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119 results

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Page 1
Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing.
Galeano M, Pallio G, Irrera N, Mannino F, Bitto A, Altavilla D, Vaccaro M, Squadrito G, Arcoraci V, Colonna MR, Lauro R, Squadrito F. Galeano M, et al. Pharmaceuticals (Basel). 2021 Oct 29;14(11):1103. doi: 10.3390/ph14111103. Pharmaceuticals (Basel). 2021. PMID: 34832885 Free PMC article. Review.
However, several diseases such as diabetes, thermal injury and ischemia could lead to an impaired wound healing process characterized by wound hypoxia, high levels of oxygen radicals, reduced angiogenesis, decreased collagen synthesis and organization. Polydeoxyribonucleotide …
However, several diseases such as diabetes, thermal injury and ischemia could lead to an impaired wound healing process characterized by wou …
Polydeoxyribonucleotide exerts opposing effects on ERK activity in human skin keratinocytes and fibroblasts.
Shin SM, Baek EJ, Kim KH, Kim KJ, Park EJ. Shin SM, et al. Mol Med Rep. 2023 Aug;28(2):148. doi: 10.3892/mmr.2023.13035. Epub 2023 Jun 23. Mol Med Rep. 2023. PMID: 37350391 Free PMC article.
Polydeoxyribonucleotide (PDRN) is a mixture of deoxyribonucleotides. It serves as an anti-inflammatory and tissue-regenerating agent. ...Overall, PDRN exerts a positive effect on skin regeneration, but the mechanism by which it promotes skin regeneration vari …
Polydeoxyribonucleotide (PDRN) is a mixture of deoxyribonucleotides. It serves as an anti-inflammatory and tissue-regenerating agent. …
Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root.
Lee KS, Lee S, Wang H, Lee G, Kim S, Ryu YH, Chang NH, Kang YW. Lee KS, et al. Molecules. 2023 Oct 24;28(21):7240. doi: 10.3390/molecules28217240. Molecules. 2023. PMID: 37959659 Free PMC article.
Polydeoxyribonucleotide (PDRN) has the ability to regenerate skin cells and improve the skin barrier and wound healing. ...This activated signal transduction, thereby regenerating skin cells and strengthening the barrier. These results were not only ob …
Polydeoxyribonucleotide (PDRN) has the ability to regenerate skin cells and improve the skin barrier and wound healing. …
Skin boosters: Definitions and varied classifications.
Yi KH, Winayanuwattikun W, Kim SY, Wan J, Vachatimanont V, Putri AI, Hidajat IJ, Yogya Y, Pamela R. Yi KH, et al. Skin Res Technol. 2024 Mar;30(3):e13627. doi: 10.1111/srt.13627. Skin Res Technol. 2024. Retraction in: Skin Res Technol. 2025 Nov;31(11):e70297. doi: 10.1111/srt.70297. PMID: 38481069 Free PMC article. Retracted. Review.
Restylane Vital and other HA fillers have been repurposed to combat skin aging and wrinkles by delivering HA directly to the dermis. OBJECTIVES: This review aims to define the term "skin booster" and to discuss the various components that constitute skin boos …
Restylane Vital and other HA fillers have been repurposed to combat skin aging and wrinkles by delivering HA directly to the dermis. …
A Mixture of Topical Forms of Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuated Skin Pigmentation and Increased Skin Elasticity by Modulating Nuclear Factor Erythroid 2-like 2.
Kim HM, Byun KA, Oh S, Yang JY, Park HJ, Chung MS, Son KH, Byun K. Kim HM, et al. Molecules. 2022 Feb 14;27(4):1276. doi: 10.3390/molecules27041276. Molecules. 2022. PMID: 35209068 Free PMC article.
It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloproteinases (MMPs), which degrade collagen and elastin fibers, leading to decreased skin elasticity. Various antioxidant agents, such as vit …
It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloprotein …
Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview.
Rho NK, Kim HS, Kim SY, Lee W. Rho NK, et al. Arch Plast Surg. 2024 Nov 13;51(6):528-541. doi: 10.1055/a-2366-3436. eCollection 2024 Nov. Arch Plast Surg. 2024. PMID: 39544509 Free PMC article.
Aging-related changes in the skin, such as dullness, dehydration, and loss of elasticity, significantly affect its appearance and integrity. ...It also evaluates the evidence for their effectiveness and safety in treating age-related skin alterations and other condi …
Aging-related changes in the skin, such as dullness, dehydration, and loss of elasticity, significantly affect its appearance and int …
Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy.
Liu Y, Hu W, Pei X, Zhu J, Meng H, Lyu Y, Qu Z. Liu Y, et al. Int J Biol Macromol. 2025 Sep;322(Pt 3):146984. doi: 10.1016/j.ijbiomac.2025.146984. Epub 2025 Aug 19. Int J Biol Macromol. 2025. PMID: 40840755
Regenerative medicine, with stem cells and tissue engineering as its core, is dedicated to the regeneration of skin and organs and the treatment of diseases. Polydeoxyribonucleic acid (PDRN) has been demonstrated to promote skin regeneration and anti-aging in the fi …
Regenerative medicine, with stem cells and tissue engineering as its core, is dedicated to the regeneration of skin and organs and th …
Effects of polydeoxyribonucleotide derived from Gynostemma pentaphyllum callus on skin barrier function.
Kim E, Choi S, Jang J, Shin HY, Ahn K, Kim SJ, Seo HH, Lee JH, Moh SH. Kim E, et al. Biochem Biophys Res Commun. 2025 Aug 30;776:152180. doi: 10.1016/j.bbrc.2025.152180. Epub 2025 Jun 8. Biochem Biophys Res Commun. 2025. PMID: 40527178
GP was extracted using a plant-based method and tested on skin cells. The study aimed to determine whether GP enhances the skin barrier similarly to SP. ...Additionally, GP treatment significantly upregulated key skin barrier proteins, including FLG and IVL, …
GP was extracted using a plant-based method and tested on skin cells. The study aimed to determine whether GP enhances the skin …
Skin regenerative potential of polydeoxyribonucleotide isolated from Saussurea involucrata.
Kim DJ, Bak SU, Lee SY, Jung MS, Jin HU, An CE. Kim DJ, et al. Cell Mol Biol (Noisy-le-grand). 2025 Dec 6;71(11):94-99. doi: 10.14715/cmb/2025.71.11.12. Cell Mol Biol (Noisy-le-grand). 2025. PMID: 41351364
Although various bioactive compounds have been identified in snow lotus, the biological activity and underlying mechanisms of DNA isolated from this plant remain unexplored. This study aimed to investigate the skin-regenerative properties of polydeoxyribonucleotide …
Although various bioactive compounds have been identified in snow lotus, the biological activity and underlying mechanisms of DNA isolated f …
PDRN prevents SIRT1 degradation by attenuating autophagy during skin aging.
Chen J, Qiu F, Shi J, Huang W, Zhao C, Han Q. Chen J, et al. PLoS One. 2025 May 9;20(5):e0321005. doi: 10.1371/journal.pone.0321005. eCollection 2025. PLoS One. 2025. PMID: 40343916 Free PMC article.
Polydeoxyribonucleotide (PDRN) is a low molecular weight linear polyribonucleotide fragment derived from salmon sperm, known for its potential in tissue regeneration and anti-inflammatory applications. ...These results suggest that PDRN has potential as a therapeutic compo …
Polydeoxyribonucleotide (PDRN) is a low molecular weight linear polyribonucleotide fragment derived from salmon sperm, known for its …
119 results