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91 results

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Page 1
Pregabalin.
Cross AL, Viswanath O, Sherman AL. Cross AL, et al. 2024 May 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2024 May 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29261857 Free Books & Documents.
Off-label applications include generalized anxiety disorder, social anxiety disorder, bipolar disorder, insomnia, and chronic pain conditions not sanctioned by the FDA. This activity prioritizes understanding pregabalin's mechanism of action, adverse e …
Off-label applications include generalized anxiety disorder, social anxiety disorder, bipolar disorder, insomnia, and chronic …
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.
Hong JSW, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, Harrison PJ, Cipriani A. Hong JSW, et al. Mol Psychiatry. 2022 Mar;27(3):1339-1349. doi: 10.1038/s41380-021-01386-6. Epub 2021 Nov 24. Mol Psychiatry. 2022. PMID: 34819636 Free PMC article.
Many of these uses are off-label for psychiatric indications, and there is increasing concern about their safety, so it is particularly important to have good evidence to justify this usage. ...Fifty-five double-blind randomised controlled trials (RCTs) and 15 open- …
Many of these uses are off-label for psychiatric indications, and there is increasing concern about their safety, so it is par …
Ongoing challenges of off-label prescribing.
Day RO. Day RO. Aust Prescr. 2023 Dec;46(4):86-89. doi: 10.18773/austprescr.2023.022. Aust Prescr. 2023. PMID: 38152320 Free PMC article. Review.
There may be additional costs to the patient if the medicine is not subsidised for the off-label indication. Prescribers should ensure patients are aware when a medicine is being prescribed off label, and informed of potential benefits and harms. Alter …
There may be additional costs to the patient if the medicine is not subsidised for the off-label indication. Prescribers shoul …
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options.
Garakani A, Murrough JW, Freire RC, Thom RP, Larkin K, Buono FD, Iosifescu DV. Garakani A, et al. Front Psychiatry. 2020 Dec 23;11:595584. doi: 10.3389/fpsyt.2020.595584. eCollection 2020. Front Psychiatry. 2020. PMID: 33424664 Free PMC article. Review.
This review's first aim is to summarize current pharmacological treatments (both approved and off-label) for panic disorder (PD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and specific phobias (SP), including selective serotonin reuptake inh …
This review's first aim is to summarize current pharmacological treatments (both approved and off-label) for panic disorder (P …
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.
Atkin T, Comai S, Gobbi G. Atkin T, et al. Pharmacol Rev. 2018 Apr;70(2):197-245. doi: 10.1124/pr.117.014381. Pharmacol Rev. 2018. PMID: 29487083 Review.
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have many side effects, including cognitive impairment, tolerance, rebound insomnia upon discontinuation, car ac …
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a …
Prescription of Controlled Substances: Benefits and Risks.
Preuss CV, Kalava A, King KC. Preuss CV, et al. 2025 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2025 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 30726003 Free Books & Documents.
For pain lasting more than 1 week, the extended-release form is preferred, as it is indicated for pain control under 24-hour management or an extended period. Tramadol has demonstrated off-label effectiveness in the management of premature ejaculation and restless l …
For pain lasting more than 1 week, the extended-release form is preferred, as it is indicated for pain control under 24-hour management or a …
"Fibromyalgia - are there any new approaches?".
Martinez JE, Guimarães I. Martinez JE, et al. Best Pract Res Clin Rheumatol. 2024 Mar;38(1):101933. doi: 10.1016/j.berh.2024.101933. Epub 2024 Feb 13. Best Pract Res Clin Rheumatol. 2024. PMID: 38355316 Review.
Medications approved by Food and Drug Administration are duloxetine, milnacipran and pregabalin. Amitriptyline, cyclobenzaprine, gabapentin and naltrexone are considered for off-label use. ...
Medications approved by Food and Drug Administration are duloxetine, milnacipran and pregabalin. Amitriptyline, cyclobenzaprine, gaba …
Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.
Farag HM, Yunusa I, Goswami H, Sultan I, Doucette JA, Eguale T. Farag HM, et al. JAMA Netw Open. 2022 May 2;5(5):e2212939. doi: 10.1001/jamanetworkopen.2022.12939. JAMA Netw Open. 2022. PMID: 35587348 Free PMC article.
IMPORTANCE: Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgi …
IMPORTANCE: Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin …
A Clinical Overview of Off-label Use of Gabapentinoid Drugs.
Goodman CW, Brett AS. Goodman CW, et al. JAMA Intern Med. 2019 May 1;179(5):695-701. doi: 10.1001/jamainternmed.2019.0086. JAMA Intern Med. 2019. PMID: 30907944 Review.
OBSERVATIONS: This report summarizes the limited published evidence to support off-label gabapentinoid uses, describes clinical cases in which off-label use is problematic, and notes how review articles and guidelines tend to overstate gabapenti …
OBSERVATIONS: This report summarizes the limited published evidence to support off-label gabapentinoid uses, describes clinica …
91 results