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Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment.
Sandquist M, Wong HR. Sandquist M, et al. Expert Rev Clin Immunol. 2014 Oct;10(10):1349-56. doi: 10.1586/1744666X.2014.949675. Epub 2014 Aug 21. Expert Rev Clin Immunol. 2014. PMID: 25142036 Free PMC article. Review.
Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64, presepsin, cfDNA and miRNAs as novel diagnostic, prognostic and treatment response biomarkers. The future of sepsis biomarkers lies in extensive validation studies of such novel biomarkers across heterogeneous populations and exploration of their power in combination. ...
Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potent …
[Research progress of presepsin in sepsis diagnosis].
Yu H, Zeng Y, Zhou C. Yu H, et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 Aug;29(8):756-759. doi: 10.3760/cma.j.issn.2095-4352.2017.08.018. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017. PMID: 28795679 Review. Chinese.
Sepsis is a frequently met syndrome with complex clinical symptoms and high mortality in emergency department. Early diagnosis of sepsis and timely treatment can improve survival. ...Soluble leukocyte differentiation antigen 14 sub type (sCD14-ST, namely presepsin) is a kind of novel biomarkers. Presepsin has a high specificity and sensitivity in the diagnosis of sepsis. ...
Sepsis is a frequently met syndrome with complex clinical symptoms and high mortality in emergency department. Early diagnosis
Novel biomarkers for sepsis: A narrative review.
Larsen FF, Petersen JA. Larsen FF, et al. Eur J Intern Med. 2017 Nov;45:46-50. doi: 10.1016/j.ejim.2017.09.030. Epub 2017 Sep 29. Eur J Intern Med. 2017. PMID: 28965741 Review.
Rapid recognition of sepsis as the cause of deterioration is desirable, so effective treatment can be initiated rapidly. Traditionally, diagnosis was based on presence of two or more positive SIRS criteria due to infection. ...RESULTS: A number of the most promising biomarkers for diagnoses and prognostication of sepsis are presented. CONCLUSION: Procalcitonin, presepsin, CD64, suPAR, and sTREM-1 are the best evaluated biomarkers for diagnosis and prognostication of sepsis to date. ...
Rapid recognition of sepsis as the cause of deterioration is desirable, so effective treatment can be initiated rapidly. Traditionall …
Presepsin in the diagnostics of sepsis.
Káňová M, Dobiáš R, Liszková K, Frelich M, Ječmínková R, Kula R. Káňová M, et al. Vnitr Lek. 2019 Summer;65(7-8):497-505. Vnitr Lek. 2019. PMID: 31487993 English.
That is the main reason why clinicians need fast, reliable and specific biomarkers for recognition of sepsis. Presepsin (sCD-14ST) is one of promising biomarkers, the level of which increases in response to a microbial infection in the host. ...Consequently, during the inflammatory reaction, sCD14-ST, known as presepsin, is cleaved away from plasma. The objective of this article is to determine the diagnostic value of presepsin in the diagnostics of sepsis, assessing its severity, and monitoring the effectiveness of therapeutic interventions, and to establish the prognostic value of this biomarker....
That is the main reason why clinicians need fast, reliable and specific biomarkers for recognition of sepsis. Presepsin (sCD-1 …
Role of presepsin in the diagnosis of late-onset neonatal sepsis in preterm infants.
Topcuoglu S, Arslanbuga C, Gursoy T, Aktas A, Karatekin G, Uluhan R, Ovali F. Topcuoglu S, et al. J Matern Fetal Neonatal Med. 2016;29(11):1834-9. doi: 10.3109/14767058.2015.1064885. Epub 2015 Jul 30. J Matern Fetal Neonatal Med. 2016. PMID: 26135765 Clinical Trial.
Presepsin is a novel and promising marker of sepsis. The aim of this study was to assess the role of presepsin in the diagnosis of LOS in preterm infants. ...However, we could not demonstrate the efficacy of presepsin for the detection of disease severity or prognosis....
Presepsin is a novel and promising marker of sepsis. The aim of this study was to assess the role of presepsin in the
Current aspects in sepsis approach. Turning things around.
