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Year Number of Results
1998 1
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2007 16
2008 20
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2011 13
2012 12
2013 12
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246 results

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Page 1
Diverse functions of cytochrome c in cell death and disease.
Zhou Z, Arroum T, Luo X, Kang R, Lee YJ, Tang D, Hüttemann M, Song X. Zhou Z, et al. Cell Death Differ. 2024 Apr;31(4):387-404. doi: 10.1038/s41418-024-01284-8. Epub 2024 Mar 23. Cell Death Differ. 2024. PMID: 38521844 Free PMC article. Review.
The redox-active protein cytochrome c is a highly positively charged hemoglobin that regulates cell fate decisions of life and death. ...In the mitochondria, cytochrome c acts as an electron carrier in the electron transport chain, …
The redox-active protein cytochrome c is a highly positively charged hemoglobin that regulates cell fate decisio …
Novel role of COX6c in the regulation of oxidative phosphorylation and diseases.
Wang C, Lv J, Xue C, Li J, Liu Y, Xu D, Jiang Y, Jiang S, Zhu M, Yang Y, Zhang S. Wang C, et al. Cell Death Discov. 2022 Jul 25;8(1):336. doi: 10.1038/s41420-022-01130-1. Cell Death Discov. 2022. PMID: 35879322 Free PMC article. Review.
Cytochrome c oxidase subunit VIc (COX6c) is one of the most important subunits of the terminal enzyme of the respiratory chain in mitochondria. Numerous studies have demonstrated that COX6c plays a critical role in the regulation of oxidative phosphory …
Cytochrome c oxidase subunit VIc (COX6c) is one of the most important subunits of the terminal enzyme of the respiratory chain …
Mitochondrial nicotinic acetylcholine receptors: Mechanisms of functioning and biological significance.
Skok M. Skok M. Int J Biochem Cell Biol. 2022 Feb;143:106138. doi: 10.1016/j.biocel.2021.106138. Epub 2021 Dec 17. Int J Biochem Cell Biol. 2022. PMID: 34929396 Review.
Nicotinic acetylcholine receptors mediate fast synaptic transmission in neuro-muscular junctions and autonomic ganglia and modulate survival, proliferation and neurotransmitter or cytokine release in the brain and non-excitable cells. The neuronal-type nicotinic acetylchol …
Nicotinic acetylcholine receptors mediate fast synaptic transmission in neuro-muscular junctions and autonomic ganglia and modulate survival …
Afferent regulation of cytochrome-c and active caspase-9 in the avian cochlear nucleus.
Wilkinson BL, Elam JS, Fadool DA, Hyson RL. Wilkinson BL, et al. Neuroscience. 2003;120(4):1071-9. doi: 10.1016/s0306-4522(03)00387-7. Neuroscience. 2003. PMID: 12927212 Free PMC article.
In the present series of experiments, the potential extrusion of cytochrome-c from the mitochondria into the cytosol, and the activation of caspases were examined in the NM following deafferentation. ...This suggests that the increased immunoreactivity of …
In the present series of experiments, the potential extrusion of cytochrome-c from the mitochondria into the cytosol, a …
Neural stem cells and cell death.
Ceccatelli S, Tamm C, Sleeper E, Orrenius S. Ceccatelli S, et al. Toxicol Lett. 2004 Apr 1;149(1-3):59-66. doi: 10.1016/j.toxlet.2003.12.060. Toxicol Lett. 2004. PMID: 15093249 Review.
Exposed cells demonstrate an apoptotic morphology, positive TUNEL staining and phosphatidyl serine exposure as labeled with Annexin V. Using an antibody specific for cytochrome c, we found that cells exposed to staurosporine or DMNQ exhibited diffuse fluoresc …
Exposed cells demonstrate an apoptotic morphology, positive TUNEL staining and phosphatidyl serine exposure as labeled with Annexin V …
Cisplatin-mediated c-myc overexpression and cytochrome c (cyt c) release result in the up-regulation of the death receptors DR4 and DR5 and the activation of caspase 3 and caspase 9, likely responsible for the TRAIL-sensitizing effect of cisplatin.
