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Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products.
Ibrahim M, Ramadan E, Elsadek NE, Emam SE, Shimizu T, Ando H, Ishima Y, Elgarhy OH, Sarhan HA, Hussein AK, Ishida T. Ibrahim M, et al. J Control Release. 2022 Nov;351:215-230. doi: 10.1016/j.jconrel.2022.09.031. Epub 2022 Sep 22. J Control Release. 2022. PMID: 36165835 Review.
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. ...The use of COVID-19 mRNA vaccines, which are composed mainly of PEGylated lipid nanoparticles (LNPs), has recen …
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier i …
Hypersensitivity to polyethylene glycol in adults and children: An emerging challenge.
Bianchi A, Bottau P, Calamelli E, Caimmi S, Crisafulli G, Franceschini F, Liotti L, Mori F, Paglialunga C, Saretta F, Tosca M, Cardinale F, Licari A, Miraglia Del Giudice M, Caffarelli C. Bianchi A, et al. Acta Biomed. 2021 Nov 29;92(S7):e2021519. doi: 10.23750/abm.v92iS7.12384. Acta Biomed. 2021. PMID: 34842597 Free PMC article. Review.
Hypersensitivity reactions to polyethylene glycol (PEG) is an emerging challenge and the interest about this disease is growing since PEG is considered one of the possible causes of coronavirus disease 2019 (COVID 19) vaccine-associated anaphylaxis. ...Lack o …
Hypersensitivity reactions to polyethylene glycol (PEG) is an emerging challenge and the interest about this disease is …
Hypersensitivity to polyethylene glycol (PEG).
Czarnobilska M, Bulanda M, Kurnik-Łucka M, Gil K. Czarnobilska M, et al. Folia Med Cracov. 2021 Dec 28;61(4):55-69. doi: 10.24425/fmc.2021.140004. Folia Med Cracov. 2021. PMID: 35180202 Free article.
The only absolute contraindication to administration of the vaccine is an anaphylactic reaction to any of its ingredients. Polyethylene glycol (PEG), widely used as an excipient in various vaccines, is considered the primary cause of allergic reactions associated wi …
The only absolute contraindication to administration of the vaccine is an anaphylactic reaction to any of its ingredients. Polyethylene …
Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.
Stone CA Jr, Liu Y, Relling MV, Krantz MS, Pratt AL, Abreo A, Hemler JA, Phillips EJ. Stone CA Jr, et al. J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1533-1540.e8. doi: 10.1016/j.jaip.2018.12.003. Epub 2018 Dec 14. J Allergy Clin Immunol Pract. 2019. PMID: 30557713 Free PMC article.
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; however, the epidemiology, mechanisms, and cross-reactivity are poorly understood. ...Our studies raise the possibility of an IgE-mediated t …
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; …
To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives.
Shi D, Beasock D, Fessler A, Szebeni J, Ljubimova JY, Afonin KA, Dobrovolskaia MA. Shi D, et al. Adv Drug Deliv Rev. 2022 Jan;180:114079. doi: 10.1016/j.addr.2021.114079. Epub 2021 Dec 10. Adv Drug Deliv Rev. 2022. PMID: 34902516 Free PMC article. Review.
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional formulations utilize PEG as either an active ingredient or an excipient. ...
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional formulations utilize PEG as either an acti …
Hidden Dangers: Recognizing Excipients as Potential Causes of Drug and Vaccine Hypersensitivity Reactions.
Caballero ML, Krantz MS, Quirce S, Phillips EJ, Stone CA Jr. Caballero ML, et al. J Allergy Clin Immunol Pract. 2021 Aug;9(8):2968-2982. doi: 10.1016/j.jaip.2021.03.002. Epub 2021 Mar 15. J Allergy Clin Immunol Pract. 2021. PMID: 33737254 Free PMC article. Review.
For both drugs and vaccines, these are rare reactions; however, for vaccines, they are the primary cause of immediate hypersensitivity. Suspicion for these "hidden dangers" should be high, in particular, when anaphylaxis has occurred in association with multiple chemically …
For both drugs and vaccines, these are rare reactions; however, for vaccines, they are the primary cause of immediate hypersensitivity …
Serum polyethylene glycol-specific IgE and IgG in patients with hypersensitivity to COVID-19 mRNA vaccines.
Mouri M, Imamura M, Suzuki S, Kawasaki T, Ishizaki Y, Sakurai K, Nagafuchi H, Matsumura N, Uchida M, Ando T, Yoshioka K, Ooka S, Sugihara T, Miyoshi H, Mori M, Okada T, Yamaguchi M, Kunishima H, Kato M, Kawahata K. Mouri M, et al. Allergol Int. 2022 Oct;71(4):512-519. doi: 10.1016/j.alit.2022.05.007. Epub 2022 Jun 6. Allergol Int. 2022. PMID: 35718709 Free PMC article.
BACKGROUND: The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is a potential antigen in the components of vaccines. ...
BACKGROUND: The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is …
Polyethylene Glycol Is a Cause of IgE-Mediated Anaphylaxis.
Giavina-Bianchi P, Kalil J. Giavina-Bianchi P, et al. J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1874-1875. doi: 10.1016/j.jaip.2019.05.001. J Allergy Clin Immunol Pract. 2019. PMID: 31279466 No abstract available.
Pegaspargase: A Review in Acute Lymphoblastic Leukaemia.
Heo YA, Syed YY, Keam SJ. Heo YA, et al. Drugs. 2019 May;79(7):767-777. doi: 10.1007/s40265-019-01120-1. Drugs. 2019. PMID: 31030380 Free PMC article. Review.
Pegaspargase treatment in patients with relapsed ALL and hypersensitivity to E. coliL-asparaginase had a similar tolerability profile to that observed in patients with newly diagnosed ALL. Given the potentially reduced immunogenicity and more convenient dosage regimen over …
Pegaspargase treatment in patients with relapsed ALL and hypersensitivity to E. coliL-asparaginase had a similar tolerability profile …
Patients with previous immediate hypersensitivity reactions to polyethylene glycol can safely receive the BNT162b2 mRNA COVID-19 vaccine.
Hurst M, Jordan A, Capstick J, Brewerton M, Cockroft R, Ingram J. Hurst M, et al. Intern Med J. 2022 Oct;52(10):1818-1820. doi: 10.1111/imj.15821. Epub 2022 Oct 6. Intern Med J. 2022. PMID: 36000384 Free PMC article.
Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contraindication to the BNT162b2 mRNA COVID-19 vaccine, which contains 50 ug of PEG at a molecular weight of 2000, and this component is thought …
Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contr …
Immediate-type hypersensitivity to polyethylene glycols: a review.
Wenande E, Garvey LH. Wenande E, et al. Clin Exp Allergy. 2016 Jul;46(7):907-22. doi: 10.1111/cea.12760. Clin Exp Allergy. 2016. PMID: 27196817 Review.
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first comprehensive review provides practical information for allergists and other healthcare professionals by describing the clinical picture of …
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first …
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.
Knop K, Hoogenboom R, Fischer D, Schubert US. Knop K, et al. Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308. doi: 10.1002/anie.200902672. Angew Chem Int Ed Engl. 2010. PMID: 20648499 Review.
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery. ...The areas that might need consideration and more intensive and careful examination can be divided into the followin …
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer …
Polyethylene Glycol-Induced Systemic Allergic Reactions (Anaphylaxis).
Sellaturay P, Nasser S, Ewan P. Sellaturay P, et al. J Allergy Clin Immunol Pract. 2021 Feb;9(2):670-675. doi: 10.1016/j.jaip.2020.09.029. Epub 2020 Oct 1. J Allergy Clin Immunol Pract. 2021. PMID: 33011299
Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers found in everyday products such as foods, cosmetics, and medications. ...
Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers found in everyday products such as foods, cosmetics, and med …
PEG-asparaginase.
Fu CH, Sakamoto KM. Fu CH, et al. Expert Opin Pharmacother. 2007 Aug;8(12):1977-84. doi: 10.1517/14656566.8.12.1977. Expert Opin Pharmacother. 2007. PMID: 17696798 Review.
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase antibodies, which neutralize their activity. PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene …
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase an …
Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging.
Senior R, Lindner JR, Edvardsen T, Cosyns B. Senior R, et al. Eur Heart J Cardiovasc Imaging. 2021 Aug 14;22(9):959-960. doi: 10.1093/ehjci/jeab120. Eur Heart J Cardiovasc Imaging. 2021. PMID: 34164650
Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, to polyethylene glycol (PEG) (macrogol), or to PEG-containing products, such as certain bowel preps for colonoscopy or laxative …
Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, t …
Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel.
Stock W, Douer D, DeAngelo DJ, Arellano M, Advani A, Damon L, Kovacsovics T, Litzow M, Rytting M, Borthakur G, Bleyer A. Stock W, et al. Leuk Lymphoma. 2011 Dec;52(12):2237-53. doi: 10.3109/10428194.2011.596963. Epub 2011 Aug 10. Leuk Lymphoma. 2011. PMID: 21827361
The most frequent toxicities of both types of ASNase are hepatic and pancreatic, with pancreatitis being the most serious. Other toxicities are hypersensitivity reactions, thrombosis, nausea/vomiting, and fatigue. Whether or not the replacement of one dose of pegASNase for …
The most frequent toxicities of both types of ASNase are hepatic and pancreatic, with pancreatitis being the most serious. Other toxicities …
Experience with polyethylene glycol allergy-guided risk management for COVID-19 vaccine anaphylaxis.
Brockow K, Mathes S, Fischer J, Volc S, Darsow U, Eberlein B, Biedermann T. Brockow K, et al. Allergy. 2022 Jul;77(7):2200-2210. doi: 10.1111/all.15183. Epub 2021 Dec 4. Allergy. 2022. PMID: 34806775 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) may elicit anaphylaxis to COVID-19 mRNA vaccines, and guidance for patients at risk is needed. ...In 421 prospective real-life patients asking for allergy workup for COVID-19 vaccine hypersensitivity in 2020/2021, risk as …
BACKGROUND: Polyethylene glycol (PEG) may elicit anaphylaxis to COVID-19 mRNA vaccines, and guidance for patients at risk is n …
Patients with polyethylene glycol allergy can experience immediate-type hypersensitivity reactions after exposure to analog substances.
Yoshimoto Y, Tezuka J. Yoshimoto Y, et al. BMJ Case Rep. 2023 Aug 29;16(8):e254040. doi: 10.1136/bcr-2022-254040. BMJ Case Rep. 2023. PMID: 37643821
Polyethylene glycol (PEG) allergy has been recently observed after COVID-19 mRNA vaccination. ...Our findings indicate that patients with PEG allergy may experience immediate-type hypersensitivity reactions to analogue substances....
Polyethylene glycol (PEG) allergy has been recently observed after COVID-19 mRNA vaccination. ...Our findings indicate that pa …
Hypersensitivity to polyethylene glycols.
Shah S, Prematta T, Adkinson NF, Ishmael FT. Shah S, et al. J Clin Pharmacol. 2013 Mar;53(3):352-5. doi: 10.1177/0091270012447122. Epub 2013 Jan 24. J Clin Pharmacol. 2013. PMID: 23444288 No abstract available.
Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey.
Özkaya E, Kılıç S. Özkaya E, et al. Contact Dermatitis. 2018 Mar;78(3):211-215. doi: 10.1111/cod.12931. Epub 2017 Nov 28. Contact Dermatitis. 2018. PMID: 29193145
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. ...
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmeti …
Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.
Ozer I, Kelly G, Gu R, Li X, Zakharov N, Sirohi P, Nair SK, Collier JH, Hershfield MS, Hucknall AM, Chilkoti A. Ozer I, et al. Adv Sci (Weinh). 2022 Apr;9(11):e2103672. doi: 10.1002/advs.202103672. Epub 2022 Feb 8. Adv Sci (Weinh). 2022. PMID: 35133079 Free PMC article.
Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. ...Here, the authors synthesize a poly(oligo(ethylene glycol …
Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyet …
Expert Consensus Statement from the American Society of Echocardiography on Hypersensitivity Reactions to Ultrasound Enhancing Agents in Patients with Allergy to Polyethylene Glycol.
