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Hypersensitivity to polyethylene glycol in adults and children: An emerging challenge.
Bianchi A, Bottau P, Calamelli E, Caimmi S, Crisafulli G, Franceschini F, Liotti L, Mori F, Paglialunga C, Saretta F, Tosca M, Cardinale F, Licari A, Miraglia Del Giudice M, Caffarelli C. Bianchi A, et al. Acta Biomed. 2021 Nov 29;92(S7):e2021519. doi: 10.23750/abm.v92iS7.12384. Acta Biomed. 2021. PMID: 34842597 Free PMC article. Review.
Hypersensitivity reactions to polyethylene glycol (PEG) is an emerging challenge and the interest about this disease is growing since PEG is considered one of the possible causes of coronavirus disease 2019 (COVID 19) vaccine-associated anaphylaxis. ...Lack o
Hypersensitivity reactions to polyethylene glycol (PEG) is an emerging challenge and the interest about this disease is
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products.
Ibrahim M, Ramadan E, Elsadek NE, Emam SE, Shimizu T, Ando H, Ishima Y, Elgarhy OH, Sarhan HA, Hussein AK, Ishida T. Ibrahim M, et al. J Control Release. 2022 Nov;351:215-230. doi: 10.1016/j.jconrel.2022.09.031. Epub 2022 Sep 22. J Control Release. 2022. PMID: 36165835 Review.
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. ...The use of COVID-19 mRNA vaccines, which are composed mainly of PEGylated lipid nanoparticles (LNPs), has recen
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier i
Hypersensitivity to polyethylene glycol (PEG).
Czarnobilska M, Bulanda M, Kurnik-Łucka M, Gil K. Czarnobilska M, et al. Folia Med Cracov. 2021 Dec 28;61(4):55-69. doi: 10.24425/fmc.2021.140004. Folia Med Cracov. 2021. PMID: 35180202 Free article.
The only absolute contraindication to administration of the vaccine is an anaphylactic reaction to any of its ingredients. Polyethylene glycol (PEG), widely used as an excipient in various vaccines, is considered the primary cause of allergic reactions associated wi …
The only absolute contraindication to administration of the vaccine is an anaphylactic reaction to any of its ingredients. Polyethylene
Polyethylene Glycol-Induced Systemic Allergic Reactions (Anaphylaxis).
Sellaturay P, Nasser S, Ewan P. Sellaturay P, et al. J Allergy Clin Immunol Pract. 2021 Feb;9(2):670-675. doi: 10.1016/j.jaip.2020.09.029. Epub 2020 Oct 1. J Allergy Clin Immunol Pract. 2021. PMID: 33011299
Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers found in everyday products such as foods, cosmetics, and medications. ...
Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers found in everyday products such as foods, cosmetics, and med
Immediate-type hypersensitivity to polyethylene glycols: a review.
Wenande E, Garvey LH. Wenande E, et al. Clin Exp Allergy. 2016 Jul;46(7):907-22. doi: 10.1111/cea.12760. Clin Exp Allergy. 2016. PMID: 27196817 Review.
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first comprehensive review provides practical information for allergists and other healthcare professionals by describing the clinical picture of
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first
Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.
Stone CA Jr, Liu Y, Relling MV, Krantz MS, Pratt AL, Abreo A, Hemler JA, Phillips EJ. Stone CA Jr, et al. J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1533-1540.e8. doi: 10.1016/j.jaip.2018.12.003. Epub 2018 Dec 14. J Allergy Clin Immunol Pract. 2019. PMID: 30557713 Free PMC article.
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; however, the epidemiology, mechanisms, and cross-reactivity are poorly understood. ...Our studies raise the possibility of an IgE-mediated t …
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; …
To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives.
Shi D, Beasock D, Fessler A, Szebeni J, Ljubimova JY, Afonin KA, Dobrovolskaia MA. Shi D, et al. Adv Drug Deliv Rev. 2022 Jan;180:114079. doi: 10.1016/j.addr.2021.114079. Epub 2021 Dec 10. Adv Drug Deliv Rev. 2022. PMID: 34902516 Free PMC article. Review.
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional formulations utilize PEG as either an active ingredient or an excipient. ...
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional formulations utilize PEG as either an acti
Allergenic components of the mRNA-1273 vaccine for COVID-19: Possible involvement of polyethylene glycol and IgG-mediated complement activation.
Klimek L, Novak N, Cabanillas B, Jutel M, Bousquet J, Akdis CA. Klimek L, et al. Allergy. 2021 Nov;76(11):3307-3313. doi: 10.1111/all.14794. Epub 2021 Jun 17. Allergy. 2021. PMID: 33657648 Free PMC article. Review.
While the culprit trigger requires investigation, initial reports suggested the excipient polyethylene glycol 2000 (PEG-2000)-contained in both vaccines as the PEG-micellar carrier system-as the potential culprit. ...
While the culprit trigger requires investigation, initial reports suggested the excipient polyethylene glycol 2000 (PEG-2000)- …
Serum polyethylene glycol-specific IgE and IgG in patients with hypersensitivity to COVID-19 mRNA vaccines.
Mouri M, Imamura M, Suzuki S, Kawasaki T, Ishizaki Y, Sakurai K, Nagafuchi H, Matsumura N, Uchida M, Ando T, Yoshioka K, Ooka S, Sugihara T, Miyoshi H, Mori M, Okada T, Yamaguchi M, Kunishima H, Kato M, Kawahata K. Mouri M, et al. Allergol Int. 2022 Oct;71(4):512-519. doi: 10.1016/j.alit.2022.05.007. Epub 2022 Jun 6. Allergol Int. 2022. PMID: 35718709 Free PMC article.
BACKGROUND: The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is a potential antigen in the components of vaccines. ...
BACKGROUND: The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is …
Pfizer's vaccine raises allergy concerns.
de Vrieze J. de Vrieze J. Science. 2021 Jan 1;371(6524):10-11. doi: 10.1126/science.371.6524.10. Science. 2021. PMID: 33384356 No abstract available.
Polyethylene Glycol Is a Cause of IgE-Mediated Anaphylaxis.
Giavina-Bianchi P, Kalil J. Giavina-Bianchi P, et al. J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1874-1875. doi: 10.1016/j.jaip.2019.05.001. J Allergy Clin Immunol Pract. 2019. PMID: 31279466 No abstract available.
Patients with previous immediate hypersensitivity reactions to polyethylene glycol can safely receive the BNT162b2 mRNA COVID-19 vaccine.
Hurst M, Jordan A, Capstick J, Brewerton M, Cockroft R, Ingram J. Hurst M, et al. Intern Med J. 2022 Oct;52(10):1818-1820. doi: 10.1111/imj.15821. Epub 2022 Oct 6. Intern Med J. 2022. PMID: 36000384 Free PMC article.
Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contraindication to the BNT162b2 mRNA COVID-19 vaccine, which contains 50 ug of PEG at a molecular weight of 2000, and this component is thought …
Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contr …
Vaccine allergy: evidence to consider for COVID-19 vaccines.
Nilsson L, Csuth Á, Storsaeter J, Garvey LH, Jenmalm MC. Nilsson L, et al. Curr Opin Allergy Clin Immunol. 2021 Aug 1;21(4):401-409. doi: 10.1097/ACI.0000000000000762. Curr Opin Allergy Clin Immunol. 2021. PMID: 34091550 Free PMC article. Review.
Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivatives are the most suspected, albeit hitherto unproven, causes. ...
Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivati …
Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging.
Senior R, Lindner JR, Edvardsen T, Cosyns B. Senior R, et al. Eur Heart J Cardiovasc Imaging. 2021 Aug 14;22(9):959-960. doi: 10.1093/ehjci/jeab120. Eur Heart J Cardiovasc Imaging. 2021. PMID: 34164650
Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, to polyethylene glycol (PEG) (macrogol), or to PEG-containing products, such as certain bowel preps for colonoscopy or laxative …
Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, t …
Pegaspargase: A Review in Acute Lymphoblastic Leukaemia.
Heo YA, Syed YY, Keam SJ. Heo YA, et al. Drugs. 2019 May;79(7):767-777. doi: 10.1007/s40265-019-01120-1. Drugs. 2019. PMID: 31030380 Free PMC article. Review.
Pegaspargase treatment in patients with relapsed ALL and hypersensitivity to E. coliL-asparaginase had a similar tolerability profile to that observed in patients with newly diagnosed ALL. Given the potentially reduced immunogenicity and more convenient dosage regimen over …
Pegaspargase treatment in patients with relapsed ALL and hypersensitivity to E. coliL-asparaginase had a similar tolerability profile …
PEG That Reaction: A Case Series of Allergy to Polyethylene Glycol.
Cox F, Khalib K, Conlon N. Cox F, et al. J Clin Pharmacol. 2021 Jun;61(6):832-835. doi: 10.1002/jcph.1824. Epub 2021 Feb 28. J Clin Pharmacol. 2021. PMID: 33543766 Free PMC article.
Polyethylene glycol (PEG), also known as macrogol, is an excipient in numerous medications, health care products, cosmetics, and foods. ...Despite its ubiquity, including in 2 of the newly launched vaccines against SARS-CoV-2, awareness of PEG allergy remains low. W
Polyethylene glycol (PEG), also known as macrogol, is an excipient in numerous medications, health care products, cosmetics, a
Safety of administration of BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG-asparaginase.
Mark C, Gupta S, Punnett A, Upton J, Orkin J, Atkinson A, Clarke L, Heisey A, McGovern C, Alexander S. Mark C, et al. Pediatr Blood Cancer. 2021 Nov;68(11):e29295. doi: 10.1002/pbc.29295. Epub 2021 Aug 16. Pediatr Blood Cancer. 2021. PMID: 34398511 Free PMC article.
Vaccinationis a critical tool in the prevention of COVID-19 infection for individuals and for communities. The mRNA vaccines contain polyethylene glycol (PEG) as a stabilizer. Currently, in North America, only the BNT162b2 (Pfizer-BioNTech) mRNA vaccine is approved …
Vaccinationis a critical tool in the prevention of COVID-19 infection for individuals and for communities. The mRNA vaccines contain poly
Hidden Dangers: Recognizing Excipients as Potential Causes of Drug and Vaccine Hypersensitivity Reactions.
Caballero ML, Krantz MS, Quirce S, Phillips EJ, Stone CA Jr. Caballero ML, et al. J Allergy Clin Immunol Pract. 2021 Aug;9(8):2968-2982. doi: 10.1016/j.jaip.2021.03.002. Epub 2021 Mar 15. J Allergy Clin Immunol Pract. 2021. PMID: 33737254 Free PMC article. Review.
For both drugs and vaccines, these are rare reactions; however, for vaccines, they are the primary cause of immediate hypersensitivity. Suspicion for these "hidden dangers" should be high, in particular, when anaphylaxis has occurred in association with multiple chemically …
For both drugs and vaccines, these are rare reactions; however, for vaccines, they are the primary cause of immediate hypersensitivity
Experience with polyethylene glycol allergy-guided risk management for COVID-19 vaccine anaphylaxis.
Brockow K, Mathes S, Fischer J, Volc S, Darsow U, Eberlein B, Biedermann T. Brockow K, et al. Allergy. 2022 Jul;77(7):2200-2210. doi: 10.1111/all.15183. Epub 2021 Dec 4. Allergy. 2022. PMID: 34806775 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) may elicit anaphylaxis to COVID-19 mRNA vaccines, and guidance for patients at risk is needed. ...In 421 prospective real-life patients asking for allergy workup for COVID-19 vaccine hypersensitivity in 2020/2021, risk as …
BACKGROUND: Polyethylene glycol (PEG) may elicit anaphylaxis to COVID-19 mRNA vaccines, and guidance for patients at risk is n …
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.
