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Page 1
Pomegranate for Prevention and Treatment of Cancer: An Update.
Sharma P, McClees SF, Afaq F. Sharma P, et al. Molecules. 2017 Jan 24;22(1):177. doi: 10.3390/molecules22010177. Molecules. 2017. PMID: 28125044 Free PMC article. Review.
Studies have shown that the pomegranate fruit as well as its juice, extract, and oil exert anti-inflammatory, anti-proliferative, and anti-tumorigenic properties by modulating multiple signaling pathways, which suggest its use as a promising chemopreventive/chemothe …
Studies have shown that the pomegranate fruit as well as its juice, extract, and oil exert anti-inflammatory, anti-proliferati …
Pomegranate in Cancer Therapy: A Review of Anticancer Potential, Mechanisms and Clinical Challenges in Breast, Colon and Prostate Cancers.
Kitic D, Miladinovic B, Randjelovic M, Szopa A, Seidel V, Sharifi-Rad J, Setzer WN, Calina D. Kitic D, et al. Phytother Res. 2026 Aug;40(8):5132-5160. doi: 10.1002/ptr.70382. Epub 2026 May 22. Phytother Res. 2026. PMID: 42174764 Free PMC article. Review.
Pomegranate ( Punica granatum L.) is a plant that has been used in traditional medicine for centuries and that has gain popularity in recent years as an anticancer dietary supplement. For the purpose of this review, a comprehensive literature search was performed to gather …
Pomegranate ( Punica granatum L.) is a plant that has been used in traditional medicine for centuries and that has gain popularity in …
Pomegranate Oil Nanoemulsion as a Nanotherapeutic Strategy Against Breast and Colon Cancer: Induction of Apoptosis and Inhibition of Cell Migration.
Aljadani M, Binothman N, Alshehri S, Altarjami LR. Aljadani M, et al. Anticancer Agents Med Chem. 2026;26(9):868-878. doi: 10.2174/0118715206437234260120080158. Anticancer Agents Med Chem. 2026. PMID: 41944113
Therefore, we aimed to develop and characterize a pomegranate (Punica granatum) oil-based nanoemulsion (PG-NE) with enhanced anticancer properties. ...DISCUSSION: The findings indicate that nanoencapsulation enhances the anticancer efficacy of pomegranate …
Therefore, we aimed to develop and characterize a pomegranate (Punica granatum) oil-based nanoemulsion (PG-NE) with enhanced a …
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer.
Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, Mansel R, Ramachandran C, Rabi T, Kaplan B, Lansky E. Kim ND, et al. Breast Cancer Res Treat. 2002 Feb;71(3):203-17. doi: 10.1023/a:1014405730585. Breast Cancer Res Treat. 2002. PMID: 12002340
Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 microg/ml medium, 75% inhibition of invasion of MCF-7 across a Matrigel membrane at 10 microg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor negative metastatic human breast …
Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 microg/ml medium, 75% inhibition of invasion of …
Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture.
Mehta R, Lansky EP. Mehta R, et al. Eur J Cancer Prev. 2004 Aug;13(4):345-8. doi: 10.1097/01.cej.0000136571.70998.5a. Eur J Cancer Prev. 2004. PMID: 15554563
We previously reported anticancer effects of pomegranate extracts in human breast cancer cells in vitro and also chemopreventive activity of pomegranate fermented juice polyphenols (W) in a mouse mammary organ culture (MMOC). ...While W effected a 42% …
We previously reported anticancer effects of pomegranate extracts in human breast cancer cells in vitro and also chemop …
Splenic Elemental Composition of Breast Cancer-Suffering Rats Supplemented with Pomegranate Seed Oil and Bitter Melon Extract.
Białek M, Lepionka T, Wojtak W, Ruszczyńska A, Bulska E, Czauderna M, Białek A. Białek M, et al. Molecules. 2024 Apr 24;29(9):1942. doi: 10.3390/molecules29091942. Molecules. 2024. PMID: 38731433 Free PMC article.
The aim of this study was to investigate how dietary modifications with pomegranate seed oil (PSO) and bitter melon aqueous extract (BME) affect mineral content in the spleen of rats both under normal physiological conditions and with coexisting mammary tumorigenesi …
The aim of this study was to investigate how dietary modifications with pomegranate seed oil (PSO) and bitter melon aqueous ex …
Pomegranate fruit extract impairs invasion and motility in human breast cancer.
Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD. Khan GN, et al. Integr Cancer Ther. 2009 Sep;8(3):242-53. doi: 10.1177/1534735409341405. Integr Cancer Ther. 2009. PMID: 19815594 Free article.
EXPERIMENTAL DESIGN: The authors investigated the effect of a novel, defined PFE consisting of both fermented juice and seed oil on the NF-kB pathway, which is constitutively active in aggressive breast cancer cell lines. ...RESULTS: Analytical characterizati …
EXPERIMENTAL DESIGN: The authors investigated the effect of a novel, defined PFE consisting of both fermented juice and seed oil on t …
Nutritional Impact on Breast Cancer in Menopausal and Post-Menopausal Patients Treated with Aromatase Inhibitors.
Popescu R, Flangea C, Vlad DC, Cobec IM, Seropian P, Marina CD, Vlad T, Dumitrascu AL, Puscasiu D. Popescu R, et al. Cancers (Basel). 2025 Dec 25;18(1):73. doi: 10.3390/cancers18010073. Cancers (Basel). 2025. PMID: 41514586 Free PMC article. Review.
Background/Objectives: Aromatase inhibitors (AIs)-specifically, letrozole, anastrozole and exemestane-represent the current gold standard for patients with estrogen-receptor-positive breast cancer (ER + BC). This narrative review highlights potential interactions be …
Background/Objectives: Aromatase inhibitors (AIs)-specifically, letrozole, anastrozole and exemestane-represent the current gold standard fo …
Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract.
Lepionka T, Białek A, Białek M, Czauderna M, Stawarska A, Wrzesień R, Bielecki W, Paśko P, Galanty A, Bobrowska-Korczak B. Lepionka T, et al. Prostaglandins Other Lipid Mediat. 2019 Jun;142:33-45. doi: 10.1016/j.prostaglandins.2019.03.005. Epub 2019 Mar 28. Prostaglandins Other Lipid Mediat. 2019. PMID: 30928411
The objective of the present study was to determine the influence of dietary supplementation with pomegranate seed oil (PSO) and/or an aqueous extract of dried bitter melon fruits (BME) on breast cancer risk and fatty acid profile in serum of female ra …
The objective of the present study was to determine the influence of dietary supplementation with pomegranate seed oil (PSO) a …
Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines.
Costantini S, Rusolo F, De Vito V, Moccia S, Picariello G, Capone F, Guerriero E, Castello G, Volpe MG. Costantini S, et al. Molecules. 2014 Jun 24;19(6):8644-60. doi: 10.3390/molecules19068644. Molecules. 2014. PMID: 24962397 Free PMC article.
In this work, we characterized conjugated linolenic acids (e.g., punicic acid) as the major components of the hydrophilic fraction (80% aqueous methanol extract) from pomegranate (Punica granatum L.) seed oil (PSO) and evaluated their anti-inflammatory potential on …
In this work, we characterized conjugated linolenic acids (e.g., punicic acid) as the major components of the hydrophilic fraction (80% aque …
21 results