Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1994 1
1995 1
2007 1
2008 1
2009 2
2010 1
2012 1
2013 1
2014 1
2015 4
2016 4
2017 6
2018 5
2019 2
2020 4
2021 11
2022 11
2023 8
2024 11
2025 15
2026 14

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

90 results

Results by year

Filters applied: . Clear all
Page 1
Advances in Mechanism Research on Polygonatum in Prevention and Treatment of Diabetes.
Liu S, Jia QJ, Peng YQ, Feng TH, Hu ST, Dong JE, Liang ZS. Liu S, et al. Front Pharmacol. 2022 Feb 8;13:758501. doi: 10.3389/fphar.2022.758501. eCollection 2022. Front Pharmacol. 2022. PMID: 35211009 Free PMC article. Review.
Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life. ...However, the research on the mechanism of these three Polygonatum spp. in diabetes has not been reviewed. This review provides a summary of the research …
Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life. ...However, the research on th …
Research progress on medicinal components and pharmacological activities of polygonatum sibiricum.
Liu R, Zhang X, Cai Y, Xu S, Xu Q, Ling C, Li X, Li W, Liu P, Liu W. Liu R, et al. J Ethnopharmacol. 2024 Jun 28;328:118024. doi: 10.1016/j.jep.2024.118024. Epub 2024 Mar 13. J Ethnopharmacol. 2024. PMID: 38484952 Review.
RESULTS: Several studies have demonstrated the strong antioxidant properties of polygonatum extract, which can be attributed to the presence of flavonoids and other polyphenol compounds; for diabetes and other metabolic-related diseases, polygonatum saponins …
RESULTS: Several studies have demonstrated the strong antioxidant properties of polygonatum extract, which can be attributed to the p …
Polygonatum sibiricum saponin Exerts Beneficial Hypoglycemic Effects in Type 2 Diabetes Mice by Improving Hepatic Insulin Resistance and Glycogen Synthesis-Related Proteins.
Chen Z, Luo J, Jia M, Chai Y, Bao Y. Chen Z, et al. Nutrients. 2022 Dec 8;14(24):5222. doi: 10.3390/nu14245222. Nutrients. 2022. PMID: 36558381 Free PMC article.
Type 2 diabetes mellitus (T2DM) is a systemic metabolic disorder characterized by insulin deficiency and insulin resistance. Recently, it has become a significant threat to public health. Polygonatum sibiricum saponin (PSS) has potential hypoglycemic effects, …
Type 2 diabetes mellitus (T2DM) is a systemic metabolic disorder characterized by insulin deficiency and insulin resistance. R …
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats.
Zhang H, Li H, Pan B, Zhang S, Su X, Sun W, Zhang T, Zhang Z, Lv S, Cui H. Zhang H, et al. Curr Drug Metab. 2023;24(4):270-282. doi: 10.2174/1389200224666230406114012. Curr Drug Metab. 2023. PMID: 37038712
BACKGROUND: Polygonatum sibiricum polysaccharide (PSP) can improve insulin resistance and inhibit oxidative stress. However, the detailed anti-diabetic mechanism of PSP is still poorly defined. METHODS: In this study, the anti-diabetic, anti-inflammatory and …
BACKGROUND: Polygonatum sibiricum polysaccharide (PSP) can improve insulin resistance and inhibit oxidative stress. However, the deta …
The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology.
Zhao P, Zhao C, Li X, Gao Q, Huang L, Xiao P, Gao W. Zhao P, et al. J Ethnopharmacol. 2018 Mar 25;214:274-291. doi: 10.1016/j.jep.2017.12.006. Epub 2017 Dec 12. J Ethnopharmacol. 2018. PMID: 29246502 Review.
A putative biosynthetic pathway of steroidal saponins and triterpenoid saponins has been established based on the compounds isolated from Polygonatum plants. The crude extracts and certain pure compounds from Polygonatum plants have shown a wide range of pharmacolog …