Knop K, Hoogenboom R, Fischer D, Schubert US. Knop K, et al. Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308. doi: 10.1002/anie.200902672. Angew Chem Int Ed Engl. 2010. PMID: 20648499 Review.
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery. ...The areas that might need consideration and more intensive and careful examination can be divided into the followin …
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer …
PEG-asparaginase.
Fu CH, Sakamoto KM. Fu CH, et al. Expert Opin Pharmacother. 2007 Aug;8(12):1977-84. doi: 10.1517/14656566.8.12.1977. Expert Opin Pharmacother. 2007. PMID: 17696798 Review.
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase antibodies, which neutralize their activity. PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase an …
Optimizing investigation of suspected allergy to polyethylene glycols.
Bruusgaard-Mouritsen MA, Jensen BM, Poulsen LK, Duus Johansen J, Garvey LH. Bruusgaard-Mouritsen MA, et al. J Allergy Clin Immunol. 2022 Jan;149(1):168-175.e4. doi: 10.1016/j.jaci.2021.05.020. Epub 2021 May 28. J Allergy Clin Immunol. 2022. PMID: 34052265 Free article. Clinical Trial.
BACKGROUND: Polyethylene glycols (PEGs) are polymers of varying molecular weight (MW) used widely as excipients in drugs and other products, including the mRNA vaccines against coronavirus disease 2019. ...
BACKGROUND: Polyethylene glycols (PEGs) are polymers of varying molecular weight (MW) used widely as excipients in drugs and o …
Expert Consensus Statement from the American Society of Echocardiography on Hypersensitivity Reactions to Ultrasound Enhancing Agents in Patients with Allergy to Polyethylene Glycol.
Lindner JR, Belcik T, Main ML, Montanaro A, Mulvagh SL, Olson J, Olyaei A, Porter TR, Senior R. Lindner JR, et al. J Am Soc Echocardiogr. 2021 Jul;34(7):707-708. doi: 10.1016/j.echo.2021.05.002. Epub 2021 May 7. J Am Soc Echocardiogr. 2021. PMID: 33971277 Free PMC article. No abstract available.
Individualized Asparaginase Dosing in Childhood Acute Lymphoblastic Leukemia.
Kloos RQH, Pieters R, Jumelet FMV, de Groot-Kruseman HA, van den Bos C, van der Sluis IM. Kloos RQH, et al. J Clin Oncol. 2020 Mar 1;38(7):715-724. doi: 10.1200/JCO.19.02292. Epub 2020 Jan 10. J Clin Oncol. 2020. PMID: 31922920
PURPOSE: In the DCOG ALL-11 protocol, polyethylene glycol-conjugated Escherichia coli asparaginase (PEGasparaginase) and Erwinia asparaginase treatment of pediatric acute lymphoblastic leukemia are individualized with therapeutic drug monitoring (TDM). ...Asparagine …
PURPOSE: In the DCOG ALL-11 protocol, polyethylene glycol-conjugated Escherichia coli asparaginase (PEGasparaginase) and Erwin …
COVID-19 Vaccines in Children with Cow's Milk and Food Allergies.
Liotti L, Bianchi A, Bottau P, Caimmi S, Crisafulli G, Franceschini F, Mori F, Paglialunga C, Saretta F, Caffarelli C. Liotti L, et al. Nutrients. 2021 Jul 30;13(8):2637. doi: 10.3390/nu13082637. Nutrients. 2021. PMID: 34444795 Free PMC article. Review.
Hypersensitivity to polyethylene glycols.
Shah S, Prematta T, Adkinson NF, Ishmael FT. Shah S, et al. J Clin Pharmacol. 2013 Mar;53(3):352-5. doi: 10.1177/0091270012447122. Epub 2013 Jan 24. J Clin Pharmacol. 2013. PMID: 23444288 No abstract available.
Anti-PEG IgE in anaphylaxis associated with polyethylene glycol.
Zhou ZH, Stone CA Jr, Jakubovic B, Phillips EJ, Sussman G, Park J, Hoang U, Kirshner SL, Levin R, Kozlowski S. Zhou ZH, et al. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1731-1733.e3. doi: 10.1016/j.jaip.2020.11.011. Epub 2020 Nov 17. J Allergy Clin Immunol Pract. 2021. PMID: 33217616 Free PMC article. No abstract available.
Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.
Ozer I, Kelly G, Gu R, Li X, Zakharov N, Sirohi P, Nair SK, Collier JH, Hershfield MS, Hucknall AM, Chilkoti A. Ozer I, et al. Adv Sci (Weinh). 2022 Apr;9(11):e2103672. doi: 10.1002/advs.202103672. Epub 2022 Feb 8. Adv Sci (Weinh). 2022. PMID: 35133079 Free PMC article.
Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. ...Here, the authors synthesize a poly(oligo(ethylene glycol
Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyet
Severe Polyethylene Glycol Allergy Considerations for Perioperative Management: A Case Report.
Wong-On-Wing A, Ruth K, Hinerth K, Deng A, Woldekiros M, Ellenbogen RG, Crowder CM. Wong-On-Wing A, et al. A A Pract. 2022 Oct 11;16(10):e01619. doi: 10.1213/XAA.0000000000001619. eCollection 2022 Oct 1. A A Pract. 2022. PMID: 36219725
Patients with severe polyethylene glycol (PEG) allergies face broad challenges, especially when presenting to the hospital for surgery, as PEG is used often as an excipient in medications and in medical supplies. ...
Patients with severe polyethylene glycol (PEG) allergies face broad challenges, especially when presenting to the hospital for …
Basophil Activation Test with Different Polyethylene Glycols in Patients with Suspected PEG Hypersensitivity Reactions.
Vespa S, Del Biondo P, Simeone P, Cavallucci E, Catitti G, Auciello R, De Bellis D, Altomare I, Pierdomenico L, Canonico B, Cicalini I, Angilletta I, Del Boccio P, Pieragostino D, Santilli F, Urbani A, De Laurenzi V, Stuppia L, Lanuti P. Vespa S, et al. Int J Mol Sci. 2022 Nov 23;23(23):14592. doi: 10.3390/ijms232314592. Int J Mol Sci. 2022. PMID: 36498922 Free PMC article.
Allergic reactions to COVID-19 vaccine components are rare but should be considered. Polyethylene glycol (PEG) is responsible for anaphylaxis in mRNA vaccines. ...To this end, among the subjects that underwent allergy counseling at the Allergy Unit of our Institutio …
Allergic reactions to COVID-19 vaccine components are rare but should be considered. Polyethylene glycol (PEG) is responsible …
Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey.
Özkaya E, Kılıç S. Özkaya E, et al. Contact Dermatitis. 2018 Mar;78(3):211-215. doi: 10.1111/cod.12931. Epub 2017 Nov 28. Contact Dermatitis. 2018. PMID: 29193145
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. ...
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmeti …
Janssen COVID-19 vaccine tolerated in 10 patients with confirmed polyethylene glycol allergy.
Bruusgaard-Mouritsen MA, Koo G, Heinrichsen AS, Melchiors BB, Krantz MS, Plager JH, Boxer M, Phillips EJ, Stone CA Jr, Garvey LH. Bruusgaard-Mouritsen MA, et al. J Allergy Clin Immunol Pract. 2022 Mar;10(3):859-862. doi: 10.1016/j.jaip.2021.12.025. Epub 2022 Jan 1. J Allergy Clin Immunol Pract. 2022. PMID: 34979336 Free PMC article. No abstract available.
Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel.
Stock W, Douer D, DeAngelo DJ, Arellano M, Advani A, Damon L, Kovacsovics T, Litzow M, Rytting M, Borthakur G, Bleyer A. Stock W, et al. Leuk Lymphoma. 2011 Dec;52(12):2237-53. doi: 10.3109/10428194.2011.596963. Epub 2011 Aug 10. Leuk Lymphoma. 2011. PMID: 21827361
The most frequent toxicities of both types of ASNase are hepatic and pancreatic, with pancreatitis being the most serious. Other toxicities are hypersensitivity reactions, thrombosis, nausea/vomiting, and fatigue. Whether or not the replacement of one dose of pegASNase for …
The most frequent toxicities of both types of ASNase are hepatic and pancreatic, with pancreatitis being the most serious. Other toxicities …
Allergen-specific immunotherapy.
Niederberger V. Niederberger V. Immunol Lett. 2009 Feb 21;122(2):131-3. doi: 10.1016/j.imlet.2008.11.012. Epub 2008 Dec 25. Immunol Lett. 2009. PMID: 19100771 Review.
Safety of COVID-19 vaccination in patients with polyethylene glycol allergy: A case series.
Picard M, Drolet JP, Masse MS, Filion CA, ALMuhizi F, Fein M, Copaescu A, Isabwe GAC, Blaquière M, Primeau MN. Picard M, et al. J Allergy Clin Immunol Pract. 2022 Feb;10(2):620-625.e1. doi: 10.1016/j.jaip.2021.11.021. Epub 2021 Dec 20. J Allergy Clin Immunol Pract. 2022. PMID: 34949564 Free PMC article. No abstract available.
Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia.
Khalil A, Würthwein G, Golitsch J, Hempel G, Fobker M, Gerss J, Möricke A, Zimmermann M, Smisek P, Zucchetti M, Nath C, Attarbaschi A, Von Stackelberg A, Gökbuget N, Rizzari C, Conter V, Schrappe M, Boos J, Lanvers-Kaminsky C. Khalil A, et al. Haematologica. 2022 Jan 1;107(1):49-57. doi: 10.3324/haematol.2020.258525. Haematologica. 2022. PMID: 33299233 Free PMC article.
Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. ...Although pre-existing anti-PEG antibodies did not boost, pre-existing anti-PEG IgG were significantly associated with firstexposure hypersens
Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. ...Alth …
Anaphylaxis and Coronavirus Disease 2019 vaccine: a danger relationship?
Tanno LK, Castells M, Caminati M, Senna G, Demoly P. Tanno LK, et al. Curr Opin Allergy Clin Immunol. 2021 Oct 1;21(5):411-417. doi: 10.1097/ACI.0000000000000778. Curr Opin Allergy Clin Immunol. 2021. PMID: 34334663 Review.
PURPOSE OF REVIEW: Anaphylactic reactions reported after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) RNA vaccines were expected to be more frequent in atopic subjects and attributed to its polyethylene glycol component. RECENT FINDINGS: Anaphylaxis t …
PURPOSE OF REVIEW: Anaphylactic reactions reported after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) RNA vaccines were expec …
The Polysorbate containing AstraZeneca COVID-19 vaccine is tolerated by polyethylene glycol (PEG) allergic patients.
Sellaturay P, Gurugama P, Harper V, Dymond T, Ewan P, Nasser S. Sellaturay P, et al. Clin Exp Allergy. 2022 Jan;52(1):12-17. doi: 10.1111/cea.14064. Epub 2021 Dec 9. Clin Exp Allergy. 2022. PMID: 34822190
BACKGROUND: Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. ...
BACKGROUND: Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. ...
Primary care provider-reported prevalence of vaccine and polyethylene glycol allergy in Canada.
Abrams EM, Greenhawt M, Shaker M, Kosowan L, Singer AG. Abrams EM, et al. Ann Allergy Asthma Immunol. 2021 Oct;127(4):446-450.e1. doi: 10.1016/j.anai.2021.05.011. Epub 2021 May 15. Ann Allergy Asthma Immunol. 2021. PMID: 34004274 Free PMC article.
