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Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products.
Ibrahim M, Ramadan E, Elsadek NE, Emam SE, Shimizu T, Ando H, Ishima Y, Elgarhy OH, Sarhan HA, Hussein AK, Ishida T. Ibrahim M, et al. J Control Release. 2022 Nov;351:215-230. doi: 10.1016/j.jconrel.2022.09.031. Epub 2022 Sep 22. J Control Release. 2022. PMID: 36165835 Review.
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. ...The use of COVID-19 mRNA vaccines, which are composed mainly of PEGylated lipid nanoparticles (LNPs), has recen …
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier i …
Hypersensitivity to polyethylene glycol in adults and children: An emerging challenge.
Bianchi A, Bottau P, Calamelli E, Caimmi S, Crisafulli G, Franceschini F, Liotti L, Mori F, Paglialunga C, Saretta F, Tosca M, Cardinale F, Licari A, Miraglia Del Giudice M, Caffarelli C. Bianchi A, et al. Acta Biomed. 2021 Nov 29;92(S7):e2021519. doi: 10.23750/abm.v92iS7.12384. Acta Biomed. 2021. PMID: 34842597 Free PMC article. Review.
Hypersensitivity reactions to polyethylene glycol (PEG) is an emerging challenge and the interest about this disease is growing since PEG is considered one of the possible causes of coronavirus disease 2019 (COVID 19) vaccine-associated anaphylaxis. ...Lack o …
Hypersensitivity reactions to polyethylene glycol (PEG) is an emerging challenge and the interest about this disease is …
Hypersensitivity to polyethylene glycol (PEG).
Czarnobilska M, Bulanda M, Kurnik-Łucka M, Gil K. Czarnobilska M, et al. Folia Med Cracov. 2021 Dec 28;61(4):55-69. doi: 10.24425/fmc.2021.140004. Folia Med Cracov. 2021. PMID: 35180202 Free article.
The only absolute contraindication to administration of the vaccine is an anaphylactic reaction to any of its ingredients. Polyethylene glycol (PEG), widely used as an excipient in various vaccines, is considered the primary cause of allergic reactions associated wi …
The only absolute contraindication to administration of the vaccine is an anaphylactic reaction to any of its ingredients. Polyethylene …
Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.
Stone CA Jr, Liu Y, Relling MV, Krantz MS, Pratt AL, Abreo A, Hemler JA, Phillips EJ. Stone CA Jr, et al. J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1533-1540.e8. doi: 10.1016/j.jaip.2018.12.003. Epub 2018 Dec 14. J Allergy Clin Immunol Pract. 2019. PMID: 30557713 Free PMC article.
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; however, the epidemiology, mechanisms, and cross-reactivity are poorly understood. ...Our studies raise the possibility of an IgE-mediated t …
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; …
Polyethylene glycol hypersensitivity, patient outcomes in a 7-year retrospective study.
Kayode OS, Nakonechna A, Siew LQC, Dziadzio M, Kennard L, Rutkowski K, Mirakian R, Wagner A. Kayode OS, et al. Ann Allergy Asthma Immunol. 2024 Jul;133(1):93-100.e4. doi: 10.1016/j.anai.2024.03.022. Epub 2024 Mar 30. Ann Allergy Asthma Immunol. 2024. PMID: 38561050
BACKGROUND: Immediate IgE-mediated hypersensitivity reactions to polyethylene glycol (PEG) are rare. Our understanding of PEG hypersensitivity is limited. ...Administration of messenger RNA COVID-19 or Oxford/AstraZeneca COVID-19 vaccines was tolerated …
BACKGROUND: Immediate IgE-mediated hypersensitivity reactions to polyethylene glycol (PEG) are rare. Our understanding …
Serum polyethylene glycol-specific IgE and IgG in patients with hypersensitivity to COVID-19 mRNA vaccines.
Mouri M, Imamura M, Suzuki S, Kawasaki T, Ishizaki Y, Sakurai K, Nagafuchi H, Matsumura N, Uchida M, Ando T, Yoshioka K, Ooka S, Sugihara T, Miyoshi H, Mori M, Okada T, Yamaguchi M, Kunishima H, Kato M, Kawahata K. Mouri M, et al. Allergol Int. 2022 Oct;71(4):512-519. doi: 10.1016/j.alit.2022.05.007. Epub 2022 Jun 6. Allergol Int. 2022. PMID: 35718709 Free PMC article.
BACKGROUND: The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is a potential antigen in the components of vaccines. However, there is little evidence that allergy after COVID-19 mRNA vaccination is relate …
BACKGROUND: The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is …
Hidden Dangers: Recognizing Excipients as Potential Causes of Drug and Vaccine Hypersensitivity Reactions.
Caballero ML, Krantz MS, Quirce S, Phillips EJ, Stone CA Jr. Caballero ML, et al. J Allergy Clin Immunol Pract. 2021 Aug;9(8):2968-2982. doi: 10.1016/j.jaip.2021.03.002. Epub 2021 Mar 15. J Allergy Clin Immunol Pract. 2021. PMID: 33737254 Free PMC article. Review.
For both drugs and vaccines, these are rare reactions; however, for vaccines, they are the primary cause of immediate hypersensitivity. Suspicion for these "hidden dangers" should be high, in particular, when anaphylaxis has occurred in association with multiple chemically …
For both drugs and vaccines, these are rare reactions; however, for vaccines, they are the primary cause of immediate hypersensitivity …
PEGylated Lipid Nanoparticle Formulations: Immunological Safety and Efficiency Perspective.
Tenchov R, Sasso JM, Zhou QA. Tenchov R, et al. Bioconjug Chem. 2023 Jun 21;34(6):941-960. doi: 10.1021/acs.bioconjchem.3c00174. Epub 2023 May 10. Bioconjug Chem. 2023. PMID: 37162501 Free PMC article. Review.
Currently in the spotlight as important constituents of the COVID-19 mRNA vaccines, LNPs play a significant role in protecting and transporting mRNA to cells. As one of their key constituents, polyethylene glycol (PEG)-lipid conjugates are important in defining LNP …
Currently in the spotlight as important constituents of the COVID-19 mRNA vaccines, LNPs play a significant role in protecting and transport …
Polyethylene glycol allergy for real this time!
Kelso JM. Kelso JM. Ann Allergy Asthma Immunol. 2024 Jul;133(1):9-10. doi: 10.1016/j.anai.2024.04.003. Ann Allergy Asthma Immunol. 2024. PMID: 38960568 No abstract available.
Expert Consensus Statement from the American Society of Echocardiography on Hypersensitivity Reactions to Ultrasound Enhancing Agents in Patients with Allergy to Polyethylene Glycol.
Lindner JR, Belcik T, Main ML, Montanaro A, Mulvagh SL, Olson J, Olyaei A, Porter TR, Senior R. Lindner JR, et al. J Am Soc Echocardiogr. 2021 Jul;34(7):707-708. doi: 10.1016/j.echo.2021.05.002. Epub 2021 May 7. J Am Soc Echocardiogr. 2021. PMID: 33971277 Free PMC article. No abstract available.
Polyethylene Glycol Is a Cause of IgE-Mediated Anaphylaxis.
Giavina-Bianchi P, Kalil J. Giavina-Bianchi P, et al. J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1874-1875. doi: 10.1016/j.jaip.2019.05.001. J Allergy Clin Immunol Pract. 2019. PMID: 31279466 No abstract available.
Polyethylene Glycol-Induced Systemic Allergic Reactions (Anaphylaxis).
Sellaturay P, Nasser S, Ewan P. Sellaturay P, et al. J Allergy Clin Immunol Pract. 2021 Feb;9(2):670-675. doi: 10.1016/j.jaip.2020.09.029. Epub 2020 Oct 1. J Allergy Clin Immunol Pract. 2021. PMID: 33011299
Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers found in everyday products such as foods, cosmetics, and medications. ...
Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers found in everyday products such as foods, cosmetics, and med …
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.
Knop K, Hoogenboom R, Fischer D, Schubert US. Knop K, et al. Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308. doi: 10.1002/anie.200902672. Angew Chem Int Ed Engl. 2010. PMID: 20648499 Review.
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery. ...The areas that might need consideration and more intensive and careful examination can be divided into the followin …
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer …
Immediate-type hypersensitivity to polyethylene glycols: a review.
Wenande E, Garvey LH. Wenande E, et al. Clin Exp Allergy. 2016 Jul;46(7):907-22. doi: 10.1111/cea.12760. Clin Exp Allergy. 2016. PMID: 27196817 Review.
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first comprehensive review provides practical information for allergists and other healthcare professionals by describing the clinical picture of …
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first …
Patients with previous immediate hypersensitivity reactions to polyethylene glycol can safely receive the BNT162b2 mRNA COVID-19 vaccine.
Hurst M, Jordan A, Capstick J, Brewerton M, Cockroft R, Ingram J. Hurst M, et al. Intern Med J. 2022 Oct;52(10):1818-1820. doi: 10.1111/imj.15821. Epub 2022 Oct 6. Intern Med J. 2022. PMID: 36000384 Free PMC article.
Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contraindication to the BNT162b2 mRNA COVID-19 vaccine, which contains 50 ug of PEG at a molecular weight of 2000, and this component is thought …
Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contr …
Patients with polyethylene glycol allergy can experience immediate-type hypersensitivity reactions after exposure to analog substances.
Yoshimoto Y, Tezuka J. Yoshimoto Y, et al. BMJ Case Rep. 2023 Aug 29;16(8):e254040. doi: 10.1136/bcr-2022-254040. BMJ Case Rep. 2023. PMID: 37643821 Free PMC article.
Polyethylene glycol (PEG) allergy has been recently observed after COVID-19 mRNA vaccination. ...Our findings indicate that patients with PEG allergy may experience immediate-type hypersensitivity reactions to analogue substances....
Polyethylene glycol (PEG) allergy has been recently observed after COVID-19 mRNA vaccination. ...Our findings indicate that pa …
Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice.
Lisiecka MZ. Lisiecka MZ. Immunol Res. 2024 Aug;72(4):675-682. doi: 10.1007/s12026-024-09473-w. Epub 2024 Mar 19. Immunol Res. 2024. PMID: 38502278 Review.
The study analysed literature data in modern databases, such as MEDLINE, PubMed, and Scopus, on allergic reactions to polyethylene glycol, using the keywords: "PEG", "polyethylene glycol", "allergy", "side effect". ...The analysis found that allergic r …
The study analysed literature data in modern databases, such as MEDLINE, PubMed, and Scopus, on allergic reactions to polyethylene …
Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging.
Senior R, Lindner JR, Edvardsen T, Cosyns B. Senior R, et al. Eur Heart J Cardiovasc Imaging. 2021 Aug 14;22(9):959-960. doi: 10.1093/ehjci/jeab120. Eur Heart J Cardiovasc Imaging. 2021. PMID: 34164650
Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, to polyethylene glycol (PEG) (macrogol), or to PEG-containing products, such as certain bowel preps for colonoscopy or laxative …
Lipid-based UCAs (SonoVue and Luminity) are contraindicated in patients who have a history of prior hypersensitivity to these UEAs, t …
PEG-asparaginase.
Fu CH, Sakamoto KM. Fu CH, et al. Expert Opin Pharmacother. 2007 Aug;8(12):1977-84. doi: 10.1517/14656566.8.12.1977. Expert Opin Pharmacother. 2007. PMID: 17696798 Review.
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase antibodies, which neutralize their activity. PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene …
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase an …
Experience with polyethylene glycol allergy-guided risk management for COVID-19 vaccine anaphylaxis.
