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Protandim Protects Oligodendrocytes against an Oxidative Insult.
Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J. Lim JL, et al. Antioxidants (Basel). 2016 Sep 7;5(3):30. doi: 10.3390/antiox5030030. Antioxidants (Basel). 2016. PMID: 27618111 Free PMC article.
Moreover, OPCs were treated with Protandim or vehicle control prior to exposing them to TNF or hydrogen peroxide for five days, which inhibited OPC differentiation. Protandim significantly promoted OPC differentiation under influence of ROS, but not TNF. ...
Moreover, OPCs were treated with Protandim or vehicle control prior to exposing them to TNF or hydrogen peroxide for five days, which …
Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis.
Abusarah J, Benabdoune H, Shi Q, Lussier B, Martel-Pelletier J, Malo M, Fernandes JC, de Souza FP, Fahmi H, Benderdour M. Abusarah J, et al. J Cell Biochem. 2017 May;118(5):1003-1013. doi: 10.1002/jcb.25659. Epub 2017 Jan 5. J Cell Biochem. 2017. PMID: 27463229
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. ...The animals were treated weekly with an intraarticular injection of 10 mul of vehicle or protandim (10 mug/ …
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenou …
NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.
Priestley JRC, Fink KE, McCord JM, Lombard JH. Priestley JRC, et al. Microcirculation. 2019 Oct;26(7):e12575. doi: 10.1111/micc.12575. Epub 2019 Jun 19. Microcirculation. 2019. PMID: 31132190 Free PMC article.
METHODS: Male Sprague-Dawley rats and Syrian hamsters were fed a HS (4.0% NaCl) diet containing ~60 mg/kg/day Protandim supplement for 2 weeks and compared to controls fed HS diet alone. ...Basilar arteries from HS-fed rats treated with Protandim exhibited significa …
METHODS: Male Sprague-Dawley rats and Syrian hamsters were fed a HS (4.0% NaCl) diet containing ~60 mg/kg/day Protandim supplement fo …
Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.
Liu J, Gu X, Robbins D, Li G, Shi R, McCord JM, Zhao Y. Liu J, et al. PLoS One. 2009;4(4):e5284. doi: 10.1371/journal.pone.0005284. Epub 2009 Apr 22. PLoS One. 2009. PMID: 19384424 Free PMC article.
At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, which indicated no overt toxicity by Protandim. ...Overall, induction of antioxidant enzymes by Protandim may serve as a prac …
At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, …
The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners.
Ueberschlag SL, Seay JR, Roberts AH, DeSpirito PC, Stith JM, Folz RJ, Carter KA, Weiss EP, Zavorsky GS. Ueberschlag SL, et al. PLoS One. 2016 Aug 11;11(8):e0160559. doi: 10.1371/journal.pone.0160559. eCollection 2016. PLoS One. 2016. PMID: 27513339 Free PMC article. Clinical Trial.
TBARS, SOD, GPX, and GSH were assayed in an out-of-state accredited lab. Running performance was not altered by Protandim or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardless of group]. There was no change in TBARS, SOD, or GPX (at rest) a …
TBARS, SOD, GPX, and GSH were assayed in an out-of-state accredited lab. Running performance was not altered by Protandim or placebo …
ALSUntangled No. 31: Protandim.
ALSUntangled Group. ALSUntangled Group. Amyotroph Lateral Scler Frontotemporal Degener. 2015;17(1-2):154-6. doi: 10.3109/21678421.2015.1088707. Epub 2015 Sep 28. Amyotroph Lateral Scler Frontotemporal Degener. 2015. PMID: 26414415 Review. No abstract available.
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.
Hybertson BM, Gao B, Bose SK, McCord JM. Hybertson BM, et al. Mol Aspects Med. 2011 Aug;32(4-6):234-46. doi: 10.1016/j.mam.2011.10.006. Epub 2011 Oct 15. Mol Aspects Med. 2011. PMID: 22020111 Free article. Review.
Gene expression microarray data on human primary vascular endothelial cells and on the SK-N-MC human neuroblastoma-derived cell line have been obtained in response to the dietary supplement Protandim, a potent composition of highly synergistic phytochemical Nrf2 activators …
Gene expression microarray data on human primary vascular endothelial cells and on the SK-N-MC human neuroblastoma-derived cell line have be …
Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway.
