaly, splenomegaly and a rash. Polyclonal …
Immunopathogenesis of systemic sclerosis.
White B. White B. Rheum Dis Clin North Am. 1996 Nov;22(4):695-708. doi: 10.1016/s0889-857x(05)70296-9. Rheum Dis Clin North Am. 1996. PMID: 8923591 Review.
V delta 1+ gamma/delta T cells are increased in both the blood and lungs of SSc patients and also show evidence of selection by antigen. B cells are activated early, with polyclonal activation leading to hypergammaglobulinemia. SSc-specific autoantibodies target DNA …
V delta 1+ gamma/delta T cells are increased in both the blood and lungs of SSc patients and also show evidence of selection by antigen. B c …
Interferon signatures fuel B cell hyperactivity and plasmablast expansion in systemic lupus erythematosus.
van Dooren HJ, Atisha-Fregoso Y, Dorjée AL, Huizinga TWJ, Mackay M, Aranow C, Toes REM, Diamond B, Suurmond J. van Dooren HJ, et al. J Autoimmun. 2025 Jun;154:103438. doi: 10.1016/j.jaut.2025.103438. Epub 2025 May 26. J Autoimmun. 2025. PMID: 40424895 Free PMC article.
The disease is also hallmarked by an expansion of plasmablasts (PB) and hypergammaglobulinemia. The mechanisms underlying this hyperactivity and its relation to autoantibody production is not clear. ...Repertoire analysis revealed a highly polyclonal expansion of PB …
The disease is also hallmarked by an expansion of plasmablasts (PB) and hypergammaglobulinemia. The mechanisms underlying this hypera …
294 results