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Effects of Pyrroloquinoline Quinone (PQQ) and Coenzyme Q10 on Mitochondrial Genes, MitomiRs and Cellular Properties in HepG2 Cell Line.
Nalbant MA, Eroğlu O. Nalbant MA, et al. Cell Mol Biol (Noisy-le-grand). 2023 Apr 30;69(4):60-69. doi: 10.14715/cmb/2023.69.4.9. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 37329547
Our study aimed to reveal the effects and changes, antioxidant metabolism (Oxidative Stress), inflammatory response, mitochondrial biogenesis and mitochondrial dysfunction characteristics in hepatocellular carcinoma cell line HepG2; that occur in genes (NRF-1, NRF-2, NFkappaB and …
Our study aimed to reveal the effects and changes, antioxidant metabolism (Oxidative Stress), inflammatory response, mitochondrial biogenesi …
An Efficient UPLC-MS/MS Method for the Determination of Pyrroloquinoline Quinone in Rat Plasma and Its Application to a Toxicokinetic Study.
Sun Q, Hong Y, Yang Z, He P, Chen C, Wang J, Weng Q. Sun Q, et al. Molecules. 2022 Nov 17;27(22):7947. doi: 10.3390/molecules27227947. Molecules. 2022. PMID: 36432048 Free PMC article.
Pyrroloquinoline quinone (PQQ) is a powerful antioxidant coenzyme existing in diet, benefiting growth, development, cognition function, and the repair of damaged organs. However, a method for detecting PQQ in vivo was rarely described, limiting the research on the b …
Pyrroloquinoline quinone (PQQ) is a powerful antioxidant coenzyme existing in diet, benefiting growth, development, cognition functio …
PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice.
Dai X, Yi X, Wang Y, Xia W, Tao J, Wu J, Miao D, Chen L. Dai X, et al. Front Endocrinol (Lausanne). 2022 Mar 7;13:781404. doi: 10.3389/fendo.2022.781404. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35340329 Free PMC article.
Alkylating agents (AAs) that are commonly used for cancer therapy cause great damage to the ovary. Pyrroloquinoline-quinine (PQQ), which was initially identified as a redox cofactor for bacterial dehydrogenases, has been demonstrated to benefit the fertility of fema …
Alkylating agents (AAs) that are commonly used for cancer therapy cause great damage to the ovary. Pyrroloquinoline-quinine (PQQ …
Pyrroloquinoline quinone alleviates oxidative damage induced by high glucose in HepG2 cells.
Alkahtani S, Alarifi S, Alkahtane AA, Albasher G, Al-Zharani M, Alhoshani NM, Al-Johani NS, Aljarba NH, Saquib Hasnain M. Alkahtani S, et al. Saudi J Biol Sci. 2021 Nov;28(11):6127-6132. doi: 10.1016/j.sjbs.2021.06.063. Epub 2021 Jun 25. Saudi J Biol Sci. 2021. PMID: 34759737 Free PMC article.
Interestingly, PQQ significantly reduced AGEs formation and (RAGE) expression, ROS formation, and inflammation induced by glucose. In conclusion, PQQ has a potentiail role as an antioxidant to reduce the oxidative damage during hyperglycemia by AGEs inhibition....
Interestingly, PQQ significantly reduced AGEs formation and (RAGE) expression, ROS formation, and inflammation induced by glucose. In …
An amperometric biosensor of L-fucose in urine for the first screening test of cancer.
Takeda K, Kusuoka R, Inukai M, Igarashi K, Ohno H, Nakamura N. Takeda K, et al. Biosens Bioelectron. 2021 Feb 15;174:112831. doi: 10.1016/j.bios.2020.112831. Epub 2020 Nov 20. Biosens Bioelectron. 2021. PMID: 33288426
Quantitative routine detection of fucose, which is a cancer marker, in urine is effective for the preliminary screening of cancer. ...The isolated PQQ domain from CcPDH was immobilized on gold nanoparticle (AuNP)-modified electrodes, which obtained a catalyti …
Quantitative routine detection of fucose, which is a cancer marker, in urine is effective for the preliminary screening of cancer …
Pyrroloquinoline quinone protected autophagy-dependent apoptosis induced by mono(2-ethylhexyl) phthalate in INS-1 cells.