Candel FJ, Borges Sá M, Belda S, Bou G, Del Pozo JL, Estrada O, Ferrer R, González Del Castillo J, Julián-Jiménez A, Martín-Loeches I, Maseda E, Matesanz M, Ramírez P, Ramos JT, Rello J, Suberviola B, Suárez de la Rica A, Vidal P. Candel FJ, et al. Rev Esp Quimioter. 2018 Aug;31(4):298-315. Epub 2018 Jun 25. Rev Esp Quimioter. 2018. PMID: 29938972 Free PMC article. Review.
Presepsin and pro-adrenomedullin are useful for early diagnosis, risk stratification and prognosis in septic patients. The combination of biomarkers is even more useful to clarify an infectious cause than any isolated biomarker. ...The main benefits of establishing a sepsis code are to decrease the time to achieve diagnosis and treatment, improve organization, unify criteria, promote teamwork to achieve common goals, increase participation, motivation and satisfaction among team members, and reduce costs....
Presepsin and pro-adrenomedullin are useful for early diagnosis, risk stratification and prognosis in septic patients.
Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis.
Yang HS, Hur M, Yi A, Kim H, Lee S, Kim SN. Yang HS, et al. PLoS One. 2018 Jan 24;13(1):e0191486. doi: 10.1371/journal.pone.0191486. eCollection 2018. PLoS One. 2018. PMID: 29364941 Free PMC article.
OBJECTIVE: Presepsin is a novel biomarker to diagnose sepsis but its prognostic value has not been comprehensively reviewed. We conducted this meta-analysis to evaluate the mortality prediction value of presepsin in sepsis. METHODS: We searched comprehensive electronic databases from PubMed, EMBASE, and Cochrane Library through September 2017 using the key words of ('presepsin' or 'sCD14-ST' or 'soluble CD14 subtype') and ('sepsis' or 'septic shock') and ('prognosis' or 'prognostic value' or 'prognostic biomarker' or 'mortality'). ...
OBJECTIVE: Presepsin is a novel biomarker to diagnose sepsis but its prognostic value has not been comprehensively revi …
Presepsin as a novel sepsis biomarker.
Zou Q, Wen W, Zhang XC. Zou Q, et al. World J Emerg Med. 2014;5(1):16-9. doi: 10.5847/wjem.j.issn.1920-8642.2014.01.002. World J Emerg Med. 2014. PMID: 25215141 Free PMC article. Review.
Presepsin as a biom1arker is not only suitable for the early diagnosis of sepsis, but also for the assessment of its severity and prognosis. CONCLUSIONS: Presepsin has a higher sensitivity and specificity in the diagnosis of sepsis as a new biomarker, and is a predictor for the prognosis of sepsis. ...
Presepsin as a biom1arker is not only suitable for the early diagnosis of sepsis, but also for the assessment of its se
Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis.
Yoon SH, Kim EH, Kim HY, Ahn JG. Yoon SH, et al. BMC Infect Dis. 2019 Aug 30;19(1):760. doi: 10.1186/s12879-019-4397-1. BMC Infect Dis. 2019. PMID: 31470804 Free PMC article.
BACKGROUND: Early diagnosis of sepsis in pediatric patients is vital but remains a major challenge. Previous studies showed that presepsin is potentially a reliable diagnostic biomarker for sepsis in adult and neonates. However, there is no pooled analysis of its efficacy as a diagnostic biomarker for sepsis in children. The aims of the present meta-analysis were to assess the overall diagnostic accuracy of presepsin in pediatric sepsis and compare it to those for C-reactive protein (CRP) and procalcitonin (PCT). ...
BACKGROUND: Early diagnosis of sepsis in pediatric patients is vital but remains a major challenge. Previous studies showed th …
Presepsin level in predicting patients' in-hospital mortality from sepsis under sepsis-3 criteria.
Wen MY, Huang LQ, Yang F, Ye JK, Cai GX, Li XS, Ding HG, Zeng HK. Wen MY, et al. Ther Clin Risk Manag. 2019 Jun 13;15:733-739. doi: 10.2147/TCRM.S209710. eCollection 2019. Ther Clin Risk Manag. 2019. PMID: 31354281 Free PMC article.
We aimed to evaluate the effect of the presepsin level on predicting the prognosis of patients with sepsis under the sepsis-3 criteria. ...Conclusions: Presepsin is a prognostic biomarker with high accuracy in predicting the prognosis of sepsis under the sepsis-3 criteria....
We aimed to evaluate the effect of the presepsin level on predicting the prognosis of patients with sepsis under the …
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