Brockow K, Mathes S, Fischer J, Volc S, Darsow U, Eberlein B, Biedermann T. Brockow K, et al. Allergy. 2022 Jul;77(7):2200-2210. doi: 10.1111/all.15183. Epub 2021 Dec 4. Allergy. 2022. PMID: 34806775 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) may elicit anaphylaxis to COVID-19 mRNA vaccines, and guidance for patients at risk is needed. ...Vaccination was recommended in all those patients. No hypersensitivity reactions were reported to vaccination including six …
BACKGROUND: Polyethylene glycol (PEG) may elicit anaphylaxis to COVID-19 mRNA vaccines, and guidance for patients at risk is n …
Endotyping of IgE-Mediated Polyethylene Glycol and/or Polysorbate 80 Allergy.
Ieven T, Coorevits L, Vandebotermet M, Tuyls S, Vanneste H, Santy L, Wets D, Proost P, Frans G, Devolder D, Breynaert C, Bullens DMA, Schrijvers R. Ieven T, et al. J Allergy Clin Immunol Pract. 2023 Oct;11(10):3146-3160. doi: 10.1016/j.jaip.2023.06.031. Epub 2023 Jun 26. J Allergy Clin Immunol Pract. 2023. PMID: 37380070 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) and polysorbate 80 (PS80) allergy preclude from SARS-CoV-2 vaccination. ...
BACKGROUND: Polyethylene glycol (PEG) and polysorbate 80 (PS80) allergy preclude from SARS-CoV-2 vaccination. ...
PEGylated liposomes for diagnosis of polyethylene glycol allergy.
Perkins GB, Tunbridge MJ, Hurtado PR, Zuiani J, Mhatre S, Yip KH, Le TA, Yuson C, Kette F, Hissaria P. Perkins GB, et al. J Allergy Clin Immunol. 2024 Aug;154(2):503-507.e1. doi: 10.1016/j.jaci.2024.03.030. Epub 2024 May 6. J Allergy Clin Immunol. 2024. PMID: 38718949 Free article.
BACKGROUND: Polyethylene glycol (PEG) is a nonprotein polymer that is present in its native (unbound) form as an excipient in a range of products. ...
BACKGROUND: Polyethylene glycol (PEG) is a nonprotein polymer that is present in its native (unbound) form as an excipient in …
Hypersensitivity to polyethylene glycols.
Shah S, Prematta T, Adkinson NF, Ishmael FT. Shah S, et al. J Clin Pharmacol. 2013 Mar;53(3):352-5. doi: 10.1177/0091270012447122. Epub 2013 Jan 24. J Clin Pharmacol. 2013. PMID: 23444288 No abstract available.
Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey.
Özkaya E, Kılıç S. Özkaya E, et al. Contact Dermatitis. 2018 Mar;78(3):211-215. doi: 10.1111/cod.12931. Epub 2017 Nov 28. Contact Dermatitis. 2018. PMID: 29193145
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. ...
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmeti …
To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives.
Shi D, Beasock D, Fessler A, Szebeni J, Ljubimova JY, Afonin KA, Dobrovolskaia MA. Shi D, et al. Adv Drug Deliv Rev. 2022 Jan;180:114079. doi: 10.1016/j.addr.2021.114079. Epub 2021 Dec 10. Adv Drug Deliv Rev. 2022. PMID: 34902516 Free PMC article. Review.
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional formulations utilize PEG as either an active ingredient or an excipient. ...
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional formulations utilize PEG as either an acti …
Basophil Activation Test with Different Polyethylene Glycols in Patients with Suspected PEG Hypersensitivity Reactions.
Vespa S, Del Biondo P, Simeone P, Cavallucci E, Catitti G, Auciello R, De Bellis D, Altomare I, Pierdomenico L, Canonico B, Cicalini I, Angilletta I, Del Boccio P, Pieragostino D, Santilli F, Urbani A, De Laurenzi V, Stuppia L, Lanuti P. Vespa S, et al. Int J Mol Sci. 2022 Nov 23;23(23):14592. doi: 10.3390/ijms232314592. Int J Mol Sci. 2022. PMID: 36498922 Free PMC article.
Allergic reactions to COVID-19 vaccine components are rare but should be considered. Polyethylene glycol (PEG) is responsible for anaphylaxis in mRNA vaccines. Skin tests have been used in the allergological work-up programs for COVID-19 vaccine evaluation. ...To th …
Allergic reactions to COVID-19 vaccine components are rare but should be considered. Polyethylene glycol (PEG) is responsible …
Vitamin B(12) Hypersensitivity: A Retrospective Multicenter Study.
El Rhermoul FZ, Mustafa A, Wagner A, Nakonechna A, Kayode OS, Rutkowski R, Siew LQC, Rutkowski K. El Rhermoul FZ, et al. J Allergy Clin Immunol Pract. 2024 Mar;12(3):699-704. doi: 10.1016/j.jaip.2023.10.037. Epub 2023 Oct 26. J Allergy Clin Immunol Pract. 2024. PMID: 37898177
OBJECTIVE: To investigate a cohort of patients with Vit B(12) hypersensitivity (VB12H) referred to 3 UK allergy centers and design a pathway for the investigation of VB12H. ...One patient with immediate VB12H reacted to polyethylene glycol (PEG) in oral cobal …
OBJECTIVE: To investigate a cohort of patients with Vit B(12) hypersensitivity (VB12H) referred to 3 UK allergy centers and design a …
Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.
Ozer I, Kelly G, Gu R, Li X, Zakharov N, Sirohi P, Nair SK, Collier JH, Hershfield MS, Hucknall AM, Chilkoti A. Ozer I, et al. Adv Sci (Weinh). 2022 Apr;9(11):e2103672. doi: 10.1002/advs.202103672. Epub 2022 Feb 8. Adv Sci (Weinh). 2022. PMID: 35133079 Free PMC article.
Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. ...Here, …
Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyet …
[Polyethylengylcole - Friend or Foe?].
Bayerl C, Herbst M. Bayerl C, et al. Laryngorhinootologie. 2022 Oct;101(10):784-786. doi: 10.1055/a-1861-7047. Epub 2022 Sep 29. Laryngorhinootologie. 2022. PMID: 36174565 German.
However, anaphylactic reactions towards the Pfizer-BioNTech Covid-19 vaccine were first reported in two patients in the UK and another 19 in the USA. Pegylation with polyethylene glycol (PEG) was thought to be the possible culprit. Pegylation is a common process in …
However, anaphylactic reactions towards the Pfizer-BioNTech Covid-19 vaccine were first reported in two patients in the UK and another 19 in …
Allergy to PEG (polyethylene glycol) - sensitivity of basophil activation test with COVID-19 mRNA-vaccine BNT162B2.
Eberlein B, Mathes S, Darsow U, Biedermann T, Brockow K. Eberlein B, et al. Hum Vaccin Immunother. 2024 Dec 31;20(1):2312600. doi: 10.1080/21645515.2024.2312600. Epub 2024 Feb 5. Hum Vaccin Immunother. 2024. PMID: 38317419 Free PMC article.
Basophil activation test (BAT) with COVID-19 mRNA vaccine seems particularly suitable for detecting sensitization to polyethylene glycol (PEG) in patients with PEG allergy. It was the aim of this study to determine the cutoffs for BAT using BNT162B2 (Comirnaty) in a …
Basophil activation test (BAT) with COVID-19 mRNA vaccine seems particularly suitable for detecting sensitization to polyethylene …
[Folliculotropic mycosis fungoides].
Baratli J, Balakirski G, Megahed M. Baratli J, et al. Hautarzt. 2014 Dec;65(12):1011-3. doi: 10.1007/s00105-014-3539-z. Hautarzt. 2014. PMID: 25355498 German.
Anti-PEG IgE in anaphylaxis associated with polyethylene glycol.
Zhou ZH, Stone CA Jr, Jakubovic B, Phillips EJ, Sussman G, Park J, Hoang U, Kirshner SL, Levin R, Kozlowski S. Zhou ZH, et al. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1731-1733.e3. doi: 10.1016/j.jaip.2020.11.011. Epub 2020 Nov 17. J Allergy Clin Immunol Pract. 2021. PMID: 33217616 Free PMC article. No abstract available.
Allergen-specific immunotherapy.
Niederberger V. Niederberger V. Immunol Lett. 2009 Feb 21;122(2):131-3. doi: 10.1016/j.imlet.2008.11.012. Epub 2008 Dec 25. Immunol Lett. 2009. PMID: 19100771 Review.
Clinical pharmacology of polyethylene glycol-L-asparaginase.
Ho DH, Brown NS, Yen A, Holmes R, Keating M, Abuchowski A, Newman RA, Krakoff IH. Ho DH, et al. Drug Metab Dispos. 1986 May-Jun;14(3):349-52. Drug Metab Dispos. 1986. PMID: 2872037
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patients of whom 27 were evaluable pharmacokinetically. ...
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patient …
Evaluation of pediatric patients with suspected polyethylene glycol and polysorbate allergy before mRNA SARS-CoV2 vaccination.
Karaaslan BG, Burtecene N, Mustu U, Ocak S, Kasapcopur O, Kıykım A, Cokugras H. Karaaslan BG, et al. Allergol Immunopathol (Madr). 2023 May 1;51(3):174-180. doi: 10.15586/aei.v51i3.800. eCollection 2023. Allergol Immunopathol (Madr). 2023. PMID: 37169575
This study aimed to retrospectively evaluate the role of polyethylene glycol (PEG) sensitivity in vaccination decision-making in pediatric patients at high risk of allergy or with suspected allergic reactions to the first dose of the severe acute respiratory syndrom …
This study aimed to retrospectively evaluate the role of polyethylene glycol (PEG) sensitivity in vaccination decision-making …
Anaphylaxis and Coronavirus Disease 2019 vaccine: a danger relationship?
Tanno LK, Castells M, Caminati M, Senna G, Demoly P. Tanno LK, et al. Curr Opin Allergy Clin Immunol. 2021 Oct 1;21(5):411-417. doi: 10.1097/ACI.0000000000000778. Curr Opin Allergy Clin Immunol. 2021. PMID: 34334663 Review.
PURPOSE OF REVIEW: Anaphylactic reactions reported after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) RNA vaccines were expected to be more frequent in atopic subjects and attributed to its polyethylene glycol component. RECENT FINDINGS: Anaphylaxis t …
PURPOSE OF REVIEW: Anaphylactic reactions reported after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) RNA vaccines were expec …
Pfizer's vaccine raises allergy concerns.
de Vrieze J. de Vrieze J. Science. 2021 Jan 1;371(6524):10-11. doi: 10.1126/science.371.6524.10. Science. 2021. PMID: 33384356 No abstract available.
Vaccine allergy: evidence to consider for COVID-19 vaccines.
Nilsson L, Csuth Á, Storsaeter J, Garvey LH, Jenmalm MC. Nilsson L, et al. Curr Opin Allergy Clin Immunol. 2021 Aug 1;21(4):401-409. doi: 10.1097/ACI.0000000000000762. Curr Opin Allergy Clin Immunol. 2021. PMID: 34091550 Free PMC article. Review.
Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivatives are the most suspected, albeit hitherto unproven, causes. ...
Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivati …
Janssen COVID-19 vaccine tolerated in 10 patients with confirmed polyethylene glycol allergy.
Bruusgaard-Mouritsen MA, Koo G, Heinrichsen AS, Melchiors BB, Krantz MS, Plager JH, Boxer M, Phillips EJ, Stone CA Jr, Garvey LH. Bruusgaard-Mouritsen MA, et al. J Allergy Clin Immunol Pract. 2022 Mar;10(3):859-862. doi: 10.1016/j.jaip.2021.12.025. Epub 2022 Jan 1. J Allergy Clin Immunol Pract. 2022. PMID: 34979336 Free PMC article. No abstract available.
