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Year Number of Results
1953 2
1954 1
1955 1
1957 1
1958 1
1960 1
1963 1
1964 2
1974 2
1975 6
1976 3
1977 2
1978 3
1979 6
1980 8
1981 19
1982 10
1983 9
1984 14
1985 14
1986 16
1987 12
1988 8
1989 10
1990 15
1991 9
1992 7
1993 11
1994 11
1995 17
1996 15
1997 13
1998 5
1999 13
2000 11
2001 12
2002 9
2003 16
2004 21
2005 23
2006 30
2007 29
2008 25
2009 28
2010 27
2011 46
2012 39
2013 49
2014 47
2015 36
2016 49
2017 40
2018 44
2019 55
2020 31
2021 3
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Immediate-type hypersensitivity to polyethylene glycols: a review.
Wenande E, Garvey LH. Wenande E, et al. Clin Exp Allergy. 2016 Jul;46(7):907-22. doi: 10.1111/cea.12760. Clin Exp Allergy. 2016. PMID: 27196817 Review.
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first comprehensive review provides practical information for allergists and other healthcare professionals by describing the clinical picture of …
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. ...This first …
Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.
Stone CA Jr, Liu Y, Relling MV, Krantz MS, Pratt AL, Abreo A, Hemler JA, Phillips EJ. Stone CA Jr, et al. J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1533-1540.e8. doi: 10.1016/j.jaip.2018.12.003. Epub 2018 Dec 14. J Allergy Clin Immunol Pract. 2019. PMID: 30557713 Free PMC article.
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; however, the epidemiology, mechanisms, and cross-reactivity are poorly understood. ...Our studies raise the possibility of an IgE-mediated t …
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; …
Polyethylene Glycol Is a Cause of IgE-Mediated Anaphylaxis.
Giavina-Bianchi P, Kalil J. Giavina-Bianchi P, et al. J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1874-1875. doi: 10.1016/j.jaip.2019.05.001. J Allergy Clin Immunol Pract. 2019. PMID: 31279466 No abstract available.
Pegaspargase: A Review in Acute Lymphoblastic Leukaemia.
Heo YA, Syed YY, Keam SJ. Heo YA, et al. Drugs. 2019 May;79(7):767-777. doi: 10.1007/s40265-019-01120-1. Drugs. 2019. PMID: 31030380 Free PMC article. Review.
Pegaspargase treatment in patients with relapsed ALL and hypersensitivity to E. coliL-asparaginase had a similar tolerability profile to that observed in patients with newly diagnosed ALL. Given the potentially reduced immunogenicity and more convenient dosage regimen over …
Pegaspargase treatment in patients with relapsed ALL and hypersensitivity to E. coliL-asparaginase had a similar tolerability profile …
Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel.
Stock W, Douer D, DeAngelo DJ, Arellano M, Advani A, Damon L, Kovacsovics T, Litzow M, Rytting M, Borthakur G, Bleyer A. Stock W, et al. Leuk Lymphoma. 2011 Dec;52(12):2237-53. doi: 10.3109/10428194.2011.596963. Epub 2011 Aug 10. Leuk Lymphoma. 2011. PMID: 21827361
The most frequent toxicities of both types of ASNase are hepatic and pancreatic, with pancreatitis being the most serious. Other toxicities are hypersensitivity reactions, thrombosis, nausea/vomiting, and fatigue. Whether or not the replacement of one dose of pegASNase for …
The most frequent toxicities of both types of ASNase are hepatic and pancreatic, with pancreatitis being the most serious. Other toxicities …
Individualized Asparaginase Dosing in Childhood Acute Lymphoblastic Leukemia.
Kloos RQH, Pieters R, Jumelet FMV, de Groot-Kruseman HA, van den Bos C, van der Sluis IM. Kloos RQH, et al. J Clin Oncol. 2020 Mar 1;38(7):715-724. doi: 10.1200/JCO.19.02292. Epub 2020 Jan 10. J Clin Oncol. 2020. PMID: 31922920
PURPOSE: In the DCOG ALL-11 protocol, polyethylene glycol-conjugated Escherichia coli asparaginase (PEGasparaginase) and Erwinia asparaginase treatment of pediatric acute lymphoblastic leukemia are individualized with therapeutic drug monitoring (TDM). ...Asparagine …
PURPOSE: In the DCOG ALL-11 protocol, polyethylene glycol-conjugated Escherichia coli asparaginase (PEGasparaginase) and Erwin …
Hypersensitivity to polyethylene glycols.
