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Year Number of Results
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1995 3
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2009 31
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833 results

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Page 1
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.
BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network; Daneman N, Rishu A, Pinto R, Rogers BA, Shehabi Y, Parke R, Cook D, Arabi Y, Muscedere J, Reynolds S, Hall R, Dwivedi DB, McArthur C, McGuinness S, Yahav D, Coburn B, Geagea A, Das P, Shin P, Detsky M, Morris A, Fralick M, Powis JE, Kandel C, Sligl W, Bagshaw SM, Singhal N, Belley-Cote E, Whitlock R, Khwaja K, Morpeth S, Kazemi A, Williams A, MacFadden DR, McIntyre L, Tsang J, Lamontagne F, Carignan A, Marshall J, Friedrich JO, Cirone R, Downing M, Graham C, Davis J, Duan E, Neary J, Evans G, Alraddadi B, Al Johani S, Martin C, Elsayed S, Ball I, Lauzier F, Turgeon A, Stelfox HT, Conly J, McDonald EG, Lee TC, Sullivan R, Grant J, Kagan I, Young P, Lawrence C, O'Callaghan K, Eustace M, Choong K, Aslanian P, Buehner U, Havey T, Binnie A, Prazak J, Reeve B, Litton E, Lother S, Kumar A, Zarychanski R, Hoffman T, Paterson D, Daley P, Commons RJ, Charbonney E, Naud JF, R… See abstract for full author list ➔ BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network, et al. N Engl J Med. 2025 Mar 13;392(11):1065-1078. doi: 10.1056/NEJMoa2404991. Epub 2024 Nov 20. N Engl J Med. 2025. PMID: 39565030 Clinical Trial.
Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. METHODS: In a multicenter, noninferiority trial, we randomly assigned hospitalized patients (including patients in the intensive care unit [ICU]) who had bl …
Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. METHODS: In a multicenter, noninferio …
An intervention to decrease catheter-related bloodstream infections in the ICU.
Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, Kepros J, Goeschel C. Pronovost P, et al. N Engl J Med. 2006 Dec 28;355(26):2725-32. doi: 10.1056/NEJMoa061115. N Engl J Med. 2006. PMID: 17192537 Free article.
BACKGROUND: Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal. METHODS: We conducted a collaborative cohort study predominantly in ICUs in Michigan. An evidence-based interv …
BACKGROUND: Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and …
Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis.
Hammond NE, Myburgh J, Seppelt I, Garside T, Vlok R, Mahendran S, Adigbli D, Finfer S, Gao Y, Goodman F, Guyatt G, Santos JA, Venkatesh B, Yao L, Di Tanna GL, Delaney A. Hammond NE, et al. JAMA. 2022 Nov 15;328(19):1922-1934. doi: 10.1001/jama.2022.19709. JAMA. 2022. PMID: 36286098 Free PMC article.
OBJECTIVE: To determine whether SDD is associated with reduced risk of death in adults receiving mechanical ventilation in intensive care units (ICUs) compared with standard care. DATA SOURCES: The primary search was conducted using MEDLINE, EMBASE, an …
OBJECTIVE: To determine whether SDD is associated with reduced risk of death in adults receiving mechanical ventilation in intensive …
Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.
SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group; Myburgh JA, Seppelt IM, Goodman F, Billot L, Correa M, Davis JS, Gordon AC, Hammond NE, Iredell J, Li Q, Micallef S, Miller J, Mysore J, Taylor C, Young PJ, Cuthbertson BH, Finfer SR. SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, et al. JAMA. 2022 Nov 15;328(19):1911-1921. doi: 10.1001/jama.2022.17927. JAMA. 2022. PMID: 36286097 Free PMC article. Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: A cluster, crossover, randomized clinical trial that recruited 5982 mechanically ventilated adults from 19 intensive care units (ICUs) in Australia between April 2018 and May 2021 (final follow-up, August 2021). ...Patients …
DESIGN, SETTING, AND PARTICIPANTS: A cluster, crossover, randomized clinical trial that recruited 5982 mechanically ventilated adults from 1 …
Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial.