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions.
Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, Rosivall L, Bavli Y, Urbanics R, Mollnes TE, Barenholz Y, Szebeni J. Kozma GT, et al. ACS Nano. 2019 Aug 27;13(8):9315-9324. doi: 10.1021/acsnano.9b03942. Epub 2019 Aug 6. ACS Nano. 2019. PMID: 31348638 Free article.
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. ...
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which …
Severe Polyethylene Glycol Allergy Considerations for Perioperative Management: A Case Report.
Wong-On-Wing A, Ruth K, Hinerth K, Deng A, Woldekiros M, Ellenbogen RG, Crowder CM. Wong-On-Wing A, et al. A A Pract. 2022 Oct 11;16(10):e01619. doi: 10.1213/XAA.0000000000001619. eCollection 2022 Oct 1. A A Pract. 2022. PMID: 36219725
Patients with severe polyethylene glycol (PEG) allergies face broad challenges, especially when presenting to the hospital for surgery, as PEG is used often as an excipient in medications and in medical supplies. ...
Patients with severe polyethylene glycol (PEG) allergies face broad challenges, especially when presenting to the hospital for …
Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia.
Khalil A, Würthwein G, Golitsch J, Hempel G, Fobker M, Gerss J, Möricke A, Zimmermann M, Smisek P, Zucchetti M, Nath C, Attarbaschi A, Von Stackelberg A, Gökbuget N, Rizzari C, Conter V, Schrappe M, Boos J, Lanvers-Kaminsky C. Khalil A, et al. Haematologica. 2022 Jan 1;107(1):49-57. doi: 10.3324/haematol.2020.258525. Haematologica. 2022. PMID: 33299233 Free PMC article.
Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. ...Although pre-existing anti-PEG antibodies did not boost, pre-existing anti-PEG IgG were significantly associated with firstexposure hypersens …
Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. ...Alth …
Coronavirus Disease 2019 mRNA Vaccination Appears Safe in Pediatric Patients With Hypersensitivity to Polyethylene Glycolated Escherichia coli L-asparaginase.
Wolfset N, Pashmineh Azar AR, Phillips CA, Stein M, Rheingold SR, Heimall J, Elgarten CW. Wolfset N, et al. J Pediatr Hematol Oncol. 2024 Mar 1;46(2):e202-e204. doi: 10.1097/MPH.0000000000002805. Epub 2024 Jan 5. J Pediatr Hematol Oncol. 2024. PMID: 38181327 Free PMC article.
Polyethylene glycol-asparaginase (PEGAsp) is an established component of acute leukemia therapy. Hypersensitivity reactions to PEGAsp occur in 10% to 15% of patients, with polyethylene glycol suggested as the antigenic culprit. ...
Polyethylene glycol-asparaginase (PEGAsp) is an established component of acute leukemia therapy. Hypersensitivity react …
The interplay between PEGylated nanoparticles and blood immune system.
Guo C, Yuan H, Wang Y, Feng Y, Zhang Y, Yin T, He H, Gou J, Tang X. Guo C, et al. Adv Drug Deliv Rev. 2023 Sep;200:115044. doi: 10.1016/j.addr.2023.115044. Epub 2023 Aug 2. Adv Drug Deliv Rev. 2023. PMID: 37541623 Review.
During the last two decades, an increasing number of reports have pointed out that the immunogenicity of polyethylene glycol (PEG) may trigger accelerated blood clearance (ABC) and hypersensitivity reaction (HSR) to PEGylated nanoparticles, which could make P …
During the last two decades, an increasing number of reports have pointed out that the immunogenicity of polyethylene glycol ( …
Adverse Impacts of PEGylated Protein Therapeutics: A Targeted Literature Review.
Lee CS, Kulkarni Y, Pierre V, Maski M, Wanner C. Lee CS, et al. BioDrugs. 2024 Nov;38(6):795-819. doi: 10.1007/s40259-024-00684-z. Epub 2024 Oct 17. BioDrugs. 2024. PMID: 39417964 Free PMC article. Review.
The beneficial effects of polyethylene glycol (PEG)-conjugated therapeutics, such as increased half-life, solubility, stability, and decreased immunogenicity, have been well described. ...Fifteen studies reported immunogenicity-related outcomes, such as the prevalen …
The beneficial effects of polyethylene glycol (PEG)-conjugated therapeutics, such as increased half-life, solubility, stabilit …
Allergenic components of the mRNA-1273 vaccine for COVID-19: Possible involvement of polyethylene glycol and IgG-mediated complement activation.
Klimek L, Novak N, Cabanillas B, Jutel M, Bousquet J, Akdis CA. Klimek L, et al. Allergy. 2021 Nov;76(11):3307-3313. doi: 10.1111/all.14794. Epub 2021 Jun 17. Allergy. 2021. PMID: 33657648 Free PMC article. Review.
While the culprit trigger requires investigation, initial reports suggested the excipient polyethylene glycol 2000 (PEG-2000)-contained in both vaccines as the PEG-micellar carrier system-as the potential culprit. ...
While the culprit trigger requires investigation, initial reports suggested the excipient polyethylene glycol 2000 (PEG-2000)- …
Interferon-induced sarcoidosis.
Cardoso C, Freire R, Alves A, Oliveira A. Cardoso C, et al. BMJ Case Rep. 2011 Apr 19;2011:bcr0320113929. doi: 10.1136/bcr.03.2011.3929. BMJ Case Rep. 2011. PMID: 22696628 Free PMC article.
Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia.
Dam M, Centanni M, Friberg LE, Centanni D, Karlsson MO, Stensig Lynggaard L, Johannsdottir IM, Wik HS, Malmros J, Vaitkeviciene GE, Griskevicius L, Hallböök H, Jónsson ÓG, Overgaard U, Schmiegelow K, Hansen SN, Heyman M, Albertsen BK. Dam M, et al. Leukemia. 2024 Apr;38(4):712-719. doi: 10.1038/s41375-024-02153-6. Epub 2024 Jan 29. Leukemia. 2024. PMID: 38287133 Free PMC article.
Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hypersensitivity reactions include clinical allergies, silent inactivation, or aller …
Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment …
Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866).
Kurtzberg J, Asselin B, Bernstein M, Buchanan GR, Pollock BH, Camitta BM. Kurtzberg J, et al. J Pediatr Hematol Oncol. 2011 Dec;33(8):610-6. doi: 10.1097/MPH.0b013e31822d4d4e. J Pediatr Hematol Oncol. 2011. PMID: 22042277 Free PMC article. Clinical Trial.
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To overcome this problem, native Escherichia coli L-asparaginase was conjugated to polyethylene glycol (PEG) to formulate PEG-L-asp …
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To ov …
A randomized, prospective, comparison study of polyethylene glycol 3350 without electrolytes and milk of magnesia for children with constipation and fecal incontinence.
Loening-Baucke V, Pashankar DS. Loening-Baucke V, et al. Pediatrics. 2006 Aug;118(2):528-35. doi: 10.1542/peds.2006-0220. Pediatrics. 2006. PMID: 16882804 Clinical Trial.
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene glycol-treated children and 43% of milk of magnesia-treated children exhibited improvement, and 33% of polyethylene glycol …
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene …
Anaphylaxis to Polyethylene Glycol (Colyte) in a Patient with Diverticulitis.
Lee SH, Hwang SH, Park JS, Park HS, Shin YS. Lee SH, et al. J Korean Med Sci. 2016 Oct;31(10):1662-3. doi: 10.3346/jkms.2016.31.10.1662. J Korean Med Sci. 2016. PMID: 27550498 Free PMC article.
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
The Polysorbate containing AstraZeneca COVID-19 vaccine is tolerated by polyethylene glycol (PEG) allergic patients.
Sellaturay P, Gurugama P, Harper V, Dymond T, Ewan P, Nasser S. Sellaturay P, et al. Clin Exp Allergy. 2022 Jan;52(1):12-17. doi: 10.1111/cea.14064. Epub 2021 Dec 9. Clin Exp Allergy. 2022. PMID: 34822190
BACKGROUND: Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. We previously demonstrated PEG allergy was a cause of severe anaphylaxis to the Pfizer/BioNTech COVID-19 vaccine. ...
BACKGROUND: Polyethylene glycol (PEG) is the excipient found in the mRNA COVID-19 vaccines. We previously demonstrated PEG all …
Primary care provider-reported prevalence of vaccine and polyethylene glycol allergy in Canada.
Abrams EM, Greenhawt M, Shaker M, Kosowan L, Singer AG. Abrams EM, et al. Ann Allergy Asthma Immunol. 2021 Oct;127(4):446-450.e1. doi: 10.1016/j.anai.2021.05.011. Epub 2021 May 15. Ann Allergy Asthma Immunol. 2021. PMID: 34004274 Free PMC article.
OBJECTIVE: To determine the prevalence of PCP-documented vaccine and polyethylene glycol (PEG) allergy using electronic medical record data from the Canadian Primary Care Sentinel Surveillance Network. ...
OBJECTIVE: To determine the prevalence of PCP-documented vaccine and polyethylene glycol (PEG) allergy using electronic medica …
Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors.
Richter AW, Akerblom E. Richter AW, et al. Int Arch Allergy Appl Immunol. 1984;74(1):36-9. doi: 10.1159/000233512. Int Arch Allergy Appl Immunol. 1984. PMID: 6706424
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing passive hemagglutination. ...During hyposensitization with monomethoxy polyethylene glycol modified ragweed extract and honey …
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing …
One to one comparison of cell-free synthesized erythropoietin conjugates modified with linear polyglycerol and polyethylene glycol.
Pouyan P, Zemella A, Schloßhauer JL, Walter RM, Haag R, Kubick S. Pouyan P, et al. Sci Rep. 2023 Apr 19;13(1):6394. doi: 10.1038/s41598-023-33463-x. Sci Rep. 2023. PMID: 37076514 Free PMC article.
With more than 20 Food and Drug Administration (FDA)-approved poly (ethylene glycol) (PEG) modified drugs on the market, PEG is the gold standard polymer in bioconjugation. ...Since PEG is not only applied in therapeutics, but can also be found in foods and cosmetics, anti …
With more than 20 Food and Drug Administration (FDA)-approved poly (ethylene glycol) (PEG) modified drugs on the market, PEG is the g …
Skin reactions to propylene glycol.
Hannuksela M, Pirilä V, Salo OP. Hannuksela M, et al. Contact Dermatitis. 1975;1(2):112-6. doi: 10.1111/j.1600-0536.1975.tb05336.x. Contact Dermatitis. 1975. PMID: 233872
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method. ...In them, positive reactions were elicited by testing with high dilutions of PG …
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a tota …
Optimizing investigation of suspected allergy to polyethylene glycols.
Bruusgaard-Mouritsen MA, Jensen BM, Poulsen LK, Duus Johansen J, Garvey LH. Bruusgaard-Mouritsen MA, et al. J Allergy Clin Immunol. 2022 Jan;149(1):168-175.e4. doi: 10.1016/j.jaci.2021.05.020. Epub 2021 May 28. J Allergy Clin Immunol. 2022. PMID: 34052265 Free article. Clinical Trial.
BACKGROUND: Polyethylene glycols (PEGs) are polymers of varying molecular weight (MW) used widely as excipients in drugs and other products, including the mRNA vaccines against coronavirus disease 2019. ...
BACKGROUND: Polyethylene glycols (PEGs) are polymers of varying molecular weight (MW) used widely as excipients in drugs and o …
COVID-19 vaccine anaphylaxis: PEG or not?