Shah S, Prematta T, Adkinson NF, Ishmael FT. Shah S, et al. J Clin Pharmacol. 2013 Mar;53(3):352-5. doi: 10.1177/0091270012447122. Epub 2013 Jan 24. J Clin Pharmacol. 2013. PMID: 23444288 No abstract available.
PEG-asparaginase.
Fu CH, Sakamoto KM. Fu CH, et al. Expert Opin Pharmacother. 2007 Aug;8(12):1977-84. doi: 10.1517/14656566.8.12.1977. Expert Opin Pharmacother. 2007. PMID: 17696798 Review.
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase antibodies, which neutralize their activity. PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene …
The efficacy of L-asparaginases has been limited by a high rate of hypersensitivity reactions and development of anti-asparaginase an …
PEGylated E. coli asparaginase desensitization: an effective and feasible option for pediatric patients with acute lymphoblastic leukemia who have developed hypersensitivity to pegaspargase in the absence of asparaginase Erwinia chrysanthemi availability.
Verma A, Chen K, Bender C, Gorney N, Leonard W, Barnette P. Verma A, et al. Pediatr Hematol Oncol. 2019 Aug;36(5):277-286. doi: 10.1080/08880018.2019.1634778. Epub 2019 Jul 12. Pediatr Hematol Oncol. 2019. PMID: 31296092 Clinical Trial.
An international shortage of erwinia asparaginase has limited the therapeutic options for those experiencing pegaspargase hypersensitivity. Here, we report pegaspargase can be safely administered, while maintaining sustained levels of asparaginase activity, to patients who …
An international shortage of erwinia asparaginase has limited the therapeutic options for those experiencing pegaspargase hypersensitivit …
Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.
Liu Y, Smith CA, Panetta JC, Yang W, Thompson LE, Counts JP, Molinelli AR, Pei D, Kornegay NM, Crews KR, Swanson H, Cheng C, Karol SE, Evans WE, Inaba H, Pui CH, Jeha S, Relling MV. Liu Y, et al. J Clin Oncol. 2019 Aug 10;37(23):2051-2061. doi: 10.1200/JCO.18.02439. Epub 2019 Jun 12. J Clin Oncol. 2019. PMID: 31188727 Free PMC article.
Serum samples (n = 5,369) were analyzed for anti-PEG-ASP immunoglobulin G by enzyme-linked immunosorbent assay. Positive samples were tested for anti-polyethylene glycol (PEG) and anti-L-ASP. We analyzed potential risk factors for reactions and associations between …
Serum samples (n = 5,369) were analyzed for anti-PEG-ASP immunoglobulin G by enzyme-linked immunosorbent assay. Positive samples were tested …
Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions.
Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, Rosivall L, Bavli Y, Urbanics R, Mollnes TE, Barenholz Y, Szebeni J. Kozma GT, et al. ACS Nano. 2019 Aug 27;13(8):9315-9324. doi: 10.1021/acsnano.9b03942. Epub 2019 Aug 6. ACS Nano. 2019. PMID: 31348638
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. ...
Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which …
Polyethylene glycol: an underrecognized compound in certolizumab pegol and Movicol that may cause anaphylaxis.
McCabe E, Tormey V, Doran JP. McCabe E, et al. Rheumatology (Oxford). 2020 Apr 1;59(4):908-910. doi: 10.1093/rheumatology/kez469. Rheumatology (Oxford). 2020. PMID: 31598712 No abstract available.
Predicting success of desensitization after pegaspargase allergy.
Swanson HD, Panetta JC, Barker PJ, Liu Y, Inaba H, Relling MV, Pui CH, Karol SE. Swanson HD, et al. Blood. 2020 Jan 2;135(1):71-75. doi: 10.1182/blood.2019003407. Blood. 2020. PMID: 31750901 Free PMC article. No abstract available.
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.
Knop K, Hoogenboom R, Fischer D, Schubert US. Knop K, et al. Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308. doi: 10.1002/anie.200902672. Angew Chem Int Ed Engl. 2010. PMID: 20648499 Review.
