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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1974 2
1975 8
1976 6
1977 7
1978 4
1979 5
1980 5
1981 7
1982 4
1983 8
1984 8
1985 7
1986 7
1987 8
1988 7
1989 9
1990 16
1991 9
1992 15
1993 14
1994 7
1995 13
1996 19
1997 30
1998 29
1999 38
2000 39
2001 42
2002 49
2003 40
2004 53
2005 69
2006 53
2007 63
2008 73
2009 75
2010 98
2011 93
2012 123
2013 166
2014 199
2015 255
2016 294
2017 359
2018 502
2019 638
2020 751
2021 1
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3,793 results
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Page 1
The personal and clinical utility of polygenic risk scores.
Torkamani A, Wineinger NE, Topol EJ. Torkamani A, et al. Nat Rev Genet. 2018 Sep;19(9):581-590. doi: 10.1038/s41576-018-0018-x. Nat Rev Genet. 2018. PMID: 29789686 Review.
Nevertheless, recent efforts have begun to demonstrate the utility of polygenic risk profiling to identify groups of individuals who could benefit from the knowledge of their probabilistic susceptibility to disease. In this context, we review the evidence supporting …
Nevertheless, recent efforts have begun to demonstrate the utility of polygenic risk profiling to identify groups of individua …
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, Natarajan P, Lander ES, Lubitz SA, Ellinor PT, Kathiresan S. Khera AV, et al. Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13. Nat Genet. 2018. PMID: 30104762 Free PMC article.
Although most disease risk is polygenic in nature(2-5), it has not yet been possible to use polygenic predictors to identify individuals at risk comparable to monogenic mutations. ...We propose that it is time to contemplate the inclusion of polygen
Although most disease risk is polygenic in nature(2-5), it has not yet been possible to use polygenic predictors to ide …
Predicting Polygenic Risk of Psychiatric Disorders.
Martin AR, Daly MJ, Robinson EB, Hyman SE, Neale BM. Martin AR, et al. Biol Psychiatry. 2019 Jul 15;86(2):97-109. doi: 10.1016/j.biopsych.2018.12.015. Epub 2018 Dec 28. Biol Psychiatry. 2019. PMID: 30737014 Free PMC article. Review.
Although genetic risk prediction has become increasingly straightforward to apply and common in published studies, there are important pitfalls to avoid. ...For all applications, it is absolutely critical that polygenic risk prediction is applied with appropr …
Although genetic risk prediction has become increasingly straightforward to apply and common in published studies, there are importan …
Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia.
Wimberley T, Gasse C, Meier SM, Agerbo E, MacCabe JH, Horsdal HT. Wimberley T, et al. Schizophr Bull. 2017 Sep 1;43(5):1064-1069. doi: 10.1093/schbul/sbx007. Schizophr Bull. 2017. PMID: 28184875 Free PMC article.
We aimed to investigate the association between a polygenic risk score for schizophrenia and treatment resistance in patients with schizophrenia. ...Moreover, a TRS-specific developed polygenic risk score would be of great interest towards early predic …
We aimed to investigate the association between a polygenic risk score for schizophrenia and treatment resistance in patients …
The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review.
Mistry S, Harrison JR, Smith DJ, Escott-Price V, Zammit S. Mistry S, et al. J Affect Disord. 2018 Jul;234:148-155. doi: 10.1016/j.jad.2018.02.005. Epub 2018 Feb 15. J Affect Disord. 2018. PMID: 29529547 Review.
The polygenic risk score (PRS) derived using data from genome-wide-association-studies can be used to explore how genetic risk is manifest in different samples. AIMS: In this systematic review, we review studies that examine associations between the MDD and B …
The polygenic risk score (PRS) derived using data from genome-wide-association-studies can be used to explore how genetic r
Polygenic risk scores in coronary artery disease.
Rao AS, Knowles JW. Rao AS, et al. Curr Opin Cardiol. 2019 Jul;34(4):435-440. doi: 10.1097/HCO.0000000000000629. Curr Opin Cardiol. 2019. PMID: 30994529 Review.
These studies have catalyzed drug discovery and generated the possibility of improved risk prediction and stratification. Here, we review the current state-of-the art in polygenic risk scores (PRSs) and look to the future, as these scores move towards clinica …
These studies have catalyzed drug discovery and generated the possibility of improved risk prediction and stratification. Here, we re …
Validity of polygenic risk scores: are we measuring what we think we are?
Janssens ACJW. Janssens ACJW. Hum Mol Genet. 2019 Nov 21;28(R2):R143-R150. doi: 10.1093/hmg/ddz205. Hum Mol Genet. 2019. PMID: 31504522 Free PMC article. Review.
Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in the prediction of disease risks. PRSs are generally constructed as weighted sum scores of risk alleles using effect sizes from genome-wide association studies as their
Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in the prediction of disease risks. PR
PRSice: Polygenic Risk Score software.
Euesden J, Lewis CM, O'Reilly PF. Euesden J, et al. Bioinformatics. 2015 May 1;31(9):1466-8. doi: 10.1093/bioinformatics/btu848. Epub 2014 Dec 29. Bioinformatics. 2015. PMID: 25550326 Free PMC article.
SUMMARY: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. ...
SUMMARY: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by eff …
Polygenic risk scoring and prediction of mental health outcomes.
Anderson JS, Shade J, DiBlasi E, Shabalin AA, Docherty AR. Anderson JS, et al. Curr Opin Psychol. 2019 Jun;27:77-81. doi: 10.1016/j.copsyc.2018.09.002. Epub 2018 Sep 20. Curr Opin Psychol. 2019. PMID: 30339992 Free PMC article. Review.
Psychiatric conditions are highly polygenic, meaning that genetic risk arises from many hundreds or thousands of genetic variants. ...Polygenic risk scores can easily be added to environmental and behavioral genetic models of latent risk, making …
Psychiatric conditions are highly polygenic, meaning that genetic risk arises from many hundreds or thousands of genetic varia …
Polygenic risk and hazard scores for Alzheimer's disease prediction.
Leonenko G, Sims R, Shoai M, Frizzati A, Bossù P, Spalletta G, Fox NC, Williams J; GERAD consortium, Hardy J, Escott-Price V. Leonenko G, et al. Ann Clin Transl Neurol. 2019 Feb 18;6(3):456-465. doi: 10.1002/acn3.716. eCollection 2019 Mar. Ann Clin Transl Neurol. 2019. PMID: 30911569 Free PMC article.
Using AD GWAS data from the International Genomics of Alzheimer's Project (IGAP), Polygenic Risk Score (PRS) was successfully applied to predict life time risk of AD development. ...RESULTS: Polygenic Risk Score significantly predicted the ri
Using AD GWAS data from the International Genomics of Alzheimer's Project (IGAP), Polygenic Risk Score (PRS) was successfully …
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