Krantz MS, Liu Y, Phillips EJ, Stone CA Jr. Krantz MS, et al. Allergy. 2021 Jun;76(6):1934-1937. doi: 10.1111/all.14722. Allergy. 2021. PMID: 34128562 Free PMC article. No abstract available.
Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines?
Eberlein B, Mathes S, Fischer J, Darsow U, Biedermann T, Brockow K. Eberlein B, et al. Allergy. 2022 Oct;77(10):2924-2936. doi: 10.1111/all.15278. Epub 2022 Mar 25. Allergy. 2022. PMID: 35266570 Free PMC article. Review.
In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release test) by using the vaccines or modified compounds containing polyethylene glycol (PEG), rather than unmodified PEGs, have proven …
In addition to recording a detailed history and performing skin tests, cellular tests (basophil activation or basophil histamine release tes …
Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient.
Sahiner UM, Yavuz ST, Gökce M, Buyuktiryaki B, Altan I, Aytac S, Tuncer M, Tuncer A, Sackesen C. Sahiner UM, et al. Pediatr Int. 2013 Aug;55(4):531-3. doi: 10.1111/ped.12131. Pediatr Int. 2013. PMID: 23910807
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG-ASP) is preferred. ...Anaphylaxis with PEG-ASP is very rare and premedication and desensitizat …
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene …
Case of Polyethylene Glycol Allergy Confirmed with Basophil Activation Test and Oral Challenge Successfully Immunized with SARS-CoV-2 Vaccine.
Pasali M, Taka S, Chliva C, Katoulis A, Makris M. Pasali M, et al. Iran J Allergy Asthma Immunol. 2023 Sep 3;22(4):409-412. doi: 10.18502/ijaai.v22i4.13615. Iran J Allergy Asthma Immunol. 2023. PMID: 37767684 Free article.
Polyethylene glycols (PEG) or macrogols are polymers of ethylene oxide widely used in drugs either as active substances or, more commonly, as excipients. ...
Polyethylene glycols (PEG) or macrogols are polymers of ethylene oxide widely used in drugs either as active substances or, mo …
Prolonged angioedema after Pfizer-BioNTech COVID-19 vaccine.
Muhamad Fauzi SM. Muhamad Fauzi SM. BMJ Case Rep. 2023 Mar 7;16(3):e252979. doi: 10.1136/bcr-2022-252979. BMJ Case Rep. 2023. PMID: 36882264 Free PMC article.
This case highlights the increasing awareness needed of polyethylene glycol (PEG) allergy and the protracted nature of her reaction. A firm conclusion cannot be reached based on a single case report. ...
This case highlights the increasing awareness needed of polyethylene glycol (PEG) allergy and the protracted nature of her rea …
Allergic reaction to polyethylene glycol in a painter.
Antolin-Amerigo D, Sánchez-González MJ, Barbarroja-Escudero J, Rodríguez-Rodríguez M, Álvarez-Perea A, Alvarez-Mon M. Antolin-Amerigo D, et al. Occup Med (Lond). 2015 Aug;65(6):502-4. doi: 10.1093/occmed/kqv072. Epub 2015 Jun 4. Occup Med (Lond). 2015. PMID: 26048329
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of a laxative solution containing polyethylene glycol (PEG) prior to colonoscopy. He described suffering from the same skin reac …
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of …
The role of skin tests with polyethylene glycol and polysorbate 80 in the vaccination campaign for COVID-19: results from an Italian multicenter survey.
Montera MC, Giordano A, Asperti C, Aruanno A, Barzaghi CE, Bignardi D, Borrelli P, Bommarito L, Busa M, Calafiore P, Carusi V, Cinquini M, Cortellini G, Cocchi R, D'Auria F, De Caro F, Demonte A, Di Leo E, Di Lizia M, Di Rienzo A, Fumagalli F, Kihlgren P, Lodi Rizzini F, Macchia D, Manzotti G, Marra AM, Mileto P, Mietta S, Montagni M, Nettis E, Nucera E, Peveri S, Pivetta D, Pirisi M, Ramirez GA, Rivolta F, Rizzi A, Savoia A, Pedicini A, Scarpa A, Zambito M, Zisa G, Yacoub MR. Montera MC, et al. Eur Ann Allergy Clin Immunol. 2024 Jan;56(1):17-25. doi: 10.23822/EurAnnACI.1764-1489.291. Epub 2023 Mar 16. Eur Ann Allergy Clin Immunol. 2024. PMID: 36927838 Free article.
International guidelines suggested skin tests with Polyethylene-glycol (PEG) and polysorbate 80 (PS-80), to investigate a possible hypersensitivity to these excipients either to identify subjects at risk of developing allergic reactions to Covid-19 vaccines, …
International guidelines suggested skin tests with Polyethylene-glycol (PEG) and polysorbate 80 (PS-80), to investigate a poss …
Management of Childhood Functional Constipation.
Philichi L. Philichi L. J Pediatr Health Care. 2018 Jan-Feb;32(1):103-111. doi: 10.1016/j.pedhc.2017.08.008. J Pediatr Health Care. 2018. PMID: 29229066 No abstract available.
Polyethylene glycol-modified ragweed pollen extract in rhinoconjunctivitis.
Juniper EF, Roberts RS, Kennedy LK, O'Connor J, Syty-Golda M, Dolovich J, Hargreave FE. Juniper EF, et al. J Allergy Clin Immunol. 1985 May;75(5):578-85. doi: 10.1016/0091-6749(85)90033-8. J Allergy Clin Immunol. 1985. PMID: 3989142 Clinical Trial.
Sixty-two ragweed-sensitive adult subjects volunteered to take part in a 2-year, placebo-controlled efficacy study of polyethylene glycol (PEG)-modified ragweed extract, in ragweed pollen-induced rhinoconjunctivitis. ...
Sixty-two ragweed-sensitive adult subjects volunteered to take part in a 2-year, placebo-controlled efficacy study of polyethylene …
Intestinal permeability: an overview.
Bjarnason I, MacPherson A, Hollander D. Bjarnason I, et al. Gastroenterology. 1995 May;108(5):1566-81. doi: 10.1016/0016-5085(95)90708-4. Gastroenterology. 1995. PMID: 7729650 Review.
Safe Administration of SARS-CoV-2 Vaccine After Desensitization to a Biologic Containing Polysorbate 80 in a Patient With Polyethylene Glycol-Induced Severe Anaphylaxis and Sensitization to Polysorbate 80.
Nin-Valencia A, Fiandor A, Lluch M, Quirce S, Caballero T, Heredia Revuelto R, González-Muñoz M, Caballero ML, Cabañas R. Nin-Valencia A, et al. J Investig Allergol Clin Immunol. 2023 Apr 18;33(2):151-153. doi: 10.18176/jiaci.0830. Epub 2022 May 31. J Investig Allergol Clin Immunol. 2023. PMID: 35638393 Free article. No abstract available.
Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics.
Verhoef JJ, Carpenter JF, Anchordoquy TJ, Schellekens H. Verhoef JJ, et al. Drug Discov Today. 2014 Dec;19(12):1945-52. doi: 10.1016/j.drudis.2014.08.015. Epub 2014 Sep 7. Drug Discov Today. 2014. PMID: 25205349 Review.
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-life. ...PEGylation has also been associated with the activation of the complement system causing severe hypersensitivity reactions. Her …
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-lif …
Anaphylaxis after Treatment with an Endodontic Material Containing Polyethylene Glycol.
Alnæs M, Storaas T, Vindenes HK, Guttormsen AB, Björkman L. Alnæs M, et al. J Endod. 2024 Nov;50(11):1649-1654. doi: 10.1016/j.joen.2024.09.002. Epub 2024 Sep 13. J Endod. 2024. PMID: 39278308 Free article.
Polyethylene glycol (PEG) is sometimes included in temporary endodontic filling materials to modify viscosity. ...
Polyethylene glycol (PEG) is sometimes included in temporary endodontic filling materials to modify viscosity. ...
Increased permeability to polyethylene glycol 4000 in rabbits with experimental colitis.
Seidman EG, Hanson DG, Walker WA. Seidman EG, et al. Gastroenterology. 1986 Jan;90(1):120-6. doi: 10.1016/0016-5085(86)90083-1. Gastroenterology. 1986. PMID: 2933289
In vivo permeability of rabbit colon to [14C]polyethylene glycol 4000 (14C-PEG) was examined in the presence of immune complex-mediated experimental colitis and compared with that of partially treated (control) and normal rabbits. ...
In vivo permeability of rabbit colon to [14C]polyethylene glycol 4000 (14C-PEG) was examined in the presence of immune complex …
Beneficial effects of propylene and polyethylene glycol and saline in the treatment of perennial rhinitis.
Spector SL, Toshener D, Gay I, Rosenman E. Spector SL, et al. Clin Allergy. 1982 Mar;12(2):187-96. doi: 10.1111/j.1365-2222.1982.tb01638.x. Clin Allergy. 1982. PMID: 7074822 Clinical Trial.
Although propylene-and-polyethylene-glycol and saline have been used in clinical studies as placebos, their possible therapeutic role as wetting agents in the treatment of perennial rhinitis was investigated. ...
Although propylene-and-polyethylene-glycol and saline have been used in clinical studies as placebos, their possible therapeut …
Coronavirus disease 2019 vaccine administration in patients with reported reactions to polyethylene glycol- and polysorbate-containing therapeutics.
Otani IM, Tsao LR, Tang M. Otani IM, et al. Ann Allergy Asthma Immunol. 2022 Jul;129(1):88-94.e1. doi: 10.1016/j.anai.2022.03.006. Epub 2022 Mar 12. Ann Allergy Asthma Immunol. 2022. PMID: 35288274 Free PMC article.
BACKGROUND: Polyethylene glycol (PEG) and polysorbate reactions were initially implicated as a likely risk factor for reacting to coronavirus disease 2019 (COVID-19) vaccines and remain a source of vaccine hesitancy despite increasing evidence that they do not pose …
BACKGROUND: Polyethylene glycol (PEG) and polysorbate reactions were initially implicated as a likely risk factor for reacting …
PEG That Reaction: A Case Series of Allergy to Polyethylene Glycol.
Cox F, Khalib K, Conlon N. Cox F, et al. J Clin Pharmacol. 2021 Jun;61(6):832-835. doi: 10.1002/jcph.1824. Epub 2021 Feb 28. J Clin Pharmacol. 2021. PMID: 33543766 Free PMC article.
Polyethylene glycol (PEG), also known as macrogol, is an excipient in numerous medications, health care products, cosmetics, and foods. ...Despite its ubiquity, including in 2 of the newly launched vaccines against SARS-CoV-2, awareness of PEG allergy remains low. W …
Polyethylene glycol (PEG), also known as macrogol, is an excipient in numerous medications, health care products, cosmetics, a …
COVID-19 Vaccines in Children with Cow's Milk and Food Allergies.
Liotti L, Bianchi A, Bottau P, Caimmi S, Crisafulli G, Franceschini F, Mori F, Paglialunga C, Saretta F, Caffarelli C. Liotti L, et al. Nutrients. 2021 Jul 30;13(8):2637. doi: 10.3390/nu13082637. Nutrients. 2021. PMID: 34444795 Free PMC article. Review.
Effects of rAmb a 1-Loaded PLGA-PEG Nanoparticles in a Murine Model of Allergic Conjunctivitis.
Cao H, Liu L, Wang J, Gong M, Yuan R, Lu J, Xiao X, Liu X. Cao H, et al. Molecules. 2022 Jan 18;27(3):598. doi: 10.3390/molecules27030598. Molecules. 2022. PMID: 35163859 Free PMC article.