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery. ...The areas that might need consideration and more intensive and careful examination can be divided into the followin …
Poly(ethylene glycol) (PEG) is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer …
Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey.
Özkaya E, Kılıç S. Özkaya E, et al. Contact Dermatitis. 2018 Mar;78(3):211-215. doi: 10.1111/cod.12931. Epub 2017 Nov 28. Contact Dermatitis. 2018. PMID: 29193145
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. ...
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmeti …
A randomized, prospective, comparison study of polyethylene glycol 3350 without electrolytes and milk of magnesia for children with constipation and fecal incontinence.
Loening-Baucke V, Pashankar DS. Loening-Baucke V, et al. Pediatrics. 2006 Aug;118(2):528-35. doi: 10.1542/peds.2006-0220. Pediatrics. 2006. PMID: 16882804 Clinical Trial.
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene glycol-treated children and 43% of milk of magnesia-treated children exhibited improvement, and 33% of polyethylene glycol …
Compliance rates were 95% for polyethylene glycol and 65% for milk of magnesia. After 12 months, 62% of polyethylene …
Anaphylaxis to Polyethylene Glycol (Colyte) in a Patient with Diverticulitis.
Lee SH, Hwang SH, Park JS, Park HS, Shin YS. Lee SH, et al. J Korean Med Sci. 2016 Oct;31(10):1662-3. doi: 10.3346/jkms.2016.31.10.1662. J Korean Med Sci. 2016. PMID: 27550498 Free PMC article.
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. ...
Anaphylactic reaction to polyethylene glycol-conjugated asparaginase: premedication and desensitization may not be sufficient.
Walenciak J, Mlynarski W, Zalewska-Szewczyk B. Walenciak J, et al. Pediatr Int. 2014 Feb;56(1):130-1. doi: 10.1111/ped.12270. Pediatr Int. 2014. PMID: 24548205 No abstract available.
Allergic reaction to polyethylene glycol in a painter.
Antolin-Amerigo D, Sánchez-González MJ, Barbarroja-Escudero J, Rodríguez-Rodríguez M, Álvarez-Perea A, Alvarez-Mon M. Antolin-Amerigo D, et al. Occup Med (Lond). 2015 Aug;65(6):502-4. doi: 10.1093/occmed/kqv072. Epub 2015 Jun 4. Occup Med (Lond). 2015. PMID: 26048329
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of a laxative solution containing polyethylene glycol (PEG) prior to colonoscopy. He described suffering from the same skin reac …
We report a case of a male painter who visited our outpatient clinic after developing a distinct skin reaction 15 min after the ingestion of …
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.
Chang CJ, Chen CH, Chen BM, Su YC, Chen YT, Hershfield MS, Lee MM, Cheng TL, Chen YT, Roffler SR, Wu JY. Chang CJ, et al. Nat Commun. 2017 Sep 12;8(1):522. doi: 10.1038/s41467-017-00622-4. Nat Commun. 2017. PMID: 28900105 Free PMC article.
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our findings may provide novel genetic markers for predicting the immunogenicity of PEG and efficacy of PEGylated therapeutics.Some individuals …
Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. ...Our …
Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.
Ganson NJ, Povsic TJ, Sullenger BA, Alexander JH, Zelenkofske SL, Sailstad JM, Rusconi CP, Hershfield MS. Ganson NJ, et al. J Allergy Clin Immunol. 2016 May;137(5):1610-1613.e7. doi: 10.1016/j.jaci.2015.10.034. Epub 2015 Dec 11. J Allergy Clin Immunol. 2016. PMID: 26688515 Free PMC article. No abstract available.
Urticaria as a Rare Side Effect of Polyethylene Glycol-3350 in a Child: Case Report.
Sari Gökay S, Çelik T, Yusuf Sari M, Ekinci F, Dinçer Yildizdaş R, Levent Yilmaz H. Sari Gökay S, et al. Acta Clin Croat. 2018 Mar;57(1):187-189. doi: 10.20471/acc.2018.57.01.26. Acta Clin Croat. 2018. PMID: 30256031 Free PMC article.
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Polyethylene glycol electrolyte (PEG-3350) solution is usually used for bowel emptying before colonoscopy in adults. ...
Contact dermatitis caused by polyethylene glycol-7 monooleate.