Joddar B, Reen RK, Firstenberg MS, Varadharaj S, McCord JM, Zweier JL, Gooch KJ. Joddar B, et al. Free Radic Biol Med. 2011 Mar 15;50(6):700-9. doi: 10.1016/j.freeradbiomed.2010.12.008. Epub 2010 Dec 15. Free Radic Biol Med. 2011. PMID: 21167278
Protandim treatment increased the activity of SOD, HO-1, and catalase 3-, 7-, and 12-fold, respectively, and decreased the levels of superoxide (O(2)(-)) and the lipid peroxidation product 4-HNE. Blocking catalase activity by cotreating with 3-amino-1,2,4-triazole abrogate …
Protandim treatment increased the activity of SOD, HO-1, and catalase 3-, 7-, and 12-fold, respectively, and decreased the levels of …
Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders.
Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Burnham EL, et al. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L688-99. doi: 10.1152/ajplung.00171.2011. Epub 2012 Jan 20. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22268125 Free PMC article. Clinical Trial.
We sought to determine if correcting pulmonary oxidative stress in the setting of AUDs would normalize alveolar epithelial permeability in a double-blinded, randomized, placebo-controlled trial of Protandim, a nutraceutical reported to enhance antioxidant activity. ...Over …
We sought to determine if correcting pulmonary oxidative stress in the setting of AUDs would normalize alveolar epithelial permeability in a …
The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis.
Robbins D, Gu X, Shi R, Liu J, Wang F, Ponville J, McCord JM, Zhao Y. Robbins D, et al. PLoS One. 2010 Jul 30;5(7):e11902. doi: 10.1371/journal.pone.0011902. PLoS One. 2010. PMID: 20689586 Free PMC article.
Therefore, we investigated the effects of the Protandim diet on apoptosis; and proposed a novel mechanism of chemoprevention utilized by the Protandim dietary combination. ...Our results suggest that suppression of p53 and induction of MnSOD may play an important ro …
Therefore, we investigated the effects of the Protandim diet on apoptosis; and proposed a novel mechanism of chemoprevention utilized …
The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice.
Qureshi MM, McClure WC, Arevalo NL, Rabon RE, Mohr B, Bose SK, McCord JM, Tseng BS. Qureshi MM, et al. J Diet Suppl. 2010 Jun 1;7(2):159-178. doi: 10.3109/19390211.2010.482041. J Diet Suppl. 2010. PMID: 20740052 Free PMC article.
After 6 months of Protandim((R)), a 48% average decrease in plasma TBARS was seen; 0.92 nmol/mg protein in controls versus 0.48 nmol/mg protein in the Protandim((R)) group (p = .006). At 6 months, plasma OPN was decreased by 57% (p = .001) in the Protandim((R …
After 6 months of Protandim((R)), a 48% average decrease in plasma TBARS was seen; 0.92 nmol/mg protein in controls versus 0.48 nmol/ …
Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim.
Velmurugan K, Alam J, McCord JM, Pugazhenthi S. Velmurugan K, et al. Free Radic Biol Med. 2009 Feb 1;46(3):430-40. doi: 10.1016/j.freeradbiomed.2008.10.050. Epub 2008 Nov 17. Free Radic Biol Med. 2009. PMID: 19056485
Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. ...The involvement of multiple signaling pathways, including PI3-kinase/Akt, p38MAPK, and PKCdelta, in HO-1 induction seems to be the probable …
Protandim was formulated with the objective of combining multiple phytochemicals at low nontoxic doses to gain synergy among them. .. …
Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise.
Bruns DR, Ehrlicher SE, Khademi S, Biela LM, Peelor FF 3rd, Miller BF, Hamilton KL. Bruns DR, et al. J Appl Physiol (1985). 2018 Aug 1;125(2):661-671. doi: 10.1152/japplphysiol.00277.2018. Epub 2018 Jun 1. J Appl Physiol (1985). 2018. PMID: 29856263 Free PMC article.
By directly measuring mitochondrial biogenesis, we demonstrate that vitamin C blunts exercise-induced adaptations. Furthermore, we show that treatment with Protandim, a purported nuclear factor (erythroid-derived 2)-like 2 activator that upregulates endogenous antioxidants …
By directly measuring mitochondrial biogenesis, we demonstrate that vitamin C blunts exercise-induced adaptations. Furthermore, we show that …
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.
Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE. Strong R, et al. Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16. Aging Cell. 2016. PMID: 27312235 Free PMC article.
We report the effects of lifelong treatment of mice with four agents not previously tested: Protandim, fish oil, ursodeoxycholic acid (UDCA) and metformin - the latter with and without rapamycin, and two drugs previously examined: 17-alpha-estradiol and nordihydroguaiareti …
We report the effects of lifelong treatment of mice with four agents not previously tested: Protandim, fish oil, ursodeoxycholic acid …
Development of a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of epigallocatechin-3-gallate, silibinin, and curcumin in plasma and different tissues after oral dosing of Protandim in rats and its application in pharmacokinetic and tissue distribution studies.
Song Y, Sun H, Xiao J, Wang F, Ding Y, Zhao J, Bai J, Cheng L, Gao K, Liu M, Guo Q, Zhang Y, Gao W, Jia Y, Wen A. Song Y, et al. J Pharm Biomed Anal. 2019 Jun 5;170:54-62. doi: 10.1016/j.jpba.2019.03.024. Epub 2019 Mar 14. J Pharm Biomed Anal. 2019. PMID: 30904740
Protandim is an over-the-counter herbal dietary supplement. The key components of Protandim, i.e., epigallocatechin-3-gallate (EGCG), silibinin (SIL), and curcumin (CUR) were simultaneously analyzed through a liquid chromatography-tandem mass spectrometric (LC-MS/MS …
Protandim is an over-the-counter herbal dietary supplement. The key components of Protandim, i.e., epigallocatechin-3-gallate …
Healthy Aging Interventions Reduce Repetitive Element Transcripts.
Wahl D, Cavalier AN, Smith M, Seals DR, LaRocca TJ. Wahl D, et al. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):805-810. doi: 10.1093/gerona/glaa302. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33257951 Free PMC article.
Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie restriction, rapamycin, acarbose, 17-alpha-estradiol, and Protandim. We also examine RE transcripts in long-lived transgenic mice, and …
Here, we analyze REs in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie r …
Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge.
Donovan EL, McCord JM, Reuland DJ, Miller BF, Hamilton KL. Donovan EL, et al. Oxid Med Cell Longev. 2012;2012:132931. doi: 10.1155/2012/132931. Epub 2012 May 22. Oxid Med Cell Longev. 2012. PMID: 22685617 Free PMC article.

Treatment of HCAEC with H(2)O(2) induced apoptosis in 34% of cells while pretreatment with Protandim resulted in only 6% apoptotic cells (P < 0.01). Nrf2 silencing significantly decreased the Protandim-induced increase in HO-1 protein (P < 0.01). ...These resu

…
Treatment of HCAEC with H(2)O(2) induced apoptosis in 34% of cells while pretreatment with Protandim resulted in only 6% apoptotic ce …
Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults.
Konopka AR, Laurin JL, Musci RV, Wolff CA, Reid JJ, Biela LM, Zhang Q, Peelor FF 3rd, Melby CL, Hamilton KL, Miller BF. Konopka AR, et al. Geroscience. 2017 Apr;39(2):175-186. doi: 10.1007/s11357-017-9968-8. Epub 2017 Mar 10. Geroscience. 2017. PMID: 28283797 Free PMC article. Clinical Trial.
Rates of myofibrillar protein synthesis were maintained despite lower mitochondrial and cytoplasmic protein syntheses after Protandim versus CON. Similarly, DNA synthesis was non-significantly lower after Protandim compared to CON. ...Overall, these data suggest tha …
Rates of myofibrillar protein synthesis were maintained despite lower mitochondrial and cytoplasmic protein syntheses after Protandim …
Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension?
Voelkel NF, Bogaard HJ, Al Husseini A, Farkas L, Gomez-Arroyo J, Natarajan R. Voelkel NF, et al. Antioxid Redox Signal. 2013 May 10;18(14):1810-7. doi: 10.1089/ars.2012.4828. Epub 2012 Sep 28. Antioxid Redox Signal. 2013. PMID: 22870869 Review.
This model, based on administration of the VEGF receptor blocker Sugen 5416 and chronic hypoxia (Su/Hx), reproduces many of the characteristic features of severe angioobliterative human PAH. Treatment of Su/Hx rats with protandim, which nuclear factor erythroid-2 related f …
This model, based on administration of the VEGF receptor blocker Sugen 5416 and chronic hypoxia (Su/Hx), reproduces many of the characterist …
Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice.
