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653 results
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Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines.
Frye RE, Rose S, Chacko J, Wynne R, Bennuri SC, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF. Frye RE, et al. Transl Psychiatry. 2016 Oct 25;6(10):e927. doi: 10.1038/tp.2016.189. Transl Psychiatry. 2016. PMID: 27779624 Free PMC article.
Propionic acid (PPA) is a ubiquitous short-chain fatty acid, which is a major fermentation product of the enteric microbiome. ...Whereas PPA is an energy substrate and has many proposed beneficial effects, it is also associated with human disorders inv
Propionic acid (PPA) is a ubiquitous short-chain fatty acid, which is a major fermentation product of the enteric mi
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism.
Gao J, Xu K, Liu H, Liu G, Bai M, Peng C, Li T, Yin Y. Gao J, et al. Front Cell Infect Microbiol. 2018 Feb 6;8:13. doi: 10.3389/fcimb.2018.00013. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 29468141 Free PMC article. Review.
Moreover, Trp, endogenous Trp metabolites (kynurenines, serotonin, and melatonin), and bacterial Trp metabolites (indole, indolic acid, skatole, and tryptamine) have profound effects on gut microbial composition, microbial metabolism, the host's immune system, the h …
Moreover, Trp, endogenous Trp metabolites (kynurenines, serotonin, and melatonin), and bacterial Trp metabolites (indole, indolic acid
Formation of propionate and butyrate by the human colonic microbiota.
Louis P, Flint HJ. Louis P, et al. Environ Microbiol. 2017 Jan;19(1):29-41. doi: 10.1111/1462-2920.13589. Epub 2016 Dec 8. Environ Microbiol. 2017. PMID: 27928878 Review.
The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. ...A detailed understanding …
The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products …
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.
Duscha A, Gisevius B, Hirschberg S, Yissachar N, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Träger P, Zaiss MM, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, Haghikia A. Duscha A, et al. Cell. 2020 Mar 19;180(6):1067-1080.e16. doi: 10.1016/j.cell.2020.02.035. Epub 2020 Mar 10. Cell. 2020. PMID: 32160527
Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and feces of subjects with MS exhibited significantly reduced PA amounts compared with controls, particularly after the first relapse. ...Function …
Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and fe …
Effect of dietary supplementation with apple cider vinegar and propionic acid on hemolymph chemistry, intestinal microbiota and histological structure of hepatopancreas in white shrimp, Litopenaeus vannamei.
Pourmozaffar S, Hajimoradloo A, Paknejad H, Rameshi H. Pourmozaffar S, et al. Fish Shellfish Immunol. 2019 Mar;86:900-905. doi: 10.1016/j.fsi.2018.12.019. Epub 2018 Dec 13. Fish Shellfish Immunol. 2019. PMID: 30553888
This experiment was conducted to evaluate the effects of dietary supplementation of Apple cider vinegar (ACV) and propionic acid (PA) on biochemical parameters of hemolymph, intestinal microbiota and histology of hepatopancreas in white shrimp (Litopenaeus va …
This experiment was conducted to evaluate the effects of dietary supplementation of Apple cider vinegar (ACV) and propionic acid
GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples.
Hoving LR, Heijink M, van Harmelen V, van Dijk KW, Giera M. Hoving LR, et al. Methods Mol Biol. 2018;1730:247-256. doi: 10.1007/978-1-4939-7592-1_17. Methods Mol Biol. 2018. PMID: 29363078
Short-chain fatty acids, the end products of fermentation of dietary fibers by the gut microbiota, have been shown to exert multiple effects on mammalian metabolism. ...The short-chain fatty acids analyzed include acetic acid, propionic acid, butyric …
Short-chain fatty acids, the end products of fermentation of dietary fibers by the gut microbiota, have been shown to exert multiple …
Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats.
Zhao ZH, Xin FZ, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu XL, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y, Fan JG. Zhao ZH, et al. Exp Mol Med. 2019 Sep 10;51(9):1-14. doi: 10.1038/s12276-019-0304-5. Exp Mol Med. 2019. PMID: 31506421 Free PMC article.
Microbial metabolites have emerged as critical components that mediate the metabolic effects of the gut microbiota. Here, we show that indole-3-propionic acid (IPA), a tryptophan metabolite produced by gut bacteria, is a potent anti-non-alcoholic steatohepati …
Microbial metabolites have emerged as critical components that mediate the metabolic effects of the gut microbiota. Here, we show tha …
Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior.
Lobzhanidze G, Lordkipanidze T, Zhvania M, Japaridze N, MacFabe DF, Pochkidze N, Gasimov E, Rzaev F. Lobzhanidze G, et al. Micron. 2019 Oct;125:102732. doi: 10.1016/j.micron.2019.102732. Epub 2019 Aug 6. Micron. 2019. PMID: 31437571
Gut microbiota plays one of the central roles in the etiology of autism. Propionic acid is one of the most abundant short-chain fatty acids, made by enteric bacteria. Propionic acid has many positive functions and acts as the main mediator betwe …
Gut microbiota plays one of the central roles in the etiology of autism. Propionic acid is one of the most abundant sho …
Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases.
Hirschberg S, Gisevius B, Duscha A, Haghikia A. Hirschberg S, et al. Int J Mol Sci. 2019 Jun 25;20(12):3109. doi: 10.3390/ijms20123109. Int J Mol Sci. 2019. PMID: 31242699 Free PMC article. Review.
For instance, the SCFA propionic acid (PA) increases the amount of intestine-derived regulatory T cells, which furthermore can positively affect the central nervous system (CNS), e.g., by increasing remyelination. ...In this review, we discuss the impact of an alter …
For instance, the SCFA propionic acid (PA) increases the amount of intestine-derived regulatory T cells, which furthermore can …
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis.
Sivaprakasam S, Prasad PD, Singh N. Sivaprakasam S, et al. Pharmacol Ther. 2016 Aug;164:144-51. doi: 10.1016/j.pharmthera.2016.04.007. Epub 2016 Apr 23. Pharmacol Ther. 2016. PMID: 27113407 Free PMC article. Review.
Butyrate, propionate and acetate, which are collectively called short-chain fatty acids (SCFAs), are generated by fermentation of dietary fibers by gut microbiota. Evidences indicate that SCFAs are key players in regulating beneficial effect of dietary fibers and gut mi
Butyrate, propionate and acetate, which are collectively called short-chain fatty acids (SCFAs), are generated by fermentation of dietary fi …
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