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Pomiferin.
Marek J, Veselá D, Lisková M, Zemlicka M. Marek J, et al. Acta Crystallogr C. 2003 Mar;59(Pt 3):o127-8. doi: 10.1107/s0108270103002300. Epub 2003 Feb 18. Acta Crystallogr C. 2003. PMID: 12711784
The crystal structure of pomiferin, 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-4H,8H-pyrano[2,3-h]chromen-4-one, C(25)H(24)O(6), has been determined. ...
The crystal structure of pomiferin, 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-4H,8H-pyrano[2,3-h]chromen- …
Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo.
Qu YQ, Song LL, Xu SW, Yu MSY, Kadioglu O, Michelangeli F, Law BYK, Efferth T, Lam CW, Wong VKW. Qu YQ, et al. Pharmacol Res. 2023 May;191:106769. doi: 10.1016/j.phrs.2023.106769. Epub 2023 Apr 13. Pharmacol Res. 2023. PMID: 37061145 Free article.
In vivo study demonstrated that pomiferin triggered calcium-mediated tumor suppression and exhibited an anti-metastatic effect in the LLC-1 lung cancer-bearing mouse model. ...Collectively, pomiferin may serve as a novel effective agent for circumventing drug resist …
In vivo study demonstrated that pomiferin triggered calcium-mediated tumor suppression and exhibited an anti-metastatic effect in the …
Pomiferin Exerts Antineuroinflammatory Effects through Activating Akt/Nrf2 Pathway and Inhibiting NF-kappaB Pathway.
Zhao Y, Sang Y, Sun Y, Wu J. Zhao Y, et al. Mediators Inflamm. 2022 Apr 4;2022:5824657. doi: 10.1155/2022/5824657. eCollection 2022. Mediators Inflamm. 2022. PMID: 35418806 Free PMC article.
We then investigated the effect of Pomiferin on the classical inflammatory pathway by Western blot methods. RESULTS: The results showed that Pomiferin inhibited the production of ROS, NO, and proinflammatory mediators (IL-6, TNF-alpha, iNOS, and COX2) in BV2 cells. …
We then investigated the effect of Pomiferin on the classical inflammatory pathway by Western blot methods. RESULTS: The results show …
Pomiferin targeting SLC9A9 based on histone acetylation modification pattern is a potential therapeutical option for gastric cancer with high malignancy.
Guang D, Xiaofei Z, Yu M, Hui N, Min S, Xiaonan S. Guang D, et al. Biochem Pharmacol. 2024 Aug;226:116333. doi: 10.1016/j.bcp.2024.116333. Epub 2024 May 31. Biochem Pharmacol. 2024. PMID: 38824966
Changes in histone acetylation status are associated with gastric cancer (GC) progression. Pomiferin is a natural flavonoid, however, the specific role of pomiferin in the treatment of GC is still unclear, and its targets are not well clarified. ...SLC9A9 expression …
Changes in histone acetylation status are associated with gastric cancer (GC) progression. Pomiferin is a natural flavonoid, however, …
Pomiferin Induces Antiproliferative and Pro-Death Effects in High-Risk Neuroblastoma Cells by Modulating Multiple Cell Death Pathways.
Gnanamony M, Thomas M, Nguyen TH, Brownstein K, de Alarcon PA. Gnanamony M, et al. Int J Mol Sci. 2025 Apr 11;26(8):3600. doi: 10.3390/ijms26083600. Int J Mol Sci. 2025. PMID: 40332068 Free PMC article.
In this study, we investigated the antiproliferative and cytotoxic potential of osajin and pomiferin in NB cell lines. Both compounds reduced proliferation and induced cytotoxicity, with pomiferin showing a lower IC50 than osajin. ...Pomiferin induced ferropt …
In this study, we investigated the antiproliferative and cytotoxic potential of osajin and pomiferin in NB cell lines. Both compounds …
Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.
Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B. Bajer MM, et al. Biochem Pharmacol. 2014 Apr 1;88(3):313-21. doi: 10.1016/j.bcp.2014.01.034. Epub 2014 Feb 7. Biochem Pharmacol. 2014. PMID: 24513322 Free PMC article.
Mechanistically, pomiferin triacetate appeared as a general inhibitor of the PI3K-Akt-mTOR-p70(S6K) cascade. ...As a consequence of the mTOR inhibition, pomiferin triacetate efficiently attenuated translation. In summary, pomiferin triacetate emerged as a nov …
Mechanistically, pomiferin triacetate appeared as a general inhibitor of the PI3K-Akt-mTOR-p70(S6K) cascade. ...As a consequence of t …
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague-Dawley rats; action mechanisms and signaling pathways.
Yildiz Deniz G, Geyikoglu F, Altun S. Yildiz Deniz G, et al. Toxicol Mech Methods. 2024 Jun;34(5):484-494. doi: 10.1080/15376516.2023.2301667. Epub 2024 Jan 15. Toxicol Mech Methods. 2024. PMID: 38223921
Pomiferin was given orally once a day at different doses (75, 150, and 300 mg/kg) for 20 d after exposure to NiCl(2). ...Pomiferin seems to counteract the deleterious effects of NiCl(2) on hepatic tissue through different cellular and signaling mechanisms. ...
Pomiferin was given orally once a day at different doses (75, 150, and 300 mg/kg) for 20 d after exposure to NiCl(2). ...Pomiferin …
Attenuation of the Severity of Acute Respiratory Distress Syndrome by Pomiferin through Blocking Inflammation and Oxidative Stress in an AKT/Foxo1 Pathway-Dependent Manner.
Tang Z, Yang Z, Feng H, Zhou X, Mao M. Tang Z, et al. Oxid Med Cell Longev. 2022 Nov 26;2022:5236908. doi: 10.1155/2022/5236908. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36471865 Free PMC article.
Meanwhile, pomiferin treatment also inhibited LPS-induced inflammation as well as oxidative stress in lung tissues. LPS stimulation significantly activated AKT/Foxo1 signal pathway in lung tissues, which could be reversed after pomiferin treatment. In vitro experime …
Meanwhile, pomiferin treatment also inhibited LPS-induced inflammation as well as oxidative stress in lung tissues. LPS stimulation s …
In vitro and ex vivo examination of topical Pomiferin treatments.
Gruber JV, Holtz R, Sikkink SK, Tobin DJ. Gruber JV, et al. Fitoterapia. 2014 Apr;94:164-71. doi: 10.1016/j.fitote.2014.01.023. Epub 2014 Feb 8. Fitoterapia. 2014. PMID: 24513505 Free article.
Pomiferin is a unique, prenylated isoflavonoid that can be isolated and purified from the fruits of Maclura pomifera (Osage Orange). The molecule typically is isolated with a small amount of a molecule called Osajin which is structurally similar to Pomiferin but lac …
Pomiferin is a unique, prenylated isoflavonoid that can be isolated and purified from the fruits of Maclura pomifera (Osage Orange). …
Antiproliferative activity of pomiferin in normal (MCF-10A) and transformed (MCF-7) breast epithelial cells.
Yang R, Hanwell H, Zhang J, Tsao R, Meckling KA. Yang R, et al. J Agric Food Chem. 2011 Dec 28;59(24):13328-36. doi: 10.1021/jf202898g. Epub 2011 Nov 29. J Agric Food Chem. 2011. PMID: 22087557
Pomiferin and osajin are prenylated isoflavones from Osage orange fruit that both have potent antioxidant activity in a variety of assays. Pomiferin, in particular, has strong activity against the superoxide anion in a photochemiluminescence (PCL) assay system. ...
Pomiferin and osajin are prenylated isoflavones from Osage orange fruit that both have potent antioxidant activity in a variety of as …
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