Allergic conjunctivitis caused by Ambrosia artemisiifolia and its related allergen-specific immunotherapy (AIT) are seldom studied at present. poly(DL-lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) is a very good nano-carrier, which has been applied in the med …
Allergic conjunctivitis caused by Ambrosia artemisiifolia and its related allergen-specific immunotherapy (AIT) are seldom studied at presen …
Allergic contact dermatitis to polyethylene glycol and nitrofurazone.
Guijarro SC, Sánchez-Pérez J, García-Díez A. Guijarro SC, et al. Am J Contact Dermat. 1999 Dec;10(4):226-7. doi: 10.1053/AJCD01000226. Am J Contact Dermat. 1999. PMID: 10594300
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene glycol. Patch tests to nickel sulfate, potassium dischromate, chloride cobalt, Furacin, nitrofurazone 1% petrolatum, polyethyle …
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene …
Clinical manifestations and impact on daily life of allergy to polyethylene glycol (PEG) in ten patients.
Bruusgaard-Mouritsen MA, Johansen JD, Garvey LH. Bruusgaard-Mouritsen MA, et al. Clin Exp Allergy. 2021 Mar;51(3):463-470. doi: 10.1111/cea.13822. Epub 2021 Jan 15. Clin Exp Allergy. 2021. PMID: 33394522
BACKGROUND: Polyethylene glycols (PEGs) are widely used as excipients in drugs, cosmetics and household products. ...
BACKGROUND: Polyethylene glycols (PEGs) are widely used as excipients in drugs, cosmetics and household products. ...
Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination.
Zhou ZH, Cortese MM, Fang JL, Wood R, Hummell DS, Risma KA, Norton AE, KuKuruga M, Kirshner S, Rabin RL, Agarabi C, Staat MA, Halasa N, Ware RE, Stahl A, McMahon M, Browning P, Maniatis P, Bolcen S, Edwards KM, Su JR, Dharmarajan S, Forshee R, Broder KR, Anderson S, Kozlowski S. Zhou ZH, et al. Vaccine. 2023 Jun 23;41(28):4183-4189. doi: 10.1016/j.vaccine.2023.05.029. Epub 2023 May 16. Vaccine. 2023. PMID: 37244808 Free PMC article.
BACKGROUND: The mechanism for anaphylaxis following mRNA COVID-19 vaccination has been widely debated; understanding this serious adverse event is important for future vaccines of similar design. A mechanism proposed is type I hypersensitivity (i.e., IgE-mediated mast cell …
BACKGROUND: The mechanism for anaphylaxis following mRNA COVID-19 vaccination has been widely debated; understanding this serious adverse ev …
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia.
Ettinger LJ, Kurtzberg J, Voûte PA, Jürgens H, Halpern SL. Ettinger LJ, et al. Cancer. 1995 Mar 1;75(5):1176-81. doi: 10.1002/1097-0142(19950301)75:5<1176::aid-cncr2820750519>3.0.co;2-y. Cancer. 1995. PMID: 7850718 Clinical Trial.
Because L-asparaginase is a foreign protein, the potential exists for severe, dose-limiting hypersensitivity reactions. To reduce this toxicity, L-asparaginase has been linked with polyethylene glycol (PEG). ...All patients had been treated previously with on …
Because L-asparaginase is a foreign protein, the potential exists for severe, dose-limiting hypersensitivity reactions. To reduce thi …
An Assay for Immunogenic Detection of Anti-PEG Antibody.
Zhu X, Luo W, Zhang D, Liu R. Zhu X, et al. Chembiochem. 2024 Aug 19;25(16):e202400316. doi: 10.1002/cbic.202400316. Epub 2024 Jul 22. Chembiochem. 2024. PMID: 38867605
With the increasing use of polyethylene glycol (PEG) based proteins and drug delivery systems, anti-PEG antibodies have commonly been detected among the population, causing the accelerated blood clearance and hypersensitivity reactions, poses potential risks …
With the increasing use of polyethylene glycol (PEG) based proteins and drug delivery systems, anti-PEG antibodies have common …
Carl Prausnitz Memorial Lecture. Suppression of antibody responses by chemically modified antigens.
Sehon AH. Sehon AH. Int Arch Allergy Appl Immunol. 1991;94(1-4):11-20. Int Arch Allergy Appl Immunol. 1991. PMID: 1937863 Review.
Some of the studies employing nonantigenic, nonallergenic and tolerogenic derivatives of antigens and allergens, synthesized by coupling onto them an optimal number (n) of molecules of monomethoxy-polyethylene glycol (mPEG), are briefly reviewed. Administration of a …
Some of the studies employing nonantigenic, nonallergenic and tolerogenic derivatives of antigens and allergens, synthesized by coupling ont …
Safety aspects of pegylated liposomal doxorubicin in patients with cancer.
Alberts DS, Garcia DJ. Alberts DS, et al. Drugs. 1997;54 Suppl 4:30-5. doi: 10.2165/00003495-199700544-00007. Drugs. 1997. PMID: 9361959 Review.
Encapsulation in polyethylene glycol-coated (pegylated; Stealth) liposomes alters the pharmacokinetic characteristics, and hence the safety and tolerability profile, of doxorubicin. ...Other adverse effects included nausea and vomiting and alopecia. Acute hyperse …
Encapsulation in polyethylene glycol-coated (pegylated; Stealth) liposomes alters the pharmacokinetic characteristics, and hen …
Successful mRNA COVID-19 Vaccination and Colonoscopy After Oral Desensitization in a Patient With Polyethylene Glycol Allergy.
Cha B, Kwon KS, Lee HL, Kim CW. Cha B, et al. J Korean Med Sci. 2022 Aug 15;37(32):e251. doi: 10.3346/jkms.2022.37.e251. J Korean Med Sci. 2022. PMID: 35971765 Free PMC article.
Anaphylaxis to polyethylene glycol (PEG) is rare and mainly occurs with the use of laxatives containing PEG. ...
Anaphylaxis to polyethylene glycol (PEG) is rare and mainly occurs with the use of laxatives containing PEG. ...
Mechanistic investigation of thermosensitive liposome immunogenicity and understanding the drivers for circulation half-life: A polyethylene glycol versus 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol study.
Lokerse WJM, Lazarian A, Kleinhempel A, Petrini M, Schwarz P, Hossann M, Holdt LM, Mailänder V, Lindner LH. Lokerse WJM, et al. J Control Release. 2021 May 10;333:1-15. doi: 10.1016/j.jconrel.2021.03.014. Epub 2021 Mar 16. J Control Release. 2021. PMID: 33741385
Sufficient circulation half-life is important and most liposomes obtain this by polyethylene glycol (PEG) surface modification. 1,2-dipalmitoyl-sn-glycero-3-phosphodiglycerol (DPPG(2)) has been described as a promising alternative which increases TSL circulation hal …
Sufficient circulation half-life is important and most liposomes obtain this by polyethylene glycol (PEG) surface modification …
Urticaria as a Rare Side Effect of Polyethylene Glycol-3350 in a Child: Case Report.
Sari Gökay S, Çelik T, Yusuf Sari M, Ekinci F, Dinçer Yildizdaş R, Levent Yilmaz H. Sari Gökay S, et al. Acta Clin Croat. 2018 Mar;57(1):187-189. doi: 10.20471/acc.2018.57.01.26. Acta Clin Croat. 2018. PMID: 30256031 Free PMC article.
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Contact urticaria due to polyethylene glycol.
Fisher AA. Fisher AA. Cutis. 1977 Apr;19(4):409-12. Cutis. 1977. PMID: 856540
'Open' testing revealed an 'immediate' urticarial reaction to polyethylene glycol, which is used as a solvent in both antifungal agents. It should be emphasized that after a patient scratches or irritates an urticarial contact dermatitis, the resulting eruption clos …
'Open' testing revealed an 'immediate' urticarial reaction to polyethylene glycol, which is used as a solvent in both antifung …
Polythylene glycol severe allergy and SARS-CoV-2 vaccines: usefulness of testing with PEG 1500 extract.
Gaspar A, Moura AL, Cruz C, Borrego LM. Gaspar A, et al. Eur Ann Allergy Clin Immunol. 2023 Nov;55(6):261-270. doi: 10.23822/EurAnnACI.1764-1489.275. Epub 2022 Dec 2. Eur Ann Allergy Clin Immunol. 2023. PMID: 36458507 Free article.
Background. Polyethylene glycol (PEG) is being used for first time as an excipient for mRNA anti-SARS-CoV-2 vaccines containing PEG 2000, highlighting it as a potential cause of anaphylaxis. ...
Background. Polyethylene glycol (PEG) is being used for first time as an excipient for mRNA anti-SARS-CoV-2 vaccines containin …
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.
Chang CJ, Chen CH, Chen BM, Su YC, Chen YT, Hershfield MS, Lee MM, Cheng TL, Chen YT, Roffler SR, Wu JY. Chang CJ, et al. Nat Commun. 2017 Sep 12;8(1):522. doi: 10.1038/s41467-017-00622-4. Nat Commun. 2017. PMID: 28900105 Free PMC article.
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our findings may provide novel genetic markers for predicting the immunogenicity of PEG and efficacy of PEGylated therapeutics.Some individuals …
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our …
Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy.
Troelnikov A, Perkins G, Yuson C, Ahamdie A, Balouch S, Hurtado PR, Hissaria P. Troelnikov A, et al. J Allergy Clin Immunol. 2021 Jul;148(1):91-95. doi: 10.1016/j.jaci.2021.04.032. Epub 2021 May 12. J Allergy Clin Immunol. 2021. PMID: 33991580
BACKGROUND: The mechanisms underpinning allergic reactions to the BNT162b2 (Pfizer) COVID-19 vaccine remain unknown, with polyethylene glycol (PEG) contained in the lipid nanoparticle suspected as being the cause. ...METHODS: Three known individuals with PEG allergy …
BACKGROUND: The mechanisms underpinning allergic reactions to the BNT162b2 (Pfizer) COVID-19 vaccine remain unknown, with polyethylene …
Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection.
Teppler H, Kaplan G, Smith KA, Montana AL, Meyn P, Cohn ZA. Teppler H, et al. J Exp Med. 1993 Feb 1;177(2):483-92. doi: 10.1084/jem.177.2.483. J Exp Med. 1993. PMID: 8093894 Free PMC article.
13 patients with human immunodeficiency virus type 1 infection class II-IV, but without opportunistic infection or neoplasm, received 6 micrograms (3.6 x 10(4) IU) of polyethylene glycol recombinant human interleukin 2 (PEG IL-2) intradermally twice a week for 4 mo …
13 patients with human immunodeficiency virus type 1 infection class II-IV, but without opportunistic infection or neoplasm, received 6 micr …
Free PEG Suppresses Anaphylaxis to PEGylated Nanomedicine in Swine.
Shen L, Li Z, Ma A, Cruz-Teran C, Talkington A, Shipley ST, Lai SK. Shen L, et al. ACS Nano. 2024 Mar 26;18(12):8733-8744. doi: 10.1021/acsnano.3c11165. Epub 2024 Mar 12. ACS Nano. 2024. PMID: 38469811
Covalent conjugation of poly(ethylene glycol) (PEG) is frequently employed to enhance the pharmacokinetics and biodistribution of various protein and nanoparticle therapeutics. ...
Covalent conjugation of poly(ethylene glycol) (PEG) is frequently employed to enhance the pharmacokinetics and biodistribution of var …
Efficacy of low doses of the polyethylene glycol derivative of interleukin-2 in modulating the immune response of patients with human immunodeficiency virus type 1 infection.
