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Protandim Protects Oligodendrocytes against an Oxidative Insult.
Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J. Lim JL, et al. Antioxidants (Basel). 2016 Sep 7;5(3):30. doi: 10.3390/antiox5030030. Antioxidants (Basel). 2016. PMID: 27618111 Free PMC article.
Moreover, OPCs were treated with Protandim or vehicle control prior to exposing them to TNF or hydrogen peroxide for five days, which inhibited OPC differentiation. Protandim significantly promoted OPC differentiation under influence of ROS, but not TNF. ...
Moreover, OPCs were treated with Protandim or vehicle control prior to exposing them to TNF or hydrogen peroxide for five days, which …
Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis.
Abusarah J, Benabdoune H, Shi Q, Lussier B, Martel-Pelletier J, Malo M, Fernandes JC, de Souza FP, Fahmi H, Benderdour M. Abusarah J, et al. J Cell Biochem. 2017 May;118(5):1003-1013. doi: 10.1002/jcb.25659. Epub 2017 Jan 5. J Cell Biochem. 2017. PMID: 27463229
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. ...The animals were treated weekly with an intraarticular injection of 10 mul of vehicle or protandim (10 mug/
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenou
The Effect of Protandim Supplementation on Athletic Performance and Oxidative Blood Markers in Runners.
Ueberschlag SL, Seay JR, Roberts AH, DeSpirito PC, Stith JM, Folz RJ, Carter KA, Weiss EP, Zavorsky GS. Ueberschlag SL, et al. PLoS One. 2016 Aug 11;11(8):e0160559. doi: 10.1371/journal.pone.0160559. eCollection 2016. PLoS One. 2016. PMID: 27513339 Free PMC article. Clinical Trial.
TBARS, SOD, GPX, and GSH were assayed in an out-of-state accredited lab. Running performance was not altered by Protandim or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardless of group]. There was no change in TBARS, SOD, or GPX (at rest) a …
TBARS, SOD, GPX, and GSH were assayed in an out-of-state accredited lab. Running performance was not altered by Protandim or placebo …
NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.
Priestley JRC, Fink KE, McCord JM, Lombard JH. Priestley JRC, et al. Microcirculation. 2019 Oct;26(7):e12575. doi: 10.1111/micc.12575. Epub 2019 Jun 19. Microcirculation. 2019. PMID: 31132190 Free PMC article.
METHODS: Male Sprague-Dawley rats and Syrian hamsters were fed a HS (4.0% NaCl) diet containing ~60 mg/kg/day Protandim supplement for 2 weeks and compared to controls fed HS diet alone. ...Basilar arteries from HS-fed rats treated with Protandim exhibited significa …
METHODS: Male Sprague-Dawley rats and Syrian hamsters were fed a HS (4.0% NaCl) diet containing ~60 mg/kg/day Protandim supplement fo …
ALSUntangled No. 31: Protandim.
ALSUntangled Group. ALSUntangled Group. Amyotroph Lateral Scler Frontotemporal Degener. 2015;17(1-2):154-6. doi: 10.3109/21678421.2015.1088707. Epub 2015 Sep 28. Amyotroph Lateral Scler Frontotemporal Degener. 2015. PMID: 26414415 Review. No abstract available.
Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim.
Velmurugan K, Alam J, McCord JM, Pugazhenthi S. Velmurugan K, et al. Free Radic Biol Med. 2009 Feb 1;46(3):430-40. doi: 10.1016/j.freeradbiomed.2008.10.050. Epub 2008 Nov 17. Free Radic Biol Med. 2009. PMID: 19056485
Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. ...The involvement of multiple signaling pathways, including PI3-kinase/Akt, p38MAPK, and PKCdelta, in HO-1 induction seems to be the probable
Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. ..
Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise.
Bruns DR, Ehrlicher SE, Khademi S, Biela LM, Peelor FF 3rd, Miller BF, Hamilton KL. Bruns DR, et al. J Appl Physiol (1985). 2018 Aug 1;125(2):661-671. doi: 10.1152/japplphysiol.00277.2018. Epub 2018 Jun 1. J Appl Physiol (1985). 2018. PMID: 29856263 Free PMC article.
By directly measuring mitochondrial biogenesis, we demonstrate that vitamin C blunts exercise-induced adaptations. Furthermore, we show that treatment with Protandim, a purported nuclear factor (erythroid-derived 2)-like 2 activator that upregulates endogenous antioxidants …
By directly measuring mitochondrial biogenesis, we demonstrate that vitamin C blunts exercise-induced adaptations. Furthermore, we show that …
Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.
Liu J, Gu X, Robbins D, Li G, Shi R, McCord JM, Zhao Y. Liu J, et al. PLoS One. 2009;4(4):e5284. doi: 10.1371/journal.pone.0005284. Epub 2009 Apr 22. PLoS One. 2009. PMID: 19384424 Free PMC article.
At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, which indicated no overt toxicity by Protandim. ...Overall, induction of antioxidant enzymes by Protandim may serve as a prac …
At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, …
Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders.
Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Burnham EL, et al. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L688-99. doi: 10.1152/ajplung.00171.2011. Epub 2012 Jan 20. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22268125 Free PMC article. Clinical Trial.
We sought to determine if correcting pulmonary oxidative stress in the setting of AUDs would normalize alveolar epithelial permeability in a double-blinded, randomized, placebo-controlled trial of Protandim, a nutraceutical reported to enhance antioxidant activity. ...Over …
We sought to determine if correcting pulmonary oxidative stress in the setting of AUDs would normalize alveolar epithelial permeability in a …
Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway.
Joddar B, Reen RK, Firstenberg MS, Varadharaj S, McCord JM, Zweier JL, Gooch KJ. Joddar B, et al. Free Radic Biol Med. 2011 Mar 15;50(6):700-9. doi: 10.1016/j.freeradbiomed.2010.12.008. Epub 2010 Dec 15. Free Radic Biol Med. 2011. PMID: 21167278
Protandim treatment increased the activity of SOD, HO-1, and catalase 3-, 7-, and 12-fold, respectively, and decreased the levels of superoxide (O(2)(-)) and the lipid peroxidation product 4-HNE. Blocking catalase activity by cotreating with 3-amino-1,2,4-triazole abrogate
Protandim treatment increased the activity of SOD, HO-1, and catalase 3-, 7-, and 12-fold, respectively, and decreased the levels of
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