OBJECTIVE: To determine the prevalence of PCP-documented vaccine and polyethylene glycol (PEG) allergy using electronic medical record data from the Canadian Primary Care Sentinel Surveillance Network. ...
OBJECTIVE: To determine the prevalence of PCP-documented vaccine and polyethylene glycol (PEG) allergy using electronic medica …
[Polyethylengylcole - Friend or Foe?].
Bayerl C, Herbst M. Bayerl C, et al. Laryngorhinootologie. 2022 Oct;101(10):784-786. doi: 10.1055/a-1861-7047. Epub 2022 Sep 29. Laryngorhinootologie. 2022. PMID: 36174565 German.
However, anaphylactic reactions towards the Pfizer-BioNTech Covid-19 vaccine were first reported in two patients in the UK and another 19 in the USA. Pegylation with polyethylene glycol (PEG) was thought to be the possible culprit. Pegylation is a common process in …
However, anaphylactic reactions towards the Pfizer-BioNTech Covid-19 vaccine were first reported in two patients in the UK and another 19 in …
Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines?
Eberlein B, Mathes S, Fischer J, Darsow U, Biedermann T, Brockow K. Eberlein B, et al. Allergy. 2022 Oct;77(10):2924-2936. doi: 10.1111/all.15278. Epub 2022 Mar 25. Allergy. 2022. PMID: 35266570 Free PMC article. Review.
In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release test) by using the vaccines or modified compounds containing polyethylene glycol (PEG), rather than unmodified PEGs, have proven …
In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release tes …
Coronavirus disease 2019 vaccine administration in patients with reported reactions to polyethylene glycol- and polysorbate-containing therapeutics.
Otani IM, Tsao LR, Tang M. Otani IM, et al. Ann Allergy Asthma Immunol. 2022 Jul;129(1):88-94.e1. doi: 10.1016/j.anai.2022.03.006. Epub 2022 Mar 12. Ann Allergy Asthma Immunol. 2022. PMID: 35288274 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) and polysorbate reactions were initially implicated as a likely risk factor for reacting to coronavirus disease 2019 (COVID-19) vaccines and remain a source of vaccine hesitancy despite increasing evidence that they do not pose …
BACKGROUND: Polyethylene glycol (PEG) and polysorbate reactions were initially implicated as a likely risk factor for reacting …
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions.
Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, Rosivall L, Bavli Y, Urbanics R, Mollnes TE, Barenholz Y, Szebeni J. Kozma GT, et al. ACS Nano. 2019 Aug 27;13(8):9315-9324. doi: 10.1021/acsnano.9b03942. Epub 2019 Aug 6. ACS Nano. 2019. PMID: 31348638 Free article.
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. ...
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which
A randomized, prospective, comparison study of polyethylene glycol 3350 without electrolytes and milk of magnesia for children with constipation and fecal incontinence.
Loening-Baucke V, Pashankar DS. Loening-Baucke V, et al. Pediatrics. 2006 Aug;118(2):528-35. doi: 10.1542/peds.2006-0220. Pediatrics. 2006. PMID: 16882804 Clinical Trial.
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene glycol-treated children and 43% of milk of magnesia-treated children exhibited improvement, and 33% of polyethylene glycol
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene
Clinical pharmacology of polyethylene glycol-L-asparaginase.
Ho DH, Brown NS, Yen A, Holmes R, Keating M, Abuchowski A, Newman RA, Krakoff IH. Ho DH, et al. Drug Metab Dispos. 1986 May-Jun;14(3):349-52. Drug Metab Dispos. 1986. PMID: 2872037
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patients of whom 27 were evaluable pharmacokinetically. ...
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patient
Activity and toxicity of intramuscular 1000 iu/m2 polyethylene glycol-E. coli L-asparaginase in the UKALL 2003 and UKALL 2011 clinical trials.
Sidhu J, Masurekar AN, Gogoi MP, Fong C, Ioannou T, Lodhi T, Parker C, Liu J, Kirkwood AA, Moorman AV, Das K, Goulden NJ, Vora A, Saha V, Krishnan S. Sidhu J, et al. Br J Haematol. 2022 Jul;198(1):142-150. doi: 10.1111/bjh.18158. Epub 2022 Mar 29. Br J Haematol. 2022. PMID: 35348200 Free PMC article. Clinical Trial.
In successive UK clinical trials (UKALL 2003, UKALL 2011) for paediatric acute lymphoblastic leukaemia (ALL), polyethylene glycol-conjugated E. coli L-asparaginase (PEG-EcASNase) 1000 iu/m(2) was administered intramuscularly with risk-stratified treatment. ...Older …
In successive UK clinical trials (UKALL 2003, UKALL 2011) for paediatric acute lymphoblastic leukaemia (ALL), polyethylene glycol
Allergic reaction to polyethylene glycol in a painter.
Antolin-Amerigo D, Sánchez-González MJ, Barbarroja-Escudero J, Rodríguez-Rodríguez M, Álvarez-Perea A, Alvarez-Mon M. Antolin-Amerigo D, et al. Occup Med (Lond). 2015 Aug;65(6):502-4. doi: 10.1093/occmed/kqv072. Epub 2015 Jun 4. Occup Med (Lond). 2015. PMID: 26048329
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of a laxative solution containing polyethylene glycol (PEG) prior to colonoscopy. He described suffering from the same skin reac …
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of …
Pegaspargase in Practice: Minimizing Toxicity, Maximizing Benefit.
Riley DO, Schlefman JM, Vitzthum Von Eckstaedt V HC, Morris AL, Keng MK, El Chaer F. Riley DO, et al. Curr Hematol Malig Rep. 2021 Jun;16(3):314-324. doi: 10.1007/s11899-021-00638-0. Epub 2021 May 12. Curr Hematol Malig Rep. 2021. PMID: 33978914 Review.
RECENT FINDINGS: Clinically significant toxicities of pegaspargase include thrombosis, hypersensitivity and inactivation, hepatotoxicity, pancreatitis, and hypertriglyceridemia. ...
RECENT FINDINGS: Clinically significant toxicities of pegaspargase include thrombosis, hypersensitivity and inactivation, hepatotoxic …
Interferon-induced sarcoidosis.
Cardoso C, Freire R, Alves A, Oliveira A. Cardoso C, et al. BMJ Case Rep. 2011 Apr 19;2011:bcr0320113929. doi: 10.1136/bcr.03.2011.3929. BMJ Case Rep. 2011. PMID: 22696628 Free PMC article.
Pegasparaginase: where do we stand?
Zeidan A, Wang ES, Wetzler M. Zeidan A, et al. Expert Opin Biol Ther. 2009 Jan;9(1):111-9. doi: 10.1517/14712590802586058. Expert Opin Biol Ther. 2009. PMID: 19063697 Review.
Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, especially the development of hypersensitivity reactions and neutralizing antibodies, and by the need for frequent administration. To ove …
Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, espe …
COVID-19 vaccine anaphylaxis: PEG or not?
Krantz MS, Liu Y, Phillips EJ, Stone CA Jr. Krantz MS, et al. Allergy. 2021 Jun;76(6):1934-1937. doi: 10.1111/all.14722. Allergy. 2021. PMID: 34128562 Free PMC article. No abstract available.
Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors.
Richter AW, Akerblom E. Richter AW, et al. Int Arch Allergy Appl Immunol. 1984;74(1):36-9. doi: 10.1159/000233512. Int Arch Allergy Appl Immunol. 1984. PMID: 6706424
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing passive hemagglutination. In untreated allergic patients and in healthy blood donors, naturally occurring anti-PEG antibody titers between …
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing …
Anaphylaxis to Polyethylene Glycol (Colyte®) in a Patient with Diverticulitis.
Lee SH, Hwang SH, Park JS, Park HS, Shin YS. Lee SH, et al. J Korean Med Sci. 2016 Oct;31(10):1662-3. doi: 10.3346/jkms.2016.31.10.1662. J Korean Med Sci. 2016. PMID: 27550498 Free PMC article.
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics.
Verhoef JJ, Carpenter JF, Anchordoquy TJ, Schellekens H. Verhoef JJ, et al. Drug Discov Today. 2014 Dec;19(12):1945-52. doi: 10.1016/j.drudis.2014.08.015. Epub 2014 Sep 7. Drug Discov Today. 2014. PMID: 25205349 Review.
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-life. ...PEGylation has also been associated with the activation of the complement system causing severe hypersensitivity reactions. Her …
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-lif …
Successful mRNA COVID-19 Vaccination and Colonoscopy After Oral Desensitization in a Patient With Polyethylene Glycol Allergy.
Cha B, Kwon KS, Lee HL, Kim CW. Cha B, et al. J Korean Med Sci. 2022 Aug 15;37(32):e251. doi: 10.3346/jkms.2022.37.e251. J Korean Med Sci. 2022. PMID: 35971765 Free PMC article.
Anaphylaxis to polyethylene glycol (PEG) is rare and mainly occurs with the use of laxatives containing PEG. ...
Anaphylaxis to polyethylene glycol (PEG) is rare and mainly occurs with the use of laxatives containing PEG. ...
Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient.
Sahiner UM, Yavuz ST, Gökce M, Buyuktiryaki B, Altan I, Aytac S, Tuncer M, Tuncer A, Sackesen C. Sahiner UM, et al. Pediatr Int. 2013 Aug;55(4):531-3. doi: 10.1111/ped.12131. Pediatr Int. 2013. PMID: 23910807
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG-ASP) is preferred. ...Anaphylaxis with PEG-ASP is very rare and premedication and desensitizat …
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene
Clinical manifestations and impact on daily life of allergy to polyethylene glycol (PEG) in ten patients.
Bruusgaard-Mouritsen MA, Johansen JD, Garvey LH. Bruusgaard-Mouritsen MA, et al. Clin Exp Allergy. 2021 Mar;51(3):463-470. doi: 10.1111/cea.13822. Epub 2021 Jan 15. Clin Exp Allergy. 2021. PMID: 33394522
BACKGROUND: Polyethylene glycols (PEGs) are widely used as excipients in drugs, cosmetics and household products. ...
BACKGROUND: Polyethylene glycols (PEGs) are widely used as excipients in drugs, cosmetics and household products. ...
Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study.
Lokerse WJM, Lazarian A, Kleinhempel A, Petrini M, Schwarz P, Hossann M, Holdt LM, Mailänder V, Lindner LH. Lokerse WJM, et al. J Control Release. 2021 May 10;333:1-15. doi: 10.1016/j.jconrel.2021.03.014. Epub 2021 Mar 16. J Control Release. 2021. PMID: 33741385
Sufficient circulation half-life is important and most liposomes obtain this by polyethylene glycol (PEG) surface modification. 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol (DPPG(2)) has been described as a promising alternative which increases TSL circulation hal …
Sufficient circulation half-life is important and most liposomes obtain this by polyethylene glycol (PEG) surface modification …
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes.
Talkington AM, McSweeney MD, Wessler T, Rath MK, Li Z, Zhang T, Yuan H, Frank JE, Forest MG, Cao Y, Lai SK. Talkington AM, et al. J Control Release. 2022 Mar;343:518-527. doi: 10.1016/j.jconrel.2022.01.022. Epub 2022 Jan 21. J Control Release. 2022. PMID: 35066099
., anti-PEG antibodies (APA). In turn, APA increase both the risk of hypersensitivity to the drug as well as potential loss of efficacy due to accelerated blood clearance of the drug. ...
