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Regulation of the conserved 3'-5' exoribonuclease EXOSC10/Rrp6 during cell division, development and cancer.
Stuparević I, Novačić A, Rahmouni AR, Fernandez A, Lamb N, Primig M. Stuparević I, et al. Among authors: primig m. Biol Rev Camb Philos Soc. 2021 Aug;96(4):1092-1113. doi: 10.1111/brv.12693. Epub 2021 Feb 18. Biol Rev Camb Philos Soc. 2021. PMID: 33599082 Free article. Review.
EXOSC10/Rrp6 is part of the multimeric nuclear RNA exosome and interacts with numerous proteins. ...Additionally, we discuss how known and predicted protein interactions and post-translational modifications influence the stability of EXOSC10/Rrp6. Fina …
EXOSC10/Rrp6 is part of the multimeric nuclear RNA exosome and interacts with numerous proteins. ...Additionally, we discuss h …
EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.
Petit FG, Jamin SP, Kernanec PY, Becker E, Halet G, Primig M. Petit FG, et al. Among authors: primig m. Dev Biol. 2022 Mar;483:58-65. doi: 10.1016/j.ydbio.2021.12.010. Epub 2021 Dec 26. Dev Biol. 2022. PMID: 34965385 Free article.
The conserved 3'-5' exoribonuclease EXOSC10/Rrp6 is required for gametogenesis, brain development, erythropoiesis and blood cell enhancer function. ...Little is known, however, about the role of Exosc10 during embryo development and organogenesis. We generate …
The conserved 3'-5' exoribonuclease EXOSC10/Rrp6 is required for gametogenesis, brain development, erythropoiesis and blood ce …
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis.
Jamin SP, Petit FG, Kervarrec C, Smagulova F, Illner D, Scherthan H, Primig M. Jamin SP, et al. Among authors: primig m. Sci Rep. 2017 Nov 8;7(1):15065. doi: 10.1038/s41598-017-14643-y. Sci Rep. 2017. PMID: 29118343 Free PMC article.
The yeast orthologue Rrp6 is required for efficient growth and gametogenesis, and becomes unstable during meiosis. ...Finally, EXOSC10 becomes unstable at later stages of gamete development. To determine Exosc10's meiotic function, we inactivated the gene spe …
The yeast orthologue Rrp6 is required for efficient growth and gametogenesis, and becomes unstable during meiosis. ...Finally, EXO …
Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice.
Demini L, Kervarrec C, Guillot L, Com E, Lavigne R, Kernanec PY, Primig M, Pineau C, Petit FG, Jamin SP. Demini L, et al. Among authors: primig m. Int J Biol Sci. 2023 Jan 31;19(4):1080-1093. doi: 10.7150/ijbs.72889. eCollection 2023. Int J Biol Sci. 2023. PMID: 36923944 Free PMC article.
EXOSC10 is a catalytic subunit of the nuclear RNA exosome, and possesses a 3'-5' exoribonuclease activity. The enzyme processes and degrades different classes of RNAs. To delineate the role of EXOSC10 during oocyte growth, specific Exosc10 inactivation was pe …
EXOSC10 is a catalytic subunit of the nuclear RNA exosome, and possesses a 3'-5' exoribonuclease activity. The enzyme processes and d …
Genetic and genomic approaches to explore roles for the conserved 3'-5' exoribonuclease EXOSC10 in normal and malignant cells.
Sain R, Primig J, Primig M. Sain R, et al. Among authors: primig m. RNA. 2026 May 18;32(6):789-801. doi: 10.1261/rna.080981.126. RNA. 2026. PMID: 41741230 Free PMC article. Review.
EXOSC10 is a conserved 3'-5' exoribonuclease involved in processing ribosomal RNAs and degrading coding and noncoding transcripts as a catalytic subunit of the nuclear RNA exosome and in cooperation with cofactors. ...Moreover, high expression of EXOSC10 in certain …
EXOSC10 is a conserved 3'-5' exoribonuclease involved in processing ribosomal RNAs and degrading coding and noncoding transcripts as …
The 5-Fluorouracil RNA Expression Viewer (5-FU(R)) Facilitates Interpreting the Effects of Drug Treatment and RRP6 Deletion on the Transcriptional Landscape in Yeast.