Lindner JR, Belcik T, Main ML, Montanaro A, Mulvagh SL, Olson J, Olyaei A, Porter TR, Senior R. Lindner JR, et al. J Am Soc Echocardiogr. 2021 Jul;34(7):707-708. doi: 10.1016/j.echo.2021.05.002. Epub 2021 May 7. J Am Soc Echocardiogr. 2021. PMID: 33971277 Free PMC article. No abstract available.
Endotyping of IgE-Mediated Polyethylene Glycol and/or Polysorbate 80 Allergy.
Ieven T, Coorevits L, Vandebotermet M, Tuyls S, Vanneste H, Santy L, Wets D, Proost P, Frans G, Devolder D, Breynaert C, Bullens DMA, Schrijvers R. Ieven T, et al. J Allergy Clin Immunol Pract. 2023 Oct;11(10):3146-3160. doi: 10.1016/j.jaip.2023.06.031. Epub 2023 Jun 26. J Allergy Clin Immunol Pract. 2023. PMID: 37380070 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) and polysorbate 80 (PS80) allergy preclude from SARS-CoV-2 vaccination. ...
BACKGROUND: Polyethylene glycol (PEG) and polysorbate 80 (PS80) allergy preclude from SARS-CoV-2 vaccination. ...
Basophil Activation Test with Different Polyethylene Glycols in Patients with Suspected PEG Hypersensitivity Reactions.
Vespa S, Del Biondo P, Simeone P, Cavallucci E, Catitti G, Auciello R, De Bellis D, Altomare I, Pierdomenico L, Canonico B, Cicalini I, Angilletta I, Del Boccio P, Pieragostino D, Santilli F, Urbani A, De Laurenzi V, Stuppia L, Lanuti P. Vespa S, et al. Int J Mol Sci. 2022 Nov 23;23(23):14592. doi: 10.3390/ijms232314592. Int J Mol Sci. 2022. PMID: 36498922 Free PMC article.
Allergic reactions to COVID-19 vaccine components are rare but should be considered. Polyethylene glycol (PEG) is responsible for anaphylaxis in mRNA vaccines. ...To this end, among the subjects that underwent allergy counseling at the Allergy Unit of our Institutio …
Allergic reactions to COVID-19 vaccine components are rare but should be considered. Polyethylene glycol (PEG) is responsible …
Allergen-specific immunotherapy.
Niederberger V. Niederberger V. Immunol Lett. 2009 Feb 21;122(2):131-3. doi: 10.1016/j.imlet.2008.11.012. Epub 2008 Dec 25. Immunol Lett. 2009. PMID: 19100771 Review.
Anti-PEG IgE in anaphylaxis associated with polyethylene glycol.
Zhou ZH, Stone CA Jr, Jakubovic B, Phillips EJ, Sussman G, Park J, Hoang U, Kirshner SL, Levin R, Kozlowski S. Zhou ZH, et al. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1731-1733.e3. doi: 10.1016/j.jaip.2020.11.011. Epub 2020 Nov 17. J Allergy Clin Immunol Pract. 2021. PMID: 33217616 Free PMC article. No abstract available.
A Randomized, Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings.
Botson JK, Saag K, Peterson J, Parikh N, Ong S, La D, LoCicero K, Obermeyer K, Xin Y, Chamberlain J, LaMoreaux B, Verma S, Sainati S, Grewal S, Majjhoo A, Tesser JRP, Weinblatt ME. Botson JK, et al. Arthritis Rheumatol. 2023 Feb;75(2):293-304. doi: 10.1002/art.42335. Epub 2022 Dec 16. Arthritis Rheumatol. 2023. PMID: 36099211 Free PMC article. Clinical Trial.
Anaphylaxis and Coronavirus Disease 2019 vaccine: a danger relationship?
Tanno LK, Castells M, Caminati M, Senna G, Demoly P. Tanno LK, et al. Curr Opin Allergy Clin Immunol. 2021 Oct 1;21(5):411-417. doi: 10.1097/ACI.0000000000000778. Curr Opin Allergy Clin Immunol. 2021. PMID: 34334663 Review.
PURPOSE OF REVIEW: Anaphylactic reactions reported after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) RNA vaccines were expected to be more frequent in atopic subjects and attributed to its polyethylene glycol component. RECENT FINDINGS: Anaphylaxis t …
PURPOSE OF REVIEW: Anaphylactic reactions reported after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) RNA vaccines were expec …
Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines.
Chen WA, Chang DY, Chen BM, Lin YC, Barenholz Y, Roffler SR. Chen WA, et al. ACS Nano. 2023 Mar 28;17(6):5757-5772. doi: 10.1021/acsnano.2c12193. Epub 2023 Mar 16. ACS Nano. 2023. PMID: 36926834 Free PMC article.
Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension, and death in the most severe cases. Because many normal individuals have pre-existing antibodies …
Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from flushing and breathing …
Vaccine allergy: evidence to consider for COVID-19 vaccines.
Nilsson L, Csuth Á, Storsaeter J, Garvey LH, Jenmalm MC. Nilsson L, et al. Curr Opin Allergy Clin Immunol. 2021 Aug 1;21(4):401-409. doi: 10.1097/ACI.0000000000000762. Curr Opin Allergy Clin Immunol. 2021. PMID: 34091550 Free PMC article. Review.
Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivatives are the most suspected, albeit hitherto unproven, causes. ...
Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivati …
Allergenic components of the mRNA-1273 vaccine for COVID-19: Possible involvement of polyethylene glycol and IgG-mediated complement activation.
Klimek L, Novak N, Cabanillas B, Jutel M, Bousquet J, Akdis CA. Klimek L, et al. Allergy. 2021 Nov;76(11):3307-3313. doi: 10.1111/all.14794. Epub 2021 Jun 17. Allergy. 2021. PMID: 33657648 Free PMC article. Review.
While the culprit trigger requires investigation, initial reports suggested the excipient polyethylene glycol 2000 (PEG-2000)-contained in both vaccines as the PEG-micellar carrier system-as the potential culprit. ...
While the culprit trigger requires investigation, initial reports suggested the excipient polyethylene glycol 2000 (PEG-2000)- …
Janssen COVID-19 vaccine tolerated in 10 patients with confirmed polyethylene glycol allergy.
Bruusgaard-Mouritsen MA, Koo G, Heinrichsen AS, Melchiors BB, Krantz MS, Plager JH, Boxer M, Phillips EJ, Stone CA Jr, Garvey LH. Bruusgaard-Mouritsen MA, et al. J Allergy Clin Immunol Pract. 2022 Mar;10(3):859-862. doi: 10.1016/j.jaip.2021.12.025. Epub 2022 Jan 1. J Allergy Clin Immunol Pract. 2022. PMID: 34979336 Free PMC article. No abstract available.
Severe Polyethylene Glycol Allergy Considerations for Perioperative Management: A Case Report.
Wong-On-Wing A, Ruth K, Hinerth K, Deng A, Woldekiros M, Ellenbogen RG, Crowder CM. Wong-On-Wing A, et al. A A Pract. 2022 Oct 11;16(10):e01619. doi: 10.1213/XAA.0000000000001619. eCollection 2022 Oct 1. A A Pract. 2022. PMID: 36219725
Patients with severe polyethylene glycol (PEG) allergies face broad challenges, especially when presenting to the hospital for surgery, as PEG is used often as an excipient in medications and in medical supplies. ...
Patients with severe polyethylene glycol (PEG) allergies face broad challenges, especially when presenting to the hospital for …
Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines?
Eberlein B, Mathes S, Fischer J, Darsow U, Biedermann T, Brockow K. Eberlein B, et al. Allergy. 2022 Oct;77(10):2924-2936. doi: 10.1111/all.15278. Epub 2022 Mar 25. Allergy. 2022. PMID: 35266570 Free PMC article. Review.
In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release test) by using the vaccines or modified compounds containing polyethylene glycol (PEG), rather than unmodified PEGs, have proven …
In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release tes …
Safety of COVID-19 vaccination in patients with polyethylene glycol allergy: A case series.
Picard M, Drolet JP, Masse MS, Filion CA, ALMuhizi F, Fein M, Copaescu A, Isabwe GAC, Blaquière M, Primeau MN. Picard M, et al. J Allergy Clin Immunol Pract. 2022 Feb;10(2):620-625.e1. doi: 10.1016/j.jaip.2021.11.021. Epub 2021 Dec 20. J Allergy Clin Immunol Pract. 2022. PMID: 34949564 Free PMC article. No abstract available.
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions.
Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, Rosivall L, Bavli Y, Urbanics R, Mollnes TE, Barenholz Y, Szebeni J. Kozma GT, et al. ACS Nano. 2019 Aug 27;13(8):9315-9324. doi: 10.1021/acsnano.9b03942. Epub 2019 Aug 6. ACS Nano. 2019. PMID: 31348638 Free article.
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. ...
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which …
Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia.
Khalil A, Würthwein G, Golitsch J, Hempel G, Fobker M, Gerss J, Möricke A, Zimmermann M, Smisek P, Zucchetti M, Nath C, Attarbaschi A, Von Stackelberg A, Gökbuget N, Rizzari C, Conter V, Schrappe M, Boos J, Lanvers-Kaminsky C. Khalil A, et al. Haematologica. 2022 Jan 1;107(1):49-57. doi: 10.3324/haematol.2020.258525. Haematologica. 2022. PMID: 33299233 Free PMC article.
Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. ...Although pre-existing anti-PEG antibodies did not boost, pre-existing anti-PEG IgG were significantly associated with firstexposure hypersens …
Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. ...Alth …
The interplay between PEGylated nanoparticles and blood immune system.
Guo C, Yuan H, Wang Y, Feng Y, Zhang Y, Yin T, He H, Gou J, Tang X. Guo C, et al. Adv Drug Deliv Rev. 2023 Sep;200:115044. doi: 10.1016/j.addr.2023.115044. Epub 2023 Aug 2. Adv Drug Deliv Rev. 2023. PMID: 37541623 Review.
During the last two decades, an increasing number of reports have pointed out that the immunogenicity of polyethylene glycol (PEG) may trigger accelerated blood clearance (ABC) and hypersensitivity reaction (HSR) to PEGylated nanoparticles, which could make P …
During the last two decades, an increasing number of reports have pointed out that the immunogenicity of polyethylene glycol ( …
The Polysorbate containing AstraZeneca COVID-19 vaccine is tolerated by polyethylene glycol (PEG) allergic patients.
Sellaturay P, Gurugama P, Harper V, Dymond T, Ewan P, Nasser S. Sellaturay P, et al. Clin Exp Allergy. 2022 Jan;52(1):12-17. doi: 10.1111/cea.14064. Epub 2021 Dec 9. Clin Exp Allergy. 2022. PMID: 34822190
BACKGROUND: Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. ...
BACKGROUND: Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. ...
[Polyethylengylcole - Friend or Foe?].
Bayerl C, Herbst M. Bayerl C, et al. Laryngorhinootologie. 2022 Oct;101(10):784-786. doi: 10.1055/a-1861-7047. Epub 2022 Sep 29. Laryngorhinootologie. 2022. PMID: 36174565 German.
However, anaphylactic reactions towards the Pfizer-BioNTech Covid-19 vaccine were first reported in two patients in the UK and another 19 in the USA. Pegylation with polyethylene glycol (PEG) was thought to be the possible culprit. Pegylation is a common process in …
However, anaphylactic reactions towards the Pfizer-BioNTech Covid-19 vaccine were first reported in two patients in the UK and another 19 in …
Primary care provider-reported prevalence of vaccine and polyethylene glycol allergy in Canada.
Abrams EM, Greenhawt M, Shaker M, Kosowan L, Singer AG. Abrams EM, et al. Ann Allergy Asthma Immunol. 2021 Oct;127(4):446-450.e1. doi: 10.1016/j.anai.2021.05.011. Epub 2021 May 15. Ann Allergy Asthma Immunol. 2021. PMID: 34004274 Free PMC article.