Conejero C, Loidi L, Hervella M. Conejero C, et al. Contact Dermatitis. 2015 Mar;72(3):185-6. doi: 10.1111/cod.12340. Epub 2015 Jan 21. Contact Dermatitis. 2015. PMID: 25604056 No abstract available.
Angioedema as a hypersensitivity reaction to polyethylene glycol oral electrolyte solution.
Assal C, Watson PY. Assal C, et al. Gastrointest Endosc. 2006 Aug;64(2):294-5. doi: 10.1016/j.gie.2006.02.008. Epub 2006 May 19. Gastrointest Endosc. 2006. PMID: 16860094 No abstract available.
Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866).
Kurtzberg J, Asselin B, Bernstein M, Buchanan GR, Pollock BH, Camitta BM. Kurtzberg J, et al. J Pediatr Hematol Oncol. 2011 Dec;33(8):610-6. doi: 10.1097/MPH.0b013e31822d4d4e. J Pediatr Hematol Oncol. 2011. PMID: 22042277 Free PMC article. Clinical Trial.
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To overcome this problem, native Escherichia coli L-asparaginase was conjugated to polyethylene glycol (PEG) to formulate PEG-L-asp …
BACKGROUND: Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To ov …
Production of a novel N-terminal PEGylated crisantaspase.
Torres-Obreque K, Meneguetti GP, Custódio D, Monteiro G, Pessoa-Junior A, de Oliveira Rangel-Yagui C. Torres-Obreque K, et al. Biotechnol Appl Biochem. 2019 May;66(3):281-289. doi: 10.1002/bab.1723. Epub 2019 Jan 7. Biotechnol Appl Biochem. 2019. PMID: 30597637
Crisantaspase is an asparaginase enzyme produced by Erwinia chrysanthemi and used to treat acute lymphoblastic leukemia (ALL) in case of hypersensitivity to Escherichia coli l-asparaginase (ASNase). The main disadvantages of crisantaspase are the short half-life (10 H) and …
Crisantaspase is an asparaginase enzyme produced by Erwinia chrysanthemi and used to treat acute lymphoblastic leukemia (ALL) in case of …
Allergic contact dermatitis to polyethylene glycol and nitrofurazone.
Guijarro SC, Sánchez-Pérez J, García-Díez A. Guijarro SC, et al. Am J Contact Dermat. 1999 Dec;10(4):226-7. doi: 10.1053/AJCD01000226. Am J Contact Dermat. 1999. PMID: 10594300
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene glycol. Patch tests to nickel sulfate, potassium dischromate, chloride cobalt, Furacin, nitrofurazone 1% petrolatum, polyethyle …
We report a case of worsening dermatitis after the application of an antibiotic ointment (Furacin) containing furazone and polyethylene …
Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors.
Richter AW, Akerblom E. Richter AW, et al. Int Arch Allergy Appl Immunol. 1984;74(1):36-9. doi: 10.1159/000233512. Int Arch Allergy Appl Immunol. 1984. PMID: 6706424
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing passive hemagglutination. In untreated allergic patients and in healthy blood donors, naturally occurring anti-PEG antibody titers between …
Antibodies to polyethylene glycol (PEG) were analyzed in patients with various allergies and in healthy blood donors employing …
[Methoxy polyethylene glycol-epoetin beta (Mircera) in the treatment of a patient with chronic kidney disease presenting late-onset hypersensitivity to other epoetins].
Dávila Fajardo CL, Peña Ortega M, Cabeza Barrera J, Prados Garrido MD. Dávila Fajardo CL, et al. Nefrologia. 2010;30(3):372-3. doi: 10.3265/Nefrologia.pre2010.Mar.10310. Nefrologia. 2010. PMID: 20514110 Free article. Spanish. No abstract available.
Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient.
Sahiner UM, Yavuz ST, Gökce M, Buyuktiryaki B, Altan I, Aytac S, Tuncer M, Tuncer A, Sackesen C. Sahiner UM, et al. Pediatr Int. 2013 Aug;55(4):531-3. doi: 10.1111/ped.12131. Pediatr Int. 2013. PMID: 23910807
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG-ASP) is preferred. ...Anaphylaxis with PEG-ASP is very rare and premedication and desensitizat …
In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene …
Clinical pharmacology of polyethylene glycol-L-asparaginase.