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In an attempt to enhance cellular immunity, low-dose recombinant human (rh) IL-2 at 10 micrograms or 180,000 units or its polyethylene glycol (PEG) derivative at 9 micrograms or 36,000 units was given by intracutaneous injection to 8 HIV-1-infected men for 30 days. …
In an attempt to enhance cellular immunity, low-dose recombinant human (rh) IL-2 at 10 micrograms or 180,000 units or its polyethylene …
Immune responses to polyethylene glycol modified L-asparaginase in mice.
Kawamura K, Igarashi T, Fujii T, Kamisaki Y, Wada H, Kishimoto S. Kawamura K, et al. Int Arch Allergy Appl Immunol. 1985;76(4):324-30. doi: 10.1159/000233715. Int Arch Allergy Appl Immunol. 1985. PMID: 3980111
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glycol (PEG, MW, 5,000) conjugated Escherichia coli A-ase. Following the administration of the mixture of A-ase and PEG-A-ase, antibody produ …
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glyco …
Asparaginase encapsulated in erythrocytes as second-line treatment in hypersensitive patients with acute lymphoblastic leukaemia.
Lynggaard LS, Vaitkeviciene G, Langenskiöld C, Lehmann AK, Lähteenmäki PM, Lepik K, El Hariry I, Schmiegelow K, Albertsen BK. Lynggaard LS, et al. Br J Haematol. 2022 Jun;197(6):745-754. doi: 10.1111/bjh.18152. Epub 2022 Mar 28. Br J Haematol. 2022. PMID: 35344210
To continue asparaginase treatment after hypersensitivity, a formulation of asparaginase encapsulated in erythrocytes (eryaspase) was developed. In NOR-GRASPALL 2016 (NCT03267030) the safety and efficacy of eryaspase was evaluated in 55 patients (aged 1-45 years; median: 6 …
To continue asparaginase treatment after hypersensitivity, a formulation of asparaginase encapsulated in erythrocytes (eryaspase) was …
Pegasparaginase: where do we stand?
Zeidan A, Wang ES, Wetzler M. Zeidan A, et al. Expert Opin Biol Ther. 2009 Jan;9(1):111-9. doi: 10.1517/14712590802586058. Expert Opin Biol Ther. 2009. PMID: 19063697 Review.
Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, especially the development of hypersensitivity reactions and neutralizing antibodies, and by the need for frequent administration. To ove …
Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, espe …
Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase.
Soares AL, Guimarães GM, Polakiewicz B, de Moraes Pitombo RN, Abrahão-Neto J. Soares AL, et al. Int J Pharm. 2002 Apr 26;237(1-2):163-70. doi: 10.1016/s0378-5173(02)00046-7. Int J Pharm. 2002. PMID: 11955814
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reactions must be considered a relevant adverse effect of asparaginase therapy. One approach to reduce the hypersensitivity reactions cau …
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reac …
Taxanes hypersensitivity is not a risk factor for severe reactions to SARS-CoV-2 vaccines.
Cortellini G, Raiteri A, Biagioni B, Liberati S, Lippolis D, Cortellini G, Piscaglia F. Cortellini G, et al. Eur Ann Allergy Clin Immunol. 2023 Sep;55(5):229-234. doi: 10.23822/EurAnnACI.1764-1489.265. Epub 2022 Sep 1. Eur Ann Allergy Clin Immunol. 2023. PMID: 36047485 Free article.
Background. Hypersensitivity reactions (HSR) to taxanes have been related to a complement activation by their excipients, polyoxyethylated castor oil and Polysorbate 80, structurally related to those of SARS-CoV-2 vaccines. ...Some patients completed the vaccination course …
Background. Hypersensitivity reactions (HSR) to taxanes have been related to a complement activation by their excipients, polyoxyethy …
Molecular weight dependence of polyethylene glycol penetration across acetone-disrupted permeability barrier.
Tsai JC, Hung PL, Sheu HM. Tsai JC, et al. Arch Dermatol Res. 2001 Jun;293(6):302-7. doi: 10.1007/s004030100229. Arch Dermatol Res. 2001. PMID: 11480590
The purpose of the present study was to investigate the dependence of permeability on molecular weight (MW) in acetone-disrupted hairless mouse skin in contrast to normal skin. Penetration of polyethylene glycol (PEG) 300, 600, and 1,000 over 12 h was measured using …
The purpose of the present study was to investigate the dependence of permeability on molecular weight (MW) in acetone-disrupted hairless mo …
Immediate allergic reactions by polyethylene glycol 4000: two cases.
Antón Gironés M, Roan Roan J, de la Hoz B, Sánchez Cano M. Antón Gironés M, et al. Allergol Immunopathol (Madr). 2008 Mar-Apr;36(2):110-2. doi: 10.1157/13120396. Allergol Immunopathol (Madr). 2008. PMID: 18479663
We performed allergy studies: skin prick tests with common inhalants, pure ES and the components (polyethylene glycol 4000 (PEG 4000), KCI, NaCO3, NaPO3, NaSO3, NaCI, neohesperydine, potasic acesulfam and orange flavouring), intradermic test, total serum IgE and sin …
We performed allergy studies: skin prick tests with common inhalants, pure ES and the components (polyethylene glycol 4000 (PE …
Eosinophilic cellulitis in response to BNT162b2 COVID-19 vaccination.
Ikediobi O, Eichenfield DZ, Barrio VR. Ikediobi O, et al. Pediatr Dermatol. 2022 Sep;39(5):823-824. doi: 10.1111/pde.15019. Epub 2022 May 6. Pediatr Dermatol. 2022. PMID: 35522122 Free PMC article.
A skin biopsy showed urticarial dermatitis with tissue eosinophilia consistent with a diagnosis of vaccine-associated eosinophilic cellulitis, with polyethylene glycol as a potential trigger....
A skin biopsy showed urticarial dermatitis with tissue eosinophilia consistent with a diagnosis of vaccine-associated eosinophilic celluliti …
Oncologist counseling practice and COVID-19 vaccination outcomes for patients with history of PEG-asparaginase hypersensitivity.
Zarnegar-Lumley S, Stone CA Jr, Smith CM, Hall LL, Luck KE, Koo G, Plager JH, Phillips EJ, Friedman DL. Zarnegar-Lumley S, et al. Pediatr Blood Cancer. 2022 Jul;69(7):e29686. doi: 10.1002/pbc.29686. Epub 2022 Mar 30. Pediatr Blood Cancer. 2022. PMID: 35353440 Free PMC article.
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective strategy to prevent serious coronavirus disease 2019 (COVID-19) and is important for oncology patients. mRNA-based COVID-19 vaccines are contraindicated in those with a history of sev …
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective strategy to prevent serious coronavirus dis …
Non-IgE-dependent hypersensitivity to macrogol 6000.
Berndt K, Kuske M, Beissert S, Spornraft-Ragaller P, Bauer A. Berndt K, et al. J Dtsch Dermatol Ges. 2018 Apr;16(4):479-481. doi: 10.1111/ddg.13479. Epub 2018 Mar 26. J Dtsch Dermatol Ges. 2018. PMID: 29578283 No abstract available.
[Intestinal permeability disorders in children].
Dupont C, Barau E, Molkhou P. Dupont C, et al. Allerg Immunol (Paris). 1991 Mar;23(3):95-103. Allerg Immunol (Paris). 1991. PMID: 2069683 Review. French.
This permeability of the intestinal mucosa, which depends mostly on the size of the molecule and the state of the mucosa, can be studied with the assistance of protein macromolecules in an allergy-immunological investigation, or with inert markers, so permitting evaluation of the …
This permeability of the intestinal mucosa, which depends mostly on the size of the molecule and the state of the mucosa, can be studied wit …
Gut permeability measured by polyethylene glycol absorption in abnormal gut fermentation as compared with food intolerance.
Eaton KK, Howard M, Howard JM. Eaton KK, et al. J R Soc Med. 1995 Feb;88(2):63-6. J R Soc Med. 1995. PMID: 7769595 Free PMC article.
Gut permeability has been studied in patients with either food intolerance or abnormal gut fermentation as well as in normal subjects. Permeability was measured by polyethylene glycol absorption, and the reasons for this choice of probe are discussed. Results show t …
Gut permeability has been studied in patients with either food intolerance or abnormal gut fermentation as well as in normal subjects. Perme …
Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.
Liu Y, Smith CA, Panetta JC, Yang W, Thompson LE, Counts JP, Molinelli AR, Pei D, Kornegay NM, Crews KR, Swanson H, Cheng C, Karol SE, Evans WE, Inaba H, Pui CH, Jeha S, Relling MV. Liu Y, et al. J Clin Oncol. 2019 Aug 10;37(23):2051-2061. doi: 10.1200/JCO.18.02439. Epub 2019 Jun 12. J Clin Oncol. 2019. PMID: 31188727 Free PMC article.
Positive samples were tested for anti-polyethylene glycol (PEG) and anti-L-ASP. We analyzed potential risk factors for reactions and associations between antibodies and reactions, rechallenge outcomes, and PEG-ASP pharmacokinetics. ...
Positive samples were tested for anti-polyethylene glycol (PEG) and anti-L-ASP. We analyzed potential risk factors for reactio …
Macrogol hypersensitivity in multiple drug allergy.
Bommarito L, Mietta S, Nebiolo F, Geuna M, Rolla G. Bommarito L, et al. Ann Allergy Asthma Immunol. 2011 Dec;107(6):542-3. doi: 10.1016/j.anai.2011.08.008. Epub 2011 Sep 14. Ann Allergy Asthma Immunol. 2011. PMID: 22123387 No abstract available.
Immunologic techniques utilized in the diagnosis of occupational lung disease.
Doll NJ, Bozelka BE. Doll NJ, et al. Clin Lab Med. 1984 Sep;4(3):523-38. Clin Lab Med. 1984. PMID: 6434225 Review.
Humoral and/or cell-mediated immune responses may contribute to the tissue injury in patients with certain types of occupational asthma, hypersensitivity pneumonitis, silicosis, and asbestosis. Numerous diagnostic modalities are available to the clinician investigating the …
Humoral and/or cell-mediated immune responses may contribute to the tissue injury in patients with certain types of occupational asthma, …
Substituting Poly(ethylene glycol) Lipids with Poly(2-ethyl-2-oxazoline) Lipids Improves Lipid Nanoparticle Repeat Dosing.
Sanchez AJDS, Loughrey D, Echeverri ES, Huayamares SG, Radmand A, Paunovska K, Hatit M, Tiegreen KE, Santangelo PJ, Dahlman JE. Sanchez AJDS, et al. Adv Healthc Mater. 2024 Jul;13(17):e2304033. doi: 10.1002/adhm.202304033. Epub 2024 Mar 10. Adv Healthc Mater. 2024. PMID: 38318754
Poly(ethylene glycol) (PEG)-lipids are used in Food-and-Drug-Administration-approved lipid nanoparticle (LNP)-RNA drugs, which are safe and effective. However, it is reported that PEG-lipids may also contribute to accelerated blood clearance and rare cases of hypersensi …
Poly(ethylene glycol) (PEG)-lipids are used in Food-and-Drug-Administration-approved lipid nanoparticle (LNP)-RNA drugs, which are sa …
Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation.
Erdeljic Turk V. Erdeljic Turk V. Clin Immunol. 2021 Jun;227:108748. doi: 10.1016/j.clim.2021.108748. Epub 2021 Apr 28. Clin Immunol. 2021. PMID: 33932618 Free PMC article.
Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assumption that polyethylene glycol (PEG) is the most likely culprit. Allergy testing to PEGs and mRNA vaccines is complex and carr …
Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assum …
Outpatient continuous intravenous interleukin-2 or subcutaneous, polyethylene glycol-modified interleukin-2 in human immunodeficiency virus-infected patients: a randomized, controlled, multicenter study. Australian IL-2 Study Group.
