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1882 1
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1893 9
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1908 2
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1913 2
1915 2
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1917 1
1918 4
1919 4
1920 11
1921 11
1922 15
1923 19
1924 11
1925 7
1926 15
1927 15
1928 16
1929 21
1930 29
1931 19
1932 17
1933 26
1934 17
1935 30
1936 16
1937 18
1938 20
1939 26
1940 16
1941 16
1942 17
1943 11
1944 14
1945 37
1946 123
1947 141
1948 121
1949 114
1950 171
1951 186
1952 187
1953 224
1954 280
1955 294
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1966 1308
1967 2223
1968 2703
1969 3173
1970 3143
1971 3476
1972 3991
1973 4003
1974 3914
1975 6857
1976 7384
1977 7562
1978 7832
1979 8558
1980 9432
1981 10020
1982 10973
1983 12430
1984 14026
1985 15365
1986 16354
1987 17759
1988 18657
1989 21864
1990 23397
1991 24923
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1993 27461
1994 29502
1995 31414
1996 33763
1997 35356
1998 37872
1999 40554
2000 45166
2001 48065
2002 52115
2003 57680
2004 65369
2005 75066
2006 83509
2007 91002
2008 100001
2009 108548
2010 122763
2011 138410
2012 154562
2013 168394
2014 183774
2015 196630
2016 210276
2017 228220
2018 245413
2019 266137
2020 328928
2021 423883
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5,624,421 results

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Page 1
Did you mean perspectiveness OR potential (5,624,430 results)?
Flavor potentiators.
Maga JA. Maga JA. Crit Rev Food Sci Nutr. 1983;18(3):231-312. doi: 10.1080/10408398309527364. Crit Rev Food Sci Nutr. 1983. PMID: 6137322 Review.
This review provides extensive presentation and evaluation of data relative to flavor potentiation, including the historical, chemical, organoleptic, metabolic, physiological, and consumptive properties of the commonly available flavor potentiators, which are primar …
This review provides extensive presentation and evaluation of data relative to flavor potentiation, including the historical, chemica …
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels.
Page DA, Ruben PC. Page DA, et al. J Gen Physiol. 2024 Jun 3;156(6):e202313505. doi: 10.1085/jgp.202313505. Epub 2024 Apr 23. J Gen Physiol. 2024. PMID: 38652080 Free PMC article.
CBD also sped activation kinetics by approximately threefold. CBD potentiation of HCN4 channels occurred via binding to the closed state of the channel. We found that CBD's mechanism of action was distinct from cAMP, as CBD also potentiated apo-HCN4 channels. The ad …
CBD also sped activation kinetics by approximately threefold. CBD potentiation of HCN4 channels occurred via binding to the closed st …
CFTR correctors potentiate gating mutants causing cystic fibrosis.
Castanier S, Elbahnsi A, Chevalier B, Berri L, Dias Wickramanayaka M, Mornon JP, Hatton A, Sermet-Gaudelus I, Edelman A, Callebaut I, Hinzpeter A. Castanier S, et al. J Cyst Fibros. 2026 Mar;25(2):305-313. doi: 10.1016/j.jcf.2025.11.008. Epub 2025 Nov 20. J Cyst Fibros. 2026. PMID: 41266217 Free article.
Results show that VX-445 potentiated gating mutants causing cystic fibrosis located in the NBDs (NBD1 G551D and NBD2 G1349D) and in the IntraCellular Loops (ICL1 G178R and ICL3 G970R). ...Potentiation could also be observed with correctors VX-809 and VX-121, indicat …
Results show that VX-445 potentiated gating mutants causing cystic fibrosis located in the NBDs (NBD1 G551D and NBD2 G1349D) and in t …
New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance.
Klobucar K, Brown ED. Klobucar K, et al. Curr Opin Chem Biol. 2022 Feb;66:102099. doi: 10.1016/j.cbpa.2021.102099. Epub 2021 Nov 19. Curr Opin Chem Biol. 2022. PMID: 34808425 Review.
In this review, we survey chemical matter which has been shown to potentiate antibiotics against Gram-negative bacteria by perturbing the OM. These include peptides, nanoparticles, macromolecules, antibiotic conjugates, and small molecules....
In this review, we survey chemical matter which has been shown to potentiate antibiotics against Gram-negative bacteria by perturbing …
(R)-vanzacaftor potentiates BK(Ca) channels in the absence of CFTR correction or potentiation.