Ho DH, Brown NS, Yen A, Holmes R, Keating M, Abuchowski A, Newman RA, Krakoff IH. Ho DH, et al. Drug Metab Dispos. 1986 May-Jun;14(3):349-52. Drug Metab Dispos. 1986. PMID: 2872037
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patients of whom 27 were evaluable pharmacokinetically. ...
Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patient …
Polyethylene glycol-modified ragweed pollen extract in rhinoconjunctivitis.
Juniper EF, Roberts RS, Kennedy LK, O'Connor J, Syty-Golda M, Dolovich J, Hargreave FE. Juniper EF, et al. J Allergy Clin Immunol. 1985 May;75(5):578-85. doi: 10.1016/0091-6749(85)90033-8. J Allergy Clin Immunol. 1985. PMID: 3989142 Clinical Trial.
Sixty-two ragweed-sensitive adult subjects volunteered to take part in a 2-year, placebo-controlled efficacy study of polyethylene glycol (PEG)-modified ragweed extract, in ragweed pollen-induced rhinoconjunctivitis. ...
Sixty-two ragweed-sensitive adult subjects volunteered to take part in a 2-year, placebo-controlled efficacy study of polyethylene …
Non-IgE-dependent hypersensitivity to macrogol 6000.
Berndt K, Kuske M, Beissert S, Spornraft-Ragaller P, Bauer A. Berndt K, et al. J Dtsch Dermatol Ges. 2018 Apr;16(4):479-481. doi: 10.1111/ddg.13479. Epub 2018 Mar 26. J Dtsch Dermatol Ges. 2018. PMID: 29578283 No abstract available.
Allergen-specific immunotherapy.
Niederberger V. Niederberger V. Immunol Lett. 2009 Feb 21;122(2):131-3. doi: 10.1016/j.imlet.2008.11.012. Epub 2008 Dec 25. Immunol Lett. 2009. PMID: 19100771 Review.
Inhibition of polyethylene glycol-induced histamine release by monomeric ethylene and diethylene glycol: a case of probable polyethylene glycol allergy.
Wenande EC, Skov PS, Mosbech H, Poulsen LK, Garvey LH. Wenande EC, et al. J Allergy Clin Immunol. 2013 May;131(5):1425-7. doi: 10.1016/j.jaci.2012.09.037. Epub 2012 Dec 8. J Allergy Clin Immunol. 2013. PMID: 23228247 No abstract available.
Allergic Epidural Effusion Following Polyetheretherketone Cranioplasty.
Qiu S, You W, Wang H, Zhou X, Yang X. Qiu S, et al. J Craniofac Surg. 2019 May/Jun;30(3):e241-e243. doi: 10.1097/SCS.0000000000005192. J Craniofac Surg. 2019. PMID: 30730518
A case of anaphylaxis caused by polyethylene glycol analogues.
Yamasuji Y, Higashi Y, Sakanoue M, Katsue H, Kawai K, Arai N, Kanekura T. Yamasuji Y, et al. Contact Dermatitis. 2013 Sep;69(3):183-5. doi: 10.1111/cod.12084. Contact Dermatitis. 2013. PMID: 23948038 No abstract available.
Non-IgE-mediated hypersensitivity induced by multivitamins containing Tween-80.
Mi YN, Yan PP, Yu RH, Xiao X, Wang J, Cao L. Mi YN, et al. Clin Exp Pharmacol Physiol. 2019 Jul;46(7):664-675. doi: 10.1111/1440-1681.13089. Epub 2019 Apr 24. Clin Exp Pharmacol Physiol. 2019. PMID: 30907442
Multivitamins have been widely used for years. Adverse reactions, especially hypersensitivity, to multivitamins are becoming noteworthy. However, the classification of hypersensitivity is confusing, and the trigger is unknown. ...However, there was no alteration in …
Multivitamins have been widely used for years. Adverse reactions, especially hypersensitivity, to multivitamins are becoming notewort …
Polyethylene glycol-L-asparaginase versus native L-asparaginase in canine non-Hodgkin's lymphoma.
Teske E, Rutteman GR, van Heerde P, Misdorp W. Teske E, et al. Eur J Cancer. 1990;26(8):891-5. doi: 10.1016/0277-5379(90)90193-w. Eur J Cancer. 1990. PMID: 2145933 Clinical Trial.