OBJECTIVE: To determine the prevalence of PCP-documented vaccine and polyethylene glycol (PEG) allergy using electronic medical record data from the Canadian Primary Care Sentinel Surveillance Network. ...
OBJECTIVE: To determine the prevalence of PCP-documented vaccine and polyethylene glycol (PEG) allergy using electronic medica …
Polyethylene glycol-modified ragweed pollen extract in rhinoconjunctivitis.
Juniper EF, Roberts RS, Kennedy LK, O'Connor J, Syty-Golda M, Dolovich J, Hargreave FE. Juniper EF, et al. J Allergy Clin Immunol. 1985 May;75(5):578-85. doi: 10.1016/0091-6749(85)90033-8. J Allergy Clin Immunol. 1985. PMID: 3989142 Clinical Trial.
Sixty-two ragweed-sensitive adult subjects volunteered to take part in a 2-year, placebo-controlled efficacy study of polyethylene glycol (PEG)-modified ragweed extract, in ragweed pollen-induced rhinoconjunctivitis. ...
Sixty-two ragweed-sensitive adult subjects volunteered to take part in a 2-year, placebo-controlled efficacy study of polyethylene …
Clinical pharmacology of polyethylene glycol-L-asparaginase.
Ho DH, Brown NS, Yen A, Holmes R, Keating M, Abuchowski A, Newman RA, Krakoff IH. Ho DH, et al. Drug Metab Dispos. 1986 May-Jun;14(3):349-52. Drug Metab Dispos. 1986. PMID: 2872037
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patients of whom 27 were evaluable pharmacokinetically. ...
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patient …
Optimizing investigation of suspected allergy to polyethylene glycols.
Bruusgaard-Mouritsen MA, Jensen BM, Poulsen LK, Duus Johansen J, Garvey LH. Bruusgaard-Mouritsen MA, et al. J Allergy Clin Immunol. 2022 Jan;149(1):168-175.e4. doi: 10.1016/j.jaci.2021.05.020. Epub 2021 May 28. J Allergy Clin Immunol. 2022. PMID: 34052265 Free article. Clinical Trial.
BACKGROUND: Polyethylene glycols (PEGs) are polymers of varying molecular weight (MW) used widely as excipients in drugs and other products, including the mRNA vaccines against coronavirus disease 2019. ...
BACKGROUND: Polyethylene glycols (PEGs) are polymers of varying molecular weight (MW) used widely as excipients in drugs and o …
Pegaspargase in Practice: Minimizing Toxicity, Maximizing Benefit.
Riley DO, Schlefman JM, Vitzthum Von Eckstaedt V HC, Morris AL, Keng MK, El Chaer F. Riley DO, et al. Curr Hematol Malig Rep. 2021 Jun;16(3):314-324. doi: 10.1007/s11899-021-00638-0. Epub 2021 May 12. Curr Hematol Malig Rep. 2021. PMID: 33978914 Review.
RECENT FINDINGS: Clinically significant toxicities of pegaspargase include thrombosis, hypersensitivity and inactivation, hepatotoxicity, pancreatitis, and hypertriglyceridemia. ...
RECENT FINDINGS: Clinically significant toxicities of pegaspargase include thrombosis, hypersensitivity and inactivation, hepatotoxic …
A randomized, prospective, comparison study of polyethylene glycol 3350 without electrolytes and milk of magnesia for children with constipation and fecal incontinence.
Loening-Baucke V, Pashankar DS. Loening-Baucke V, et al. Pediatrics. 2006 Aug;118(2):528-35. doi: 10.1542/peds.2006-0220. Pediatrics. 2006. PMID: 16882804 Clinical Trial.
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene glycol-treated children and 43% of milk of magnesia-treated children exhibited improvement, and 33% of polyethylene glycol …
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene …
PEGylated Lipid Nanoparticle Formulations: Immunological Safety and Efficiency Perspective.
Tenchov R, Sasso JM, Zhou QA. Tenchov R, et al. Bioconjug Chem. 2023 Jun 21;34(6):941-960. doi: 10.1021/acs.bioconjchem.3c00174. Epub 2023 May 10. Bioconjug Chem. 2023. PMID: 37162501 Free PMC article. Review.
Currently in the spotlight as important constituents of the COVID-19 mRNA vaccines, LNPs play a significant role in protecting and transporting mRNA to cells. As one of their key constituents, polyethylene glycol (PEG)-lipid conjugates are important in defining LNP …
Currently in the spotlight as important constituents of the COVID-19 mRNA vaccines, LNPs play a significant role in protecting and transport …
Interferon-induced sarcoidosis.
Cardoso C, Freire R, Alves A, Oliveira A. Cardoso C, et al. BMJ Case Rep. 2011 Apr 19;2011:bcr0320113929. doi: 10.1136/bcr.03.2011.3929. BMJ Case Rep. 2011. PMID: 22696628 Free PMC article.
Coronavirus disease 2019 vaccine administration in patients with reported reactions to polyethylene glycol- and polysorbate-containing therapeutics.
Otani IM, Tsao LR, Tang M. Otani IM, et al. Ann Allergy Asthma Immunol. 2022 Jul;129(1):88-94.e1. doi: 10.1016/j.anai.2022.03.006. Epub 2022 Mar 12. Ann Allergy Asthma Immunol. 2022. PMID: 35288274 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) and polysorbate reactions were initially implicated as a likely risk factor for reacting to coronavirus disease 2019 (COVID-19) vaccines and remain a source of vaccine hesitancy despite increasing evidence that they do not pose …
BACKGROUND: Polyethylene glycol (PEG) and polysorbate reactions were initially implicated as a likely risk factor for reacting …
Evaluation of pediatric patients with suspected polyethylene glycol and polysorbate allergy before mRNA SARS-CoV2 vaccination.
Karaaslan BG, Burtecene N, Mustu U, Ocak S, Kasapcopur O, Kıykım A, Cokugras H. Karaaslan BG, et al. Allergol Immunopathol (Madr). 2023 May 1;51(3):174-180. doi: 10.15586/aei.v51i3.800. eCollection 2023. Allergol Immunopathol (Madr). 2023. PMID: 37169575
This study aimed to retrospectively evaluate the role of polyethylene glycol (PEG) sensitivity in vaccination decision-making in pediatric patients at high risk of allergy or with suspected allergic reactions to the first dose of the severe acute respiratory syndrom …
This study aimed to retrospectively evaluate the role of polyethylene glycol (PEG) sensitivity in vaccination decision-making …
Activity and toxicity of intramuscular 1000 iu/m2 polyethylene glycol-E. coli L-asparaginase in the UKALL 2003 and UKALL 2011 clinical trials.
Sidhu J, Masurekar AN, Gogoi MP, Fong C, Ioannou T, Lodhi T, Parker C, Liu J, Kirkwood AA, Moorman AV, Das K, Goulden NJ, Vora A, Saha V, Krishnan S. Sidhu J, et al. Br J Haematol. 2022 Jul;198(1):142-150. doi: 10.1111/bjh.18158. Epub 2022 Mar 29. Br J Haematol. 2022. PMID: 35348200 Free PMC article. Clinical Trial.
In successive UK clinical trials (UKALL 2003, UKALL 2011) for paediatric acute lymphoblastic leukaemia (ALL), polyethylene glycol-conjugated E. coli L-asparaginase (PEG-EcASNase) 1000 iu/m(2) was administered intramuscularly with risk-stratified treatment. ...Older …
In successive UK clinical trials (UKALL 2003, UKALL 2011) for paediatric acute lymphoblastic leukaemia (ALL), polyethylene glycol …
Pegasparaginase: where do we stand?
Zeidan A, Wang ES, Wetzler M. Zeidan A, et al. Expert Opin Biol Ther. 2009 Jan;9(1):111-9. doi: 10.1517/14712590802586058. Expert Opin Biol Ther. 2009. PMID: 19063697 Review.
Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, especially the development of hypersensitivity reactions and neutralizing antibodies, and by the need for frequent administration. To ove …
Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, espe …
Pegaspargase hypersensitivity reactions: intravenous infusion versus intramuscular injection - a review.
Beaupin LK, Bostrom B, Barth MJ, Franklin I, Jaeger R, Kamath P, Schreiber B, Bleyer A. Beaupin LK, et al. Leuk Lymphoma. 2017 Apr;58(4):766-772. doi: 10.1080/10428194.2016.1218004. Epub 2016 Sep 19. Leuk Lymphoma. 2017. PMID: 27643446 Review.
When intravenous (IV) infusion replaced intramuscular (IM) injection as the standard route of administration, there were early reports suggested an increased hypersensitivity reactions (HSRs) rate with IV administration. There have since been eight published reports compar …
When intravenous (IV) infusion replaced intramuscular (IM) injection as the standard route of administration, there were early reports sugge …
Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics.
Verhoef JJ, Carpenter JF, Anchordoquy TJ, Schellekens H. Verhoef JJ, et al. Drug Discov Today. 2014 Dec;19(12):1945-52. doi: 10.1016/j.drudis.2014.08.015. Epub 2014 Sep 7. Drug Discov Today. 2014. PMID: 25205349 Review.
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-life. ...PEGylation has also been associated with the activation of the complement system causing severe hypersensitivity reactions. Her …
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-lif …
Polyethylene glycol-modified ragweed extract: comparison of two treatment regimens.
Juniper EF, O'Connor J, Roberts RS, Evans S, Hargreave FE, Dolovich J. Juniper EF, et al. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):851-6. doi: 10.1016/0091-6749(86)90229-0. J Allergy Clin Immunol. 1986. PMID: 3782653 Clinical Trial.
Fifty ragweed-sensitive subjects were each administered a course of 12 injections of polyethylene glycol-modified ragweed extract. To investigate the effect of two treatment regimens, subjects were paired according to their skin sensitivity to ragweed extract and th …
Fifty ragweed-sensitive subjects were each administered a course of 12 injections of polyethylene glycol-modified ragweed extr …
One to one comparison of cell-free synthesized erythropoietin conjugates modified with linear polyglycerol and polyethylene glycol.
Pouyan P, Zemella A, Schloßhauer JL, Walter RM, Haag R, Kubick S. Pouyan P, et al. Sci Rep. 2023 Apr 19;13(1):6394. doi: 10.1038/s41598-023-33463-x. Sci Rep. 2023. PMID: 37076514 Free PMC article.
With more than 20 Food and Drug Administration (FDA)-approved poly (ethylene glycol) (PEG) modified drugs on the market, PEG is the gold standard polymer in bioconjugation. ...Since PEG is not only applied in therapeutics, but can also be found in foods and cosmetics, anti …
With more than 20 Food and Drug Administration (FDA)-approved poly (ethylene glycol) (PEG) modified drugs on the market, PEG is the g …
PEG That Reaction: A Case Series of Allergy to Polyethylene Glycol.
Cox F, Khalib K, Conlon N. Cox F, et al. J Clin Pharmacol. 2021 Jun;61(6):832-835. doi: 10.1002/jcph.1824. Epub 2021 Feb 28. J Clin Pharmacol. 2021. PMID: 33543766 Free PMC article.
Polyethylene glycol (PEG), also known as macrogol, is an excipient in numerous medications, health care products, cosmetics, and foods. ...Despite its ubiquity, including in 2 of the newly launched vaccines against SARS-CoV-2, awareness of PEG allergy remains low. W …
Polyethylene glycol (PEG), also known as macrogol, is an excipient in numerous medications, health care products, cosmetics, a …
Final report on the safety assessment of Triethylene Glycol and PEG-4.
[No authors listed] [No authors listed] Int J Toxicol. 2006;25 Suppl 2:121-38. doi: 10.1080/10915810600964642. Int J Toxicol. 2006. PMID: 17090481 Review.
Triethylene Glycol and PEG-4 (polyethylene glycol) are polymers of ethylene oxide alcohol. ...There were no treatment-related effects on rats exposed to supersaturated Triethylene Glycol vapor for 13 months nor in rats that consumed 0.533 cc Triethylen …
Triethylene Glycol and PEG-4 (polyethylene glycol) are polymers of ethylene oxide alcohol. ...There were no treatment-r …
Prolonged angioedema after Pfizer-BioNTech COVID-19 vaccine.