., anti-PEG antibodies (APA). In turn, APA increase both the risk of hypersensitivity to the drug as well as potential loss of effica …
Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866).
Kurtzberg J, Asselin B, Bernstein M, Buchanan GR, Pollock BH, Camitta BM. Kurtzberg J, et al. J Pediatr Hematol Oncol. 2011 Dec;33(8):610-6. doi: 10.1097/MPH.0b013e31822d4d4e. J Pediatr Hematol Oncol. 2011. PMID: 22042277 Free PMC article. Clinical Trial.
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To overcome this problem, native Escherichia coli L-asparaginase was conjugated to polyethylene glycol (PEG) to formulate PEG-L-asp …
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To ov …
Oncologist counseling practice and COVID-19 vaccination outcomes for patients with history of PEG-asparaginase hypersensitivity.
Zarnegar-Lumley S, Stone CA Jr, Smith CM, Hall LL, Luck KE, Koo G, Plager JH, Phillips EJ, Friedman DL. Zarnegar-Lumley S, et al. Pediatr Blood Cancer. 2022 Jul;69(7):e29686. doi: 10.1002/pbc.29686. Epub 2022 Mar 30. Pediatr Blood Cancer. 2022. PMID: 35353440 Free PMC article.
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective strategy to prevent serious coronavirus disease 2019 (COVID-19) and is important for oncology patients. mRNA-based COVID-19 vaccines are contraindicated in those with a history of sev …
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective strategy to prevent serious coronavirus dis …
Non-IgE-dependent hypersensitivity to macrogol 6000.
Berndt K, Kuske M, Beissert S, Spornraft-Ragaller P, Bauer A. Berndt K, et al. J Dtsch Dermatol Ges. 2018 Apr;16(4):479-481. doi: 10.1111/ddg.13479. Epub 2018 Mar 26. J Dtsch Dermatol Ges. 2018. PMID: 29578283 No abstract available.
Effects of rAmb a 1-Loaded PLGA-PEG Nanoparticles in a Murine Model of Allergic Conjunctivitis.
Cao H, Liu L, Wang J, Gong M, Yuan R, Lu J, Xiao X, Liu X. Cao H, et al. Molecules. 2022 Jan 18;27(3):598. doi: 10.3390/molecules27030598. Molecules. 2022. PMID: 35163859 Free PMC article.
Allergic conjunctivitis caused by Ambrosia artemisiifolia and its related allergen-specific immunotherapy (AIT) are seldom studied at present. poly(DL-lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) is a very good nano-carrier, which has been applied in the med …
Allergic conjunctivitis caused by Ambrosia artemisiifolia and its related allergen-specific immunotherapy (AIT) are seldom studied at presen …
Pegaspargase hypersensitivity reactions: intravenous infusion versus intramuscular injection - a review.
Beaupin LK, Bostrom B, Barth MJ, Franklin I, Jaeger R, Kamath P, Schreiber B, Bleyer A. Beaupin LK, et al. Leuk Lymphoma. 2017 Apr;58(4):766-772. doi: 10.1080/10428194.2016.1218004. Epub 2016 Sep 19. Leuk Lymphoma. 2017. PMID: 27643446 Review.
When intravenous (IV) infusion replaced intramuscular (IM) injection as the standard route of administration, there were early reports suggested an increased hypersensitivity reactions (HSRs) rate with IV administration. There have since been eight published reports compar …
When intravenous (IV) infusion replaced intramuscular (IM) injection as the standard route of administration, there were early reports sugge …
Polyethylene glycol-L-asparaginase versus native L-asparaginase in canine non-Hodgkin's lymphoma.
Teske E, Rutteman GR, van Heerde P, Misdorp W. Teske E, et al. Eur J Cancer. 1990;26(8):891-5. doi: 10.1016/0277-5379(90)90193-w. Eur J Cancer. 1990. PMID: 2145933 Clinical Trial.
No side-effects were noted in the dogs treated with PEG-L-asparaginase, whereas 14 (48%) of the L-asparaginase treated dogs had side-effects related to this drug, including anaphylactic shock (9), anorexia or vomiting (4), hypersensitivity-related oedema (3), seizures (1) …
No side-effects were noted in the dogs treated with PEG-L-asparaginase, whereas 14 (48%) of the L-asparaginase treated dogs had side-effects …
Final report on the safety assessment of Triethylene Glycol and PEG-4.
[No authors listed] [No authors listed] Int J Toxicol. 2006;25 Suppl 2:121-38. doi: 10.1080/10915810600964642. Int J Toxicol. 2006. PMID: 17090481 Review.
Triethylene Glycol and PEG-4 (polyethylene glycol) are polymers of ethylene oxide alcohol. ...There were no treatment-related effects on rats exposed to supersaturated Triethylene Glycol vapor for 13 months nor in rats that consumed 0.533 cc Triethylen …
Triethylene Glycol and PEG-4 (polyethylene glycol) are polymers of ethylene oxide alcohol. ...There were no treatment-r …
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.
Chang CJ, Chen CH, Chen BM, Su YC, Chen YT, Hershfield MS, Lee MM, Cheng TL, Chen YT, Roffler SR, Wu JY. Chang CJ, et al. Nat Commun. 2017 Sep 12;8(1):522. doi: 10.1038/s41467-017-00622-4. Nat Commun. 2017. PMID: 28900105 Free PMC article.
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our findings may provide novel genetic markers for predicting the immunogenicity of PEG and efficacy of PEGylated therapeutics.Some individuals …
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our …
Asparaginase encapsulated in erythrocytes as second-line treatment in hypersensitive patients with acute lymphoblastic leukaemia.
Lynggaard LS, Vaitkeviciene G, Langenskiöld C, Lehmann AK, Lähteenmäki PM, Lepik K, El Hariry I, Schmiegelow K, Albertsen BK. Lynggaard LS, et al. Br J Haematol. 2022 Jun;197(6):745-754. doi: 10.1111/bjh.18152. Epub 2022 Mar 28. Br J Haematol. 2022. PMID: 35344210
To continue asparaginase treatment after hypersensitivity, a formulation of asparaginase encapsulated in erythrocytes (eryaspase) was developed. In NOR-GRASPALL 2016 (NCT03267030) the safety and efficacy of eryaspase was evaluated in 55 patients (aged 1-45 years; median: 6 …
To continue asparaginase treatment after hypersensitivity, a formulation of asparaginase encapsulated in erythrocytes (eryaspase) was …
Pegaspargase.
Alfieri DR. Alfieri DR. Pediatr Nurs. 1995 Sep-Oct;21(5):471-4, 490. Pediatr Nurs. 1995. PMID: 8684851
It has become a significant part of most chemotherapy protocols, however, its use is sometimes limited by the development of hypersensitivity reactions. Pegaspargase offers leukemia patients adequate asparagine depletion with a reduced incidence of hypersensitivity. …
It has become a significant part of most chemotherapy protocols, however, its use is sometimes limited by the development of hypersensiti
Immune responses to polyethylene glycol modified L-asparaginase in mice.
Kawamura K, Igarashi T, Fujii T, Kamisaki Y, Wada H, Kishimoto S. Kawamura K, et al. Int Arch Allergy Appl Immunol. 1985;76(4):324-30. doi: 10.1159/000233715. Int Arch Allergy Appl Immunol. 1985. PMID: 3980111
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glycol (PEG, MW, 5,000) conjugated Escherichia coli A-ase. ...PEG-A-ase administration also suppressed the delayed type hypersensitivity
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glyco
Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation.
Erdeljic Turk V. Erdeljic Turk V. Clin Immunol. 2021 Jun;227:108748. doi: 10.1016/j.clim.2021.108748. Epub 2021 Apr 28. Clin Immunol. 2021. PMID: 33932618 Free PMC article.
Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assumption that polyethylene glycol (PEG) is the most likely culprit. Allergy testing to PEGs and mRNA vaccines is complex and carr …
Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assum …
Comparison of hypersensitivity rates to intravenous and intramuscular PEG-asparaginase in children with acute lymphoblastic leukemia: A meta-analysis and systematic review.
Hasan H, Shaikh OM, Rassekh SR, Howard AF, Goddard K. Hasan H, et al. Pediatr Blood Cancer. 2017 Jan;64(1):81-88. doi: 10.1002/pbc.26200. Epub 2016 Aug 31. Pediatr Blood Cancer. 2017. PMID: 27578304 Review.
The study objective was to perform a meta-analysis and systematic review to compare and generate pooled hypersensitivity rates for IM and IV PEG-ASP. METHODS: A systematic literature search was conducted for all epidemiological studies that investigated IV and IM hypers
The study objective was to perform a meta-analysis and systematic review to compare and generate pooled hypersensitivity rates for IM …
Eosinophilic cellulitis in response to BNT162b2 COVID-19 vaccination.
Ikediobi O, Eichenfield DZ, Barrio VR. Ikediobi O, et al. Pediatr Dermatol. 2022 Sep;39(5):823-824. doi: 10.1111/pde.15019. Epub 2022 May 6. Pediatr Dermatol. 2022. PMID: 35522122 Free PMC article.
A skin biopsy showed urticarial dermatitis with tissue eosinophilia consistent with a diagnosis of vaccine-associated eosinophilic cellulitis, with polyethylene glycol as a potential trigger....
A skin biopsy showed urticarial dermatitis with tissue eosinophilia consistent with a diagnosis of vaccine-associated eosinophilic celluliti …
Production of a novel N-terminal PEGylated crisantaspase.
Torres-Obreque K, Meneguetti GP, Custódio D, Monteiro G, Pessoa-Junior A, de Oliveira Rangel-Yagui C. Torres-Obreque K, et al. Biotechnol Appl Biochem. 2019 May;66(3):281-289. doi: 10.1002/bab.1723. Epub 2019 Jan 7. Biotechnol Appl Biochem. 2019. PMID: 30597637
Crisantaspase is an asparaginase enzyme produced by Erwinia chrysanthemi and used to treat acute lymphoblastic leukemia (ALL) in case of hypersensitivity to Escherichia coli l-asparaginase (ASNase). The main disadvantages of crisantaspase are the short half-life (10 H) and …
Crisantaspase is an asparaginase enzyme produced by Erwinia chrysanthemi and used to treat acute lymphoblastic leukemia (ALL) in case of …
Management of Childhood Functional Constipation.
Philichi L. Philichi L. J Pediatr Health Care. 2018 Jan-Feb;32(1):103-111. doi: 10.1016/j.pedhc.2017.08.008. J Pediatr Health Care. 2018. PMID: 29229066 No abstract available.
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease.
Ousingsawat J, Centeio R, Cabrita I, Talbi K, Zimmer O, Graf M, Göpferich A, Schreiber R, Kunzelmann K. Ousingsawat J, et al. Int J Mol Sci. 2022 Jan 19;23(3):1085. doi: 10.3390/ijms23031085. Int J Mol Sci. 2022. PMID: 35163010 Free PMC article.
While systemic application of niclosamide may lead to unwanted side effects, local administration via aerosol may circumvent these problems, particularly when the drug is encapsulated into small polyethylene glycol (PEG) hydrospheres. In the present study, we examin …
While systemic application of niclosamide may lead to unwanted side effects, local administration via aerosol may circumvent these problems, …
Allergic contact dermatitis to polyethylene glycol and nitrofurazone.
Guijarro SC, Sánchez-Pérez J, García-Díez A. Guijarro SC, et al. Am J Contact Dermat. 1999 Dec;10(4):226-7. doi: 10.1053/AJCD01000226. Am J Contact Dermat. 1999. PMID: 10594300
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene glycol. Patch tests to nickel sulfate, potassium dischromate, chloride cobalt, Furacin, nitrofurazone 1% petrolatum, polyethyle
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene
[Folliculotropic mycosis fungoides].
