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Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity.
Dirikoc S, Priola SA, Marella M, Zsürger N, Chabry J. Dirikoc S, et al. J Neurosci. 2007 Sep 5;27(36):9537-44. doi: 10.1523/JNEUROSCI.1942-07.2007. J Neurosci. 2007. PMID: 17804615 Free PMC article.
Prion diseases are transmissible neurodegenerative disorders characterized by the accumulation in the CNS of the protease-resistant prion protein (PrPres), a structurally misfolded isoform of its physiological counterpart PrPsen. Both neuropathogenesis and prion …
Prion diseases are transmissible neurodegenerative disorders characterized by the accumulation in the CNS of the protease-resistant …
Emerging potential of cannabidiol in reversing proteinopathies.
Dash R, Ali MC, Jahan I, Munni YA, Mitra S, Hannan MA, Timalsina B, Oktaviani DF, Choi HJ, Moon IS. Dash R, et al. Ageing Res Rev. 2021 Jan;65:101209. doi: 10.1016/j.arr.2020.101209. Epub 2020 Nov 9. Ageing Res Rev. 2021. PMID: 33181336 Review.
Along with oxidative stress and neuroinflammation, disruption in protein homeostasis (proteostasis), a network that constitutes protein surveillance system, plays a pivotal role in the pathobiology of these dementia disorders. Cannabidiol (CBD), a non-psychotropic phytocan …
Along with oxidative stress and neuroinflammation, disruption in protein homeostasis (proteostasis), a network that constitutes protein surv …
Cannabidiol: a promising drug for neurodegenerative disorders?
Iuvone T, Esposito G, De Filippis D, Scuderi C, Steardo L. Iuvone T, et al. CNS Neurosci Ther. 2009 Winter;15(1):65-75. doi: 10.1111/j.1755-5949.2008.00065.x. CNS Neurosci Ther. 2009. PMID: 19228180 Free PMC article. Review.
Nevertheless, among Cannabis compounds, cannabidiol (CBD), which lacks any unwanted psychotropic effect, may represent a very promising agent with the highest prospect for therapeutic use....
Nevertheless, among Cannabis compounds, cannabidiol (CBD), which lacks any unwanted psychotropic effect, may represent a very promisi …
Cannabidiol: a prion therapy for mice?
Dicou E. Dicou E. J Neurosci Res. 2008 May 1;86(6):1417-8. doi: 10.1002/jnr.21694. J Neurosci Res. 2008. PMID: 18338806 No abstract available.
Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and delta(9)-tetrahydrocannabinol.
Kanyo R, Amin MR, Locskai LF, Bouvier DD, Olthuis AM, Allison WT, Ali DW. Kanyo R, et al. Sci Rep. 2021 Jun 1;11(1):11515. doi: 10.1038/s41598-021-90902-3. Sci Rep. 2021. PMID: 34075141 Free PMC article.
Here, zebrafish embryos were exposed to cannabidiol (CBD) and delta(9)-tetrahydrocannabinol (THC) until the end of gastrulation (1-10 h post-fertilization) and analyzed later in development (4-5 days post-fertilization). ...
Here, zebrafish embryos were exposed to cannabidiol (CBD) and delta(9)-tetrahydrocannabinol (THC) until the end of gastrulation (1-10 …