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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 2
1996 2
1997 6
1998 11
1999 9
2000 24
2001 33
2002 39
2003 51
2004 60
2005 59
2006 54
2007 82
2008 83
2009 67
2010 82
2011 75
2012 71
2013 87
2014 95
2015 94
2016 80
2017 80
2018 93
2019 87
2020 65
2021 75
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2025 72
2026 40

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1,622 results

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Page 1
Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity.
Xu K, Yin N, Peng M, Stamatiades EG, Shyu A, Li P, Zhang X, Do MH, Wang Z, Capistrano KJ, Chou C, Levine AG, Rudensky AY, Li MO. Xu K, et al. Science. 2021 Jan 22;371(6527):405-410. doi: 10.1126/science.abb2683. Science. 2021. PMID: 33479154 Free PMC article.
Thus, nutrient metabolism and growth factor signaling are highly integrated processes, with glycolytic ATP serving as a rheostat to gauge PI3K-Akt-Foxo1 signaling in the control of T cell immunity. Such a bioenergetic mechanism for the regulation of …
Thus, nutrient metabolism and growth factor signaling are highly integrated processes, with glycolytic ATP serving as a rheostat to g …
KRAS Mutation Subtypes and Their Association with Other Driver Mutations in Oncogenic Pathways.
Mondal K, Posa MK, Shenoy RP, Roychoudhury S. Mondal K, et al. Cells. 2024 Jul 19;13(14):1221. doi: 10.3390/cells13141221. Cells. 2024. PMID: 39056802 Free PMC article. Review.
The KRAS mutation stands out as one of the most influential oncogenic mutations, which directly regulates the hallmark features of cancer and interacts with other cancer-causing driver mutations. ...We also noticed similar observations in the case of PIK3CA and APC mutatio …
The KRAS mutation stands out as one of the most influential oncogenic mutations, which directly regulates the hallmark features of ca …
Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics.
Nascimbeni AC, Codogno P, Morel E. Nascimbeni AC, et al. FEBS J. 2017 May;284(9):1267-1278. doi: 10.1111/febs.13987. Epub 2017 Jan 5. FEBS J. 2017. PMID: 27973739 Free article. Review.
Phosphatidylinositol-3-phosphate (PI3P) is a key player in membrane dynamics and trafficking regulation. ...The enzyme responsible for most PI3P synthesis, VPS34 and proteins such as Beclin1 and ATG14L that regulate PI3P levels are positive modulators …
Phosphatidylinositol-3-phosphate (PI3P) is a key player in membrane dynamics and trafficking regulation. ...The enzyme respons …
Induction of macrophage efferocytosis in pancreatic cancer via PI3Kgamma inhibition and radiotherapy promotes tumour control.
Russell SN, Demetriou C, Valenzano G, Evans A, Go S, Stanly T, Hazini A, Willenbrock F, Gordon-Weeks AN, Mukherjee S, Tesson M, Morton JP, O'Neill E, Jones KI. Russell SN, et al. Gut. 2025 Apr 7;74(5):825-839. doi: 10.1136/gutjnl-2024-333492. Gut. 2025. PMID: 39788719 Free PMC article.
BACKGROUND: The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogr …
BACKGROUND: The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implic …
Dapagliflozin mitigates cellular stress and inflammation through PI3K/AKT pathway modulation in cardiomyocytes, aortic endothelial cells, and stem cell-derived β cells.
Alsereidi FR, Khashim Z, Marzook H, Al-Rawi AM, Salomon T, Almansoori MK, Madkour MM, Hamam AM, Ramadan MM, Peterson QP, Saleh MA. Alsereidi FR, et al. Cardiovasc Diabetol. 2024 Oct 29;23(1):388. doi: 10.1186/s12933-024-02481-y. Cardiovasc Diabetol. 2024. PMID: 39472869 Free PMC article.