Baratli J, Balakirski G, Megahed M. Baratli J, et al. Hautarzt. 2014 Dec;65(12):1011-3. doi: 10.1007/s00105-014-3539-z. Hautarzt. 2014. PMID: 25355498 German.
Pegaspargase: a review of clinical studies.
Graham ML. Graham ML. Adv Drug Deliv Rev. 2003 Sep 26;55(10):1293-302. doi: 10.1016/s0169-409x(03)00110-8. Adv Drug Deliv Rev. 2003. PMID: 14499708 Review.
Allergic reactions to coronavirus disease 2019 vaccines and addressing vaccine hesitancy: Northwell Health experience.
Kaplan B, Farzan S, Coscia G, Rosenthal DW, McInerney A, Jongco AM, Ponda P, Bonagura VR. Kaplan B, et al. Ann Allergy Asthma Immunol. 2022 Feb;128(2):161-168.e1. doi: 10.1016/j.anai.2021.10.019. Epub 2021 Oct 24. Ann Allergy Asthma Immunol. 2022. PMID: 34699968 Free PMC article.
BACKGROUND: Allergic and nonallergic adverse reactions have been reported with global coronavirus disease 2019 (COVID-19) vaccination. It was previously hypothesized that polyethylene glycol (PEG) may be responsible for anaphylactic reactions to messenger RNA (mRNA) …
BACKGROUND: Allergic and nonallergic adverse reactions have been reported with global coronavirus disease 2019 (COVID-19) vaccination. It wa …
Safety aspects of pegylated liposomal doxorubicin in patients with cancer.
Alberts DS, Garcia DJ. Alberts DS, et al. Drugs. 1997;54 Suppl 4:30-5. doi: 10.2165/00003495-199700544-00007. Drugs. 1997. PMID: 9361959 Review.
Encapsulation in polyethylene glycol-coated (pegylated; Stealth) liposomes alters the pharmacokinetic characteristics, and hence the safety and tolerability profile, of doxorubicin. ...Other adverse effects included nausea and vomiting and alopecia. Acute hyperse
Encapsulation in polyethylene glycol-coated (pegylated; Stealth) liposomes alters the pharmacokinetic characteristics, and hen …
How to solve the problem of hypersensitivity to asparaginase?
Pui CH, Liu Y, Relling MV. Pui CH, et al. Pediatr Blood Cancer. 2018 Mar;65(3):10.1002/pbc.26884. doi: 10.1002/pbc.26884. Epub 2017 Nov 22. Pediatr Blood Cancer. 2018. PMID: 29165928 Free PMC article. No abstract available.
Increased permeability to polyethylene glycol 4000 in rabbits with experimental colitis.
Seidman EG, Hanson DG, Walker WA. Seidman EG, et al. Gastroenterology. 1986 Jan;90(1):120-6. doi: 10.1016/0016-5085(86)90083-1. Gastroenterology. 1986. PMID: 2933289
Little information is available regarding colonic permeability to macromolecules in health or disease states. In vivo permeability of rabbit colon to [14C]polyethylene glycol 4000 (14C-PEG) was examined in the presence of immune complex-mediated experimental colitis …
Little information is available regarding colonic permeability to macromolecules in health or disease states. In vivo permeability of rabbit …
Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase.
Soares AL, Guimarães GM, Polakiewicz B, de Moraes Pitombo RN, Abrahão-Neto J. Soares AL, et al. Int J Pharm. 2002 Apr 26;237(1-2):163-70. doi: 10.1016/s0378-5173(02)00046-7. Int J Pharm. 2002. PMID: 11955814
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reactions must be considered a relevant adverse effect of asparaginase therapy. One approach to reduce the hypersensitivity reactions cau …
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reac …
Hypersensitivity Reaction to Carbon Fiber-Polyetheretherketone Composite Spinal Implant: A Case Report.
Bueno BT, Henry M, Cho SK. Bueno BT, et al. JBJS Case Connect. 2022 Jun 15;12(2). doi: 10.2106/JBJS.CC.21.00731. eCollection 2022 Apr 1. JBJS Case Connect. 2022. PMID: 35703153
CASE: A 52-year-old woman presented with localized hypersensitivity symptoms immediately after insertion of a carbon fiber-polyetheretherketone (CF-PEEK) vertebral fusion device. ...As far as we know, this is the first reported case of a hypersensitivity reaction to …
CASE: A 52-year-old woman presented with localized hypersensitivity symptoms immediately after insertion of a carbon fiber-polyethere …
Predicting success of desensitization after pegaspargase allergy.
Swanson HD, Panetta JC, Barker PJ, Liu Y, Inaba H, Relling MV, Pui CH, Karol SE. Swanson HD, et al. Blood. 2020 Jan 2;135(1):71-75. doi: 10.1182/blood.2019003407. Blood. 2020. PMID: 31750901 Free PMC article. No abstract available.
Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies.
Kishimoto TK. Kishimoto TK. Front Immunol. 2020 May 20;11:969. doi: 10.3389/fimmu.2020.00969. eCollection 2020. Front Immunol. 2020. PMID: 32508839 Free PMC article. Review.
The development of anti-drug antibodies (ADAs) is a common cause for treatment failure and hypersensitivity reactions for many biologics. The focus of this review is the development of ImmTOR, a platform technology designed to prevent the formation of ADAs that can be appl …
The development of anti-drug antibodies (ADAs) is a common cause for treatment failure and hypersensitivity reactions for many biolog …
A case of anaphylaxis caused by polyethylene glycol analogues.
Yamasuji Y, Higashi Y, Sakanoue M, Katsue H, Kawai K, Arai N, Kanekura T. Yamasuji Y, et al. Contact Dermatitis. 2013 Sep;69(3):183-5. doi: 10.1111/cod.12084. Contact Dermatitis. 2013. PMID: 23948038 No abstract available.
Urticaria as a Rare Side Effect of Polyethylene Glycol-3350 in a Child: Case Report.
Sari Gökay S, Çelik T, Yusuf Sari M, Ekinci F, Dinçer Yildizdaş R, Levent Yilmaz H. Sari Gökay S, et al. Acta Clin Croat. 2018 Mar;57(1):187-189. doi: 10.20471/acc.2018.57.01.26. Acta Clin Croat. 2018. PMID: 30256031 Free PMC article.
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Molecular weight dependence of polyethylene glycol penetration across acetone-disrupted permeability barrier.
Tsai JC, Hung PL, Sheu HM. Tsai JC, et al. Arch Dermatol Res. 2001 Jun;293(6):302-7. doi: 10.1007/s004030100229. Arch Dermatol Res. 2001. PMID: 11480590
The purpose of the present study was to investigate the dependence of permeability on molecular weight (MW) in acetone-disrupted hairless mouse skin in contrast to normal skin. Penetration of polyethylene glycol (PEG) 300, 600, and 1,000 over 12 h was measured using …
The purpose of the present study was to investigate the dependence of permeability on molecular weight (MW) in acetone-disrupted hairless mo …
Skin reactions to propylene glycol.
Hannuksela M, Pirilä V, Salo OP. Hannuksela M, et al. Contact Dermatitis. 1975;1(2):112-6. doi: 10.1111/j.1600-0536.1975.tb05336.x. Contact Dermatitis. 1975. PMID: 233872
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method. ...In them, positive reactions were elicited by testing with high dilutions of PG …
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a tota …
Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group.
Brigitha LJ, Fiocco M, Pieters R, Albertsen BK, Escherich G, Lopez-Lopez E, Mondelaers V, Vora A, Vrooman L, Schmiegelow K, van der Sluis IM; Ponte di Legno Toxicity Working Group. Brigitha LJ, et al. Eur J Cancer. 2022 Feb;162:65-75. doi: 10.1016/j.ejca.2021.11.016. Epub 2021 Dec 23. Eur J Cancer. 2022. PMID: 34954438 Free article.
BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli (E.coli) asparaginase. ...Meta-analyses were conducted to estimate the incidence of three types of hypersensitivity (allergy, allergi …
BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli …
Failure of desensitization with Pfizer-BioNTech COVID-19 vaccine in two asthmatic patients.
Iemoli E, Ortolani VGR, Preziosi D, Caron L, Giardina C, Carlevatti V, Giovine N. Iemoli E, et al. Eur Ann Allergy Clin Immunol. 2022 Sep;54(5):240-241. doi: 10.23822/EurAnnACI.1764-1489.236. Epub 2021 Nov 5. Eur Ann Allergy Clin Immunol. 2022. PMID: 34753281 Free article.
In mRNA vaccines, the component currently suspected of causing allergic reactions is the polyethylene glycol excipient (PEG or macrogol). In patients who have shown an immediate allergic reaction to vaccine and who are negative to skin tests for PEG, desensitization …
In mRNA vaccines, the component currently suspected of causing allergic reactions is the polyethylene glycol excipient (PEG or …
Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
Abshire TC, Pollock BH, Billett AL, Bradley P, Buchanan GR. Abshire TC, et al. Blood. 2000 Sep 1;96(5):1709-15. Blood. 2000. PMID: 10961868 Free article. Clinical Trial.
The relapse rate in childhood acute lymphoblastic leukemia (ALL) is approximately 30% but few reinduction regimens have investigated the intensive use of polyethylene glycol Escherichia coli asparaginase (PEG-Asp). Therefore, we assessed the pharmocokinetics and eff …
The relapse rate in childhood acute lymphoblastic leukemia (ALL) is approximately 30% but few reinduction regimens have investigated the int …
Beneficial effects of propylene and polyethylene glycol and saline in the treatment of perennial rhinitis.
Spector SL, Toshener D, Gay I, Rosenman E. Spector SL, et al. Clin Allergy. 1982 Mar;12(2):187-96. doi: 10.1111/j.1365-2222.1982.tb01638.x. Clin Allergy. 1982. PMID: 7074822 Clinical Trial.
Although propylene-and-polyethylene-glycol and saline have been used in clinical studies as placebos, their possible therapeutic role as wetting agents in the treatment of perennial rhinitis was investigated. ...
Although propylene-and-polyethylene-glycol and saline have been used in clinical studies as placebos, their possible therapeut …
Clinical and demographic factors contributing to asparaginase-associated toxicities in children with acute lymphoblastic leukemia.
Dharia P, Swartz MD, Bernhardt MB, Chen H, Gramatges MM, Lupo PJ, Brown AL, Scheurer ME. Dharia P, et al. Leuk Lymphoma. 2022 Dec;63(12):2948-2954. doi: 10.1080/10428194.2022.2102621. Epub 2022 Jul 27. Leuk Lymphoma. 2022. PMID: 35895075
A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3% …
A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pe …
Gut permeability measured by polyethylene glycol absorption in abnormal gut fermentation as compared with food intolerance.
Eaton KK, Howard M, Howard JM. Eaton KK, et al. J R Soc Med. 1995 Feb;88(2):63-6. J R Soc Med. 1995. PMID: 7769595 Free PMC article.
Gut permeability has been studied in patients with either food intolerance or abnormal gut fermentation as well as in normal subjects. Permeability was measured by polyethylene glycol absorption, and the reasons for this choice of probe are discussed. ...
Gut permeability has been studied in patients with either food intolerance or abnormal gut fermentation as well as in normal subjects. Perme …
Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy.