No side-effects were noted in the dogs treated with PEG-L-asparaginase, whereas 14 (48%) of the L-asparaginase treated dogs had side-effects related to this drug, including anaphylactic shock (9), anorexia or vomiting (4), hypersensitivity-related oedema (3), seizures (1) …
No side-effects were noted in the dogs treated with PEG-L-asparaginase, whereas 14 (48%) of the L-asparaginase treated dogs had side-effects …
Site specific PEGylation of β-lactoglobulin at glutamine residues and its influence on conformation and antigenicity.
Luo S, Lu X, Liu C, Zhong J, Zhou L, Chen T. Luo S, et al. Food Res Int. 2019 Sep;123:623-630. doi: 10.1016/j.foodres.2019.05.038. Epub 2019 May 29. Food Res Int. 2019. PMID: 31285011
beta-lactoglobulin (beta-LG) is one of the main allergens in milk. Polyethylene glycol (PEG) modification (PEGylation) was found to have the ability to reduce the antigenicity of proteins. To determine the effect of site specific PEGylation on beta-LG antigenicity a …
beta-lactoglobulin (beta-LG) is one of the main allergens in milk. Polyethylene glycol (PEG) modification (PEGylation) was fou …
Polyethylene glycols and polysorbates: Two still neglected ingredients causing true IgE-mediated reactions.
Calogiuri G, Foti C, Nettis E, Di Leo E, Macchia L, Vacca A. Calogiuri G, et al. J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2509-2510. doi: 10.1016/j.jaip.2019.05.058. J Allergy Clin Immunol Pract. 2019. PMID: 31495440 No abstract available.
Multiple Drug Allergy Due to Hypersensitivity to Polyethylene Glycols of Various Molecular Weights.
Badiu I, Guida G, Heffler E, Rolla G. Badiu I, et al. J Investig Allergol Clin Immunol. 2015;25(5):368-9. J Investig Allergol Clin Immunol. 2015. PMID: 26727768 Free article. No abstract available.
Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase.
Soares AL, Guimarães GM, Polakiewicz B, de Moraes Pitombo RN, Abrahão-Neto J. Soares AL, et al. Int J Pharm. 2002 Apr 26;237(1-2):163-70. doi: 10.1016/s0378-5173(02)00046-7. Int J Pharm. 2002. PMID: 11955814
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reactions must be considered a relevant adverse effect of asparaginase therapy. One approach to reduce the hypersensitivity reactions cau …
L-asparaginase obtained from E. coli strains is an important enzyme widely used in leukemia treatment. However, hypersensitivity reac …
[Allergy against components of medical and cosmetic external preparations. Polyethylene glycol, propylene glycol, hexantriole].
Pevny I, Uhlich M. Pevny I, et al. Hautarzt. 1975 May;26(5):252-4. Hautarzt. 1975. PMID: 125250 German. No abstract available.
Recurrent Immediate Type Hypersensitivity Reaction Induced by Macrogol in a 3-Year-Old Boy.
Hamano S, Nishima D, Satake M, Kudo K, Yanagita K, Tezuka J. Hamano S, et al. J Investig Allergol Clin Immunol. 2020 Feb;30(1):72-73. doi: 10.18176/jiaci.0447. J Investig Allergol Clin Immunol. 2020. PMID: 32077856 Free article. No abstract available.
Immune responses to polyethylene glycol modified L-asparaginase in mice.
Kawamura K, Igarashi T, Fujii T, Kamisaki Y, Wada H, Kishimoto S. Kawamura K, et al. Int Arch Allergy Appl Immunol. 1985;76(4):324-30. doi: 10.1159/000233715. Int Arch Allergy Appl Immunol. 1985. PMID: 3980111
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glycol (PEG, MW, 5,000) conjugated Escherichia coli A-ase. ...PEG-A-ase administration also suppressed the delayed type hypersensitivity …
Suppression of anti-L-asparaginase (anti-A-ase) IgG and IgE antibody responses was achieved in Balb/c mice with polyethylene glyco …
Location and reduction of icarapin antigenicity by site specific coupling to polyethylene glycol.
Wong KL, Li H, Wong KK, Jiang T, Shaw PC. Wong KL, et al. Protein Pept Lett. 2012 Feb;19(2):238-43. doi: 10.2174/092986612799080211. Protein Pept Lett. 2012. PMID: 21838698
A 12-steps desensitization protocol for pediatric patients with hypersensitivity to pegylated asparaginase.