Muhamad Fauzi SM. Muhamad Fauzi SM. BMJ Case Rep. 2023 Mar 7;16(3):e252979. doi: 10.1136/bcr-2022-252979. BMJ Case Rep. 2023. PMID: 36882264 Free PMC article.
She was discharged with advice to avoid further mRNA vaccines. This case highlights the increasing awareness needed of polyethylene glycol (PEG) allergy and the protracted nature of her reaction. ...
She was discharged with advice to avoid further mRNA vaccines. This case highlights the increasing awareness needed of polyethylene …
Non-IgE-dependent hypersensitivity to macrogol 6000.
Berndt K, Kuske M, Beissert S, Spornraft-Ragaller P, Bauer A. Berndt K, et al. J Dtsch Dermatol Ges. 2018 Apr;16(4):479-481. doi: 10.1111/ddg.13479. Epub 2018 Mar 26. J Dtsch Dermatol Ges. 2018. PMID: 29578283 No abstract available.
Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866).
Kurtzberg J, Asselin B, Bernstein M, Buchanan GR, Pollock BH, Camitta BM. Kurtzberg J, et al. J Pediatr Hematol Oncol. 2011 Dec;33(8):610-6. doi: 10.1097/MPH.0b013e31822d4d4e. J Pediatr Hematol Oncol. 2011. PMID: 22042277 Free PMC article. Clinical Trial.
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To overcome this problem, native Escherichia coli L-asparaginase was conjugated to polyethylene glycol (PEG) to formulate PEG-L-asp …
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To ov …
Pfizer's vaccine raises allergy concerns.
de Vrieze J. de Vrieze J. Science. 2021 Jan 1;371(6524):10-11. doi: 10.1126/science.371.6524.10. Science. 2021. PMID: 33384356 No abstract available.
Clinical manifestations and impact on daily life of allergy to polyethylene glycol (PEG) in ten patients.
Bruusgaard-Mouritsen MA, Johansen JD, Garvey LH. Bruusgaard-Mouritsen MA, et al. Clin Exp Allergy. 2021 Mar;51(3):463-470. doi: 10.1111/cea.13822. Epub 2021 Jan 15. Clin Exp Allergy. 2021. PMID: 33394522
BACKGROUND: Polyethylene glycols (PEGs) are widely used as excipients in drugs, cosmetics and household products. ...
BACKGROUND: Polyethylene glycols (PEGs) are widely used as excipients in drugs, cosmetics and household products. ...
Anaphylaxis to Polyethylene Glycol (Colyte®) in a Patient with Diverticulitis.
Lee SH, Hwang SH, Park JS, Park HS, Shin YS. Lee SH, et al. J Korean Med Sci. 2016 Oct;31(10):1662-3. doi: 10.3346/jkms.2016.31.10.1662. J Korean Med Sci. 2016. PMID: 27550498 Free PMC article.
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
COVID-19 Vaccines in Children with Cow's Milk and Food Allergies.
Liotti L, Bianchi A, Bottau P, Caimmi S, Crisafulli G, Franceschini F, Mori F, Paglialunga C, Saretta F, Caffarelli C. Liotti L, et al. Nutrients. 2021 Jul 30;13(8):2637. doi: 10.3390/nu13082637. Nutrients. 2021. PMID: 34444795 Free PMC article. Review.
Comparison of hypersensitivity rates to intravenous and intramuscular PEG-asparaginase in children with acute lymphoblastic leukemia: A meta-analysis and systematic review.
Hasan H, Shaikh OM, Rassekh SR, Howard AF, Goddard K. Hasan H, et al. Pediatr Blood Cancer. 2017 Jan;64(1):81-88. doi: 10.1002/pbc.26200. Epub 2016 Aug 31. Pediatr Blood Cancer. 2017. PMID: 27578304 Review.
The study objective was to perform a meta-analysis and systematic review to compare and generate pooled hypersensitivity rates for IM and IV PEG-ASP. METHODS: A systematic literature search was conducted for all epidemiological studies that investigated IV and IM hypers …
The study objective was to perform a meta-analysis and systematic review to compare and generate pooled hypersensitivity rates for IM …
Polyethylene glycol-L-asparaginase versus native L-asparaginase in canine non-Hodgkin's lymphoma.
Teske E, Rutteman GR, van Heerde P, Misdorp W. Teske E, et al. Eur J Cancer. 1990;26(8):891-5. doi: 10.1016/0277-5379(90)90193-w. Eur J Cancer. 1990. PMID: 2145933 Clinical Trial.
No side-effects were noted in the dogs treated with PEG-L-asparaginase, whereas 14 (48%) of the L-asparaginase treated dogs had side-effects related to this drug, including anaphylactic shock (9), anorexia or vomiting (4), hypersensitivity-related oedema (3), seizures (1) …
No side-effects were noted in the dogs treated with PEG-L-asparaginase, whereas 14 (48%) of the L-asparaginase treated dogs had side-effects …
Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient.
Sahiner UM, Yavuz ST, Gökce M, Buyuktiryaki B, Altan I, Aytac S, Tuncer M, Tuncer A, Sackesen C. Sahiner UM, et al. Pediatr Int. 2013 Aug;55(4):531-3. doi: 10.1111/ped.12131. Pediatr Int. 2013. PMID: 23910807
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG-ASP) is preferred. ...Anaphylaxis with PEG-ASP is very rare and premedication and desensitizat …
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene …
Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study.
Lokerse WJM, Lazarian A, Kleinhempel A, Petrini M, Schwarz P, Hossann M, Holdt LM, Mailänder V, Lindner LH. Lokerse WJM, et al. J Control Release. 2021 May 10;333:1-15. doi: 10.1016/j.jconrel.2021.03.014. Epub 2021 Mar 16. J Control Release. 2021. PMID: 33741385
Sufficient circulation half-life is important and most liposomes obtain this by polyethylene glycol (PEG) surface modification. 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol (DPPG(2)) has been described as a promising alternative which increases TSL circulation hal …
Sufficient circulation half-life is important and most liposomes obtain this by polyethylene glycol (PEG) surface modification …
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.
Chang CJ, Chen CH, Chen BM, Su YC, Chen YT, Hershfield MS, Lee MM, Cheng TL, Chen YT, Roffler SR, Wu JY. Chang CJ, et al. Nat Commun. 2017 Sep 12;8(1):522. doi: 10.1038/s41467-017-00622-4. Nat Commun. 2017. PMID: 28900105 Free PMC article.
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our findings may provide novel genetic markers for predicting the immunogenicity of PEG and efficacy of PEGylated therapeutics.Some individuals …
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our …
Production of a novel N-terminal PEGylated crisantaspase.
Torres-Obreque K, Meneguetti GP, Custódio D, Monteiro G, Pessoa-Junior A, de Oliveira Rangel-Yagui C. Torres-Obreque K, et al. Biotechnol Appl Biochem. 2019 May;66(3):281-289. doi: 10.1002/bab.1723. Epub 2019 Jan 7. Biotechnol Appl Biochem. 2019. PMID: 30597637
Crisantaspase is an asparaginase enzyme produced by Erwinia chrysanthemi and used to treat acute lymphoblastic leukemia (ALL) in case of hypersensitivity to Escherichia coli l-asparaginase (ASNase). The main disadvantages of crisantaspase are the short half-life (10 H) and …
Crisantaspase is an asparaginase enzyme produced by Erwinia chrysanthemi and used to treat acute lymphoblastic leukemia (ALL) in case of …
Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies.
Kishimoto TK. Kishimoto TK. Front Immunol. 2020 May 20;11:969. doi: 10.3389/fimmu.2020.00969. eCollection 2020. Front Immunol. 2020. PMID: 32508839 Free PMC article. Review.
The development of anti-drug antibodies (ADAs) is a common cause for treatment failure and hypersensitivity reactions for many biologics. The focus of this review is the development of ImmTOR, a platform technology designed to prevent the formation of ADAs that can be appl …
The development of anti-drug antibodies (ADAs) is a common cause for treatment failure and hypersensitivity reactions for many biolog …
Successful mRNA COVID-19 Vaccination and Colonoscopy After Oral Desensitization in a Patient With Polyethylene Glycol Allergy.
Cha B, Kwon KS, Lee HL, Kim CW. Cha B, et al. J Korean Med Sci. 2022 Aug 15;37(32):e251. doi: 10.3346/jkms.2022.37.e251. J Korean Med Sci. 2022. PMID: 35971765 Free PMC article.
Anaphylaxis to polyethylene glycol (PEG) is rare and mainly occurs with the use of laxatives containing PEG. ...
Anaphylaxis to polyethylene glycol (PEG) is rare and mainly occurs with the use of laxatives containing PEG. ...
Individualized Asparaginase Dosing in Childhood Acute Lymphoblastic Leukemia.
Kloos RQH, Pieters R, Jumelet FMV, de Groot-Kruseman HA, van den Bos C, van der Sluis IM. Kloos RQH, et al. J Clin Oncol. 2020 Mar 1;38(7):715-724. doi: 10.1200/JCO.19.02292. Epub 2020 Jan 10. J Clin Oncol. 2020. PMID: 31922920
PURPOSE: In the DCOG ALL-11 protocol, polyethylene glycol-conjugated Escherichia coli asparaginase (PEGasparaginase) and Erwinia asparaginase treatment of pediatric acute lymphoblastic leukemia are individualized with therapeutic drug monitoring (TDM). ...Asparagine …
PURPOSE: In the DCOG ALL-11 protocol, polyethylene glycol-conjugated Escherichia coli asparaginase (PEGasparaginase) and Erwin …
Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors.
Richter AW, Akerblom E. Richter AW, et al. Int Arch Allergy Appl Immunol. 1984;74(1):36-9. doi: 10.1159/000233512. Int Arch Allergy Appl Immunol. 1984. PMID: 6706424
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing passive hemagglutination. In untreated allergic patients and in healthy blood donors, naturally occurring anti-PEG antibody titers between …
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing …
Safe Administration of SARS-CoV-2 Vaccine After Desensitization to a Biologic Containing Polysorbate 80 in a Patient With Polyethylene Glycol-Induced Severe Anaphylaxis and Sensitization to Polysorbate 80.
Nin-Valencia A, Fiandor A, Lluch M, Quirce S, Caballero T, Heredia Revuelto R, González-Muñoz M, Caballero ML, Cabañas R. Nin-Valencia A, et al. J Investig Allergol Clin Immunol. 2023 Apr 18;33(2):151-153. doi: 10.18176/jiaci.0830. Epub 2022 May 31. J Investig Allergol Clin Immunol. 2023. PMID: 35638393 Free article. No abstract available.
Allergic reaction to polyethylene glycol in a painter.
Antolin-Amerigo D, Sánchez-González MJ, Barbarroja-Escudero J, Rodríguez-Rodríguez M, Álvarez-Perea A, Alvarez-Mon M. Antolin-Amerigo D, et al. Occup Med (Lond). 2015 Aug;65(6):502-4. doi: 10.1093/occmed/kqv072. Epub 2015 Jun 4. Occup Med (Lond). 2015. PMID: 26048329
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of a laxative solution containing polyethylene glycol (PEG) prior to colonoscopy. He described suffering from the same skin reac …
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of …
Management of Childhood Functional Constipation.
Philichi L. Philichi L. J Pediatr Health Care. 2018 Jan-Feb;32(1):103-111. doi: 10.1016/j.pedhc.2017.08.008. J Pediatr Health Care. 2018. PMID: 29229066 No abstract available.
COVID-19 vaccine anaphylaxis: PEG or not?
Krantz MS, Liu Y, Phillips EJ, Stone CA Jr. Krantz MS, et al. Allergy. 2021 Jun;76(6):1934-1937. doi: 10.1111/all.14722. Allergy. 2021. PMID: 34128562 Free PMC article. No abstract available.
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes.