Huang SS, Septimus E, Kleinman K, Moody J, Hickok J, Heim L, Gombosev A, Avery TR, Haffenreffer K, Shimelman L, Hayden MK, Weinstein RA, Spencer-Smith C, Kaganov RE, Murphy MV, Forehand T, Lankiewicz J, Coady MH, Portillo L, Sarup-Patel J, Jernigan JA, Perlin JB, Platt R; ABATE Infection trial team. Huang SS, et al. Lancet. 2019 Mar 23;393(10177):1205-1215. doi: 10.1016/S0140-6736(18)32593-5. Epub 2019 Mar 5. Lancet. 2019. PMID: 30850112 Free PMC article. Clinical Trial.
BACKGROUND: Universal skin and nasal decolonisation reduces multidrug-resistant pathogens and bloodstream infections in intensive care units. The effect of universal decolonisation on pathogens and infections in non-critical-care units is unknow …
BACKGROUND: Universal skin and nasal decolonisation reduces multidrug-resistant pathogens and bloodstream infections in intensive …
Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.
Loiodice A, Bailly S, Ruckly S, Buetti N, Barbier F, Staiquly Q, Tabah A, Timsit JF; EUROBACT-2 Study Group, the European Society of Intensive Care Medicine (ESICM), the European Society of Clinical Microbiology, the Infectious Diseases (ESCMID) Study Group for Infections in Critically Ill Patients (ESGCIP) and the OUTCOMEREA Network. Loiodice A, et al. Clin Microbiol Infect. 2024 Dec;30(12):1559-1568. doi: 10.1016/j.cmi.2024.09.011. Epub 2024 Sep 24. Clin Microbiol Infect. 2024. PMID: 39326671 Free article.
OBJECTIVES: Hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU) are common life-threatening events. We aimed to investigate the association between early adequate antibiotic therapy and 28-day mortality in ICU patients wh …
OBJECTIVES: Hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU) are common life-threaten …
EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double-blind, placebo-controlled, cross-over study.
Schaumburg T, Köhler N, Breitenstein Y, Kolbe-Busch S, Hasenclever D, Chaberny IF. Schaumburg T, et al. Intensive Care Med. 2024 Dec;50(12):2073-2082. doi: 10.1007/s00134-024-07667-2. Epub 2024 Oct 17. Intensive Care Med. 2024. PMID: 39417875 Free PMC article. Clinical Trial.
Previous studies have shown the efficacy of antiseptic bathing in high-risk environments, such as intensive care units (ICUs), using chlorhexidine. In this study we aimed to evaluate the effectiveness of octenidine as a potential alternative due to its establ …
Previous studies have shown the efficacy of antiseptic bathing in high-risk environments, such as intensive care units …
Structural equation modeling the "control of gut overgrowth" in the prevention of ICU-acquired Gram-negative infection.
Hurley JC. Hurley JC. Crit Care. 2020 May 4;24(1):189. doi: 10.1186/s13054-020-02906-6. Crit Care. 2020. PMID: 32366267 Free PMC article.
METHODS: Seven candidate generalized structural equation models founded on COGO concepts were confronted with Pseudomonas and Acinetobacter bacteremia as well as ventilator-associated pneumonia data derived from > 200 infection prevention studies. The foll …
METHODS: Seven candidate generalized structural equation models founded on COGO concepts were confronted with Pseudomonas and Acineto …
Incidence of coagulase-negative staphylococcal bacteremia among ICU patients: decontamination studies as a natural experiment.
Hurley JC. Hurley JC. Eur J Clin Microbiol Infect Dis. 2020 Apr;39(4):657-664. doi: 10.1007/s10096-019-03763-0. Epub 2019 Dec 4. Eur J Clin Microbiol Infect Dis. 2020. PMID: 31802335 Free PMC article.
The epidemiology of coagulase-negative staphylococcal (CNS) bacteremia among adult ICU patients remains unclear. Decontamination studies among ICU patients provide a unique opportunity to study the impacts of different diagnostic criteria, exposure to various …
The epidemiology of coagulase-negative staphylococcal (CNS) bacteremia among adult ICU patients remains unclear. Decontaminati …
833 results