Concha S, Barriga F, Ovalle P, Hoyos-Bachiloglu R. Concha S, et al. Ann Allergy Asthma Immunol. 2020 Feb;124(2):208-210. doi: 10.1016/j.anai.2019.11.001. Epub 2019 Nov 14. Ann Allergy Asthma Immunol. 2020. PMID: 31734333 No abstract available.
[Telaprevir-induced pityriasis rubra pilaris].
Schmutz JL, Trechot P. Schmutz JL, et al. Ann Dermatol Venereol. 2013 May;140(5):414-5. doi: 10.1016/j.annder.2013.01.336. Epub 2013 Mar 6. Ann Dermatol Venereol. 2013. PMID: 23663723 Review. French. No abstract available.
Pegasparaginase: where do we stand?
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Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, especially the development of hypersensitivity reactions and neutralizing antibodies, and by the need for frequent administration. To ove …
Despite its well-proven clinical efficacy, the use of unmodified Escherichia coli ASP (EC-ASP) has been limited by frequent toxicities, espe …
In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Polyelectrolyte Nanocapsules Functionalized with Two Different Polymers: Poly-L-Glutamic Acid or PEG.
Karabasz A, Szczepanowicz K, Cierniak A, Mezyk-Kopec R, Dyduch G, Szczęch M, Bereta J, Bzowska M. Karabasz A, et al. Int J Nanomedicine. 2019 Dec 5;14:9587-9602. doi: 10.2147/IJN.S230865. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31824153 Free PMC article.
BACKGROUND: The functionalization of a nanoparticle surface with PEG (polyethylene glycol) is an approach most often used for extending nanomaterial circulation time, enhancing its delivery and retention in the target tissues, and decreasing systemic toxicity of nan …
BACKGROUND: The functionalization of a nanoparticle surface with PEG (polyethylene glycol) is an approach most often used for …
Management of Childhood Functional Constipation.
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Asparaginase treatment in infants with acute lymphoblastic leukemia; pharmacokinetics and asparaginase hypersensitivity in Interfant-06.
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All patients without hypersensitivity had sufficiently high enzyme activity levels during treatment with both preparations. Patients with hypersensitivity reactions during treatment, characterized by the presence of either or not of clinical symptoms and no measurab …
All patients without hypersensitivity had sufficiently high enzyme activity levels during treatment with both preparations. Patients …
Comparison of hypersensitivity rates to intravenous and intramuscular PEG-asparaginase in children with acute lymphoblastic leukemia: A meta-analysis and systematic review.
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The study objective was to perform a meta-analysis and systematic review to compare and generate pooled hypersensitivity rates for IM and IV PEG-ASP. METHODS: A systematic literature search was conducted for all epidemiological studies that investigated IV and IM hypers …
The study objective was to perform a meta-analysis and systematic review to compare and generate pooled hypersensitivity rates for IM …
Bactroban allergy due to polyethylene glycol.
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Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics.
Verhoef JJ, Carpenter JF, Anchordoquy TJ, Schellekens H. Verhoef JJ, et al. Drug Discov Today. 2014 Dec;19(12):1945-52. doi: 10.1016/j.drudis.2014.08.015. Epub 2014 Sep 7. Drug Discov Today. 2014. PMID: 25205349 Review.
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-life. ...PEGylation has also been associated with the activation of the complement system causing severe hypersensitivity reactions. Her …
Conjugation of polyethylene glycol (PEG) to therapeutics has proven to be an effective approach to increase the serum half-lif …
[Potential Use of Sacran Hydrogels as Wound Dressing Material].
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Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
Abshire TC, Pollock BH, Billett AL, Bradley P, Buchanan GR. Abshire TC, et al. Blood. 2000 Sep 1;96(5):1709-15. Blood. 2000. PMID: 10961868 Clinical Trial.
The relapse rate in childhood acute lymphoblastic leukemia (ALL) is approximately 30% but few reinduction regimens have investigated the intensive use of polyethylene glycol Escherichia coli asparaginase (PEG-Asp). Therefore, we assessed the pharmocokinetics and eff …
The relapse rate in childhood acute lymphoblastic leukemia (ALL) is approximately 30% but few reinduction regimens have investigated the int …