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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1974 2
1975 8
1976 6
1977 7
1978 4
1979 5
1980 5
1981 7
1982 4
1983 8
1984 8
1985 7
1986 7
1987 8
1988 7
1989 9
1990 16
1991 9
1992 15
1993 14
1994 7
1995 13
1996 19
1997 30
1998 29
1999 38
2000 39
2001 42
2002 49
2003 40
2004 53
2005 69
2006 53
2007 63
2008 73
2009 75
2010 98
2011 93
2012 123
2013 166
2014 199
2015 258
2016 293
2017 361
2018 504
2019 643
2020 892
2021 1108
2022 7
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4,891 results
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Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, Natarajan P, Lander ES, Lubitz SA, Ellinor PT, Kathiresan S. Khera AV, et al. Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13. Nat Genet. 2018. PMID: 30104762 Free PMC article.
Proposed clinical applications have largely focused on finding carriers of rare monogenic mutations at several-fold increased risk. Although most disease risk is polygenic in nature(2-5), it has not yet been possible to use polygenic predictors to iden …
Proposed clinical applications have largely focused on finding carriers of rare monogenic mutations at several-fold increased risk. A …
Polygenic risk scores: from research tools to clinical instruments.
Lewis CM, Vassos E. Lewis CM, et al. Genome Med. 2020 May 18;12(1):44. doi: 10.1186/s13073-020-00742-5. Genome Med. 2020. PMID: 32423490 Free PMC article. Review.
These variants can be combined into a polygenic risk score that captures part of an individual's susceptibility to diseases. ...Polygenic risk scores may be used to estimate an individual's lifetime genetic risk of disease, but the current discr …
These variants can be combined into a polygenic risk score that captures part of an individual's susceptibility to diseases. . …
The personal and clinical utility of polygenic risk scores.
Torkamani A, Wineinger NE, Topol EJ. Torkamani A, et al. Nat Rev Genet. 2018 Sep;19(9):581-590. doi: 10.1038/s41576-018-0018-x. Nat Rev Genet. 2018. PMID: 29789686 Review.
Nevertheless, recent efforts have begun to demonstrate the utility of polygenic risk profiling to identify groups of individuals who could benefit from the knowledge of their probabilistic susceptibility to disease. In this context, we review the evidence supporting …
Nevertheless, recent efforts have begun to demonstrate the utility of polygenic risk profiling to identify groups of individua …
Tutorial: a guide to performing polygenic risk score analyses.
Choi SW, Mak TS, O'Reilly PF. Choi SW, et al. Nat Protoc. 2020 Sep;15(9):2759-2772. doi: 10.1038/s41596-020-0353-1. Epub 2020 Jul 24. Nat Protoc. 2020. PMID: 32709988 Review.
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's genetic liability to a trait or disease, calculated according to their genotype profile and relevant genome-wide association study (GWAS) data. ...
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's genetic liability to a trait or …
Validity of polygenic risk scores: are we measuring what we think we are?
Janssens ACJW. Janssens ACJW. Hum Mol Genet. 2019 Nov 21;28(R2):R143-R150. doi: 10.1093/hmg/ddz205. Hum Mol Genet. 2019. PMID: 31504522 Free PMC article. Review.
Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in the prediction of disease risks. PRSs are generally constructed as weighted sum scores of risk alleles using effect sizes from genome-wide association studies as their
Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in the prediction of disease risks. PR
Polygenic Risk Scores in Coronary Artery Disease and Atrial Fibrillation.
Gladding PA, Legget M, Fatkin D, Larsen P, Doughty R. Gladding PA, et al. Heart Lung Circ. 2020 Apr;29(4):634-640. doi: 10.1016/j.hlc.2019.12.004. Epub 2019 Dec 27. Heart Lung Circ. 2020. PMID: 31974023 Review.
Common genetic variants that affect disease susceptibility have been identified by genome-wide association studies, but the predictive value of any single variant is limited. To address this issue, polygenic risk scores (PRS), comprised of suites of disease-associat …
Common genetic variants that affect disease susceptibility have been identified by genome-wide association studies, but the predictive value …
Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.
Mosley JD, Gupta DK, Tan J, Yao J, Wells QS, Shaffer CM, Kundu S, Robinson-Cohen C, Psaty BM, Rich SS, Post WS, Guo X, Rotter JI, Roden DM, Gerszten RE, Wang TJ. Mosley JD, et al. JAMA. 2020 Feb 18;323(7):627-635. doi: 10.1001/jama.2019.21782. JAMA. 2020. PMID: 32068817 Free PMC article.
OBJECTIVE: To determine whether a polygenic risk score improves prediction of CHD compared with a guideline-recommended clinical risk equation. ...These findings suggest that a polygenic risk score may not enhance risk prediction in a gen …
OBJECTIVE: To determine whether a polygenic risk score improves prediction of CHD compared with a guideline-recommended clinic …
Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease.
Elliott J, Bodinier B, Bond TA, Chadeau-Hyam M, Evangelou E, Moons KGM, Dehghan A, Muller DC, Elliott P, Tzoulaki I. Elliott J, et al. JAMA. 2020 Feb 18;323(7):636-645. doi: 10.1001/jama.2019.22241. JAMA. 2020. PMID: 32068818 Free PMC article.
OBJECTIVE: To examine whether a polygenic risk score for CAD improves risk prediction beyond pooled cohort equations. ...EXPOSURES: Polygenic risk score for CAD, pooled cohort equations, and both combined. ...
OBJECTIVE: To examine whether a polygenic risk score for CAD improves risk prediction beyond pooled cohort equations. . …
Polygenic risk scores in coronary artery disease.
Rao AS, Knowles JW. Rao AS, et al. Curr Opin Cardiol. 2019 Jul;34(4):435-440. doi: 10.1097/HCO.0000000000000629. Curr Opin Cardiol. 2019. PMID: 30994529 Review.
PURPOSE OF REVIEW: Large genome-wide association studies (GWAS) have identified variants accounting for a substantial portion of the heritable risk for coronary artery disease (CAD). These studies have catalyzed drug discovery and generated the possibility of improved r
PURPOSE OF REVIEW: Large genome-wide association studies (GWAS) have identified variants accounting for a substantial portion of the heritab …
Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk: Clinical Perspectives and Basic Implications.
Aragam KG, Natarajan P. Aragam KG, et al. Circ Res. 2020 Apr 24;126(9):1159-1177. doi: 10.1161/CIRCRESAHA.120.315928. Epub 2020 Apr 23. Circ Res. 2020. PMID: 32324503 Free PMC article. Review.
With growing knowledge of the genetic basis of atherosclerotic cardiovascular disease-in particular, coronary artery disease-and its contribution to disease pathogenesis, there is increased interest in understanding the potential clinical utility of a genetic predictor that might …
With growing knowledge of the genetic basis of atherosclerotic cardiovascular disease-in particular, coronary artery disease-and its contrib …
4,891 results