Zhu X, Zhang K, Wang Q, Chen S, Gou Y, Cui Y, Li Q. Zhu X, et al. Med Oncol. 2015 Apr;32(4):133. doi: 10.1007/s12032-015-0588-9. Epub 2015 Mar 22. Med Oncol. 2015. PMID: 25796504
To study the synergistic effects of cisplatin and TRAIL, we investigated the mechanism by which TRAIL reverses multidrug resistance, the role of c-myc in modulating the death receptors DR4 and DR5 and the relationship between cisplatin and cytochrome c (cyt c) re …
To study the synergistic effects of cisplatin and TRAIL, we investigated the mechanism by which TRAIL reverses multidrug resistance, the rol …
Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Kudo T, Nakazawa D, Watanabe-Kusunoki K, Kanda M, Shiratori-Aso S, Abe N, Nishio S, Koga JI, Iwasaki S, Tsuji T, Fukasawa Y, Yamasaki M, Watanabe M, Masuda S, Tomaru U, Murakami M, Aratani Y, Ishizu A, Atsumi T. Kudo T, et al. Arthritis Rheumatol. 2023 Jan;75(1):71-83. doi: 10.1002/art.42314. Epub 2022 Nov 25. Arthritis Rheumatol. 2023. PMID: 35905194
RESULTS: In vitro experiments showed that pharmacologic and genetic inhibition of CypD suppressed ANCA-induced NET formation via the suppression of reactive oxygen species and cytochrome c release from the mitochondria. RNA-sequencing analyses in ANCA- …
RESULTS: In vitro experiments showed that pharmacologic and genetic inhibition of CypD suppressed ANCA-induced NET formation via the suppres …
Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism.
Jang BC, Choi ES, Im KJ, Baek WK, Kwon TK, Suh MH, Kim SP, Park JW, Suh SI. Jang BC, et al. Int J Mol Med. 2003 Nov;12(5):733-9. Int J Mol Med. 2003. PMID: 14533002
Se-MSC increased time- and dose-dependent cytochrome c accumulation in the cytosol, which was greatly inhibited by overexpression of Bcl-2, suggesting that the apoptotic effect by Se-MSC in U937 cells is mitochondrial-dependent. ...Together, our data suggest the apo …
Se-MSC increased time- and dose-dependent cytochrome c accumulation in the cytosol, which was greatly inhibited by overexpress …
Mechanisms controlling cellular suicide: role of Bcl-2 and caspases.
Allen RT, Cluck MW, Agrawal DK. Allen RT, et al. Cell Mol Life Sci. 1998 May;54(5):427-45. doi: 10.1007/s000180050171. Cell Mol Life Sci. 1998. PMID: 9645223 Free PMC article. Review.
In this article, we present up-to-date information and recent discoveries regarding biochemical functions of Bcl-2 family proteins, positive and negative interactions between these proteins, and their modification and regulation by either proteolytic cleavage or by …
In this article, we present up-to-date information and recent discoveries regarding biochemical functions of Bcl-2 family proteins, posit …
p38alpha and p38beta regulate osmostress-induced apoptosis.
Ben Messaoud N, López JM. Ben Messaoud N, et al. J Biol Chem. 2025 Jan;301(1):108061. doi: 10.1016/j.jbc.2024.108061. Epub 2024 Dec 7. J Biol Chem. 2025. PMID: 39653241 Free PMC article.
Hyperosmotic shock induces cytochrome c release and caspase-3 activation in Xenopus oocytes. Different signaling pathways engaged by osmostress converge on the mitochondria to trigger cell death. ...We find that p38alpha, p38beta, and p38gamma are earl …
Hyperosmotic shock induces cytochrome c release and caspase-3 activation in Xenopus oocytes. Different signaling pathwa …
246 results