Carr A, Emery S, Lloyd A, Hoy J, Garsia R, French M, Stewart G, Fyfe G, Cooper DA. Carr A, et al. J Infect Dis. 1998 Oct;178(4):992-9. doi: 10.1086/515653. J Infect Dis. 1998. PMID: 9806026 Clinical Trial.
The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2) or a slow-release, polyethylene glycol (PEG)-modified IL-2 were studied in human immunodeficiency virus (HIV)-infected persons with CD4 cell counts between 200 and 500/mm3. . …
The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2) or a slow-release, polyethylene glycol …
Allergy Workup in the Diagnosis of COVID-19 Vaccines-Induced Hypersensitivity Reactions and Its Impact on Vaccination.
Petrelli F, Giannini D, Pucci C, Del Corso I, Rocchi V, Dolcher MP, Pieve G, Pratesi F, Migliorini P, Puxeddu I. Petrelli F, et al. Int Arch Allergy Immunol. 2023;184(1):54-62. doi: 10.1159/000526764. Epub 2022 Oct 20. Int Arch Allergy Immunol. 2023. PMID: 36265449 Free PMC article.
INTRODUCTION: Immediate and delayed hypersensitivity reactions (HSR) to COVID-19 vaccines are rare adverse events that need to be prevented, diagnosed, and managed in order to guarantee adherence to the vaccination campaign. ...
INTRODUCTION: Immediate and delayed hypersensitivity reactions (HSR) to COVID-19 vaccines are rare adverse events that need to be pre …
Cutaneous anaphylactoid reaction to polyoxyethylene hydrogenated castor oil in dogs.
Sugiyama Y, Kawarai S, Ansai S, Bist P, Abraham SN, Maruo T. Sugiyama Y, et al. Vet Dermatol. 2024 Jun;35(3):263-272. doi: 10.1111/vde.13228. Epub 2023 Dec 18. Vet Dermatol. 2024. PMID: 38111025
BACKGROUND: Polyoxyethylene hydrogenated castor oil (HCO ethoxylates) is a nonionic surfactant used as an excipient for ointments and injections in human and veterinary drugs. Several polyethylene glycol (PEG) derivatives can be obtained depending on the number of m …
BACKGROUND: Polyoxyethylene hydrogenated castor oil (HCO ethoxylates) is a nonionic surfactant used as an excipient for ointments and inject …
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease.
Ousingsawat J, Centeio R, Cabrita I, Talbi K, Zimmer O, Graf M, Göpferich A, Schreiber R, Kunzelmann K. Ousingsawat J, et al. Int J Mol Sci. 2022 Jan 19;23(3):1085. doi: 10.3390/ijms23031085. Int J Mol Sci. 2022. PMID: 35163010 Free PMC article.
While systemic application of niclosamide may lead to unwanted side effects, local administration via aerosol may circumvent these problems, particularly when the drug is encapsulated into small polyethylene glycol (PEG) hydrospheres. In the present study, we examin …
While systemic application of niclosamide may lead to unwanted side effects, local administration via aerosol may circumvent these problems, …
Polyethylene glycol-modified ragweed extract: comparison of two treatment regimens.
Juniper EF, O'Connor J, Roberts RS, Evans S, Hargreave FE, Dolovich J. Juniper EF, et al. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):851-6. doi: 10.1016/0091-6749(86)90229-0. J Allergy Clin Immunol. 1986. PMID: 3782653 Clinical Trial.
Fifty ragweed-sensitive subjects were each administered a course of 12 injections of polyethylene glycol-modified ragweed extract. To investigate the effect of two treatment regimens, subjects were paired according to their skin sensitivity to ragweed extract and th …
Fifty ragweed-sensitive subjects were each administered a course of 12 injections of polyethylene glycol-modified ragweed extr …
Allergic reactions to coronavirus disease 2019 vaccines and addressing vaccine hesitancy: Northwell Health experience.
Kaplan B, Farzan S, Coscia G, Rosenthal DW, McInerney A, Jongco AM, Ponda P, Bonagura VR. Kaplan B, et al. Ann Allergy Asthma Immunol. 2022 Feb;128(2):161-168.e1. doi: 10.1016/j.anai.2021.10.019. Epub 2021 Oct 24. Ann Allergy Asthma Immunol. 2022. PMID: 34699968 Free PMC article.
It was previously hypothesized that polyethylene glycol (PEG) may be responsible for anaphylactic reactions to messenger RNA (mRNA) COVID-19 vaccines. ...Most severe postvaccination allergic symptoms are not caused by hypersensitivity to PEG. Most people with …
It was previously hypothesized that polyethylene glycol (PEG) may be responsible for anaphylactic reactions to messenger RNA ( …
Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase.
Hershfield MS, Buckley RH, Greenberg ML, Melton AL, Schiff R, Hatem C, Kurtzberg J, Markert ML, Kobayashi RH, Kobayashi AL, et al. Hershfield MS, et al. N Engl J Med. 1987 Mar 5;316(10):589-96. doi: 10.1056/NEJM198703053161005. N Engl J Med. 1987. PMID: 3807953
We conclude that from the standpoints of efficacy, convenience, and safety, polyethylene glycol-modified adenosine deaminase is preferable to red-cell transfusion as a treatment for adenosine deaminase deficiency. Patients with other inherited metabolic diseases in …
We conclude that from the standpoints of efficacy, convenience, and safety, polyethylene glycol-modified adenosine deaminase i …
IgE-Mediated Anaphylaxis Induced by Macrogol 6000.
Caballero ML, Lluch-Bernal M, Vilà-Nadal G, Lluncor M, Quirce S. Caballero ML, et al. J Investig Allergol Clin Immunol. 2016;26(6):398-400. doi: 10.18176/jiaci.0089. J Investig Allergol Clin Immunol. 2016. PMID: 27996956 Free article. No abstract available.
A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors.
Taylor CW, Dorr RT, Fanta P, Hersh EM, Salmon SE. Taylor CW, et al. Cancer Chemother Pharmacol. 2001;47(1):83-8. doi: 10.1007/s002800000207. Cancer Chemother Pharmacol. 2001. PMID: 11221967 Clinical Trial.
PURPOSE: To evaluate the in vitro activity of polyethylene glycol-conjugated L-asparaginase (PEG-Lasparaginase) against fresh human tumor specimens, using the human tumor clonogenic assay (HTCA), and to perform a phase I dose-escalation clinical trial of PEG-L-aspar …
PURPOSE: To evaluate the in vitro activity of polyethylene glycol-conjugated L-asparaginase (PEG-Lasparaginase) against fresh …
Acute lymphoblastic leukaemia patients treated with PEGasparaginase develop antibodies to PEG and the succinate linker.
Kloos R, van der Sluis IM, Mastrobattista E, Hennink W, Pieters R, Verhoef JJ. Kloos R, et al. Br J Haematol. 2020 May;189(3):442-451. doi: 10.1111/bjh.16254. Epub 2019 Dec 27. Br J Haematol. 2020. PMID: 31883112
Polyethylene glycol (PEG) conjugated asparaginase (PEGasparaginase) is essential for treatment of paediatric acute lymphoblastic leukaemia. We developed an assay identifying antibodies against the PEG-moiety, the linker and the drug itself in patients experiencing …
Polyethylene glycol (PEG) conjugated asparaginase (PEGasparaginase) is essential for treatment of paediatric acute lymphoblast …
Effects of PEG antibodies on in vivo performance of LNP-mRNA vaccines.
Yang M, Zhang Z, Jin P, Jiang K, Xu Y, Pan F, Tian K, Yuan Z, Liu XE, Fu J, Wang B, Yan H, Zhan C, Zhang Z. Yang M, et al. Int J Pharm. 2024 Jan 25;650:123695. doi: 10.1016/j.ijpharm.2023.123695. Epub 2023 Dec 9. Int J Pharm. 2024. PMID: 38081560
Polyethylene glycol (PEG) plays important roles in stabilizing and lengthening circulation time of lipid nanoparticle (LNP) vaccines. ...
Polyethylene glycol (PEG) plays important roles in stabilizing and lengthening circulation time of lipid nanoparticle (LNP) va …
Bioavailability of components of resin-based materials which are applied to teeth.
Hume WR, Gerzina TM. Hume WR, et al. Crit Rev Oral Biol Med. 1996;7(2):172-9. doi: 10.1177/10454411960070020501. Crit Rev Oral Biol Med. 1996. PMID: 8875031 Review.
Direct measurement of component release has shown that triethylene glycol dimethacrylate (TEGDMA), hydroxyethyl methacrylate (HEMA), and, in the case of some orthodontic cements, bis-glycidyl methacrylate and benzoyl peroxide can move into an aqueous medium from a range of …
Direct measurement of component release has shown that triethylene glycol dimethacrylate (TEGDMA), hydroxyethyl methacrylate (HEMA), …
A randomized, double-blind, placebo-controlled trial of polyethylene glycol effects on fasting and postprandial rectal sensitivity and symptoms in hypersensitive constipation-predominant irritable bowel syndrome.
Awad RA, Camacho S. Awad RA, et al. Colorectal Dis. 2010 Nov;12(11):1131-8. doi: 10.1111/j.1463-1318.2009.01990.x. Colorectal Dis. 2010. PMID: 19575740 Clinical Trial.
AIM: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension and symptoms in hypersensitive constipation-predominant irritable bowel syndrome (IBS-C). ...The results support the concept that visc …
AIM: To assess the effect of polyethylene glycol 3350 (PEG) on fasting and postprandial (PP) perception of rectal distension a …
Alternative algorithm for L-asparaginase allergy in children with acute lymphoblastic leukemia.
Soyer OU, Aytac S, Tuncer A, Cetin M, Yetgin S, Sekerel BE. Soyer OU, et al. J Allergy Clin Immunol. 2009 Apr;123(4):895-9. doi: 10.1016/j.jaci.2008.10.034. Epub 2008 Dec 10. J Allergy Clin Immunol. 2009. PMID: 19081614
RESULTS: Nineteen patients (13 male patients) with a mean age of 7.4 +/- 4.7 years experienced a systemic hypersensitivity reaction to E coli-asparaginase during a 4-year period. Polyethylene glycol-asparaginase could be used for 3 patients. ...Polyethylen …
RESULTS: Nineteen patients (13 male patients) with a mean age of 7.4 +/- 4.7 years experienced a systemic hypersensitivity reaction t …
Urticaria induced by Etoxisclerol (polidocanol).
Henriquez-Santana A, Fernandez-Guarino M, González de Olano D, Gonzalez-Cervera J, Huertas-Barbudo B, Aldanondo I. Henriquez-Santana A, et al. J Eur Acad Dermatol Venereol. 2008 Feb;22(2):261-2. doi: 10.1111/j.1468-3083.2007.02313.x. J Eur Acad Dermatol Venereol. 2008. PMID: 18211438 No abstract available.
L-asparaginase activity and anti-L-asparaginase antibody as biomarkers in estimating PEG-asp-related anaphylaxis risk in childhood acute lymphoblastic leukemia patients.
Cui J, Jiang L, Xu B, Bai Y. Cui J, et al. Allergol Immunopathol (Madr). 2023 May 1;51(3):28-35. doi: 10.15586/aei.v51i3.771. eCollection 2023. Allergol Immunopathol (Madr). 2023. PMID: 37169557
BACKGROUND: L-Asparaginase (L-asp), the unconjugated form of polyethylene glycol-conjugated L-asparaginase (PEG-asp), regulates T cell stimulation, antibody production, and lysosomal protease activity to mediate PEG-asp-related anaphylaxis. ...
