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Page 1
Septin and actin contributions to endothelial cell-cell junctions and monolayer integrity.
Kim J, Mooren OL, Onken MD, Cooper JA. Kim J, et al. Cytoskeleton (Hoboken). 2023 Jul-Aug;80(7-8):228-241. doi: 10.1002/cm.21732. Epub 2022 Oct 17. Cytoskeleton (Hoboken). 2023. PMID: 36205643 Free PMC article. Review.
Endothelial monolayer disruption from loss of septins is also associated with decreased transendothelial electric resistance (TEER) and increased levels of transendothelial migration (TEM) by immune and cancer cells, owing to the gaps in the monolayer. A current working model is …
Endothelial monolayer disruption from loss of septins is also associated with decreased transendothelial electric resistance (TEER) and incr …
The Effect of the Nanoparticle Shape on T Cell Activation.
Oh J, Xia X, Wong WKR, Wong SHD, Yuan W, Wang H, Lai CHN, Tian Y, Ho YP, Zhang H, Zhang Y, Li G, Lin Y, Bian L. Oh J, et al. Small. 2022 Sep;18(36):e2107373. doi: 10.1002/smll.202107373. Epub 2022 Mar 16. Small. 2022. PMID: 35297179
High membrane tension observed in large AR AuNRs regulates actin filament and focal adhesion assembly and develops maturation-related morphological features in T cells such as membrane ruffle formation, cell spreading, and large T cell receptor (TCR) cluster …
High membrane tension observed in large AR AuNRs regulates actin filament and focal adhesion assembly and develops maturation- …
Rai14 is a novel interactor of Invariant chain that regulates macropinocytosis.
Lobos Patorniti N, Zulkefli KL, McAdam ME, Vargas P, Bakke O, Progida C. Lobos Patorniti N, et al. Front Immunol. 2023 Jul 21;14:1182180. doi: 10.3389/fimmu.2023.1182180. eCollection 2023. Front Immunol. 2023. PMID: 37545539 Free PMC article.
In line with this, we found that Rai14 localizes to membrane ruffles, where it forms macropinosomes. Depletion of Rai14 in antigen-presenting cells delays MHC II internalization, affecting macropinocytic activity. Intriguingly, we demonstrated that, similar to Ii, Rai14 is …
In line with this, we found that Rai14 localizes to membrane ruffles, where it forms macropinosomes. Depletion of Rai14 in antigen-pr …
Gene expression analysis for pneumonia caused by Gram-positive bacterial infection.
Jia R, Yang J, Cui Y, Guo D, Li T. Jia R, et al. Exp Ther Med. 2018 Apr;15(4):3989-3996. doi: 10.3892/etm.2018.5904. Epub 2018 Feb 28. Exp Ther Med. 2018. PMID: 29581747 Free PMC article.
Gram-positive bacteria are an important pathogenic factor for bacterial pneumonia. The aim of the present study was to identify the differentially expressed genes (DEGs) and to explore their associated pathways or expression patterns. ...In the GO category cellular compone …
Gram-positive bacteria are an important pathogenic factor for bacterial pneumonia. The aim of the present study was to identify the d …
Abi1 is essential for the formation and activation of a WAVE2 signalling complex.
Innocenti M, Zucconi A, Disanza A, Frittoli E, Areces LB, Steffen A, Stradal TE, Di Fiore PP, Carlier MF, Scita G. Innocenti M, et al. Nat Cell Biol. 2004 Apr;6(4):319-27. doi: 10.1038/ncb1105. Epub 2004 Mar 28. Nat Cell Biol. 2004. PMID: 15048123
Instead, it forms macromolecular complexes that have been reported to exert both positive and negative modes of regulation. How these complexes are assembled, localized and activated in vivo remains to be established. ...Abi1 interacts directly with the WHD domain o …
Instead, it forms macromolecular complexes that have been reported to exert both positive and negative modes of regulation. Ho …
Drebrin particles: components in the ensemble of proteins regulating actin dynamics of lamellipodia and filopodia.
Peitsch WK, Hofmann I, Prätzel S, Grund C, Kuhn C, Moll I, Langbein L, Franke WW. Peitsch WK, et al. Eur J Cell Biol. 2001 Sep;80(9):567-79. doi: 10.1078/0171-9335-00194. Eur J Cell Biol. 2001. PMID: 11675932
By immunofluorescence and immunoelectron microscopy, drebrin-positive material often appeared as "granules" up to 400 nm in diameter, in some cell types clustered near the Golgi apparatus or in lamellipodia, particularly at leading edges, or in dense-packed submembranous m …
By immunofluorescence and immunoelectron microscopy, drebrin-positive material often appeared as "granules" up to 400 nm in diameter, …
E-cadherin-driven adherens junction reinforcement promotes spheroid-mediated invasion and progression in ALK-rearranged lung cancer chemoresistance.
Hong D, Kwon HJ, Jeong J, Yoon S, Chung JH, Jeong S. Hong D, et al. Mol Cells. 2026 Apr;49(4):100329. doi: 10.1016/j.mocell.2026.100329. Epub 2026 Feb 10. Mol Cells. 2026. PMID: 41679471 Free PMC article.
This was accompanied by pronounced cytoskeleton-associated remodeling, characterized by enrichment of gene sets related to ruffle assembly, tissue morphogenesis, and the positive regulation of cell motility. Knockdown of E-cadherin disrupted spheroid a …
This was accompanied by pronounced cytoskeleton-associated remodeling, characterized by enrichment of gene sets related to ruffle …
Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes.
Rescher U, Ruhe D, Ludwig C, Zobiack N, Gerke V. Rescher U, et al. J Cell Sci. 2004 Jul 15;117(Pt 16):3473-80. doi: 10.1242/jcs.01208. Epub 2004 Jun 29. J Cell Sci. 2004. PMID: 15226372
Annexin 2 is a Ca(2+)-regulated membrane protein and an F-actin-binding protein enriched at actin assembly sites both, on the plasma membrane and on endosomal vesicles. ...Thus, the direct interaction of annexin 2 with PtdIns(4,5)P(2) is a means of specifically recr …
Annexin 2 is a Ca(2+)-regulated membrane protein and an F-actin-binding protein enriched at actin assembly sites both, on the …