Talkington AM, McSweeney MD, Wessler T, Rath MK, Li Z, Zhang T, Yuan H, Frank JE, Forest MG, Cao Y, Lai SK. Talkington AM, et al. J Control Release. 2022 Mar;343:518-527. doi: 10.1016/j.jconrel.2022.01.022. Epub 2022 Jan 21. J Control Release. 2022. PMID: 35066099 Free PMC article.
., anti-PEG antibodies (APA). In turn, APA increase both the risk of hypersensitivity to the drug as well as potential loss of efficacy due to accelerated blood clearance of the drug. ...
., anti-PEG antibodies (APA). In turn, APA increase both the risk of hypersensitivity to the drug as well as potential loss of effica …
Pegaspargase.
Alfieri DR. Alfieri DR. Pediatr Nurs. 1995 Sep-Oct;21(5):471-4, 490. Pediatr Nurs. 1995. PMID: 8684851
It has become a significant part of most chemotherapy protocols, however, its use is sometimes limited by the development of hypersensitivity reactions. Pegaspargase offers leukemia patients adequate asparagine depletion with a reduced incidence of hypersensitivity. …
It has become a significant part of most chemotherapy protocols, however, its use is sometimes limited by the development of hypersensiti …
[Folliculotropic mycosis fungoides].
Baratli J, Balakirski G, Megahed M. Baratli J, et al. Hautarzt. 2014 Dec;65(12):1011-3. doi: 10.1007/s00105-014-3539-z. Hautarzt. 2014. PMID: 25355498 German.
Oncologist counseling practice and COVID-19 vaccination outcomes for patients with history of PEG-asparaginase hypersensitivity.
Zarnegar-Lumley S, Stone CA Jr, Smith CM, Hall LL, Luck KE, Koo G, Plager JH, Phillips EJ, Friedman DL. Zarnegar-Lumley S, et al. Pediatr Blood Cancer. 2022 Jul;69(7):e29686. doi: 10.1002/pbc.29686. Epub 2022 Mar 30. Pediatr Blood Cancer. 2022. PMID: 35353440 Free PMC article.
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective strategy to prevent serious coronavirus disease 2019 (COVID-19) and is important for oncology patients. mRNA-based COVID-19 vaccines are contraindicated in those with a history of sev …
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective strategy to prevent serious coronavirus dis …
Asparaginase encapsulated in erythrocytes as second-line treatment in hypersensitive patients with acute lymphoblastic leukaemia.
Lynggaard LS, Vaitkeviciene G, Langenskiöld C, Lehmann AK, Lähteenmäki PM, Lepik K, El Hariry I, Schmiegelow K, Albertsen BK. Lynggaard LS, et al. Br J Haematol. 2022 Jun;197(6):745-754. doi: 10.1111/bjh.18152. Epub 2022 Mar 28. Br J Haematol. 2022. PMID: 35344210
To continue asparaginase treatment after hypersensitivity, a formulation of asparaginase encapsulated in erythrocytes (eryaspase) was developed. In NOR-GRASPALL 2016 (NCT03267030) the safety and efficacy of eryaspase was evaluated in 55 patients (aged 1-45 years; median: 6 …
To continue asparaginase treatment after hypersensitivity, a formulation of asparaginase encapsulated in erythrocytes (eryaspase) was …
Effects of rAmb a 1-Loaded PLGA-PEG Nanoparticles in a Murine Model of Allergic Conjunctivitis.
Cao H, Liu L, Wang J, Gong M, Yuan R, Lu J, Xiao X, Liu X. Cao H, et al. Molecules. 2022 Jan 18;27(3):598. doi: 10.3390/molecules27030598. Molecules. 2022. PMID: 35163859 Free PMC article.
Allergic conjunctivitis caused by Ambrosia artemisiifolia and its related allergen-specific immunotherapy (AIT) are seldom studied at present. poly(DL-lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) is a very good nano-carrier, which has been applied in the med …
Allergic conjunctivitis caused by Ambrosia artemisiifolia and its related allergen-specific immunotherapy (AIT) are seldom studied at presen …
Case of Polyethylene Glycol Allergy Confirmed with Basophil Activation Test and Oral Challenge Successfully Immunized with SARS-CoV-2 Vaccine.
Pasali M, Taka S, Chliva C, Katoulis A, Makris M. Pasali M, et al. Iran J Allergy Asthma Immunol. 2023 Sep 3;22(4):409-412. doi: 10.18502/ijaai.v22i4.13615. Iran J Allergy Asthma Immunol. 2023. PMID: 37767684 Free article.
Polyethylene glycols (PEG) or macrogols are polymers of ethylene oxide widely used in drugs either as active substances or, more commonly, as excipients. ...
Polyethylene glycols (PEG) or macrogols are polymers of ethylene oxide widely used in drugs either as active substances or, mo …
Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination.
Zhou ZH, Cortese MM, Fang JL, Wood R, Hummell DS, Risma KA, Norton AE, KuKuruga M, Kirshner S, Rabin RL, Agarabi C, Staat MA, Halasa N, Ware RE, Stahl A, McMahon M, Browning P, Maniatis P, Bolcen S, Edwards KM, Su JR, Dharmarajan S, Forshee R, Broder KR, Anderson S, Kozlowski S. Zhou ZH, et al. Vaccine. 2023 Jun 23;41(28):4183-4189. doi: 10.1016/j.vaccine.2023.05.029. Epub 2023 May 16. Vaccine. 2023. PMID: 37244808 Free PMC article.
BACKGROUND: The mechanism for anaphylaxis following mRNA COVID-19 vaccination has been widely debated; understanding this serious adverse event is important for future vaccines of similar design. A mechanism proposed is type I hypersensitivity (i.e., IgE-mediated mast cell …
BACKGROUND: The mechanism for anaphylaxis following mRNA COVID-19 vaccination has been widely debated; understanding this serious adverse ev …
Safety aspects of pegylated liposomal doxorubicin in patients with cancer.
Alberts DS, Garcia DJ. Alberts DS, et al. Drugs. 1997;54 Suppl 4:30-5. doi: 10.2165/00003495-199700544-00007. Drugs. 1997. PMID: 9361959 Review.
Encapsulation in polyethylene glycol-coated (pegylated; Stealth) liposomes alters the pharmacokinetic characteristics, and hence the safety and tolerability profile, of doxorubicin. ...Other adverse effects included nausea and vomiting and alopecia. Acute hyperse …
Encapsulation in polyethylene glycol-coated (pegylated; Stealth) liposomes alters the pharmacokinetic characteristics, and hen …
Immune responses to polyethylene glycol modified L-asparaginase in mice.
Kawamura K, Igarashi T, Fujii T, Kamisaki Y, Wada H, Kishimoto S. Kawamura K, et al. Int Arch Allergy Appl Immunol. 1985;76(4):324-30. doi: 10.1159/000233715. Int Arch Allergy Appl Immunol. 1985. PMID: 3980111
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glycol (PEG, MW, 5,000) conjugated Escherichia coli A-ase. ...PEG-A-ase administration also suppressed the delayed type hypersensitivity …
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glyco …
Urticaria as a Rare Side Effect of Polyethylene Glycol-3350 in a Child: Case Report.
Sari Gökay S, Çelik T, Yusuf Sari M, Ekinci F, Dinçer Yildizdaş R, Levent Yilmaz H. Sari Gökay S, et al. Acta Clin Croat. 2018 Mar;57(1):187-189. doi: 10.20471/acc.2018.57.01.26. Acta Clin Croat. 2018. PMID: 30256031 Free PMC article.
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease.
Ousingsawat J, Centeio R, Cabrita I, Talbi K, Zimmer O, Graf M, Göpferich A, Schreiber R, Kunzelmann K. Ousingsawat J, et al. Int J Mol Sci. 2022 Jan 19;23(3):1085. doi: 10.3390/ijms23031085. Int J Mol Sci. 2022. PMID: 35163010 Free PMC article.
While systemic application of niclosamide may lead to unwanted side effects, local administration via aerosol may circumvent these problems, particularly when the drug is encapsulated into small polyethylene glycol (PEG) hydrospheres. In the present study, we examin …
While systemic application of niclosamide may lead to unwanted side effects, local administration via aerosol may circumvent these problems, …
Pegaspargase: a review of clinical studies.
Graham ML. Graham ML. Adv Drug Deliv Rev. 2003 Sep 26;55(10):1293-302. doi: 10.1016/s0169-409x(03)00110-8. Adv Drug Deliv Rev. 2003. PMID: 14499708 Review.
Beneficial effects of propylene and polyethylene glycol and saline in the treatment of perennial rhinitis.
Spector SL, Toshener D, Gay I, Rosenman E. Spector SL, et al. Clin Allergy. 1982 Mar;12(2):187-96. doi: 10.1111/j.1365-2222.1982.tb01638.x. Clin Allergy. 1982. PMID: 7074822 Clinical Trial.
Although propylene-and-polyethylene-glycol and saline have been used in clinical studies as placebos, their possible therapeutic role as wetting agents in the treatment of perennial rhinitis was investigated. ...
Although propylene-and-polyethylene-glycol and saline have been used in clinical studies as placebos, their possible therapeut …
Contact urticaria due to polyethylene glycol.
Fisher AA. Fisher AA. Cutis. 1977 Apr;19(4):409-12. Cutis. 1977. PMID: 856540
'Open' testing revealed an 'immediate' urticarial reaction to polyethylene glycol, which is used as a solvent in both antifungal agents. ...Apparently, this is the first written report of such an 'immediate' reaction to polyethylene glycol. Although th …
'Open' testing revealed an 'immediate' urticarial reaction to polyethylene glycol, which is used as a solvent in both antifung …
Eosinophilic cellulitis in response to BNT162b2 COVID-19 vaccination.
Ikediobi O, Eichenfield DZ, Barrio VR. Ikediobi O, et al. Pediatr Dermatol. 2022 Sep;39(5):823-824. doi: 10.1111/pde.15019. Epub 2022 May 6. Pediatr Dermatol. 2022. PMID: 35522122 Free PMC article.
A skin biopsy showed urticarial dermatitis with tissue eosinophilia consistent with a diagnosis of vaccine-associated eosinophilic cellulitis, with polyethylene glycol as a potential trigger....
A skin biopsy showed urticarial dermatitis with tissue eosinophilia consistent with a diagnosis of vaccine-associated eosinophilic celluliti …
Predicting success of desensitization after pegaspargase allergy.
Swanson HD, Panetta JC, Barker PJ, Liu Y, Inaba H, Relling MV, Pui CH, Karol SE. Swanson HD, et al. Blood. 2020 Jan 2;135(1):71-75. doi: 10.1182/blood.2019003407. Blood. 2020. PMID: 31750901 Free PMC article. No abstract available.
Allergic reactions to coronavirus disease 2019 vaccines and addressing vaccine hesitancy: Northwell Health experience.
Kaplan B, Farzan S, Coscia G, Rosenthal DW, McInerney A, Jongco AM, Ponda P, Bonagura VR. Kaplan B, et al. Ann Allergy Asthma Immunol. 2022 Feb;128(2):161-168.e1. doi: 10.1016/j.anai.2021.10.019. Epub 2021 Oct 24. Ann Allergy Asthma Immunol. 2022. PMID: 34699968 Free PMC article.
BACKGROUND: Allergic and nonallergic adverse reactions have been reported with global coronavirus disease 2019 (COVID-19) vaccination. It was previously hypothesized that polyethylene glycol (PEG) may be responsible for anaphylactic reactions to messenger RNA (mRNA) …
BACKGROUND: Allergic and nonallergic adverse reactions have been reported with global coronavirus disease 2019 (COVID-19) vaccination. It wa …
Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation.
Erdeljic Turk V. Erdeljic Turk V. Clin Immunol. 2021 Jun;227:108748. doi: 10.1016/j.clim.2021.108748. Epub 2021 Apr 28. Clin Immunol. 2021. PMID: 33932618 Free PMC article.
Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assumption that polyethylene glycol (PEG) is the most likely culprit. Allergy testing to PEGs and mRNA vaccines is complex and carr …
Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assum …
Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase.
