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Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis.
Abusarah J, Benabdoune H, Shi Q, Lussier B, Martel-Pelletier J, Malo M, Fernandes JC, de Souza FP, Fahmi H, Benderdour M. Abusarah J, et al. J Cell Biochem. 2017 May;118(5):1003-1013. doi: 10.1002/jcb.25659. Epub 2017 Jan 5. J Cell Biochem. 2017. PMID: 27463229
Human OA chondrocytes were treated with 1 ng/ml IL-1β in the presence or absence of protandim (0-10 μg/ml) or 6-gingerol (0-10 μM). ...Interestingly, protandim administration reduced OA score in DMM mice. Altogether, our data indicate that protandim and 6-gin …
Human OA chondrocytes were treated with 1 ng/ml IL-1β in the presence or absence of protandim (0-10 μg/ml) or 6-gingerol (0-10 μM). . …
Protandim Protects Oligodendrocytes against an Oxidative Insult.
Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J. Lim JL, et al. Antioxidants (Basel). 2016 Sep 7;5(3):30. doi: 10.3390/antiox5030030. Antioxidants (Basel). 2016. PMID: 27618111 Free PMC article.
Protandim most potently promoted oligodendrocyte cell survival as measured by live/death viability assay. Moreover, OPCs were treated with Protandim or vehicle control prior to exposing them to TNF or hydrogen peroxide for five days, which inhibited OPC differentiat
Protandim most potently promoted oligodendrocyte cell survival as measured by live/death viability assay. Moreover, OPCs were treated
Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise.
Bruns DR, Ehrlicher SE, Khademi S, Biela LM, Peelor FF 3rd, Miller BF, Hamilton KL. Bruns DR, et al. J Appl Physiol (1985). 2018 Aug 1;125(2):661-671. doi: 10.1152/japplphysiol.00277.2018. Epub 2018 Jun 1. J Appl Physiol (1985). 2018. PMID: 29856263 Free PMC article.
Furthermore, we show that treatment with Protandim, a purported nuclear factor (erythroid-derived 2)-like 2 activator that upregulates endogenous antioxidants, permits mitochondrial biogenesis. We confirm that vitamin C blunts aerobic exercise adaptions, whereas Protand
Furthermore, we show that treatment with Protandim, a purported nuclear factor (erythroid-derived 2)-like 2 activator that upregulate …
ALSUntangled No. 31: Protandim.
ALSUntangled Group. ALSUntangled Group. Amyotroph Lateral Scler Frontotemporal Degener. 2015;17(1-2):154-6. doi: 10.3109/21678421.2015.1088707. Epub 2015 Sep 28. Amyotroph Lateral Scler Frontotemporal Degener. 2015. PMID: 26414415 Review. No abstract available.
NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.
Priestley JRC, Fink KE, McCord JM, Lombard JH. Priestley JRC, et al. Microcirculation. 2019 Oct;26(7):e12575. doi: 10.1111/micc.12575. Epub 2019 Jun 19. Microcirculation. 2019. PMID: 31132190 Free PMC article.
METHODS: Male Sprague-Dawley rats and Syrian hamsters were fed a HS (4.0% NaCl) diet containing ~60 mg/kg/day Protandim supplement for 2 weeks and compared to controls fed HS diet alone. ...Basilar arteries from HS-fed rats treated with Protandim exhibited significa …
METHODS: Male Sprague-Dawley rats and Syrian hamsters were fed a HS (4.0% NaCl) diet containing ~60 mg/kg/day Protandim supplement fo …
Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.
Liu J, Gu X, Robbins D, Li G, Shi R, McCord JM, Zhao Y. Liu J, et al. PLoS One. 2009;4(4):e5284. doi: 10.1371/journal.pone.0005284. Epub 2009 Apr 22. PLoS One. 2009. PMID: 19384424 Free PMC article.
At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, which indicated no overt toxicity by Protandim. ...Overall, induction of antioxidant enzymes by Protandim may serve as a prac …
At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, …
Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim.
Velmurugan K, Alam J, McCord JM, Pugazhenthi S. Velmurugan K, et al. Free Radic Biol Med. 2009 Feb 1;46(3):430-40. doi: 10.1016/j.freeradbiomed.2008.10.050. Epub 2008 Nov 17. Free Radic Biol Med. 2009. PMID: 19056485
Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. A recent clinical study demonstrated the in vivo antioxidant effects of Protandim (S.K. Nelson et al., 2006, Free Radic. Biol. ...
Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. A
The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis.
Robbins D, Gu X, Shi R, Liu J, Wang F, Ponville J, McCord JM, Zhao Y. Robbins D, et al. PLoS One. 2010 Jul 30;5(7):e11902. doi: 10.1371/journal.pone.0011902. PLoS One. 2010. PMID: 20689586 Free PMC article.
Therefore, we investigated the effects of the Protandim diet on apoptosis; and proposed a novel mechanism of chemoprevention utilized by the Protandim dietary combination. ...Our results showed that Protandim suppressed the mitochondrial translocation of p53 …
Therefore, we investigated the effects of the Protandim diet on apoptosis; and proposed a novel mechanism of chemoprevention utilized …
Development of a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of epigallocatechin-3-gallate, silibinin, and curcumin in plasma and different tissues after oral dosing of Protandim in rats and its application in pharmacokinetic and tissue distribution studies.
Song Y, Sun H, Xiao J, Wang F, Ding Y, Zhao J, Bai J, Cheng L, Gao K, Liu M, Guo Q, Zhang Y, Gao W, Jia Y, Wen A. Song Y, et al. J Pharm Biomed Anal. 2019 Jun 5;170:54-62. doi: 10.1016/j.jpba.2019.03.024. Epub 2019 Mar 14. J Pharm Biomed Anal. 2019. PMID: 30904740
Protandim is an over-the-counter herbal dietary supplement. The key components of Protandim, i.e., epigallocatechin-3-gallate (EGCG), silibinin (SIL), and curcumin (CUR) were simultaneously analyzed through a liquid chromatography-tandem mass spectrometric (LC-MS/MS
Protandim is an over-the-counter herbal dietary supplement. The key components of Protandim, i.e., epigallocatechin-3-gallate
Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders.
Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Burnham EL, et al. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L688-99. doi: 10.1152/ajplung.00171.2011. Epub 2012 Jan 20. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22268125 Free PMC article. Clinical Trial.
We randomized 30 otherwise healthy AUD subjects to receive directly observed inpatient oral therapy with either Protandim (1,350 mg/day) or placebo. ...These results suggest that Protandim for 7 days in individuals with AUDs who are newly abstinent does not alter al …
We randomized 30 otherwise healthy AUD subjects to receive directly observed inpatient oral therapy with either Protandim (1,350 mg/d …
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