Shi L, Jiang L, Zhang X, Yang G, Zhang C, Yao X, Wu X, Fu M, Sun X, Liu X. Shi L, et al. Hum Exp Toxicol. 2020 Feb;39(2):194-211. doi: 10.1177/0960327119882983. Epub 2019 Oct 29. Hum Exp Toxicol. 2020. PMID: 31661991
PQQ improved this process by downregulating ROS and provided a degree of protection. Our study provides a new perspective for MEHP on the cytotoxic mechanism and PQQ protection in INS-1 cells....
PQQ improved this process by downregulating ROS and provided a degree of protection. Our study provides a new perspective for MEHP on …
Apoptotic effect of pyrroloquinoline quinone on chondrosarcoma cells through activation of the mitochondrial caspase‑dependent and caspase‑independent pathways.
Wu R, Pan J, Shen M, Xing C. Wu R, et al. Oncol Rep. 2018 Sep;40(3):1614-1620. doi: 10.3892/or.2018.6569. Epub 2018 Jul 12. Oncol Rep. 2018. PMID: 30015942
Chondrosarcomas are malignant tumors of the bone that exhibit resistance to chemotherapy and radiation. Pyrroloquinoline quinone (PQQ) is a bacterial redox co-factor and antioxidant that has been found to induce apoptosis in various cancer cells. ...We confirmed tha …
Chondrosarcomas are malignant tumors of the bone that exhibit resistance to chemotherapy and radiation. Pyrroloquinoline quinone (PQQ …
Pyrroloquinoline quinone attenuates cachexia-induced muscle atrophy via suppression of reactive oxygen species.
Xu T, Yang X, Wu C, Qiu J, Fang Q, Wang L, Yu S, Sun H. Xu T, et al. J Thorac Dis. 2018 May;10(5):2752-2759. doi: 10.21037/jtd.2018.04.112. J Thorac Dis. 2018. PMID: 29997937 Free PMC article.
BACKGROUND: Cachexia, a wasting syndrome, is most commonly observed in individuals with advanced cancer including lung cancer, esophageal cancer, liver cancer, etc. ...CONCLUSIONS: PQQ resists atrophic effect dependent on, at least in part, decr …
BACKGROUND: Cachexia, a wasting syndrome, is most commonly observed in individuals with advanced cancer including lung cancer, …
Pyrroloquinoline quinone induces chondrosarcoma cell apoptosis by increasing intracellular reactive oxygen species.
Wen L, Lu X, Wang R, Jin X, Hu L, You C. Wen L, et al. Mol Med Rep. 2018 May;17(5):7184-7190. doi: 10.3892/mmr.2018.8745. Epub 2018 Mar 14. Mol Med Rep. 2018. PMID: 29568949 Free PMC article.
Pyrroloquinoline quinone (PQQ) has been reported to contribute to cancer cell apoptosis and death; however, little is known of its underlying mechanisms. The present study was designed to investigate the role of PQQ in chondrosarcoma cell apoptosis and the un …
Pyrroloquinoline quinone (PQQ) has been reported to contribute to cancer cell apoptosis and death; however, little is known of …
The Effect of Pyrroloquinoline Quinone on the Expression of WISP1 in Traumatic Brain Injury.
Ye Y, Zhang P, Qian Y, Yin B, Yan M. Ye Y, et al. Stem Cells Int. 2017;2017:4782820. doi: 10.1155/2017/4782820. Epub 2017 Aug 16. Stem Cells Int. 2017. PMID: 28883836 Free PMC article.
Although some studies have confirmed that WISP1 is concerned with colon cancer and lung cancer, there is little report about the influence of WISP1 in traumatic brain injury. ...Compared with the negative control group, WISP1 expression reduced obviously in SHSY5Y c …
Although some studies have confirmed that WISP1 is concerned with colon cancer and lung cancer, there is little report about t …
24 results