Troelnikov A, Perkins G, Yuson C, Ahamdie A, Balouch S, Hurtado PR, Hissaria P. Troelnikov A, et al. J Allergy Clin Immunol. 2021 Jul;148(1):91-95. doi: 10.1016/j.jaci.2021.04.032. Epub 2021 May 12. J Allergy Clin Immunol. 2021. PMID: 33991580
BACKGROUND: The mechanisms underpinning allergic reactions to the BNT162b2 (Pfizer) COVID-19 vaccine remain unknown, with polyethylene glycol (PEG) contained in the lipid nanoparticle suspected as being the cause. ...METHODS: Three known individuals with PEG allergy …
BACKGROUND: The mechanisms underpinning allergic reactions to the BNT162b2 (Pfizer) COVID-19 vaccine remain unknown, with polyethylene
Tolerability and Efficacy of a 1-Bag Pegaspargase Densensitization Protocol in Pediatric Oncology Patients.
Cramer J, Graff J, Serebin D. Cramer J, et al. J Pediatr Hematol Oncol. 2022 Apr 1;44(3):e623-e627. doi: 10.1097/MPH.0000000000002241. J Pediatr Hematol Oncol. 2022. PMID: 34133383
Desensitization to pegaspargase has been previously attempted in patients who have a hypersensitivity reaction to pegaspargase when Erwinia asparaginase is not an available alternative because of supply issues. ...Four of the 5 patients that did experience a hypersensit
Desensitization to pegaspargase has been previously attempted in patients who have a hypersensitivity reaction to pegaspargase when E …
Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.
Liu Y, Smith CA, Panetta JC, Yang W, Thompson LE, Counts JP, Molinelli AR, Pei D, Kornegay NM, Crews KR, Swanson H, Cheng C, Karol SE, Evans WE, Inaba H, Pui CH, Jeha S, Relling MV. Liu Y, et al. J Clin Oncol. 2019 Aug 10;37(23):2051-2061. doi: 10.1200/JCO.18.02439. Epub 2019 Jun 12. J Clin Oncol. 2019. PMID: 31188727 Free PMC article.
Serum samples (n = 5,369) were analyzed for anti-PEG-ASP immunoglobulin G by enzyme-linked immunosorbent assay. Positive samples were tested for anti-polyethylene glycol (PEG) and anti-L-ASP. We analyzed potential risk factors for reactions and associations between …
Serum samples (n = 5,369) were analyzed for anti-PEG-ASP immunoglobulin G by enzyme-linked immunosorbent assay. Positive samples were tested …
Alternative algorithm for L-asparaginase allergy in children with acute lymphoblastic leukemia.
Soyer OU, Aytac S, Tuncer A, Cetin M, Yetgin S, Sekerel BE. Soyer OU, et al. J Allergy Clin Immunol. 2009 Apr;123(4):895-9. doi: 10.1016/j.jaci.2008.10.034. Epub 2008 Dec 10. J Allergy Clin Immunol. 2009. PMID: 19081614
Polyethylene glycol-asparaginase could be used for 3 patients. Eight of the remaining 16 children, who had experienced anaphylaxis, were premedicated and desensitized with E coli-asparaginase, and in 7 patients treatment was tolerated. ...Polyethylene glyc
Polyethylene glycol-asparaginase could be used for 3 patients. Eight of the remaining 16 children, who had experienced anaphyl
[Sarcoidosis following pegylated interferon therapy: two cases].
Benali S, Boustière C, Castellani P, Cesari C, Jullien M, Lecomte L, Lebars O, Lambot G, Loyer R, Masseboeuf A, Perrier H, Oules V, Bourlière M. Benali S, et al. Gastroenterol Clin Biol. 2006 Apr;30(4):615-9. doi: 10.1016/s0399-8320(06)73238-9. Gastroenterol Clin Biol. 2006. PMID: 16733389 Free article. Review. French.
Ectopic expression of finger millet calmodulin confers drought and salinity tolerance in Arabidopsis thaliana.
Jamra G, Agarwal A, Singh N, Sanyal SK, Kumar A, Pandey GK. Jamra G, et al. Plant Cell Rep. 2021 Nov;40(11):2205-2223. doi: 10.1007/s00299-021-02743-z. Epub 2021 Jul 11. Plant Cell Rep. 2021. PMID: 34250550
Overexpression of EcCaM in Arabidopsis makes the plant tolerant to polyethylene glycol (PEG) induced drought and salt stress (NaCl) as demonstrated by post-germination based phenotypic assay, ion leakage, MDA and proline estimation, ROS detection under stressed and …
Overexpression of EcCaM in Arabidopsis makes the plant tolerant to polyethylene glycol (PEG) induced drought and salt stress ( …
Specific targeting and noninvasive magnetic resonance imaging of an asthma biomarker in the lung using polyethylene glycol functionalized magnetic nanocarriers.
Al Faraj A, Shaik AS, Afzal S, Al-Muhsen S, Halwani R. Al Faraj A, et al. Contrast Media Mol Imaging. 2016 May;11(3):172-83. doi: 10.1002/cmmi.1678. Epub 2015 Dec 28. Contrast Media Mol Imaging. 2016. PMID: 26708935 Free article.
In this study, superparamagnetic iron oxide nanoparticles were conjugated with anti-IL4Ralpha blocking antibodies via polyethylene glycol (PEG) polymers. The delivery of these blocking antibodies to the inflammatory sites in the lung via the developed nanocarriers w …
In this study, superparamagnetic iron oxide nanoparticles were conjugated with anti-IL4Ralpha blocking antibodies via polyethylene
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia.
Ettinger LJ, Kurtzberg J, Voûte PA, Jürgens H, Halpern SL. Ettinger LJ, et al. Cancer. 1995 Mar 1;75(5):1176-81. doi: 10.1002/1097-0142(19950301)75:5<1176::aid-cncr2820750519>3.0.co;2-y. Cancer. 1995. PMID: 7850718 Clinical Trial.
Because L-asparaginase is a foreign protein, the potential exists for severe, dose-limiting hypersensitivity reactions. To reduce this toxicity, L-asparaginase has been linked with polyethylene glycol (PEG). ...All patients had been treated previously with on …
Because L-asparaginase is a foreign protein, the potential exists for severe, dose-limiting hypersensitivity reactions. To reduce thi …
Comparison of hypersensitivity reactions to PEG-asparaginase in children after intravenous and intramuscular administration.
August KJ, Miller WP, Dalton A, Shinnick S. August KJ, et al. J Pediatr Hematol Oncol. 2013 Oct;35(7):e283-6. doi: 10.1097/MPH.0b013e31828e5471. J Pediatr Hematol Oncol. 2013. PMID: 23619117
INTRODUCTION: Polyethylene-glycolated (PEG)-asparaginase (PEG-ASP) is a crucial component of pediatric acute lymphoblastic leukemia therapy. ...RESULTS: Of 68 patients studied, 7 experienced a hypersensitivity reaction (10.3%). Two of 16 patients (12.5%) who receive …
INTRODUCTION: Polyethylene-glycolated (PEG)-asparaginase (PEG-ASP) is a crucial component of pediatric acute lymphoblastic leukemia t …
Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase.
Hershfield MS, Buckley RH, Greenberg ML, Melton AL, Schiff R, Hatem C, Kurtzberg J, Markert ML, Kobayashi RH, Kobayashi AL, et al. Hershfield MS, et al. N Engl J Med. 1987 Mar 5;316(10):589-96. doi: 10.1056/NEJM198703053161005. N Engl J Med. 1987. PMID: 3807953
We conclude that from the standpoints of efficacy, convenience, and safety, polyethylene glycol-modified adenosine deaminase is preferable to red-cell transfusion as a treatment for adenosine deaminase deficiency. Patients with other inherited metabolic diseases in …
We conclude that from the standpoints of efficacy, convenience, and safety, polyethylene glycol-modified adenosine deaminase i …
[Allergic reactions to COVID-19 vaccines: evidence and practice-oriented approach].
Klimek L, Eckrich J, Hagemann J, Casper I, Huppertz J. Klimek L, et al. Internist (Berl). 2021 Mar;62(3):326-332. doi: 10.1007/s00108-021-00959-5. Epub 2021 Feb 13. Internist (Berl). 2021. PMID: 33580823 Free PMC article. German.
Differences from established vaccines are addressed and the allergic potential of liposomes, polyethylene glycol, tromethamine/trometamol, and mRNA are discussed. ...
Differences from established vaccines are addressed and the allergic potential of liposomes, polyethylene glycol, tromethamine …
Site specific PEGylation of β-lactoglobulin at glutamine residues and its influence on conformation and antigenicity.
Luo S, Lu X, Liu C, Zhong J, Zhou L, Chen T. Luo S, et al. Food Res Int. 2019 Sep;123:623-630. doi: 10.1016/j.foodres.2019.05.038. Epub 2019 May 29. Food Res Int. 2019. PMID: 31285011
beta-lactoglobulin (beta-LG) is one of the main allergens in milk. Polyethylene glycol (PEG) modification (PEGylation) was found to have the ability to reduce the antigenicity of proteins. To determine the effect of site specific PEGylation on beta-LG antigenicity a …
beta-lactoglobulin (beta-LG) is one of the main allergens in milk. Polyethylene glycol (PEG) modification (PEGylation) was fou …
Effect of superoxide dismutase on a rabbit model of chronic allergic asthma.
Assa'ad AH, Ballard ET, Sebastian KD, Loven DP, Boivin GP, Lierl MB. Assa'ad AH, et al. Ann Allergy Asthma Immunol. 1998 Mar;80(3):215-24. doi: 10.1016/S1081-1206(10)62960-2. Ann Allergy Asthma Immunol. 1998. PMID: 9532968
The rabbits were then randomized into two groups that received every 48 hours an intravenous dose of either superoxide dismutase-polyethylene glycol 10,000 U/kg or inactivated superoxide dismutase-polyethylene glycol as control, followed by a 1-hour ex …
The rabbits were then randomized into two groups that received every 48 hours an intravenous dose of either superoxide dismutase-polyethy
Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro.
Neun BW, Barenholz Y, Szebeni J, Dobrovolskaia MA. Neun BW, et al. Molecules. 2018 Jul 12;23(7):1700. doi: 10.3390/molecules23071700. Molecules. 2018. PMID: 30002298 Free PMC article.
However, it is largely unknown why some patients develop reactions to nanomedicines while others do not, and why some nanoparticles are more reactogenic than others. One of the theories is that the pre-existing anti-polyethylene glycol (PEG) antibodies initiate the …
However, it is largely unknown why some patients develop reactions to nanomedicines while others do not, and why some nanoparticles are more …
Immediate allergic reactions by polyethylene glycol 4000: two cases.
Antón Gironés M, Roan Roan J, de la Hoz B, Sánchez Cano M. Antón Gironés M, et al. Allergol Immunopathol (Madr). 2008 Mar-Apr;36(2):110-2. doi: 10.1157/13120396. Allergol Immunopathol (Madr). 2008. PMID: 18479663
We performed allergy studies: skin prick tests with common inhalants, pure ES and the components (polyethylene glycol 4000 (PEG 4000), KCI, NaCO3, NaPO3, NaSO3, NaCI, neohesperydine, potasic acesulfam and orange flavouring), intradermic test, total serum IgE and sin …
We performed allergy studies: skin prick tests with common inhalants, pure ES and the components (polyethylene glycol 4000 (PE …
Acute lymphoblastic leukaemia patients treated with PEGasparaginase develop antibodies to PEG and the succinate linker.
