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Did you mean positive regulation of mapk cascades (650 results)?
Understanding MAPK Signaling Pathways in Apoptosis.
Yue J, López JM. Yue J, et al. Int J Mol Sci. 2020 Mar 28;21(7):2346. doi: 10.3390/ijms21072346. Int J Mol Sci. 2020. PMID: 32231094 Free PMC article. Review.
MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. ...As we will see, apoptosis is plagued with multiple positive feedback loops. We hope this review will h …
MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through mu …
AP-1 as a regulator of cell life and death.
Shaulian E, Karin M. Shaulian E, et al. Nat Cell Biol. 2002 May;4(5):E131-6. doi: 10.1038/ncb0502-e131. Nat Cell Biol. 2002. PMID: 11988758 Review.
Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse …
Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positiv …
A novel OsCRK14-OsRLCK57-MAPK signaling module activates OsbZIP66 to confer drought resistance in rice.
Ye T, Wang H, Zhang L, Li X, Tu H, Guo Z, Gao T, Zhang Y, Ye Y, Li B, Yang W, Li Y, Lai X, Dong F, Xiong H, Xiong L. Ye T, et al. Mol Plant. 2025 Aug 4;18(8):1390-1408. doi: 10.1016/j.molp.2025.07.011. Epub 2025 Jul 16. Mol Plant. 2025. PMID: 40676839
In this study, we identified a CRK, OsCRK14, as a key positive regulator of drought resistance in rice. We demonstrated that plasma membrane-localized OsCRK14 phosphorylates the receptor-like cytoplasmic kinase OsRLCK57 under drought stress, leading to activa …
In this study, we identified a CRK, OsCRK14, as a key positive regulator of drought resistance in rice. We demonstrated that p …
The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host.
Guo Z, Kang S, Wu Q, Wang S, Crickmore N, Zhou X, Bravo A, Soberón M, Zhang Y. Guo Z, et al. PLoS Pathog. 2021 Sep 8;17(9):e1009917. doi: 10.1371/journal.ppat.1009917. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34495986 Free PMC article.
Host-pathogen interactions are central components of ecological networks where the MAPK signaling pathways act as central hubs of these complex interactions. We have previously shown that an insect hormone modulated MAPK signaling cascade partic …
Host-pathogen interactions are central components of ecological networks where the MAPK signaling pathways act as central hubs …
NF-Y in invertebrates.
Yamaguchi M, Ali MS, Yoshioka Y, Ly LL, Yoshida H. Yamaguchi M, et al. Biochim Biophys Acta Gene Regul Mech. 2017 May;1860(5):630-635. doi: 10.1016/j.bbagrm.2016.10.008. Epub 2016 Oct 26. Biochim Biophys Acta Gene Regul Mech. 2017. PMID: 27793714 Review.
Studies with eye imaginal disc-specific dNF-Y-knockdown flies revealed that dNF-Y positively regulates the sevenless gene encoding a receptor tyrosine kinase, a component of the ERK pathway and negatively regulates the Sensless gene encoding a transcri …
Studies with eye imaginal disc-specific dNF-Y-knockdown flies revealed that dNF-Y positively regulates the sevenless gene enco …
G protein regulation of MAPK networks.
Goldsmith ZG, Dhanasekaran DN. Goldsmith ZG, et al. Oncogene. 2007 May 14;26(22):3122-42. doi: 10.1038/sj.onc.1210407. Oncogene. 2007. PMID: 17496911 Review.
G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and are critically involved in the regulation of different mitogen-activated protein kinase (MAPK) networks. The four classes of G proteins, defined by the G(s), G(i), G(q) a …
G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and are critically involved in the regulation of …
ERK1/2-RSK regulation of oestrogen homeostasis.
Wright EB, Lannigan DA. Wright EB, et al. FEBS J. 2023 Apr;290(8):1943-1953. doi: 10.1111/febs.16407. Epub 2022 Feb 28. FEBS J. 2023. PMID: 35176205 Free PMC article. Review.
ERK1/2 and its downstream effector, p90 ribosomal S6 kinase (RSK), control homeostasis in the mammary gland by limiting oestrogen-mediated ERalpha responsiveness. ERK1/2 drives degradation coupled ERalpha-mediated transcription, whereas RSK2 acts as a negative re …
ERK1/2 and its downstream effector, p90 ribosomal S6 kinase (RSK), control homeostasis in the mammary gland by limiting oestro …
Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans.
Robinson-Thiewes S, Dufour B, Martel PO, Lechasseur X, Brou AAD, Roy V, Chen Y, Kimble J, Narbonne P. Robinson-Thiewes S, et al. Cell Rep. 2021 May 25;35(8):109162. doi: 10.1016/j.celrep.2021.109162. Cell Rep. 2021. PMID: 34038716 Free PMC article.
Extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) is a major positive regulator of cell proliferation, which is often upregulated in cancer. However, few studies have addressed ERK/MAPK regulati …
Extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) is a major positive …
Activation of P38 MAPK Signaling Cascade is Linked with Clinical Outcomes and Therapeutic Responses in Human Cancers.
Emelyanova A, Zolotovskaia M, Poddubskaya E, Modestov A, Buzdin A, Kuzmin D. Emelyanova A, et al. Biochemistry (Mosc). 2024 Dec;89(12):2155-2173. doi: 10.1134/S0006297924120058. Biochemistry (Mosc). 2024. PMID: 39865029
Activation of the p38 mitogen-activated protein kinase (MAPK) pathways is vital in regulating cell growth, differentiation, apoptosis, and stress response, significantly affecting tumorigenesis and cancer progression. ...Hence, the p38 pathway activation leve …
Activation of the p38 mitogen-activated protein kinase (MAPK) pathways is vital in regulating cell growth, differentiat …
The atypical MAPK ERK3 controls positive selection of thymocytes.
Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque N. Sirois J, et al. Immunology. 2015 May;145(1):161-9. doi: 10.1111/imm.12433. Immunology. 2015. PMID: 25521218 Free PMC article.
Extracellular signal-regulated kinase 3 (ERK3 )is an atypical member of the mitogen-activated protein kinase (MAPK) family. ...Using a knock-in mouse model in which the coding sequence of ERK3 is replaced by the gene encoding for the beta-galactosidase …
Extracellular signal-regulated kinase 3 (ERK3 )is an atypical member of the mitogen-activated protein kinase (MAPK …
3,026 results