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Page 1
Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.
Che X, Ranjan A, Guo C, Zhang K, Goldsmith R, Levine S, Moneghetti KJ, Zhai Y, Ge L, Mishra N, Hornig M, Bateman L, Klimas NG, Montoya JG, Peterson DL, Klein SL, Fiehn O, Komaroff AL, Lipkin WI. Che X, et al. NPJ Metab Health Dis. 2025 Sep 3;3(1):34. doi: 10.1038/s44324-025-00079-w. NPJ Metab Health Dis. 2025. PMID: 40903540 Free PMC article.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ...Our findings may inform development of targeted therapeutic interventions for ME/CFS …
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional …
Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence.
Scheibenbogen C, Wirth KJ. Scheibenbogen C, et al. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13669. doi: 10.1002/jcsm.13669. J Cachexia Sarcopenia Muscle. 2025. PMID: 39727052 Free PMC article. Review.
We try to explain which risk factors and mechanisms are responsible for a subgroup of patients with post COVID syndrome (PCS) to develop ME/CFS (PC-ME/CFS). RESULTS: Mitochondrial dysfunction is a long-held assumption to explain cardinal symptoms of ME/CFS. . …
We try to explain which risk factors and mechanisms are responsible for a subgroup of patients with post COVID syndrome (PCS) to develop ME/ …
ME/CFS and Post-Exertional Malaise among Patients with Long COVID.
Jason LA, Dorri JA. Jason LA, et al. Neurol Int. 2022 Dec 20;15(1):1-11. doi: 10.3390/neurolint15010001. Neurol Int. 2022. PMID: 36648965 Free PMC article.
This study sought to ascertain the prevalence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among a sample of 465 patients with Long COVID. The participants completed three questionnaires: (1) a new questionnaire measuring both the frequency and severity o …
This study sought to ascertain the prevalence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among a sample of 465 pa …
Pain-Related Post-Exertional Malaise in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia: A Systematic Review and Three-Level Meta-Analysis.
Barhorst EE, Boruch AE, Cook DB, Lindheimer JB. Barhorst EE, et al. Pain Med. 2022 May 30;23(6):1144-1157. doi: 10.1093/pm/pnab308. Pain Med. 2022. PMID: 34668532 Free article.
These individuals can experience post-exertional malaise (PEM), a phenomenon in which symptom severity is worsened for 24 hours or longer after physical stress, but the pain-related component of PEM is not well characterized. ...METHODS: Case-control studies …
These individuals can experience post-exertional malaise (PEM), a phenomenon in which symptom severity is worsened for …
Focus on post-exertional malaise when approaching ME/CFS in specialist healthcare improves satisfaction and reduces deterioration.
Wormgoor MEA, Rodenburg SC. Wormgoor MEA, et al. Front Neurol. 2023 Dec 1;14:1247698. doi: 10.3389/fneur.2023.1247698. eCollection 2023. Front Neurol. 2023. PMID: 38107643 Free PMC article.
BACKGROUND: Post-exertional malaise (PEM) is considered a hallmark characteristic of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This may also apply to subgroups of patients with long COVID-induced ME/CFS. However, it is uncerta …
BACKGROUND: Post-exertional malaise (PEM) is considered a hallmark characteristic of myalgic encephalomyelitis/chronic …
ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature.
Komaroff AL, Lipkin WI. Komaroff AL, et al. Front Med (Lausanne). 2023 Jun 2;10:1187163. doi: 10.3389/fmed.2023.1187163. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37342500 Free PMC article. Review.
They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people …
They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional …
Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome.
Haunhorst S, Dudziak D, Scheibenbogen C, Seifert M, Sotzny F, Finke C, Behrends U, Aden K, Schreiber S, Brockmann D, Burggraf P, Bloch W, Ellert C, Ramoji A, Popp J, Reuken P, Walter M, Stallmach A, Puta C. Haunhorst S, et al. Infection. 2025 Feb;53(1):1-13. doi: 10.1007/s15010-024-02386-8. Epub 2024 Sep 6. Infection. 2025. PMID: 39240417 Free PMC article. Review.
BACKGROUND: A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has been recognized as one of the most frequent manifestations …
BACKGROUND: A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as P …
Long COVID in pediatrics-epidemiology, diagnosis, and management.
Toepfner N, Brinkmann F, Augustin S, Stojanov S, Behrends U. Toepfner N, et al. Eur J Pediatr. 2024 Apr;183(4):1543-1553. doi: 10.1007/s00431-023-05360-y. Epub 2024 Jan 27. Eur J Pediatr. 2024. PMID: 38279014 Free PMC article. Review.
Some patients present with postural tachycardia syndrome (PoTS), and a small number of cases fulfill the clinical criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To date, no diagnostic marker has been established, and differential diagnostics remai …
Some patients present with postural tachycardia syndrome (PoTS), and a small number of cases fulfill the clinical criteria of myalgic enceph …
Chronic Fatigue Syndrome: Diagnosis, Treatment, and Future Direction.
Graves BS, Patel M, Newgent H, Parvathy G, Nasri A, Moxam J, Gill GS, Sawhney V, Gupta M. Graves BS, et al. Cureus. 2024 Oct 1;16(10):e70616. doi: 10.7759/cureus.70616. eCollection 2024 Oct. Cureus. 2024. PMID: 39483544 Free PMC article. Review.
Along with fatigue, patients experience various symptoms, including cognitive impairments, post-exertional malaise, muscle and joint pain, sleep disturbances, and immune system dysfunction. Diagnosing CFS/ME is challenging due to the absence of definit …
Along with fatigue, patients experience various symptoms, including cognitive impairments, post-exertional malaise, mus …
Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.
Che X, Ranjan A, Guo C, Zhang K, Goldsmith R, Levine S, Moneghetti KJ, Zhai Y, Ge L, Mishra N, Hornig M, Bateman L, Klimas NG, Montoya JG, Peterson DL, Klein SL, Fiehn O, Komaroff AL, Lipkin WI. Che X, et al. medRxiv [Preprint]. 2025 Jul 24:2025.07.23.25332049. doi: 10.1101/2025.07.23.25332049. medRxiv. 2025. Update in: NPJ Metab Health Dis. 2025 Sep 3;3(1):34. doi: 10.1038/s44324-025-00079-w. PMID: 40778181 Free PMC article. Updated. Preprint.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ...Our findings may inform targeted therapeutic interventions for ME/CFS and PEM....
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional …
300 results