Kloos R, van der Sluis IM, Mastrobattista E, Hennink W, Pieters R, Verhoef JJ. Kloos R, et al. Br J Haematol. 2020 May;189(3):442-451. doi: 10.1111/bjh.16254. Epub 2019 Dec 27. Br J Haematol. 2020. PMID: 31883112
Polyethylene glycol (PEG) conjugated asparaginase (PEGasparaginase) is essential for treatment of paediatric acute lymphoblastic leukaemia. We developed an assay identifying antibodies against the PEG-moiety, the linker and the drug itself in patients experiencing
Polyethylene glycol (PEG) conjugated asparaginase (PEGasparaginase) is essential for treatment of paediatric acute lymphoblast
Pegloticase hypersensitivity desensitisation: an outpatient, 3-bag, 12-step protocol.
Botson JK. Botson JK. BMJ Case Rep. 2020 Jun 21;13(6):e234721. doi: 10.1136/bcr-2020-234721. BMJ Case Rep. 2020. PMID: 32565437 Free PMC article.
Desensitisation, a procedure to tolerise a patient to a medication previously causing a hypersensitivity reaction, has been used successfully in oncology for chemotherapy treatment. ...
Desensitisation, a procedure to tolerise a patient to a medication previously causing a hypersensitivity reaction, has been used succ …
Pegaspargase: Two Pediatric Case Studies of Delayed Urticaria Preceding Anaphylactic Reactions Postadministration.
Busack KR. Busack KR. Clin J Oncol Nurs. 2021 Oct 1;25(5):511-513. doi: 10.1188/21.CJON.511-513. Clin J Oncol Nurs. 2021. PMID: 34533506
Pegaspargase, a chemotherapy drug known to improve survival outcomes in acute lymphoblastic leukemia, is associated with a risk for hypersensitivity reactions. At a children's hospital in the midwestern United States, two patients developed unusual reactions consisting of …
Pegaspargase, a chemotherapy drug known to improve survival outcomes in acute lymphoblastic leukemia, is associated with a risk for hyper
A randomized, double-blind, placebo-controlled trial of polyethylene glycol effects on fasting and postprandial rectal sensitivity and symptoms in hypersensitive constipation-predominant irritable bowel syndrome.
Awad RA, Camacho S. Awad RA, et al. Colorectal Dis. 2010 Nov;12(11):1131-8. doi: 10.1111/j.1463-1318.2009.01990.x. Colorectal Dis. 2010. PMID: 19575740 Clinical Trial.
AIM: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension and symptoms in hypersensitive constipation-predominant irritable bowel syndrome (IBS-C). ...The results support the concept that visc …
AIM: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension a …
Acute hypersensitivity to dentifrice.
Ito M, Watanabe D, Kobayashi M, Tamada Y, Matsumoto Y. Ito M, et al. Contact Dermatitis. 2006 Apr;54(4):225. doi: 10.1111/j.0105-1873.2006.0775k.x. Contact Dermatitis. 2006. PMID: 16650107 No abstract available.
A rare case of anaphylaxis to bowel prep: a case report and review of the literature.
Savitz JA, Durning SJ. Savitz JA, et al. Mil Med. 2011 Aug;176(8):944-5. doi: 10.7205/milmed-d-09-00176. Mil Med. 2011. PMID: 21882787 Review.
Polyethylene glycols (PEGs) are commonly utilized as a bowel prep prior to colonoscopy. ...
Polyethylene glycols (PEGs) are commonly utilized as a bowel prep prior to colonoscopy. ...
Surfactant Free Delivery of Docetaxel by Poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate]-Based Polymeric Micelles for Effective Melanoma Treatments.
Luo Z, Jiang L, Ding C, Hu B, Loh XJ, Li Z, Wu YL. Luo Z, et al. Adv Healthc Mater. 2018 Dec;7(23):e1801221. doi: 10.1002/adhm.201801221. Epub 2018 Nov 6. Adv Healthc Mater. 2018. PMID: 30398017
., ethanol and Tween 80), which are reported to cause severe hemolysis, hypersensitivity reactions, or neurotoxic toxicity and greatly hinders patient tolerance or compliance. In this report, a novel low-toxic, biodegradable, and amphiphilic poly[(R)-3-hydroxybutyrate-(R)- …
., ethanol and Tween 80), which are reported to cause severe hemolysis, hypersensitivity reactions, or neurotoxic toxicity and greatl …
Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection.
Teppler H, Kaplan G, Smith KA, Montana AL, Meyn P, Cohn ZA. Teppler H, et al. J Exp Med. 1993 Feb 1;177(2):483-92. doi: 10.1084/jem.177.2.483. J Exp Med. 1993. PMID: 8093894 Free PMC article.
13 patients with human immunodeficiency virus type 1 infection class II-IV, but without opportunistic infection or neoplasm, received 6 micrograms (3.6 x 10(4) IU) of polyethylene glycol recombinant human interleukin 2 (PEG IL-2) intradermally twice a week for 4 mo …
13 patients with human immunodeficiency virus type 1 infection class II-IV, but without opportunistic infection or neoplasm, received 6 micr …
A preliminary study on the evaluation of asparaginase. Polyethylene glycol conjugate against canine malignant lymphoma.
MacEwen EG, Rosenthal R, Matus R, Viau AT, Abuchowski A. MacEwen EG, et al. Cancer. 1987 Jun 15;59(12):2011-5. doi: 10.1002/1097-0142(19870615)59:12<2011::aid-cncr2820591207>3.0.co;2-m. Cancer. 1987. PMID: 3567863
Thirty-seven dogs with malignant lymphoma were treated with either polyethylene glycol conjugated (PEG) asparaginase alone (10-30 IU/kg intraperitoneally [IP] weekly--20 dogs) or PEG-asparaginase combined with one cycle of chemotherapy (vincristine, cyclophosphamide …
Thirty-seven dogs with malignant lymphoma were treated with either polyethylene glycol conjugated (PEG) asparaginase alone (10 …
Carl Prausnitz Memorial Lecture. Suppression of antibody responses by chemically modified antigens.
Sehon AH. Sehon AH. Int Arch Allergy Appl Immunol. 1991;94(1-4):11-20. Int Arch Allergy Appl Immunol. 1991. PMID: 1937863 Review.
Some of the studies employing nonantigenic, nonallergenic and tolerogenic derivatives of antigens and allergens, synthesized by coupling onto them an optimal number (n) of molecules of monomethoxy-polyethylene glycol (mPEG), are briefly reviewed. Administration of a …
Some of the studies employing nonantigenic, nonallergenic and tolerogenic derivatives of antigens and allergens, synthesized by coupling ont …
[Hypersensitivity reactions associated with the use of asparaginase in children with acute lymphoblastic leukemia].
Ovalle B P, Azócar M M, Nicklas D C, Villarroel C M, Morales V J. Ovalle B P, et al. Andes Pediatr. 2021 Apr;92(2):182-192. doi: 10.32641/andespediatr.v92i2.2151. Andes Pediatr. 2021. PMID: 34106156 Spanish.
INTRODUCTION: The treatment of acute lymphoblastic leukemia (ALL) includes the use of asparaginase (ASP), a drug associated with hypersensitivity reactions (HSR) that requires discontinuing its use. OBJECTIVE: To determine the incidence of HSR associated with ASP that requ …
INTRODUCTION: The treatment of acute lymphoblastic leukemia (ALL) includes the use of asparaginase (ASP), a drug associated with hypersen
Allergic contact dermatitis to copolymers in cosmetics--case report and review of the literature.
Quartier S, Garmyn M, Becart S, Goossens A. Quartier S, et al. Contact Dermatitis. 2006 Nov;55(5):257-67. doi: 10.1111/j.1600-0536.2006.00960.x. Contact Dermatitis. 2006. PMID: 17026690 Review.
We report a case of allergic contact dermatitis to polyvinylpyrrolidone (PVP)/hexadecene copolymer in a purple-colored lipstick and review the literature on allergic contact dermatitis to 7 copolymers: PVP/hexadecene, PVP/eicosene, PVP/1-triacontene, methoxy polyethyleneglycol (P …
We report a case of allergic contact dermatitis to polyvinylpyrrolidone (PVP)/hexadecene copolymer in a purple-colored lipstick and review t …
A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors.
Taylor CW, Dorr RT, Fanta P, Hersh EM, Salmon SE. Taylor CW, et al. Cancer Chemother Pharmacol. 2001;47(1):83-8. doi: 10.1007/s002800000207. Cancer Chemother Pharmacol. 2001. PMID: 11221967 Clinical Trial.
PURPOSE: To evaluate the in vitro activity of polyethylene glycol-conjugated L-asparaginase (PEG-Lasparaginase) against fresh human tumor specimens, using the human tumor clonogenic assay (HTCA), and to perform a phase I dose-escalation clinical trial of PEG-L-aspar …
PURPOSE: To evaluate the in vitro activity of polyethylene glycol-conjugated L-asparaginase (PEG-Lasparaginase) against fresh …
Time Course and Management of Protracted Anaphylaxis Due to PEG-Asparaginase.
Fertal SA, Bradeen HA, Friesen E, Heath JL. Fertal SA, et al. J Pediatr Hematol Oncol. 2021 Apr 1;43(3):e385-e387. doi: 10.1097/MPH.0000000000001906. J Pediatr Hematol Oncol. 2021. PMID: 32815880
Polyethylene glycosylated (PEG)-asparaginase is a cornerstone of treatment for acute lymphoblastic leukemia (ALL), and effective administration is associated with better outcomes. PEG-asparaginase is associated with a uniphasic hypersensitivity reaction in 10% to 20
Polyethylene glycosylated (PEG)-asparaginase is a cornerstone of treatment for acute lymphoblastic leukemia (ALL), and effective admi
Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production.
Moghimi SM, Hamad I, Andresen TL, Jørgensen K, Szebeni J. Moghimi SM, et al. FASEB J. 2006 Dec;20(14):2591-3. doi: 10.1096/fj.06-6186fje. Epub 2006 Oct 25. FASEB J. 2006. PMID: 17065229
Methoxy(polyethylene glycol), mPEG, -grafted liposomes are known to exhibit prolonged circulation time in the blood, but their infusion into a substantial percentage of human subjects triggers immediate non-IgE-mediated hypersensitivity reactions. ...
Methoxy(polyethylene glycol), mPEG, -grafted liposomes are known to exhibit prolonged circulation time in the blood, but their …
Assessing the role of the biomaterial Aquavene in patient reactions to Landmark midline catheters.
Silverstein B, Witkin KM, Frankos VH, Terr AI. Silverstein B, et al. Regul Toxicol Pharmacol. 1997 Feb;25(1):60-7. doi: 10.1006/rtph.1996.1057. Regul Toxicol Pharmacol. 1997. PMID: 9056501 Review.
They are constructed of an inner layer of polyurethane and an outer layer of the biomaterial Aquavene, a blend of polyurethane and polyethylene oxide to which butylated hyroxyanisole (BHA), butylated hydroxytoluene (BHT), and triallyl-s-triazine trione (TTT) are added. ... …
They are constructed of an inner layer of polyurethane and an outer layer of the biomaterial Aquavene, a blend of polyurethane and polyet
Near-infrared reflectance spectrometry in the study of atopy. Part 2. Interactions between the skin and polyethylene glycol 400, isopropyl myristate and hydrogel.
Dreassi E, Ceramelli G, Mura P, Perruccio PL, Vocioni F, Bartalini P, Corti P. Dreassi E, et al. Analyst. 1997 Aug;122(8):771-6. doi: 10.1039/a701257h. Analyst. 1997. PMID: 9338986
Three compounds were taken as models: a prevalently hydrophilic solvent (polyethylene glycol, PEG 400), a prevalently lipophilic solvent (isopropyl myristate) and a hydrophilic pharmaceutical (gel) used to promote contact in electrocardiography. ...
