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Did you mean e potential drug target (20,738 results)?
The cellular thermal shift assay for evaluating drug target interactions in cells.
Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundbäck T, Nordlund P, Martinez Molina D. Jafari R, et al. Nat Protoc. 2014 Sep;9(9):2100-22. doi: 10.1038/nprot.2014.138. Epub 2014 Aug 7. Nat Protoc. 2014. PMID: 25101824
The method allows studies of target engagement of drug candidates in a cellular context, herein exemplified with experimental data on the human kinases p38alpha and ERK1/2. ...One approach involves sample workup and detection using quantitative western blotting, whe …
The method allows studies of target engagement of drug candidates in a cellular context, herein exemplified with experimental …
A comprehensive map of molecular drug targets.
Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, Karlsson A, Al-Lazikani B, Hersey A, Oprea TI, Overington JP. Santos R, et al. Nat Rev Drug Discov. 2017 Jan;16(1):19-34. doi: 10.1038/nrd.2016.230. Epub 2016 Dec 2. Nat Rev Drug Discov. 2017. PMID: 27910877 Free PMC article. Review.
The success of mechanism-based drug discovery depends on the definition of the drug target. This definition becomes even more important as we try to link drug response to genetic variation, understand stratified clinical efficacy and safety, rationaliz …
The success of mechanism-based drug discovery depends on the definition of the drug target. This definition becomes eve …
Indole-3-Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target.
Esposito N, Konas DW, Goodey NM. Esposito N, et al. Chembiochem. 2022 Jan 19;23(2):e202100314. doi: 10.1002/cbic.202100314. Epub 2021 Sep 20. Chembiochem. 2022. PMID: 34383995 Free PMC article. Review.
Several TB drugs have lost efficacy due to emerging drug resistance and new anti-TB targets are needed. Recent research suggests that indole-3-glycerol phosphate synthase (IGPS) in M. tuberculosis (MtIGPS) could be such a target. ...We also discuss MtIGPS crystal st …
Several TB drugs have lost efficacy due to emerging drug resistance and new anti-TB targets are needed. Recent research suggests that …
Phosphodiesterase-4 as a potential drug target.
Zhang KY, Ibrahim PN, Gillette S, Bollag G. Zhang KY, et al. Expert Opin Ther Targets. 2005 Dec;9(6):1283-305. doi: 10.1517/14728222.9.6.1283. Expert Opin Ther Targets. 2005. PMID: 16300476 Review.
Consequently, PDE4 plays a crucial role in cell signalling and, as such, it has been the target of clinical drug development of various indications, ranging from anti-inflammation to memory enhancement. ...Finally, recent advances in the structural biology of PDE4 a …
Consequently, PDE4 plays a crucial role in cell signalling and, as such, it has been the target of clinical drug development o …
Cytochrome bc1-aa3 Oxidase Supercomplex As Emerging and Potential Drug Target Against Tuberculosis.
Sindhu T, Debnath P. Sindhu T, et al. Curr Mol Pharmacol. 2022;15(2):380-392. doi: 10.2174/1874467214666210928152512. Curr Mol Pharmacol. 2022. PMID: 34602044 Review.
Cytochrome bc1-aa3 supercomplex in M. tuberculosis is, therefore, a major drug target for antibiotic action. In recent years, several respiratory chain components have been targeted for developing new candidate drugs, illustrating the therapeutic potential of …
Cytochrome bc1-aa3 supercomplex in M. tuberculosis is, therefore, a major drug target for antibiotic action. In recent years, …
Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target.
Mertz C, Krarup S, Jensen CD, Lindholm SEH, Kjær C, Pinborg LH, Bak LK. Mertz C, et al. Neurochem Res. 2020 Jun;45(6):1247-1255. doi: 10.1007/s11064-019-02853-x. Epub 2019 Aug 14. Neurochem Res. 2020. PMID: 31414342 Review.
Thus, there is a need for new pharmacological approaches including novel drug targets for the management of epilepsy. Despite the fact that a role for cAMP signaling in epileptogenesis and seizures was first suggested some four decades ago, none of the current medications …
Thus, there is a need for new pharmacological approaches including novel drug targets for the management of epilepsy. Despite the fac …
Therapeutic strategies against hDOT1L as a potential drug target in MLL-rearranged leukemias.
Banday S, Farooq Z, Ganai SA, Altaf M. Banday S, et al. Clin Epigenetics. 2020 May 25;12(1):73. doi: 10.1186/s13148-020-00860-2. Clin Epigenetics. 2020. PMID: 32450905 Free PMC article. Review.
MLL fusion protein mediated mistargeting of DOT1L to aberrant gene locations results in ectopic H3K79 methylation culminating in aberrant expression of leukemogenic genes like HOXA9 and MEIS1. hDOT1L has thus been proposed as a potential target for therapeutic inter …
MLL fusion protein mediated mistargeting of DOT1L to aberrant gene locations results in ectopic H3K79 methylation culminating in aberrant ex …
Twist-BRD4 complex: potential drug target for basal-like breast cancer.
Shi J, Cao J, Zhou BP. Shi J, et al. Curr Pharm Des. 2015;21(10):1256-61. doi: 10.2174/1381612821666141211153853. Curr Pharm Des. 2015. PMID: 25506891 Free PMC article. Review.
During cancer progression, Twist induces epithelial-mesenchymal transition (EMT), potentiating cancer cell invasion and metastasis. Although many studies have revealed its multiple biological roles, it remained unclear how Twist transcriptionally activates targeted genes. …
During cancer progression, Twist induces epithelial-mesenchymal transition (EMT), potentiating cancer cell invasion and metastasis. A …
RNA therapeutics.
Hastings ML, Krainer AR. Hastings ML, et al. RNA. 2023 Apr;29(4):393-395. doi: 10.1261/rna.079626.123. RNA. 2023. PMID: 36928165 Free PMC article.
"RNA therapeutics" refers to a disease treatment or drug that utilizes RNA as a component. In this context, RNA may be the direct target of a small-molecule drug or RNA itself may be the drug, designed to bind to a protein, or to mimic or target …
"RNA therapeutics" refers to a disease treatment or drug that utilizes RNA as a component. In this context, RNA may be the direct …
Antiviral Drug Target Identification and Ligand Discovery.
Patel H, Sengupta D. Patel H, et al. Methods Mol Biol. 2024;2714:85-99. doi: 10.1007/978-1-0716-3441-7_4. Methods Mol Biol. 2024. PMID: 37676593 Review.
This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we explain how the structure for a potential viral protein target can be obtained and then highlight some of the main consideratio …
This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we e …
250,649 results
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