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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 4
2003 1
2004 1
2006 2
2009 3
2013 1
2014 2
2017 1
2019 3
2020 3
2021 6
2022 6
2023 4
2024 5
2025 2
2026 2

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43 results

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Page 1
Modulation of MAPK ERK1 and ERK2 in VDR-positive and -negative breast cancer cell lines.
Cordes T, Diesing D, Becker S, Diedrich K, Reichrath J, Friedrich M. Cordes T, et al. Anticancer Res. 2006 Jul-Aug;26(4A):2749-53. Anticancer Res. 2006. PMID: 16886687 Free article.
The effects of calcitriol were measured by semi-quantitative Western blotting. Calcitriol stimulated the MAP-kinases ERK1 and ERK2. A biphasic activation was found for calcitriol in VDR-positive cells after incubation for 5 to 20 min and from 2 to 24 h. Howev …
The effects of calcitriol were measured by semi-quantitative Western blotting. Calcitriol stimulated the MAP-kinases ERK1 and ERK2 …
Down Regulation of EGF and AZGP1 Were Associated with Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps: An Observation Study.
Jin P, Zhang Q, Zang Y, Zhao L, Zhang H, Yu K, Liang X, Zi X, Shi L. Jin P, et al. J Inflamm Res. 2023 Oct 28;16:4885-4898. doi: 10.2147/JIR.S428238. eCollection 2023. J Inflamm Res. 2023. PMID: 37920240 Free PMC article.
RESULTS: Sixty-eight co-DEGs including 8 upregulated and 60 downregulated genes were identified and GO analyses identified the terms including positive regulation of ERK1 and ERK2 cascade, transforming growth factor beta receptor signaling pathw …
RESULTS: Sixty-eight co-DEGs including 8 upregulated and 60 downregulated genes were identified and GO analyses identified the terms includi …
The Evolving Role of TRAFs in Mediating Inflammatory Responses.
Dhillon B, Aleithan F, Abdul-Sater Z, Abdul-Sater AA. Dhillon B, et al. Front Immunol. 2019 Feb 4;10:104. doi: 10.3389/fimmu.2019.00104. eCollection 2019. Front Immunol. 2019. PMID: 30778351 Free PMC article. Review.
The biological role of TRAFs is largely due to their ability to positively or negatively regulate canonical and non-canonical NF-kappaB signaling. While TRAF-mediated signaling regulates various immune cell functions, this review is focused on the recent adva …
The biological role of TRAFs is largely due to their ability to positively or negatively regulate canonical and non-canonical …
Stromal transcriptomics uncover LIF as a key effector in high tumor budding triple-negative breast cancer.
Phankeaw P, Khanaruksombat S, Numprasit W, Jamjuntra P, Augsornworawat P, Warnnissorn M, Thuwajit P, Thuwajit C. Phankeaw P, et al. Sci Rep. 2025 Nov 25;15(1):45309. doi: 10.1038/s41598-025-28439-y. Sci Rep. 2025. PMID: 41290930 Free PMC article.
High TB was observed in 46.5% of TNBC patients and significantly associated with shorter OS, in which the upregulated MAPK cascade, ERK1/ERK2 signaling, and protein kinase B regulation signaling pathways were involved. In FAP-positive CAFs, path …
High TB was observed in 46.5% of TNBC patients and significantly associated with shorter OS, in which the upregulated MAPK cascade, …
Comprehensive Landscape of Immune Infiltration and Aberrant Pathway Activation in Ischemic Stroke.
Liu R, Song P, Gu X, Liang W, Sun W, Hua Q, Zhang Y, Qiu Z. Liu R, et al. Front Immunol. 2022 Jan 24;12:766724. doi: 10.3389/fimmu.2021.766724. eCollection 2021. Front Immunol. 2022. PMID: 35140708 Free PMC article.
GSEA showed that the IS-24h group had significantly increased inflammation-related pathway activity(myeloid leukocyte activation, positive regulation of tumor necrosis factor biosynthetic process, myeloid leukocyte migration and leukocyte chemotaxis), platelet-relat …
GSEA showed that the IS-24h group had significantly increased inflammation-related pathway activity(myeloid leukocyte activation, positiv …
A functional role of mitogen-activated protein kinases, erk1 and erk2, in the differentiation of a human leukemia cell line, UT-7/GM: a possible key factor for cell fate determination toward erythroid and megakaryocytic lineages.
Uchida M, Kirito K, Shimizu R, Miura Y, Ozawa K, Komatsu N. Uchida M, et al. Int J Hematol. 2001 Jan;73(1):78-83. doi: 10.1007/BF02981906. Int J Hematol. 2001. PMID: 11372759
The mitogen-activated protein (MAP) kinase cascade is a key regulator of mammalian cell proliferation and differentiation. In this study, we examined the roles of 2 members of the MAP kinase family, extracellular signal-regulated kinase 1 (Erk1) and …
The mitogen-activated protein (MAP) kinase cascade is a key regulator of mammalian cell proliferation and differentiation. In …
Exploring the mechanism of Danggui Sini Decoction in the treatment of myocardial infarction: A systematic review, network pharmacology, and molecular docking.
Li Z, Liu S, Zhang R, Li B. Li Z, et al. Medicine (Baltimore). 2024 Oct 18;103(42):e40073. doi: 10.1097/MD.0000000000040073. Medicine (Baltimore). 2024. PMID: 39432628 Free PMC article.
Gene ontology and Kyoto encyclopedia of gene and genome analyses revealed that DSD treatment of MI mainly involves the positive regulation of the ERK1 and ERK2 cascades, positive regulation of cell proliferation, inflammatory respo …
Gene ontology and Kyoto encyclopedia of gene and genome analyses revealed that DSD treatment of MI mainly involves the positive re …
Ulk1 regulates T cell development and response to Listeria monocytogenes stimulation.
Xu Y, Wang Z, Deng J, Li S, Gao L, Liu G, Chen G. Xu Y, et al. J Leukoc Biol. 2024 Dec 31;117(1):qiae183. doi: 10.1093/jleuko/qiae183. J Leukoc Biol. 2024. PMID: 39183699
Our research revealed a key role for a protein called ULK1, a serine/threonine protein kinase, in regulating T-cell development and function. During T-cell maturation, the absence of Ulk1 (as in Ulk1-/- mice) leads to an increase in a cell type called DN3 in the thymus. .. …
Our research revealed a key role for a protein called ULK1, a serine/threonine protein kinase, in regulating T-cell development and f …
Revealing the genetic basis of eyelid pigmentation in Hereford cattle.
Jara E, Peñagaricano F, Armstrong E, Ciappesoni G, Iriarte A, Navajas EA. Jara E, et al. J Anim Sci. 2022 May 1;100(5):skac110. doi: 10.1093/jas/skac110. J Anim Sci. 2022. PMID: 35390123 Free PMC article.
The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. ...
The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melan …
Total ERK1/2 activity regulates cell proliferation.
Lefloch R, Pouysségur J, Lenormand P. Lefloch R, et al. Cell Cycle. 2009 Mar 1;8(5):705-11. doi: 10.4161/cc.8.5.7734. Epub 2009 Mar 29. Cell Cycle. 2009. PMID: 19242111
By combining single and double silencings of ERK1 and ERK2 we recently demonstrated that the apparent dominant role of ERK2 to regulate cell proliferation was due to its markedly higher expression level than ERK1. ...After integrating signals fr …
By combining single and double silencings of ERK1 and ERK2 we recently demonstrated that the apparent dominant role of ERK2 …
43 results