Soares AL, Guimarães GM, Polakiewicz B, de Moraes Pitombo RN, Abrahão-Neto J. Soares AL, et al. Int J Pharm. 2002 Apr 26;237(1-2):163-70. doi: 10.1016/s0378-5173(02)00046-7. Int J Pharm. 2002. PMID: 11955814
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reactions must be considered a relevant adverse effect of asparaginase therapy. One approach to reduce the hypersensitivity reactions cau …
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reac …
Increased permeability to polyethylene glycol 4000 in rabbits with experimental colitis.
Seidman EG, Hanson DG, Walker WA. Seidman EG, et al. Gastroenterology. 1986 Jan;90(1):120-6. doi: 10.1016/0016-5085(86)90083-1. Gastroenterology. 1986. PMID: 2933289
Little information is available regarding colonic permeability to macromolecules in health or disease states. In vivo permeability of rabbit colon to [14C]polyethylene glycol 4000 (14C-PEG) was examined in the presence of immune complex-mediated experimental colitis …
Little information is available regarding colonic permeability to macromolecules in health or disease states. In vivo permeability of rabbit …
Polythylene glycol severe allergy and SARS-CoV-2 vaccines: usefulness of testing with PEG 1500 extract.
Gaspar A, Moura AL, Cruz C, Borrego LM. Gaspar A, et al. Eur Ann Allergy Clin Immunol. 2023 Nov;55(6):261-270. doi: 10.23822/EurAnnACI.1764-1489.275. Epub 2022 Dec 2. Eur Ann Allergy Clin Immunol. 2023. PMID: 36458507 Free article.
Background. Polyethylene glycol (PEG) is being used for first time as an excipient for mRNA anti-SARS-CoV-2 vaccines containing PEG 2000, highlighting it as a potential cause of anaphylaxis. ...
Background. Polyethylene glycol (PEG) is being used for first time as an excipient for mRNA anti-SARS-CoV-2 vaccines containin …
Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.
Liu Y, Smith CA, Panetta JC, Yang W, Thompson LE, Counts JP, Molinelli AR, Pei D, Kornegay NM, Crews KR, Swanson H, Cheng C, Karol SE, Evans WE, Inaba H, Pui CH, Jeha S, Relling MV. Liu Y, et al. J Clin Oncol. 2019 Aug 10;37(23):2051-2061. doi: 10.1200/JCO.18.02439. Epub 2019 Jun 12. J Clin Oncol. 2019. PMID: 31188727 Free PMC article.
Serum samples (n = 5,369) were analyzed for anti-PEG-ASP immunoglobulin G by enzyme-linked immunosorbent assay. Positive samples were tested for anti-polyethylene glycol (PEG) and anti-L-ASP. We analyzed potential risk factors for reactions and associations between …
Serum samples (n = 5,369) were analyzed for anti-PEG-ASP immunoglobulin G by enzyme-linked immunosorbent assay. Positive samples were tested …
Skin reactions to propylene glycol.
Hannuksela M, Pirilä V, Salo OP. Hannuksela M, et al. Contact Dermatitis. 1975;1(2):112-6. doi: 10.1111/j.1600-0536.1975.tb05336.x. Contact Dermatitis. 1975. PMID: 233872
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method. ...In them, positive reactions were elicited by testing with high dilutions of PG …
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a tota …
Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
Abshire TC, Pollock BH, Billett AL, Bradley P, Buchanan GR. Abshire TC, et al. Blood. 2000 Sep 1;96(5):1709-15. Blood. 2000. PMID: 10961868 Free article. Clinical Trial.
The relapse rate in childhood acute lymphoblastic leukemia (ALL) is approximately 30% but few reinduction regimens have investigated the intensive use of polyethylene glycol Escherichia coli asparaginase (PEG-Asp). Therefore, we assessed the pharmocokinetics and eff …
The relapse rate in childhood acute lymphoblastic leukemia (ALL) is approximately 30% but few reinduction regimens have investigated the int …
Allergic contact dermatitis to polyethylene glycol and nitrofurazone.
Guijarro SC, Sánchez-Pérez J, García-Díez A. Guijarro SC, et al. Am J Contact Dermat. 1999 Dec;10(4):226-7. doi: 10.1053/AJCD01000226. Am J Contact Dermat. 1999. PMID: 10594300
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene glycol. Patch tests to nickel sulfate, potassium dischromate, chloride cobalt, Furacin, nitrofurazone 1% petrolatum, polyethyle …
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene …
Site specific PEGylation of β-lactoglobulin at glutamine residues and its influence on conformation and antigenicity.
Luo S, Lu X, Liu C, Zhong J, Zhou L, Chen T. Luo S, et al. Food Res Int. 2019 Sep;123:623-630. doi: 10.1016/j.foodres.2019.05.038. Epub 2019 May 29. Food Res Int. 2019. PMID: 31285011
beta-lactoglobulin (beta-LG) is one of the main allergens in milk. Polyethylene glycol (PEG) modification (PEGylation) was found to have the ability to reduce the antigenicity of proteins. To determine the effect of site specific PEGylation on beta-LG antigenicity a …
beta-lactoglobulin (beta-LG) is one of the main allergens in milk. Polyethylene glycol (PEG) modification (PEGylation) was fou …
Acute lymphoblastic leukaemia patients treated with PEGasparaginase develop antibodies to PEG and the succinate linker.
Kloos R, van der Sluis IM, Mastrobattista E, Hennink W, Pieters R, Verhoef JJ. Kloos R, et al. Br J Haematol. 2020 May;189(3):442-451. doi: 10.1111/bjh.16254. Epub 2019 Dec 27. Br J Haematol. 2020. PMID: 31883112 Free article.
Polyethylene glycol (PEG) conjugated asparaginase (PEGasparaginase) is essential for treatment of paediatric acute lymphoblastic leukaemia. We developed an assay identifying antibodies against the PEG-moiety, the linker and the drug itself in patients experiencing …
Polyethylene glycol (PEG) conjugated asparaginase (PEGasparaginase) is essential for treatment of paediatric acute lymphoblast …
Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group.
Brigitha LJ, Fiocco M, Pieters R, Albertsen BK, Escherich G, Lopez-Lopez E, Mondelaers V, Vora A, Vrooman L, Schmiegelow K, van der Sluis IM; Ponte di Legno Toxicity Working Group. Brigitha LJ, et al. Eur J Cancer. 2022 Feb;162:65-75. doi: 10.1016/j.ejca.2021.11.016. Epub 2021 Dec 23. Eur J Cancer. 2022. PMID: 34954438 Free article.
BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli (E.coli) asparaginase. ...Meta-analyses were conducted to estimate the incidence of three types of hypersensitivity (allergy, allergi …
BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli …
Taxanes hypersensitivity is not a risk factor for severe reactions to SARS-CoV-2 vaccines.
Cortellini G, Raiteri A, Biagioni B, Liberati S, Lippolis D, Cortellini G, Piscaglia F. Cortellini G, et al. Eur Ann Allergy Clin Immunol. 2023 Sep;55(5):229-234. doi: 10.23822/EurAnnACI.1764-1489.265. Epub 2022 Sep 1. Eur Ann Allergy Clin Immunol. 2023. PMID: 36047485 Free article.
Background. Hypersensitivity reactions (HSR) to taxanes have been related to a complement activation by their excipients, polyoxyethylated castor oil and Polysorbate 80, structurally related to those of SARS-CoV-2 vaccines. ...Some patients completed the vaccination course …
Background. Hypersensitivity reactions (HSR) to taxanes have been related to a complement activation by their excipients, polyoxyethy …
A case of anaphylaxis caused by polyethylene glycol analogues.
Yamasuji Y, Higashi Y, Sakanoue M, Katsue H, Kawai K, Arai N, Kanekura T. Yamasuji Y, et al. Contact Dermatitis. 2013 Sep;69(3):183-5. doi: 10.1111/cod.12084. Contact Dermatitis. 2013. PMID: 23948038 No abstract available.
Molecular weight dependence of polyethylene glycol penetration across acetone-disrupted permeability barrier.
Tsai JC, Hung PL, Sheu HM. Tsai JC, et al. Arch Dermatol Res. 2001 Jun;293(6):302-7. doi: 10.1007/s004030100229. Arch Dermatol Res. 2001. PMID: 11480590
The purpose of the present study was to investigate the dependence of permeability on molecular weight (MW) in acetone-disrupted hairless mouse skin in contrast to normal skin. Penetration of polyethylene glycol (PEG) 300, 600, and 1,000 over 12 h was measured using …
The purpose of the present study was to investigate the dependence of permeability on molecular weight (MW) in acetone-disrupted hairless mo …
Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro.
Neun BW, Barenholz Y, Szebeni J, Dobrovolskaia MA. Neun BW, et al. Molecules. 2018 Jul 12;23(7):1700. doi: 10.3390/molecules23071700. Molecules. 2018. PMID: 30002298 Free PMC article.
However, it is largely unknown why some patients develop reactions to nanomedicines while others do not, and why some nanoparticles are more reactogenic than others. One of the theories is that the pre-existing anti-polyethylene glycol (PEG) antibodies initiate the …
However, it is largely unknown why some patients develop reactions to nanomedicines while others do not, and why some nanoparticles are more …
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia.
Ettinger LJ, Kurtzberg J, Voûte PA, Jürgens H, Halpern SL. Ettinger LJ, et al. Cancer. 1995 Mar 1;75(5):1176-81. doi: 10.1002/1097-0142(19950301)75:5<1176::aid-cncr2820750519>3.0.co;2-y. Cancer. 1995. PMID: 7850718 Clinical Trial.
Because L-asparaginase is a foreign protein, the potential exists for severe, dose-limiting hypersensitivity reactions. To reduce this toxicity, L-asparaginase has been linked with polyethylene glycol (PEG). ...All patients had been treated previously with on …
Because L-asparaginase is a foreign protein, the potential exists for severe, dose-limiting hypersensitivity reactions. To reduce thi …
Clinical and demographic factors contributing to asparaginase-associated toxicities in children with acute lymphoblastic leukemia.
Dharia P, Swartz MD, Bernhardt MB, Chen H, Gramatges MM, Lupo PJ, Brown AL, Scheurer ME. Dharia P, et al. Leuk Lymphoma. 2022 Dec;63(12):2948-2954. doi: 10.1080/10428194.2022.2102621. Epub 2022 Jul 27. Leuk Lymphoma. 2022. PMID: 35895075
A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3% …
A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pe …
Surfactant Free Delivery of Docetaxel by Poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate]-Based Polymeric Micelles for Effective Melanoma Treatments.
Luo Z, Jiang L, Ding C, Hu B, Loh XJ, Li Z, Wu YL. Luo Z, et al. Adv Healthc Mater. 2018 Dec;7(23):e1801221. doi: 10.1002/adhm.201801221. Epub 2018 Nov 6. Adv Healthc Mater. 2018. PMID: 30398017
., ethanol and Tween 80), which are reported to cause severe hemolysis, hypersensitivity reactions, or neurotoxic toxicity and greatly hinders patient tolerance or compliance. In this report, a novel low-toxic, biodegradable, and amphiphilic poly[(R)-3-hydroxybutyrate-(R)- …
., ethanol and Tween 80), which are reported to cause severe hemolysis, hypersensitivity reactions, or neurotoxic toxicity and greatl …
Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy.
Troelnikov A, Perkins G, Yuson C, Ahamdie A, Balouch S, Hurtado PR, Hissaria P. Troelnikov A, et al. J Allergy Clin Immunol. 2021 Jul;148(1):91-95. doi: 10.1016/j.jaci.2021.04.032. Epub 2021 May 12. J Allergy Clin Immunol. 2021. PMID: 33991580
BACKGROUND: The mechanisms underpinning allergic reactions to the BNT162b2 (Pfizer) COVID-19 vaccine remain unknown, with polyethylene glycol (PEG) contained in the lipid nanoparticle suspected as being the cause. ...METHODS: Three known individuals with PEG allergy …
BACKGROUND: The mechanisms underpinning allergic reactions to the BNT162b2 (Pfizer) COVID-19 vaccine remain unknown, with polyethylene …
A double-blind study comparing monomethoxy polyethylene glycol-modified honeybee venom and unmodified honeybee venom for immunotherapy. I. Clinical results.