BACKGROUND: L-Asparaginase (L-asp), the unconjugated form of polyethylene glycol-conjugated L-asparaginase (PEG-asp), regulate …
Steroid Allergy: Clinical Features and the Importance of Excipient Testing in a Diagnostic Algorithm.
Li PH, Wagner A, Thomas I, Watts TJ, Rutkowski R, Rutkowski K. Li PH, et al. J Allergy Clin Immunol Pract. 2018 Sep-Oct;6(5):1655-1661. doi: 10.1016/j.jaip.2018.01.007. Epub 2018 Jan 31. J Allergy Clin Immunol Pract. 2018. PMID: 29408496
OBJECTIVE: The objective of this study was to evaluate the clinical characteristics and frequency of excipient allergy in patients with confirmed type I hypersensitivity to systemic CS preparations. METHODS: Patients with a confirmed diagnosis of allergy (positive skin tes …
OBJECTIVE: The objective of this study was to evaluate the clinical characteristics and frequency of excipient allergy in patients with conf …
Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes.
Judge A, McClintock K, Phelps JR, Maclachlan I. Judge A, et al. Mol Ther. 2006 Feb;13(2):328-37. doi: 10.1016/j.ymthe.2005.09.014. Epub 2005 Nov 7. Mol Ther. 2006. PMID: 16275098 Free article.
This phenomenon is characterized by a loss of disease site targeting, accelerated clearance from the blood, and acute hypersensitivity. These effects are fully attributable to a surprisingly robust, long-lived antibody response generated against polyethylene glyc …
This phenomenon is characterized by a loss of disease site targeting, accelerated clearance from the blood, and acute hypersensitivity …
A double-blind study comparing monomethoxy polyethylene glycol-modified honeybee venom and unmodified honeybee venom for immunotherapy. I. Clinical results.
Müller U, Rabson AR, Bischof M, Lomnitzer R, Dreborg S, Lanner A. Müller U, et al. J Allergy Clin Immunol. 1987 Sep;80(3 Pt 1):252-61. doi: 10.1016/0091-6749(87)90027-3. J Allergy Clin Immunol. 1987. PMID: 3624680 Clinical Trial.
Thirty-five patients were allocated at random to immunotherapy (IT) in a double-blind way with either monomethoxy polyethylene glycol (mPEG)-modified honeybee venom (HBV) or HBV. The two groups were well matched regarding age, sex, skin sensitivity, HBV-specific ser …
Thirty-five patients were allocated at random to immunotherapy (IT) in a double-blind way with either monomethoxy polyethylene gly …
Immediate and delayed allergic contact reactions to polyethylene glycol.
Fisher AA. Fisher AA. Contact Dermatitis. 1978 Jun;4(3):135-8. doi: 10.1111/j.1600-0536.1978.tb03759.x. Contact Dermatitis. 1978. PMID: 668343
The lower molecular weight liquid polyethylene glycols (PEG) varying from 200 to 700 are extensively used as solvent vehicles in topical medicaments. Four patients showed allergic reactions to these liquid polyethylene glycols in topical medications. T …
The lower molecular weight liquid polyethylene glycols (PEG) varying from 200 to 700 are extensively used as solvent vehicles …
Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis.
Luo L, Chen N, Li Z, Zhao C, Dong Y, Wang L, Li X, Zhou W, Li Y, Gao C, Guo X. Luo L, et al. Immun Inflamm Dis. 2024 Apr;12(4):e1245. doi: 10.1002/iid3.1245. Immun Inflamm Dis. 2024. PMID: 38629759 Free PMC article.
Here, we provide a deep insight into the frontier hotspot and future direction in the field of drug hypersensitivity. METHODS: A knowledge map is portrayed based on publications related to drug hypersensitivity from Web of Science Core Collection using CiteSpace. .. …
Here, we provide a deep insight into the frontier hotspot and future direction in the field of drug hypersensitivity. METHODS: A know …
Near-infrared reflectance spectrometry in the study of atopy. Part 2. Interactions between the skin and polyethylene glycol 400, isopropyl myristate and hydrogel.
Dreassi E, Ceramelli G, Mura P, Perruccio PL, Vocioni F, Bartalini P, Corti P. Dreassi E, et al. Analyst. 1997 Aug;122(8):771-6. doi: 10.1039/a701257h. Analyst. 1997. PMID: 9338986
Three compounds were taken as models: a prevalently hydrophilic solvent (polyethylene glycol, PEG 400), a prevalently lipophilic solvent (isopropyl myristate) and a hydrophilic pharmaceutical (gel) used to promote contact in electrocardiography. ...
Three compounds were taken as models: a prevalently hydrophilic solvent (polyethylene glycol, PEG 400), a prevalently lipophil …
Failure of desensitization with Pfizer-BioNTech COVID-19 vaccine in two asthmatic patients.
Iemoli E, Ortolani VGR, Preziosi D, Caron L, Giardina C, Carlevatti V, Giovine N. Iemoli E, et al. Eur Ann Allergy Clin Immunol. 2022 Sep;54(5):240-241. doi: 10.23822/EurAnnACI.1764-1489.236. Epub 2021 Nov 5. Eur Ann Allergy Clin Immunol. 2022. PMID: 34753281 Free article.
In mRNA vaccines, the component currently suspected of causing allergic reactions is the polyethylene glycol excipient (PEG or macrogol). In patients who have shown an immediate allergic reaction to vaccine and who are negative to skin tests for PEG, desensitization …
In mRNA vaccines, the component currently suspected of causing allergic reactions is the polyethylene glycol excipient (PEG or …
Assessing the role of the biomaterial Aquavene in patient reactions to Landmark midline catheters.
Silverstein B, Witkin KM, Frankos VH, Terr AI. Silverstein B, et al. Regul Toxicol Pharmacol. 1997 Feb;25(1):60-7. doi: 10.1006/rtph.1996.1057. Regul Toxicol Pharmacol. 1997. PMID: 9056501 Review.
They are constructed of an inner layer of polyurethane and an outer layer of the biomaterial Aquavene, a blend of polyurethane and polyethylene oxide to which butylated hyroxyanisole (BHA), butylated hydroxytoluene (BHT), and triallyl-s-triazine trione (TTT) are added. ... …
They are constructed of an inner layer of polyurethane and an outer layer of the biomaterial Aquavene, a blend of polyurethane and polyet …
Development of novel pegylated imidazobenzodiazepines as inhaled asthma drug candidates.
Kowalczyk ET, Medubi KM, Meyer MJ, Toriola MA, Haasch TJ, Vesperman MR, Webb DA, Stafford DC, Yocum GT, Emala CW, Arnold LA. Kowalczyk ET, et al. Respir Med. 2025 Nov-Dec;249:108449. doi: 10.1016/j.rmed.2025.108449. Epub 2025 Oct 22. Respir Med. 2025. PMID: 41135912
These compounds combine good affinity towards the gamma aminobutyric acid (A) receptors (GABA(A)Rs) expressed in the lungs and a polyethylene glycol (PEG) chain for excellent aqueous solubility to allow nebulization. As expected, the aqueous solubility of these deri …
These compounds combine good affinity towards the gamma aminobutyric acid (A) receptors (GABA(A)Rs) expressed in the lungs and a polyethy …
Clinical and demographic factors contributing to asparaginase-associated toxicities in children with acute lymphoblastic leukemia.
Dharia P, Swartz MD, Bernhardt MB, Chen H, Gramatges MM, Lupo PJ, Brown AL, Scheurer ME. Dharia P, et al. Leuk Lymphoma. 2022 Dec;63(12):2948-2954. doi: 10.1080/10428194.2022.2102621. Epub 2022 Jul 27. Leuk Lymphoma. 2022. PMID: 35895075 Free PMC article.
A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3% …
A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pe …
Intestinal permeability in patients with eczema and food allergy.
Jackson PG, Lessof MH, Baker RW, Ferrett J, MacDonald DM. Jackson PG, et al. Lancet. 1981 Jun 13;1(8233):1285-6. doi: 10.1016/s0140-6736(81)92459-4. Lancet. 1981. PMID: 6112605
Polyethylene glycol (PEG) was used as a probe molecule to investigate intestinal absorption in eight patients with eczema and evidence of food allergy and ten with eczema alone. ...
Polyethylene glycol (PEG) was used as a probe molecule to investigate intestinal absorption in eight patients with eczema and …
Development of anti-PEG IgG/IgM/IgE ELISA assays for profiling anti-PEG immunoglobulin response in PEG-sensitized individuals and patients with alpha-gal allergy.
Li Z, Ma A, Miller I, Starnes R, Talkington A, Stone CA, Phillips EJ, Choudhary SK, Commins SP, Lai SK. Li Z, et al. J Control Release. 2024 Feb;366:342-348. doi: 10.1016/j.jconrel.2024.01.003. Epub 2024 Jan 8. J Control Release. 2024. PMID: 38182056 Free PMC article.
Polyethylene glycol (PEG) is frequently used in various protein and nanomedicine therapeutics. ...Although IgE is a frequent cause of immediate hypersensitivity reactions (IHR), the role of IgE APA in PEG-related IHR is not well understood, due in part to a l …
Polyethylene glycol (PEG) is frequently used in various protein and nanomedicine therapeutics. ...Although IgE is a frequent c …
Safety of administration of BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG-asparaginase.
Mark C, Gupta S, Punnett A, Upton J, Orkin J, Atkinson A, Clarke L, Heisey A, McGovern C, Alexander S. Mark C, et al. Pediatr Blood Cancer. 2021 Nov;68(11):e29295. doi: 10.1002/pbc.29295. Epub 2021 Aug 16. Pediatr Blood Cancer. 2021. PMID: 34398511 Free PMC article.
Vaccinationis a critical tool in the prevention of COVID-19 infection for individuals and for communities. The mRNA vaccines contain polyethylene glycol (PEG) as a stabilizer. Currently, in North America, only the BNT162b2 (Pfizer-BioNTech) mRNA vaccine is approved …
Vaccinationis a critical tool in the prevention of COVID-19 infection for individuals and for communities. The mRNA vaccines contain poly …
Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group.
Brigitha LJ, Fiocco M, Pieters R, Albertsen BK, Escherich G, Lopez-Lopez E, Mondelaers V, Vora A, Vrooman L, Schmiegelow K, van der Sluis IM; Ponte di Legno Toxicity Working Group. Brigitha LJ, et al. Eur J Cancer. 2022 Feb;162:65-75. doi: 10.1016/j.ejca.2021.11.016. Epub 2021 Dec 23. Eur J Cancer. 2022. PMID: 34954438 Free article.
BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli (E.coli) asparaginase. ...Route of administration, number of doses, dosage and number of PEGasparaginase-free weeks did not significantly in …
BACKGROUND: Hypersensitivity reactions to asparaginase challenge its use and occur frequently (30-75%) after native Escherichia Coli …
Short-term intratracheal use of PEG-modified IL-2 and glucocorticoid persistently alleviates asthma in a mouse model.
Wu K, Ma J, Bai W, Cui X, Han T, Wang S, Xie Y, Xie Y. Wu K, et al. Sci Rep. 2016 Aug 16;6:31562. doi: 10.1038/srep31562. Sci Rep. 2016. PMID: 27527926 Free PMC article.
In this study, we show that short-term intratracheal use of IL-2 combined with glucocorticoid alleviates antigen-induced airway inflammation and reduces airway hyperresponsiveness by expanding antigen-nonspecific Treg cells, with a decrease in T helper 2 (Th2) cells and Th2-assoc …
In this study, we show that short-term intratracheal use of IL-2 combined with glucocorticoid alleviates antigen-induced airway inflammation …
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