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64 results

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Page 1
Sperm capacitation triggers transcriptomic changes linked to the proteasome-mediated ubiquitin-dependent catabolic pathway.
Caballero-Campo P, Casas-Ortega C, Hernández-Silva G, Lira-Albarrán S, Barrera D, Larrea F, Chirinos M. Caballero-Campo P, et al. Reproduction. 2025 Aug 21;170(3):e250168. doi: 10.1530/REP-25-0168. Print 2025 Sep 1. Reproduction. 2025. PMID: 40840531
IN BRIEF: Molecular changes during human sperm in vitro capacitation were investigated through RNA sequencing and bioinformatic analysis. The ubiquitin-dependent protein catabolic process emerged as a key pathway, and proteomic analysis supporte …
IN BRIEF: Molecular changes during human sperm in vitro capacitation were investigated through RNA sequencing and bioinformatic analysis. Th …
E6AP inhibits G-CSFR turnover and functions by promoting its ubiquitin-dependent proteasome degradation.
Chhabra S, Kumar Y, Thacker G, Kapoor I, Lochab S, Sanyal S, Bhatt MLB, Chattopadhyay N, Trivedi AK. Chhabra S, et al. Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1545-1553. doi: 10.1016/j.bbamcr.2017.05.026. Epub 2017 Jun 1. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28578910 Free article.
Previously, we demonstrated that Fbw7alpha negatively regulates G-CSFR and its downstream signaling through ubiquitin-proteasome mediated degradation. However, whether additional ubiquitin ligases for G-CSFR exist is not known. ...Here, for the first time we demonst …
Previously, we demonstrated that Fbw7alpha negatively regulates G-CSFR and its downstream signaling through ubiquitin-proteasome m …
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
Jiang N, Shen Y, Fei X, Sheng K, Sun P, Qiu Y, Larner J, Cao L, Kong X, Mi J. Jiang N, et al. Cell Death Dis. 2013 May 30;4(5):e647. doi: 10.1038/cddis.2013.171. Cell Death Dis. 2013. PMID: 23722536 Free PMC article.
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent …
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of gl …
The levels of MDM2 protein are decreased by a proteasome-mediated proteolysis prior to caspase-3-dependent pRb and PARP cleavages.
Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH. Cho JW, et al. J Korean Med Sci. 2001 Apr;16(2):135-9. doi: 10.3346/jkms.2001.16.2.135. J Korean Med Sci. 2001. PMID: 11306736 Free PMC article.
Thus, we investigated whether MDM2 is degraded through a ubiquitin-dependent proteasome pathway in the absence of p53. When HL-60 cells, p53 null, were treated with etoposide, MDM2 was markedly decreased prior to caspase-3-dependent retinoblastoma tumor suppressor …
Thus, we investigated whether MDM2 is degraded through a ubiquitin-dependent proteasome pathway in the absence of p53. When HL …
Selective autophagy: ubiquitin-mediated recognition and beyond.
Kraft C, Peter M, Hofmann K. Kraft C, et al. Nat Cell Biol. 2010 Sep;12(9):836-41. doi: 10.1038/ncb0910-836. Nat Cell Biol. 2010. PMID: 20811356
Proteasome-mediated degradation requires previous ubiquitylation of the cargo, which is then recognized by ubiquitin receptors directing it to 26S proteasomes. ...Recent evidence also suggests active crosstalk between proteasome-mediated degradation an …
Proteasome-mediated degradation requires previous ubiquitylation of the cargo, which is then recognized by ubiquitin receptors …
The multiomics landscape of plasma exosomes in first-episode drug-naïve of schizophrenia.
Dong Y, Wang S, Li M, Su Q, Bi F, Sun X, Qiu Y, Li J. Dong Y, et al. BMC Psychiatry. 2025 Aug 6;25(1):764. doi: 10.1186/s12888-025-07205-4. BMC Psychiatry. 2025. PMID: 40770299 Free PMC article.
The potential target genes of DE miRNAs were predicted, and GO and KEGG enrichment analysis showed that they were associated with RNA catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process …
The potential target genes of DE miRNAs were predicted, and GO and KEGG enrichment analysis showed that they were associated with RNA cat …
Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11.
Li J, Zhang Y, Da Silva Sil Dos Santos B, Wang F, Ma Y, Perez C, Yang Y, Peng J, Cohen SM, Chou TF, Hilton ST, Deshaies RJ. Li J, et al. Cell Chem Biol. 2018 Nov 15;25(11):1350-1358.e9. doi: 10.1016/j.chembiol.2018.07.012. Epub 2018 Aug 23. Cell Chem Biol. 2018. PMID: 30146242 Free PMC article.
The 26S proteasome is the major proteolytic machine for breaking down cytosolic and nuclear proteins in eukaryotes. Due to the lack of a suitable assay, it is difficult to measure routinely and quantitatively the breakdown of proteins by the 26S proteasome in vitro. …
The 26S proteasome is the major proteolytic machine for breaking down cytosolic and nuclear proteins in eukaryotes. Due to the lack o …
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases.
Marmor MD, Yarden Y. Marmor MD, et al. Oncogene. 2004 Mar 15;23(11):2057-70. doi: 10.1038/sj.onc.1207390. Oncogene. 2004. PMID: 15021893 Review.
Recent studies uncovered the role of protein ubiquitylation in vesicular trafficking of growth factor receptors. Decoration of ligand-activated receptors by multiple monomeric ubiquitins distinguishes this degradative route from the proteasome-mediated pathwa …
Recent studies uncovered the role of protein ubiquitylation in vesicular trafficking of growth factor receptors. Decoration of ligand …
Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stress.
Sidibe DK, Smith EM, Spivey ML, Vogel MC, Maday S. Sidibe DK, et al. PLoS One. 2026 Apr 20;21(4):e0345890. doi: 10.1371/journal.pone.0345890. eCollection 2026. PLoS One. 2026. PMID: 42008552 Free PMC article.
Sequestosome 1/p62 (hereafter referred to as p62) is a multifunctional protein that orchestrates various cellular stress response pathways including autophagy, proteasome-mediated degradation, antioxidant defense, nutrient sensing, and inflammatory signaling. …
Sequestosome 1/p62 (hereafter referred to as p62) is a multifunctional protein that orchestrates various cellular stress response pat …
Targeting retinoblastoma protein for degradation by proteasomes.
Ying H, Xiao ZX. Ying H, et al. Cell Cycle. 2006 Mar;5(5):506-8. doi: 10.4161/cc.5.5.2515. Epub 2006 Mar 1. Cell Cycle. 2006. PMID: 16552188
Inactivation of retinoblastoma protein (Rb) plays a key role in human tumorigenesis. Although the regulation of Rb by phosphorylation has been extensively studied, the regulation of proteasome-mediated Rb protein degradation is largely unknown. Viral o …
Inactivation of retinoblastoma protein (Rb) plays a key role in human tumorigenesis. Although the regulation of Rb by phosphorylation …
64 results