In aortic endothelial cells (AECs), DAPA exhibited notable anti-inflammatory properties by restoring AKT and phosphoinositide 3-kinase (PI3K) expression, enhancing mitogen-activated protein kinase (MAPK) activation, and downregulating inflammatory cytokines at both …
In aortic endothelial cells (AECs), DAPA exhibited notable anti-inflammatory properties by restoring AKT and phosphoinositide 3-ki …
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.
Chagpar RB, Links PH, Pastor MC, Furber LA, Hawrysh AD, Chamberlain MD, Anderson DH. Chagpar RB, et al. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5471-6. doi: 10.1073/pnas.0908899107. Epub 2010 Mar 8. Proc Natl Acad Sci U S A. 2010. PMID: 20212113 Free PMC article.
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in many human diseases including cancer, diabetes, obesity, and autoimmunity. ...The p110-PI3K enzyme generates the key signaling lipid phosphatidylinositol 3,4,5-t …
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in many human diseases including cance …
Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway.
Zhang ZY, Yang ZH, Wang S, Feng SL, Wang XL, Mao JY. Zhang ZY, et al. J Ethnopharmacol. 2024 Aug 10;330:118264. doi: 10.1016/j.jep.2024.118264. Epub 2024 Apr 29. J Ethnopharmacol. 2024. PMID: 38692417
Finally, we detected the positive expression of apoptosis and ferroptosis markers and core indicators of signaling pathways by immunohistochemistry; detected the mean fluorescence intensity of core indicators of signaling pathways by immunofluorescence; detec …
Finally, we detected the positive expression of apoptosis and ferroptosis markers and core indicators of signaling pathways by …
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, Brohl AS, Sindiri S, Catchpoole D, Badgett T, Getz G, Mora J, Anderson JR, Skapek SX, Barr FG, Meyerson M, Hawkins DS, Khan J. Shern JF, et al. Cancer Discov. 2014 Feb;4(2):216-31. doi: 10.1158/2159-8290.CD-13-0639. Epub 2014 Jan 23. Cancer Discov. 2014. PMID: 24436047 Free PMC article.
Two genotypes are evident in rhabdomyosarcoma tumors: those characterized by the PAX3 or PAX7 fusion and those that lack these fusions but harbor mutations in key signaling pathways. The overall burden of somatic mutations in rhabdomyosarcoma is relatively low, especially …
Two genotypes are evident in rhabdomyosarcoma tumors: those characterized by the PAX3 or PAX7 fusion and those that lack these fusions but h …
Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling.
Omori SA, Cato MH, Anzelon-Mills A, Puri KD, Shapiro-Shelef M, Calame K, Rickert RC. Omori SA, et al. Immunity. 2006 Oct;25(4):545-57. doi: 10.1016/j.immuni.2006.08.015. Epub 2006 Sep 28. Immunity. 2006. PMID: 17000121 Free article.
Class-switch recombination (CSR) is essential for humoral immunity. However, the regulation of CSR is not completely understood. Here we demonstrate that phosphatidylinositol 3-kinase (PI3K) actively suppressed the onset and frequency of CSR in primary …
Class-switch recombination (CSR) is essential for humoral immunity. However, the regulation of CSR is not completely understood. Here …
Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
Hartmann W, Küchler J, Koch A, Friedrichs N, Waha A, Endl E, Czerwitzki J, Metzger D, Steiner S, Wurst P, Leuschner I, von Schweinitz D, Buettner R, Pietsch T. Hartmann W, et al. Clin Cancer Res. 2009 Jul 15;15(14):4538-45. doi: 10.1158/1078-0432.CCR-08-2878. Epub 2009 Jul 7. Clin Cancer Res. 2009. PMID: 19584164
PURPOSE: Hepatoblastoma represents the most frequent malignant liver tumor in childhood. The phosphatidylinositol-3'-kinase (PI3K)/AKT pathway is crucial in downstream signaling of multiple receptor tyrosine kinases of pathogenic importance in hepatobl …
PURPOSE: Hepatoblastoma represents the most frequent malignant liver tumor in childhood. The phosphatidylinositol-3'-kinase …
1,622 results