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1,545 results

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Page 1
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.
Liu Y, Flamier A, Bell GW, Diao AJ, Whitfield TW, Wang HC, Wu Y, Schulte F, Friesen M, Guo R, Mitalipova M, Liu XS, Vos SM, Young RA, Jaenisch R. Liu Y, et al. Neuron. 2024 Jun 19;112(12):1943-1958.e10. doi: 10.1016/j.neuron.2024.04.007. Epub 2024 May 1. Neuron. 2024. PMID: 38697112 Free article.
MECP2 occupies CpG-rich promoter-proximal regions in over four thousand genes in human neurons, including a plethora of autism risk genes, together with RNA polymerase II (RNA Pol II). MECP2 directly interacts with RNA Pol II, and …
MECP2 occupies CpG-rich promoter-proximal regions in over four thousand genes in human neurons, including a plethora of autism risk genes, t …
P-TEFb: The master regulator of transcription elongation.
Fujinaga K, Huang F, Peterlin BM. Fujinaga K, et al. Mol Cell. 2023 Feb 2;83(3):393-403. doi: 10.1016/j.molcel.2022.12.006. Epub 2023 Jan 3. Mol Cell. 2023. PMID: 36599353 Free PMC article. Review.
The positive transcription elongation factor b (P-TEFb) is composed of cyclins T1 or T2 and cyclin-dependent kinase 9 that regulate the elongation phase of transcription by RNA polymerase II. By antagonizing negative elongation fac …
The positive transcription elongation factor b (P-TEFb) is composed of cyclins T1 or T2 and cyclin-dependent kinase 9 that …
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.
Hu S, Peng L, Xu C, Wang Z, Song A, Chen FX. Hu S, et al. Mol Cell. 2021 Nov 4;81(21):4425-4439.e6. doi: 10.1016/j.molcel.2021.08.029. Epub 2021 Sep 16. Mol Cell. 2021. PMID: 34534457 Free article.
Here we utilize a rapid degradation system and reveal crucial functions of SPT5 in maintaining cellular and chromatin RNA polymerase II (Pol II) levels. Rapid SPT5 depletion causes a pronounced reduction of paused Pol II at promoters and enhance …
Here we utilize a rapid degradation system and reveal crucial functions of SPT5 in maintaining cellular and chromatin RNA polymera …
Transcriptional regulation of autophagy by RNA polymerase II.
Lei Y, Huang T, Jiang G, Zhang Y, Liu S, Li H, Lu K. Lei Y, et al. Autophagy. 2023 Jun;19(6):1867-1868. doi: 10.1080/15548627.2022.2138141. Epub 2022 Oct 27. Autophagy. 2023. PMID: 36264778 Free PMC article.
However, how the transcriptional activation of autophagy genes occurs is not well understood. We recently found that in yeast, the RNA polymerase II subunit Rpb9 specifically and efficiently upregulates the transcription of the autophagy gene AT …
However, how the transcriptional activation of autophagy genes occurs is not well understood. We recently found that in yeast, the …
Functional partitioning of transcriptional regulators by patterned charge blocks.
Lyons H, Veettil RT, Pradhan P, Fornero C, De La Cruz N, Ito K, Eppert M, Roeder RG, Sabari BR. Lyons H, et al. Cell. 2023 Jan 19;186(2):327-345.e28. doi: 10.1016/j.cell.2022.12.013. Epub 2023 Jan 4. Cell. 2023. PMID: 36603581 Free PMC article.
Components of transcriptional machinery are selectively partitioned into specific condensates, often mediated by protein disorder, yet we know little about how this specificity is achieved. Here, we show that condensates composed of the intrinsically disordered region (IDR …
Components of transcriptional machinery are selectively partitioned into specific condensates, often mediated by protein disorder, ye …
Transcription attenuation.
Gollnick P, Babitzke P. Gollnick P, et al. Biochim Biophys Acta. 2002 Sep 13;1577(2):240-50. doi: 10.1016/s0167-4781(02)00455-4. Biochim Biophys Acta. 2002. PMID: 12213655 Review.
RNA-binding proteins regulate attenuation, particularly in gram-positive bacteria such as Bacillus subtilis. ...Finally, antisense RNA is involved in mediating transcription attenuation to control copy number of several plasmids....
RNA-binding proteins regulate attenuation, particularly in gram-positive bacteria such as Bacillus subtilis. ...Finally …
Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation.
Versluis P, Graham TGW, Eng V, Ebenezer J, Darzacq X, Zipfel WR, Lis JT. Versluis P, et al. Mol Cell. 2024 Aug 8;84(15):2856-2869.e9. doi: 10.1016/j.molcel.2024.07.009. Mol Cell. 2024. PMID: 39121843 Free PMC article.
RNA polymerase II (RNA Pol II)-mediated transcription is a critical, highly regulated process aided by protein complexes at distinct steps. ...Additionally, we found that PAF1 and Spt6 are only recruited after positive tr …
RNA polymerase II (RNA Pol II)-mediated transcription is a critical, highly regulated proce …
TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome.
Cenik BK, Aoi Y, Iwanaszko M, Howard BC, Morgan MA, Andersen GD, Bartom ET, Shilatifard A. Cenik BK, et al. Mol Cell. 2024 Dec 19;84(24):4929-4944.e8. doi: 10.1016/j.molcel.2024.11.007. Mol Cell. 2024. PMID: 39706164 Free PMC article.
Regulation of gene expression during development and stress response requires the concerted action of transcription factors and chromatin-binding proteins. ...Validating TurboCas at the FOS promoter, we identify proteins recruited upon heat shock, cross-validated vi …
Regulation of gene expression during development and stress response requires the concerted action of transcription factors an …
Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation.
Zhao Y, Sun HL, Li W, Ye C, Dou X, Peng Y, Wu T, Wang P, Ju CW, Liu S, Zhong Y, Dai Q, Pajdzik K, He C. Zhao Y, et al. Nat Commun. 2025 Oct 30;16(1):9595. doi: 10.1038/s41467-025-64668-5. Nat Commun. 2025. PMID: 41168165 Free PMC article.
Whether and how psi may regulate transcription have not been adequately studied. Here, we report that pseudouridine synthase 7 (PUS7) can mediate pseudouridylation of 7SK small nuclear RNA (snRNA), a regulator of RNA polymerase II …
Whether and how psi may regulate transcription have not been adequately studied. Here, we report that pseudouridine synthase 7 …
P-TEFb goes viral.
Zaborowska J, Isa NF, Murphy S. Zaborowska J, et al. Bioessays. 2016 Jul;38 Suppl 1:S75-85. doi: 10.1002/bies.201670912. Bioessays. 2016. PMID: 27417125 Review.
Positive transcription elongation factor b (P-TEFb), which comprises cyclin-dependent kinase 9 (CDK9) kinase and cyclin T subunits, is an essential kinase complex in human cells. Phosphorylation of the negative elongation factors by P-TEFb is required for productive …
Positive transcription elongation factor b (P-TEFb), which comprises cyclin-dependent kinase 9 (CDK9) kinase and cyclin T subu …
1,545 results