Szachnowski U, Sallou O, Boudet M, Bretaudeau A, Wery M, Morillon A, Primig M. Szachnowski U, et al. Among authors: primig m. Yeast. 2024 Oct;41(10):629-640. doi: 10.1002/yea.3982. Epub 2024 Sep 30. Yeast. 2024. PMID: 39345013
Since 5-FU inhibits the activity of the 3'-5'-exoribonuclease Rrp6 in yeast and mammals, earlier work has compared the effect of 5-FU treatment and RRP6 deletion at the transcriptome level in diploid synchronized yeast cells. ...The expression data are useful for re …
Since 5-FU inhibits the activity of the 3'-5'-exoribonuclease Rrp6 in yeast and mammals, earlier work has compared the effect of 5-FU …
Tho2 is critical for the recruitment of Rrp6 to chromatin in response to perturbed mRNP biogenesis.
Beauvais V, Moreau K, Žunar B, Hervouet-Coste N, Novačić A, Le Dantec A, Primig M, Mosrin-Huaman C, Stuparević I, Rahmouni AR. Beauvais V, et al. Among authors: primig m. RNA. 2023 Dec 18;30(1):89-98. doi: 10.1261/rna.079707.123. RNA. 2023. PMID: 37914399 Free PMC article.
Once formed, mRNPs undergo a quality control step that marks them either for active transport to the cytoplasm, or Rrp6/RNA exosome-mediated degradation in the nucleus. However, the mechanism behind the quality control of nascent mRNPs is still unclear. ...In addition to i …
Once formed, mRNPs undergo a quality control step that marks them either for active transport to the cytoplasm, or Rrp6/RNA exosome-m …
Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.
Sain R, Le Page Y, Percevault F, Becker E, Negroni L, Fernandez A, Cantero M, Muñoz-Santos D, Montoliu L, Garnier C, Primig M. Sain R, et al. Among authors: primig m. Mol Oncol. 2026 May 15. doi: 10.1002/1878-0261.70239. Online ahead of print. Mol Oncol. 2026. PMID: 42138069 Free article.
The 3'-5' exoribonuclease EXOSC10 degrades aberrant mRNAs and noncoding RNAs in cooperation with the nuclear RNA exosome. ...Furthermore, we find that the EXOSC10(S402T) allele identified in colon cancer and located within a motif for targeted proteolysis is stable, …
The 3'-5' exoribonuclease EXOSC10 degrades aberrant mRNAs and noncoding RNAs in cooperation with the nuclear RNA exosome. ...Furtherm …
The anti-cancer drug 5-fluorouracil affects cell cycle regulators and potential regulatory long non-coding RNAs in yeast.
Xie B, Becker E, Stuparevic I, Wery M, Szachnowski U, Morillon A, Primig M. Xie B, et al. Among authors: primig m. RNA Biol. 2019 Jun;16(6):727-741. doi: 10.1080/15476286.2019.1581596. Epub 2019 Mar 20. RNA Biol. 2019. PMID: 30760080 Free PMC article.
The drug was later found to also affect the conserved 3'-5' exoribonuclease EXOSC10/Rrp6, a catalytic subunit of the RNA exosome that degrades and processes protein-coding and non-coding transcripts. ...We also observe widespread accumulation of different lncRNA typ …
The drug was later found to also affect the conserved 3'-5' exoribonuclease EXOSC10/Rrp6, a catalytic subunit of the RNA exoso …
Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6.
Lardenois A, Liu Y, Walther T, Chalmel F, Evrard B, Granovskaia M, Chu A, Davis RW, Steinmetz LM, Primig M. Lardenois A, et al. Among authors: primig m. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1058-63. doi: 10.1073/pnas.1016459108. Epub 2010 Dec 13. Proc Natl Acad Sci U S A. 2011. PMID: 21149693 Free PMC article.
Meiotic unannotated transcripts (MUTs) are mitotic targets of the conserved exosome component Rrp6, which itself is degraded after the onset of meiosis when MUTs and other ncRNAs accumulate in successive waves. Diploid cells lacking Rrp6 fail to initiate premeiotic …
Meiotic unannotated transcripts (MUTs) are mitotic targets of the conserved exosome component Rrp6, which itself is degraded after th …
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