Müller U, Rabson AR, Bischof M, Lomnitzer R, Dreborg S, Lanner A. Müller U, et al. J Allergy Clin Immunol. 1987 Sep;80(3 Pt 1):252-61. doi: 10.1016/0091-6749(87)90027-3. J Allergy Clin Immunol. 1987. PMID: 3624680 Clinical Trial.
Thirty-five patients were allocated at random to immunotherapy (IT) in a double-blind way with either monomethoxy polyethylene glycol (mPEG)-modified honeybee venom (HBV) or HBV. The two groups were well matched regarding age, sex, skin sensitivity, HBV-specific ser …
Thirty-five patients were allocated at random to immunotherapy (IT) in a double-blind way with either monomethoxy polyethylene gly …
A randomized, double-blind, placebo-controlled trial of polyethylene glycol effects on fasting and postprandial rectal sensitivity and symptoms in hypersensitive constipation-predominant irritable bowel syndrome.
Awad RA, Camacho S. Awad RA, et al. Colorectal Dis. 2010 Nov;12(11):1131-8. doi: 10.1111/j.1463-1318.2009.01990.x. Colorectal Dis. 2010. PMID: 19575740 Clinical Trial.
AIM: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension and symptoms in hypersensitive constipation-predominant irritable bowel syndrome (IBS-C). ...The results support the concept that visc …
AIM: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension a …
Hypersensitivity Reaction to Carbon Fiber-Polyetheretherketone Composite Spinal Implant: A Case Report.
Bueno BT, Henry M, Cho SK. Bueno BT, et al. JBJS Case Connect. 2022 Jun 15;12(2). doi: 10.2106/JBJS.CC.21.00731. eCollection 2022 Apr 1. JBJS Case Connect. 2022. PMID: 35703153
CASE: A 52-year-old woman presented with localized hypersensitivity symptoms immediately after insertion of a carbon fiber-polyetheretherketone (CF-PEEK) vertebral fusion device. ...As far as we know, this is the first reported case of a hypersensitivity reaction to …
CASE: A 52-year-old woman presented with localized hypersensitivity symptoms immediately after insertion of a carbon fiber-polyethere …
Failure of desensitization with Pfizer-BioNTech COVID-19 vaccine in two asthmatic patients.
Iemoli E, Ortolani VGR, Preziosi D, Caron L, Giardina C, Carlevatti V, Giovine N. Iemoli E, et al. Eur Ann Allergy Clin Immunol. 2022 Sep;54(5):240-241. doi: 10.23822/EurAnnACI.1764-1489.236. Epub 2021 Nov 5. Eur Ann Allergy Clin Immunol. 2022. PMID: 34753281 Free article.
In mRNA vaccines, the component currently suspected of causing allergic reactions is the polyethylene glycol excipient (PEG or macrogol). In patients who have shown an immediate allergic reaction to vaccine and who are negative to skin tests for PEG, desensitization …
In mRNA vaccines, the component currently suspected of causing allergic reactions is the polyethylene glycol excipient (PEG or …
Improvement of Certolizumab Fab' properties by PASylation technology.
Mazaheri S, Talebkhan Y, Mahboudi F, Nematollahi L, Cohan RA, Mirabzadeh Ardakani E, Bayat E, Sabzalinejad M, Sardari S, Torkashvand F. Mazaheri S, et al. Sci Rep. 2020 Oct 28;10(1):18464. doi: 10.1038/s41598-020-74549-0. Sci Rep. 2020. PMID: 33116155 Free PMC article.
PEGylation may have disadvantages including immunogenicity, hypersensitivity, vacuolation, decreased binding affinity and biological activity of the protein. ...
PEGylation may have disadvantages including immunogenicity, hypersensitivity, vacuolation, decreased binding affinity and biological …
Outpatient continuous intravenous interleukin-2 or subcutaneous, polyethylene glycol-modified interleukin-2 in human immunodeficiency virus-infected patients: a randomized, controlled, multicenter study. Australian IL-2 Study Group.
Carr A, Emery S, Lloyd A, Hoy J, Garsia R, French M, Stewart G, Fyfe G, Cooper DA. Carr A, et al. J Infect Dis. 1998 Oct;178(4):992-9. doi: 10.1086/515653. J Infect Dis. 1998. PMID: 9806026 Clinical Trial.
The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2) or a slow-release, polyethylene glycol (PEG)-modified IL-2 were studied in human immunodeficiency virus (HIV)-infected persons with CD4 cell counts between 200 and 500/mm3. . …
The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2) or a slow-release, polyethylene glycol …
Tolerability and Efficacy of a 1-Bag Pegaspargase Densensitization Protocol in Pediatric Oncology Patients.
Cramer J, Graff J, Serebin D. Cramer J, et al. J Pediatr Hematol Oncol. 2022 Apr 1;44(3):e623-e627. doi: 10.1097/MPH.0000000000002241. J Pediatr Hematol Oncol. 2022. PMID: 34133383
Desensitization to pegaspargase has been previously attempted in patients who have a hypersensitivity reaction to pegaspargase when Erwinia asparaginase is not an available alternative because of supply issues. ...Four of the 5 patients that did experience a hypersensit …
Desensitization to pegaspargase has been previously attempted in patients who have a hypersensitivity reaction to pegaspargase when E …
Steroid Allergy: Clinical Features and the Importance of Excipient Testing in a Diagnostic Algorithm.
Li PH, Wagner A, Thomas I, Watts TJ, Rutkowski R, Rutkowski K. Li PH, et al. J Allergy Clin Immunol Pract. 2018 Sep-Oct;6(5):1655-1661. doi: 10.1016/j.jaip.2018.01.007. Epub 2018 Jan 31. J Allergy Clin Immunol Pract. 2018. PMID: 29408496
OBJECTIVE: The objective of this study was to evaluate the clinical characteristics and frequency of excipient allergy in patients with confirmed type I hypersensitivity to systemic CS preparations. METHODS: Patients with a confirmed diagnosis of allergy (positive skin tes …
OBJECTIVE: The objective of this study was to evaluate the clinical characteristics and frequency of excipient allergy in patients with conf …
Specific targeting and noninvasive magnetic resonance imaging of an asthma biomarker in the lung using polyethylene glycol functionalized magnetic nanocarriers.
Al Faraj A, Shaik AS, Afzal S, Al-Muhsen S, Halwani R. Al Faraj A, et al. Contrast Media Mol Imaging. 2016 May;11(3):172-83. doi: 10.1002/cmmi.1678. Epub 2015 Dec 28. Contrast Media Mol Imaging. 2016. PMID: 26708935 Free article.
In this study, superparamagnetic iron oxide nanoparticles were conjugated with anti-IL4Ralpha blocking antibodies via polyethylene glycol (PEG) polymers. The delivery of these blocking antibodies to the inflammatory sites in the lung via the developed nanocarriers w …
In this study, superparamagnetic iron oxide nanoparticles were conjugated with anti-IL4Ralpha blocking antibodies via polyethylene …
Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase.
Hershfield MS, Buckley RH, Greenberg ML, Melton AL, Schiff R, Hatem C, Kurtzberg J, Markert ML, Kobayashi RH, Kobayashi AL, et al. Hershfield MS, et al. N Engl J Med. 1987 Mar 5;316(10):589-96. doi: 10.1056/NEJM198703053161005. N Engl J Med. 1987. PMID: 3807953
We conclude that from the standpoints of efficacy, convenience, and safety, polyethylene glycol-modified adenosine deaminase is preferable to red-cell transfusion as a treatment for adenosine deaminase deficiency. Patients with other inherited metabolic diseases in …
We conclude that from the standpoints of efficacy, convenience, and safety, polyethylene glycol-modified adenosine deaminase i …
Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection.
Teppler H, Kaplan G, Smith KA, Montana AL, Meyn P, Cohn ZA. Teppler H, et al. J Exp Med. 1993 Feb 1;177(2):483-92. doi: 10.1084/jem.177.2.483. J Exp Med. 1993. PMID: 8093894 Free PMC article.
13 patients with human immunodeficiency virus type 1 infection class II-IV, but without opportunistic infection or neoplasm, received 6 micrograms (3.6 x 10(4) IU) of polyethylene glycol recombinant human interleukin 2 (PEG IL-2) intradermally twice a week for 4 mo …
13 patients with human immunodeficiency virus type 1 infection class II-IV, but without opportunistic infection or neoplasm, received 6 micr …
Assessing the role of the biomaterial Aquavene in patient reactions to Landmark midline catheters.
Silverstein B, Witkin KM, Frankos VH, Terr AI. Silverstein B, et al. Regul Toxicol Pharmacol. 1997 Feb;25(1):60-7. doi: 10.1006/rtph.1996.1057. Regul Toxicol Pharmacol. 1997. PMID: 9056501 Review.
They are constructed of an inner layer of polyurethane and an outer layer of the biomaterial Aquavene, a blend of polyurethane and polyethylene oxide to which butylated hyroxyanisole (BHA), butylated hydroxytoluene (BHT), and triallyl-s-triazine trione (TTT) are added. ... …
They are constructed of an inner layer of polyurethane and an outer layer of the biomaterial Aquavene, a blend of polyurethane and polyet …
Clinical Characteristics of Intravenous PEG-Asparaginase Hypersensitivity Reactions in Patients Undergoing Treatment for Acute Lymphoblastic Leukemia [Formula: see text].
Browne EK, Moore C, Sykes A, Lu Z, Jeha S, Mandrell BN. Browne EK, et al. J Pediatr Oncol Nurs. 2018 Mar/Apr;35(2):103-109. doi: 10.1177/1043454217741868. Epub 2017 Nov 21. J Pediatr Oncol Nurs. 2018. PMID: 29161979 Free PMC article.
BACKGROUND: Asparaginase poses a substantial risk for hypersensitivity reactions during and after administration; however, these reactions vary by asparaginase formulation and administration route. ...RESULTS: Sixty-three patients (12.8%) developed a hypersensitivity …
BACKGROUND: Asparaginase poses a substantial risk for hypersensitivity reactions during and after administration; however, these reac …
A rare case of anaphylaxis to bowel prep: a case report and review of the literature.
Savitz JA, Durning SJ. Savitz JA, et al. Mil Med. 2011 Aug;176(8):944-5. doi: 10.7205/milmed-d-09-00176. Mil Med. 2011. PMID: 21882787 Review.
Polyethylene glycols (PEGs) are commonly utilized as a bowel prep prior to colonoscopy. ...
Polyethylene glycols (PEGs) are commonly utilized as a bowel prep prior to colonoscopy. ...
Impact of Polymer Bioconjugation on Protein Stability and Activity Investigated with Discrete Conjugates: Alternatives to PEGylation.
Morgenstern J, Gil Alvaradejo G, Bluthardt N, Beloqui A, Delaittre G, Hubbuch J. Morgenstern J, et al. Biomacromolecules. 2018 Nov 12;19(11):4250-4262. doi: 10.1021/acs.biomac.8b01020. Epub 2018 Oct 5. Biomacromolecules. 2018. PMID: 30222929
Covalent attachment of synthetic polymers to proteins, known as protein-polymer conjugation, is currently one of the main approaches for improving the physicochemical properties of these biomolecules. The most commonly employed polymer is polyethylene glycol (PEG), …
Covalent attachment of synthetic polymers to proteins, known as protein-polymer conjugation, is currently one of the main approaches for imp …
Asparaginase treatment in infants with acute lymphoblastic leukemia; pharmacokinetics and asparaginase hypersensitivity in Interfant-06.
Albertsen BK, Harila-Saari A, Jahnukainen K, Lähteenmäki P, Riikonen P, Möttönen M, Lausen B. Albertsen BK, et al. Leuk Lymphoma. 2019 Jun;60(6):1469-1475. doi: 10.1080/10428194.2018.1538507. Epub 2019 Jan 11. Leuk Lymphoma. 2019. PMID: 30632847
All patients without hypersensitivity had sufficiently high enzyme activity levels during treatment with both preparations. Patients with hypersensitivity reactions during treatment, characterized by the presence of either or not of clinical symptoms and no measurab …
All patients without hypersensitivity had sufficiently high enzyme activity levels during treatment with both preparations. Patients …
Effect of superoxide dismutase on a rabbit model of chronic allergic asthma.