A putative biosynthetic pathway of steroidal saponins and triterpenoid saponins has been established based on the compounds isolated from …
Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives.
Shi Y, Si D, Chen D, Zhang X, Han Z, Yu Q, Liu J, Si J. Shi Y, et al. Food Chem. 2023 May 15;408:135183. doi: 10.1016/j.foodchem.2022.135183. Epub 2022 Dec 12. Food Chem. 2023. PMID: 36566543 Free article. Review.
Diabetes mellitus (DM) is one of the most serious health problems worldwide. Species in the genus Polygonatum are traditional food and medicinal plants, which play an important role in controlling blood glucose. In this reveiw, we systematically summarized th …
Diabetes mellitus (DM) is one of the most serious health problems worldwide. Species in the genus Polygonatum are tradi …
Polygonatum sibiricum polysaccharides ameliorate diabetes-induced vascular endothelial injury partly through Nrf2/GPX4 activation.
Wu D, Zhao J, Yang Q, Fang R, Xu S. Wu D, et al. Biochem Biophys Rep. 2026 Apr 7;46:102570. doi: 10.1016/j.bbrep.2026.102570. eCollection 2026 Jun. Biochem Biophys Rep. 2026. PMID: 42004546 Free PMC article.
Diabetes mellitus is a chronic metabolic disorder in which endothelial dysfunction plays a pivotal role in disease progression. ...In this study, PSP treatment markedly alleviated diabetes-induced vascular endothelial injury, reduced serum TG and LDL levels i …
Diabetes mellitus is a chronic metabolic disorder in which endothelial dysfunction plays a pivotal role in disease progression …
Polygonatum sibiricum polysaccharides: A promising strategy in the treatment of neurodegenerative disease.
Jiang X, Wang Y, Lin Z, Li C, Wang Q, Zhang J, Liu X, Li Z, Cui C. Jiang X, et al. Neurochem Int. 2024 Dec;181:105902. doi: 10.1016/j.neuint.2024.105902. Epub 2024 Nov 13. Neurochem Int. 2024. PMID: 39542041 Review.
Neurodegenerative diseases (NDDs), as a neurological disorder characterised by neuronal degeneration and death, are a serious threat to human health and have long attracted attention due to their complex pathogenesis and the ineffectiveness of therapeutic drugs. Existing studies …
Neurodegenerative diseases (NDDs), as a neurological disorder characterised by neuronal degeneration and death, are a serious threat to huma …
Pharmacological properties of Polygonatum and its active ingredients for the prevention and treatment of cardiovascular diseases.
Lin H, Wang W, Peng M, Kong Y, Zhang X, Wei X, Shang H. Lin H, et al. Chin Med. 2024 Jan 2;19(1):1. doi: 10.1186/s13020-023-00871-0. Chin Med. 2024. PMID: 38163901 Free PMC article. Review.
Furthermore, we summarized the pharmacological effects of Polygonatum's active components in preventing and treating CVDs, and its relevant toxicological investigations. Finally, we emphasize the potential of Polygonatum in the prevention and treatment of CVDs....
Furthermore, we summarized the pharmacological effects of Polygonatum's active components in preventing and treating CVDs, and its re …
Advances in Polygonatum sibiricum polysaccharides: Extraction, purification, structure, biosynthesis, and bioactivity.
Liu D, Tang W, Han C, Nie S. Liu D, et al. Front Nutr. 2022 Dec 5;9:1074671. doi: 10.3389/fnut.2022.1074671. eCollection 2022. Front Nutr. 2022. PMID: 36545471 Free PMC article. Review.
Polygonatum sibiricum has been used as food and medicine for thousands of years, and P. sibiricum polysaccharides (PSPs) have become the hot research spot due to their various health-promoting functions. ...Notably, it is concluded that PSPs mainly contain several types of …
Polygonatum sibiricum has been used as food and medicine for thousands of years, and P. sibiricum polysaccharides (PSPs) have become …
90 results