Cheatham MA, Edge RM, Homma K, Leserman EL, Dallos P, Zheng J. Cheatham MA, et al. PLoS One. 2015 Dec 18;10(12):e0145428. doi: 10.1371/journal.pone.0145428. eCollection 2015. PLoS One. 2015. PMID: 26682723 Free PMC article.
Because oxidative stress is implicated in OHC death, another group of 499 prestin KI mice was fed the antioxidant diet, Protandim. 499 KI mice were also backcrossed onto the FVB murine strain, which retains excellent high-frequency hearing well into adulthood, to reduce th …
Because oxidative stress is implicated in OHC death, another group of 499 prestin KI mice was fed the antioxidant diet, Protandim. 49 …
Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress.
Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, Miller BF, Hamilton KL. Reuland DJ, et al. Free Radic Biol Med. 2013 Mar;56:102-11. doi: 10.1016/j.freeradbiomed.2012.11.016. Epub 2012 Nov 30. Free Radic Biol Med. 2013. PMID: 23201694
The purpose of these experiments was to determine if treatment of cardiomyocytes with this phytochemical composition, marketed as Protandim, activates Nrf2, induces phase II detoxification enzymes, and protects cardiomyocytes from oxidant-induced apoptosis in a Nrf2-depend …
The purpose of these experiments was to determine if treatment of cardiomyocytes with this phytochemical composition, marketed as Protand …
The role of manganese superoxide dismutase in skin cancer.
Robbins D, Zhao Y. Robbins D, et al. Enzyme Res. 2011;2011:409295. doi: 10.4061/2011/409295. Epub 2011 Mar 23. Enzyme Res. 2011. PMID: 21603266 Free PMC article.
This method effectively reduced oxidative injury and proliferation without interfering with apoptosis. In another approach, Protandim, a combination of 5 well-studied medicinal plants, was given via dietary administration and significantly decreased tumor incidence and mul …
This method effectively reduced oxidative injury and proliferation without interfering with apoptosis. In another approach, Protandim …
Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.
Lisk C, McCord J, Bose S, Sullivan T, Loomis Z, Nozik-Grayck E, Schroeder T, Hamilton K, Irwin DC. Lisk C, et al. Free Radic Biol Med. 2013 Oct;63:264-73. doi: 10.1016/j.freeradbiomed.2013.05.024. Epub 2013 May 27. Free Radic Biol Med. 2013. PMID: 23722164 Free PMC article.
Of nine drugs tested, with the exception of dexamethasone, only drugs that showed the ability to activate Nrf2 (Protandim, methazolamide, nifedipine, amlodipine, ambrisentan, and sitaxentan) decreased high-altitude-induced cerebral vascular leak in vivo. ...
Of nine drugs tested, with the exception of dexamethasone, only drugs that showed the ability to activate Nrf2 (Protandim, methazolam …
Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.
Bogaard HJ, Natarajan R, Henderson SC, Long CS, Kraskauskas D, Smithson L, Ockaili R, McCord JM, Voelkel NF. Bogaard HJ, et al. Circulation. 2009 Nov 17;120(20):1951-60. doi: 10.1161/CIRCULATIONAHA.109.883843. Epub 2009 Nov 2. Circulation. 2009. PMID: 19884466
Induction of myocardial nuclear factor E2-related factor 2 and heme-oxygenase 1 with a dietary supplement (Protandim) prevented fibrosis and capillary loss and preserved RV function despite continuing pressure overload. ...
Induction of myocardial nuclear factor E2-related factor 2 and heme-oxygenase 1 with a dietary supplement (Protandim) prevented fibro …
The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy.
Nelson SK, Bose SK, Grunwald GK, Myhill P, McCord JM. Nelson SK, et al. Free Radic Biol Med. 2006 Jan 15;40(2):341-7. doi: 10.1016/j.freeradbiomed.2005.08.043. Free Radic Biol Med. 2006. PMID: 16413416
A composition consisting of extracts of five widely studied medicinal plants (Protandim) was administered to healthy human subjects ranging in age from 20 to 78 years. ...
A composition consisting of extracts of five widely studied medicinal plants (Protandim) was administered to healthy human subjects r …

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