Assa'ad AH, Ballard ET, Sebastian KD, Loven DP, Boivin GP, Lierl MB. Assa'ad AH, et al. Ann Allergy Asthma Immunol. 1998 Mar;80(3):215-24. doi: 10.1016/S1081-1206(10)62960-2. Ann Allergy Asthma Immunol. 1998. PMID: 9532968
The rabbits were then randomized into two groups that received every 48 hours an intravenous dose of either superoxide dismutase-polyethylene glycol 10,000 U/kg or inactivated superoxide dismutase-polyethylene glycol as control, followed by a 1-hour ex …
The rabbits were then randomized into two groups that received every 48 hours an intravenous dose of either superoxide dismutase-polyethy …
Alternative algorithm for L-asparaginase allergy in children with acute lymphoblastic leukemia.
Soyer OU, Aytac S, Tuncer A, Cetin M, Yetgin S, Sekerel BE. Soyer OU, et al. J Allergy Clin Immunol. 2009 Apr;123(4):895-9. doi: 10.1016/j.jaci.2008.10.034. Epub 2008 Dec 10. J Allergy Clin Immunol. 2009. PMID: 19081614
Polyethylene glycol-asparaginase could be used for 3 patients. Eight of the remaining 16 children, who had experienced anaphylaxis, were premedicated and desensitized with E coli-asparaginase, and in 7 patients treatment was tolerated. ...Polyethylene glyc …
Polyethylene glycol-asparaginase could be used for 3 patients. Eight of the remaining 16 children, who had experienced anaphyl …
Gut permeability measured by polyethylene glycol absorption in abnormal gut fermentation as compared with food intolerance.
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Gut permeability has been studied in patients with either food intolerance or abnormal gut fermentation as well as in normal subjects. Permeability was measured by polyethylene glycol absorption, and the reasons for this choice of probe are discussed. ...
Gut permeability has been studied in patients with either food intolerance or abnormal gut fermentation as well as in normal subjects. Perme …
Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group.
Rau RE, Dreyer Z, Choi MR, Liang W, Skowronski R, Allamneni KP, Devidas M, Raetz EA, Adamson PC, Blaney SM, Loh ML, Hunger SP. Rau RE, et al. Pediatr Blood Cancer. 2018 Mar;65(3):10.1002/pbc.26873. doi: 10.1002/pbc.26873. Epub 2017 Nov 1. Pediatr Blood Cancer. 2018. PMID: 29090524 Free PMC article. Clinical Trial.
BACKGROUND: Erwinia asparaginase is a Food and Drug Administration approved agent for the treatment of acute lymphoblastic leukemia (ALL) for patients who develop hypersensitivity to Escherichia coli derived asparaginases. Erwinia asparaginase is efficacious, but has a sho …
BACKGROUND: Erwinia asparaginase is a Food and Drug Administration approved agent for the treatment of acute lymphoblastic leukemia (ALL) fo …
[Sarcoidosis following pegylated interferon therapy: two cases].
Benali S, Boustière C, Castellani P, Cesari C, Jullien M, Lecomte L, Lebars O, Lambot G, Loyer R, Masseboeuf A, Perrier H, Oules V, Bourlière M. Benali S, et al. Gastroenterol Clin Biol. 2006 Apr;30(4):615-9. doi: 10.1016/s0399-8320(06)73238-9. Gastroenterol Clin Biol. 2006. PMID: 16733389 Free article. Review. French.
A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors.
Taylor CW, Dorr RT, Fanta P, Hersh EM, Salmon SE. Taylor CW, et al. Cancer Chemother Pharmacol. 2001;47(1):83-8. doi: 10.1007/s002800000207. Cancer Chemother Pharmacol. 2001. PMID: 11221967 Clinical Trial.
PURPOSE: To evaluate the in vitro activity of polyethylene glycol-conjugated L-asparaginase (PEG-Lasparaginase) against fresh human tumor specimens, using the human tumor clonogenic assay (HTCA), and to perform a phase I dose-escalation clinical trial of PEG-L-aspar …
PURPOSE: To evaluate the in vitro activity of polyethylene glycol-conjugated L-asparaginase (PEG-Lasparaginase) against fresh …
Complement Activation: A Potential Threat on the Safety of Poly(ethylene glycol)-Coated Nanomedicines.
Gabizon A, Szebeni J. Gabizon A, et al. ACS Nano. 2020 Jul 28;14(7):7682-7688. doi: 10.1021/acsnano.0c03648. Epub 2020 Jul 9. ACS Nano. 2020. PMID: 32643376
In this issue of ACS Nano, Chen et al. provide in vitro and in vivo evidence for monoclonal anti-poly(ethylene glycol) (anti-PEG) antibody-triggered, complement terminal complex-mediated damage to PEGylated liposomal doxorubicin, entailing the release of the encapsulated d …
In this issue of ACS Nano, Chen et al. provide in vitro and in vivo evidence for monoclonal anti-poly(ethylene glycol) (anti-PEG) ant …
A preliminary study on the evaluation of asparaginase. Polyethylene glycol conjugate against canine malignant lymphoma.
MacEwen EG, Rosenthal R, Matus R, Viau AT, Abuchowski A. MacEwen EG, et al. Cancer. 1987 Jun 15;59(12):2011-5. doi: 10.1002/1097-0142(19870615)59:12<2011::aid-cncr2820591207>3.0.co;2-m. Cancer. 1987. PMID: 3567863
Thirty-seven dogs with malignant lymphoma were treated with either polyethylene glycol conjugated (PEG) asparaginase alone (10-30 IU/kg intraperitoneally [IP] weekly--20 dogs) or PEG-asparaginase combined with one cycle of chemotherapy (vincristine, cyclophosphamide …
Thirty-seven dogs with malignant lymphoma were treated with either polyethylene glycol conjugated (PEG) asparaginase alone (10 …
Immediate allergic reactions by polyethylene glycol 4000: two cases.
Antón Gironés M, Roan Roan J, de la Hoz B, Sánchez Cano M. Antón Gironés M, et al. Allergol Immunopathol (Madr). 2008 Mar-Apr;36(2):110-2. doi: 10.1157/13120396. Allergol Immunopathol (Madr). 2008. PMID: 18479663
We performed allergy studies: skin prick tests with common inhalants, pure ES and the components (polyethylene glycol 4000 (PEG 4000), KCI, NaCO3, NaPO3, NaSO3, NaCI, neohesperydine, potasic acesulfam and orange flavouring), intradermic test, total serum IgE and sin …
We performed allergy studies: skin prick tests with common inhalants, pure ES and the components (polyethylene glycol 4000 (PE …
Comparison of hypersensitivity reactions to PEG-asparaginase in children after intravenous and intramuscular administration.
August KJ, Miller WP, Dalton A, Shinnick S. August KJ, et al. J Pediatr Hematol Oncol. 2013 Oct;35(7):e283-6. doi: 10.1097/MPH.0b013e31828e5471. J Pediatr Hematol Oncol. 2013. PMID: 23619117
INTRODUCTION: Polyethylene-glycolated (PEG)-asparaginase (PEG-ASP) is a crucial component of pediatric acute lymphoblastic leukemia therapy. ...RESULTS: Of 68 patients studied, 7 experienced a hypersensitivity reaction (10.3%). Two of 16 patients (12.5%) who receive …
INTRODUCTION: Polyethylene-glycolated (PEG)-asparaginase (PEG-ASP) is a crucial component of pediatric acute lymphoblastic leukemia t …
[Allergic reactions to COVID-19 vaccines: evidence and practice-oriented approach].
Klimek L, Eckrich J, Hagemann J, Casper I, Huppertz J. Klimek L, et al. Internist (Berl). 2021 Mar;62(3):326-332. doi: 10.1007/s00108-021-00959-5. Epub 2021 Feb 13. Internist (Berl). 2021. PMID: 33580823 Free PMC article. German.
Differences from established vaccines are addressed and the allergic potential of liposomes, polyethylene glycol, tromethamine/trometamol, and mRNA are discussed. ...
Differences from established vaccines are addressed and the allergic potential of liposomes, polyethylene glycol, tromethamine …
PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity.
Zheng W, Gao Y, Ke X, Zhang W, Su L, Ren H, Lin N, Xie Y, Tu M, Liu W, Ping L, Ying Z, Zhang C, Deng L, Wang X, Song Y, Zhu J. Zheng W, et al. BMC Cancer. 2018 Sep 21;18(1):910. doi: 10.1186/s12885-018-4782-y. BMC Cancer. 2018. PMID: 30241515 Free PMC article. Clinical Trial.
BACKGROUND: The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivity reactions of L-ASP in some patients limited its …
BACKGROUND: The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient w …
L-asparaginase activity and anti-L-asparaginase antibody as biomarkers in estimating PEG-asp-related anaphylaxis risk in childhood acute lymphoblastic leukemia patients.
Cui J, Jiang L, Xu B, Bai Y. Cui J, et al. Allergol Immunopathol (Madr). 2023 May 1;51(3):28-35. doi: 10.15586/aei.v51i3.771. eCollection 2023. Allergol Immunopathol (Madr). 2023. PMID: 37169557
BACKGROUND: L-Asparaginase (L-asp), the unconjugated form of polyethylene glycol-conjugated L-asparaginase (PEG-asp), regulates T cell stimulation, antibody production, and lysosomal protease activity to mediate PEG-asp-related anaphylaxis. ...
BACKGROUND: L-Asparaginase (L-asp), the unconjugated form of polyethylene glycol-conjugated L-asparaginase (PEG-asp), regulate …
Circulating immune complexes in IgA deficiency.
Kwitko AO, McKenzie PE, Shearman DJ, Gormly AA, Woodroffe AJ. Kwitko AO, et al. Clin Exp Immunol. 1979 Oct;38(1):45-51. Clin Exp Immunol. 1979. PMID: 527254 Free PMC article.
The presence of cryoglobulins (thirteen out of thirty-one patients) and increased polyethylene glycol precipitation (ten out of thirty patients) provided additional evidence for the presence of IC. ...
The presence of cryoglobulins (thirteen out of thirty-one patients) and increased polyethylene glycol precipitation (ten out o …
In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Polyelectrolyte Nanocapsules Functionalized with Two Different Polymers: Poly-L-Glutamic Acid or PEG.
Karabasz A, Szczepanowicz K, Cierniak A, Mezyk-Kopec R, Dyduch G, Szczęch M, Bereta J, Bzowska M. Karabasz A, et al. Int J Nanomedicine. 2019 Dec 5;14:9587-9602. doi: 10.2147/IJN.S230865. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31824153 Free PMC article.
BACKGROUND: The functionalization of a nanoparticle surface with PEG (polyethylene glycol) is an approach most often used for extending nanomaterial circulation time, enhancing its delivery and retention in the target tissues, and decreasing systemic toxicity of nan …
BACKGROUND: The functionalization of a nanoparticle surface with PEG (polyethylene glycol) is an approach most often used for …
Safety of administration of BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG-asparaginase.
Mark C, Gupta S, Punnett A, Upton J, Orkin J, Atkinson A, Clarke L, Heisey A, McGovern C, Alexander S. Mark C, et al. Pediatr Blood Cancer. 2021 Nov;68(11):e29295. doi: 10.1002/pbc.29295. Epub 2021 Aug 16. Pediatr Blood Cancer. 2021. PMID: 34398511 Free PMC article.
Vaccinationis a critical tool in the prevention of COVID-19 infection for individuals and for communities. The mRNA vaccines contain polyethylene glycol (PEG) as a stabilizer. Currently, in North America, only the BNT162b2 (Pfizer-BioNTech) mRNA vaccine is approved …
Vaccinationis a critical tool in the prevention of COVID-19 infection for individuals and for communities. The mRNA vaccines contain poly …