Three compounds were taken as models: a prevalently hydrophilic solvent (polyethylene glycol, PEG 400), a prevalently lipophil …
Improvement of Certolizumab Fab' properties by PASylation technology.
Mazaheri S, Talebkhan Y, Mahboudi F, Nematollahi L, Cohan RA, Mirabzadeh Ardakani E, Bayat E, Sabzalinejad M, Sardari S, Torkashvand F. Mazaheri S, et al. Sci Rep. 2020 Oct 28;10(1):18464. doi: 10.1038/s41598-020-74549-0. Sci Rep. 2020. PMID: 33116155 Free PMC article.
PEGylation may have disadvantages including immunogenicity, hypersensitivity, vacuolation, decreased binding affinity and biological activity of the protein. ...
PEGylation may have disadvantages including immunogenicity, hypersensitivity, vacuolation, decreased binding affinity and biological …
Modification of Escherichia coli B glutathione synthetase with polyethylene glycol for clinical application to enzyme replacement therapy for glutathione deficiency.
Inoue Y, Sugiyama K, Ueminami H, Izawa S, Kimura A. Inoue Y, et al. Clin Diagn Lab Immunol. 1996 Nov;3(6):663-8. doi: 10.1128/cdli.3.6.663-668.1996. Clin Diagn Lab Immunol. 1996. PMID: 8914756 Free PMC article.
Glutathione synthetase of Escherichia coli B was modified with polyethylene glycol, and the properties of the resultant modified enzyme were investigated. ...
Glutathione synthetase of Escherichia coli B was modified with polyethylene glycol, and the properties of the resultant modifi …
A double-blind study comparing monomethoxy polyethylene glycol-modified honeybee venom and unmodified honeybee venom for immunotherapy. I. Clinical results.
Müller U, Rabson AR, Bischof M, Lomnitzer R, Dreborg S, Lanner A. Müller U, et al. J Allergy Clin Immunol. 1987 Sep;80(3 Pt 1):252-61. doi: 10.1016/0091-6749(87)90027-3. J Allergy Clin Immunol. 1987. PMID: 3624680 Clinical Trial.
Thirty-five patients were allocated at random to immunotherapy (IT) in a double-blind way with either monomethoxy polyethylene glycol (mPEG)-modified honeybee venom (HBV) or HBV. The two groups were well matched regarding age, sex, skin sensitivity, HBV-specific ser …
Thirty-five patients were allocated at random to immunotherapy (IT) in a double-blind way with either monomethoxy polyethylene gly
Circulating immune complexes in IgA deficiency.
Kwitko AO, McKenzie PE, Shearman DJ, Gormly AA, Woodroffe AJ. Kwitko AO, et al. Clin Exp Immunol. 1979 Oct;38(1):45-51. Clin Exp Immunol. 1979. PMID: 527254 Free PMC article.
The presence of cryoglobulins (thirteen out of thirty-one patients) and increased polyethylene glycol precipitation (ten out of thirty patients) provided additional evidence for the presence of IC. ...
The presence of cryoglobulins (thirteen out of thirty-one patients) and increased polyethylene glycol precipitation (ten out o …
Determination of IgE-containing immune complexes in human sera. Evaluation of polyethylene glycol precipitation of monomeric and complex IgE and of the detectability of IgE in the complexes.
Djurup R, Kappelgaard E, Stahl Skov P, Permin H, Nielsen H. Djurup R, et al. Allergy. 1984 Jul;39(5):395-406. doi: 10.1111/j.1398-9995.1984.tb01958.x. Allergy. 1984. PMID: 6465483
We studied the polyethylene (PEG) precipitability of monomeric human IgE, and of human IgE artificially complexed with rabbit anti-human IgE. ...
We studied the polyethylene (PEG) precipitability of monomeric human IgE, and of human IgE artificially complexed with rabbit anti-hu …
IgE-Mediated Anaphylaxis Induced by Macrogol 6000.
Caballero ML, Lluch-Bernal M, Vilà-Nadal G, Lluncor M, Quirce S. Caballero ML, et al. J Investig Allergol Clin Immunol. 2016;26(6):398-400. doi: 10.18176/jiaci.0089. J Investig Allergol Clin Immunol. 2016. PMID: 27996956 Free article. No abstract available.
Liposomal doxorubicin: the good, the bad and the not-so-ugly.
Szebeni J, Fülöp T, Dézsi L, Metselaar B, Storm G. Szebeni J, et al. J Drug Target. 2016 Nov;24(9):765-767. doi: 10.3109/1061186X.2016.1172591. Epub 2016 Apr 27. J Drug Target. 2016. PMID: 27030293
These include (1) the decreased uptake of the drug by the MPS which may entail enhanced tumor uptake, and, hence, improved therapeutic efficacy; (2) the use of slow infusion protocols in reducing the risk of hypersensitivity (infusion) reactions; and (3), possible protecti …
These include (1) the decreased uptake of the drug by the MPS which may entail enhanced tumor uptake, and, hence, improved therapeutic effic …
Influence of nanoparticle size on blood-brain barrier penetration and the accumulation of anti-seizure medicines in the brain.
Meng Q, Meng H, Pan Y, Liu J, Li J, Qi Y, Huang Y. Meng Q, et al. J Mater Chem B. 2022 Jan 5;10(2):271-281. doi: 10.1039/d1tb02015c. J Mater Chem B. 2022. PMID: 34897348
However, some of them are associated with serious side effects including hepatotoxicity and hypersensitivity. Furthermore, the blood-brain barrier (BBB) is an insurmountable obstacle for brain drug delivery. ...Therefore, we designed a methoxy poly(lactide-co-glycolide)-b- …
However, some of them are associated with serious side effects including hepatotoxicity and hypersensitivity. Furthermore, the blood- …
Outpatient continuous intravenous interleukin-2 or subcutaneous, polyethylene glycol-modified interleukin-2 in human immunodeficiency virus-infected patients: a randomized, controlled, multicenter study. Australian IL-2 Study Group.
Carr A, Emery S, Lloyd A, Hoy J, Garsia R, French M, Stewart G, Fyfe G, Cooper DA. Carr A, et al. J Infect Dis. 1998 Oct;178(4):992-9. doi: 10.1086/515653. J Infect Dis. 1998. PMID: 9806026 Clinical Trial.
The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2) or a slow-release, polyethylene glycol (PEG)-modified IL-2 were studied in human immunodeficiency virus (HIV)-infected persons with CD4 cell counts between 200 and 500/mm3. . …
The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2) or a slow-release, polyethylene glycol
The devil is in the denominator.
Koretz RL. Koretz RL. Gastroenterology. 2006 Jun;130(7):2240-2; discussion 2242. doi: 10.1053/j.gastro.2006.03.057. Gastroenterology. 2006. PMID: 16762649 No abstract available.
A Reactive Oxygen Species-Scavenging 'Stealth' Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors.
d'Arcy R, El Mohtadi F, Francini N, DeJulius CR, Back H, Gennari A, Geven M, Lopez-Cavestany M, Turhan ZY, Yu F, Lee JB, King MR, Kagan L, Duvall CL, Tirelli N. d'Arcy R, et al. J Am Chem Soc. 2022 Nov 23;144(46):21304-21317. doi: 10.1021/jacs.2c09232. Epub 2022 Nov 11. J Am Chem Soc. 2022. PMID: 36367536 Free PMC article.
This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome immunogenicity and suboptimal pharmacokinetics of, for example, therapeutic proteins but has significant drawbacks …
This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common me …
Steroid Allergy: Clinical Features and the Importance of Excipient Testing in a Diagnostic Algorithm.
Li PH, Wagner A, Thomas I, Watts TJ, Rutkowski R, Rutkowski K. Li PH, et al. J Allergy Clin Immunol Pract. 2018 Sep-Oct;6(5):1655-1661. doi: 10.1016/j.jaip.2018.01.007. Epub 2018 Jan 31. J Allergy Clin Immunol Pract. 2018. PMID: 29408496
OBJECTIVE: The objective of this study was to evaluate the clinical characteristics and frequency of excipient allergy in patients with confirmed type I hypersensitivity to systemic CS preparations. METHODS: Patients with a confirmed diagnosis of allergy (positive skin tes …
OBJECTIVE: The objective of this study was to evaluate the clinical characteristics and frequency of excipient allergy in patients with conf …
Complement Activation: A Potential Threat on the Safety of Poly(ethylene glycol)-Coated Nanomedicines.
Gabizon A, Szebeni J. Gabizon A, et al. ACS Nano. 2020 Jul 28;14(7):7682-7688. doi: 10.1021/acsnano.0c03648. Epub 2020 Jul 9. ACS Nano. 2020. PMID: 32643376
In this issue of ACS Nano, Chen et al. provide in vitro and in vivo evidence for monoclonal anti-poly(ethylene glycol) (anti-PEG) antibody-triggered, complement terminal complex-mediated damage to PEGylated liposomal doxorubicin, entailing the release of the encapsulated d …
In this issue of ACS Nano, Chen et al. provide in vitro and in vivo evidence for monoclonal anti-poly(ethylene glycol) (anti-PEG) ant …
Anti-PEG antibody bioanalysis: a clinical case study with PEG-IFN-λ-1a and PEG-IFN-α2a in naive patients.
Myler H, Hruska MW, Srinivasan S, Cooney E, Kong G, Dodge R, Krishna M, Zhu J, Felix T, Gleason C, Piccoli SP, DeSilva B. Myler H, et al. Bioanalysis. 2015;7(9):1093-106. doi: 10.4155/bio.15.36. Bioanalysis. 2015. PMID: 26039807
BACKGROUND: Extensive use of polyethylene glycol (PEG) in consumer products necessitates the assessment of anti-PEG antibodies (APAb). ...APAb were earlier onset, less frequent, less persistent and lower titer than AIAb. No associated hypersensitivity events …
BACKGROUND: Extensive use of polyethylene glycol (PEG) in consumer products necessitates the assessment of anti-PEG antibodies …
Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes.
Judge A, McClintock K, Phelps JR, Maclachlan I. Judge A, et al. Mol Ther. 2006 Feb;13(2):328-37. doi: 10.1016/j.ymthe.2005.09.014. Epub 2005 Nov 7. Mol Ther. 2006. PMID: 16275098 Free article.
This phenomenon is characterized by a loss of disease site targeting, accelerated clearance from the blood, and acute hypersensitivity. These effects are fully attributable to a surprisingly robust, long-lived antibody response generated against polyethylene glyc
This phenomenon is characterized by a loss of disease site targeting, accelerated clearance from the blood, and acute hypersensitivity
Impact of Polymer Bioconjugation on Protein Stability and Activity Investigated with Discrete Conjugates: Alternatives to PEGylation.
Morgenstern J, Gil Alvaradejo G, Bluthardt N, Beloqui A, Delaittre G, Hubbuch J. Morgenstern J, et al. Biomacromolecules. 2018 Nov 12;19(11):4250-4262. doi: 10.1021/acs.biomac.8b01020. Epub 2018 Oct 5. Biomacromolecules. 2018. PMID: 30222929
Covalent attachment of synthetic polymers to proteins, known as protein-polymer conjugation, is currently one of the main approaches for improving the physicochemical properties of these biomolecules. The most commonly employed polymer is polyethylene glycol (PEG), …
Covalent attachment of synthetic polymers to proteins, known as protein-polymer conjugation, is currently one of the main approaches for imp …
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