Kolski-Andreaco A, Hahn SA, Sembrat J, Straub AC, Butterworth MB, Devor DC. Kolski-Andreaco A, et al. Am J Physiol Cell Physiol. 2025 Oct 1;329(4):C1130-C1138. doi: 10.1152/ajpcell.00654.2025. Epub 2025 Sep 8. Am J Physiol Cell Physiol. 2025. PMID: 40920663 Free PMC article.
This potentiation of BK(Ca) resulted in altered vasoreactivity and neuronal excitability. We postulated novel compounds could be identified that would potentiate BK(Ca) while not affecting CFTR. ...We now demonstrate that the enantiomer of vanzacaftor, R-VX-121, …
This potentiation of BK(Ca) resulted in altered vasoreactivity and neuronal excitability. We postulated novel compounds could be iden …
Antibiotic Potentiation as a Promising Strategy to Combat Macrolide Resistance in Bacterial Pathogens.
Paul D, Chawla M, Ahrodia T, Narendrakumar L, Das B. Paul D, et al. Antibiotics (Basel). 2023 Dec 11;12(12):1715. doi: 10.3390/antibiotics12121715. Antibiotics (Basel). 2023. PMID: 38136749 Free PMC article. Review.
Thus, potentiating the existing antibiotics is one of the promising approaches to tackle and minimize the impact of antimicrobial resistance (AMR). Several natural and synthetic compounds have demonstrated effectiveness in potentiating macrolide antibiotics against …
Thus, potentiating the existing antibiotics is one of the promising approaches to tackle and minimize the impact of antimicrobial res …
Glutamate potentiates heterologously expressed homomeric acid-sensing ion channel 1a.
Shteinikov V, Evlanenkov K, Bolshakov K, Tikhonov D. Shteinikov V, et al. Synapse. 2022 Apr;76(5-6):e22227. doi: 10.1002/syn.22227. Epub 2022 Feb 25. Synapse. 2022. PMID: 35157787
This has stimulated attempts to find endogenous ASIC potentiators that could enhance ASIC-mediated currents to physiologically relevant values. ...At pH=6.5 glutamate had maximum potentiation of 87% with an EC(50) value of 0.65 mM. The mechanism of potentiation …
This has stimulated attempts to find endogenous ASIC potentiators that could enhance ASIC-mediated currents to physiologically releva …
Is action potential duration of the intact dog heart related to contractility or stimulus rate?
Drake AJ, Noble MI, Schouten V, Seed A, Ter Keurs HE, Wohlfart B. Drake AJ, et al. J Physiol. 1982 Oct;331:499-510. doi: 10.1113/jphysiol.1982.sp014386. J Physiol. 1982. PMID: 7153914 Free PMC article.
Prior to the test interval (priming period) a variety of potentiating stimulus trains were introduced.3. When the frequency of stimulation was increased in the priming period (frequency potentiation), there was an inverse relationship between action potential …
Prior to the test interval (priming period) a variety of potentiating stimulus trains were introduced.3. When the frequency of stimul …
Arginine vasopressin potentiates inspiratory bursting in hypoglossal motoneurons of neonatal mice.
Bolte KN, Wealing JC, Revill AL. Bolte KN, et al. Respir Physiol Neurobiol. 2023 Aug;314:104087. doi: 10.1016/j.resp.2023.104087. Epub 2023 Jun 2. Respir Physiol Neurobiol. 2023. PMID: 37269889 Free PMC article.
Bath or local application of AVP potentiated inspiratory bursting compared to baseline XII inspiratory burst amplitude. Antagonizing V1a receptors revealed significant attenuation of the AVP-mediated potentiation of inspiratory bursting, while antagonism of oxytocin …
Bath or local application of AVP potentiated inspiratory bursting compared to baseline XII inspiratory burst amplitude. Antagonizing …
Potentiating SLC transporter activity: Emerging drug discovery opportunities.
Rives ML, Javitch JA, Wickenden AD. Rives ML, et al. Biochem Pharmacol. 2017 Jul 1;135:1-11. doi: 10.1016/j.bcp.2017.02.010. Epub 2017 Feb 16. Biochem Pharmacol. 2017. PMID: 28214518 Review.
In this commentary, we discuss several strategies for potentiating SLC transporter function, from direct acting potentiators to modulators of transcription, translation or trafficking. We review the progress made in recent years toward the understanding of the struc …
In this commentary, we discuss several strategies for potentiating SLC transporter function, from direct acting potentiators t …
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