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101 results

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Page 1
TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.
Wang Z, Shen N, Wang Z, Yu L, Yang S, Wang Y, Liu Y, Han G, Zhang Q. Wang Z, et al. Cell Death Differ. 2024 Jan;31(1):53-64. doi: 10.1038/s41418-023-01239-5. Epub 2023 Nov 17. Cell Death Differ. 2024. PMID: 37978273 Free PMC article.
In this study, we identified TRIM3, an E3 ubiquitin-protein ligase, as a key regulator of ferroptosis. TRIM3 is downregulated in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), two major types of non-small cell lung cancer (NSCLC). ...Mechanistic …
In this study, we identified TRIM3, an E3 ubiquitin-protein ligase, as a key regulator of ferroptosis. TRIM3 is downregulated …
TRIM21-Mediated K11-Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma.
Li L, Wang Y, Tian R, Yang T, Liu Y, Shan B, Zhao L. Li L, et al. Adv Sci (Weinh). 2025 Sep;12(35):e02501. doi: 10.1002/advs.202502501. Epub 2025 Jul 13. Adv Sci (Weinh). 2025. PMID: 40652518 Free PMC article.
However, the mechanisms regulating ID1 ubiquitination in ESCC are not well understood. This study identifies TRIM21 as a novel E3 ubiquitin ligase that targets ID1 for K11-linked ubiquitination at lysine 91. Unlike typical ubiquitination …
However, the mechanisms regulating ID1 ubiquitination in ESCC are not well understood. This study identifies TRIM21 as a novel E3 …
Macrophage TRIM21 knockout inhibits septic acute lung injury by downregulating autophagy regulator protein ubiquitination.
Xie F, Fan JX, Wang H, Song QL, Xu YS, Lan QS, Jiang XM, Cheng J, Hou YM, Yang HR, Zhang X, Zhang QT, Wang P, Liu LH, Qian JY, Qin WD, Zhang MX, Pang JJ, Chen YG. Xie F, et al. Autophagy. 2025 Dec;21(12):2650-2669. doi: 10.1080/15548627.2025.2519063. Epub 2025 Jun 24. Autophagy. 2025. PMID: 40509575 Free PMC article.
Inducing macrophage macroautophagy/autophagy is a critical strategy to combat the inflammatory response in septic ALI. The E3 ubiquitin ligase TRIM21 plays important roles in autophagy. However, the mechanism connecting macrophage TRIM21-associated autophagy to ALI develop …
Inducing macrophage macroautophagy/autophagy is a critical strategy to combat the inflammatory response in septic ALI. The E3 ubiquitin …
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
Xiao K, Peng S, Lu J, Zhou T, Hong X, Chen S, Liu G, Li H, Huang J, Chen X, Lin T. Xiao K, et al. Cell Death Dis. 2023 Jul 8;14(7):408. doi: 10.1038/s41419-023-05938-2. Cell Death Dis. 2023. PMID: 37422473 Free PMC article.
Mechanistically, UBE2S interacted with tripartite motif containing 21 (TRIM21) and jointly induced the ubiquitination of lipoma preferred partner (LPP) via K11-linked polyubiquitination but not K48- or K63-linked polyubiquitination. ...In conclusion, our stud …
Mechanistically, UBE2S interacted with tripartite motif containing 21 (TRIM21) and jointly induced the ubiquitination of lipoma prefe …
RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13.
Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T, Zhong B, Lin D. Zhang ZD, et al. Adv Sci (Weinh). 2022 May;9(16):e2105391. doi: 10.1002/advs.202105391. Epub 2022 Mar 28. Adv Sci (Weinh). 2022. PMID: 35343654 Free PMC article.
The subcellular localization and intracellular trafficking of Toll-like receptors (TLRs) critically regulate TLRs-mediated antimicrobial immunity and autoimmunity. Here, it is demonstrated that the E3 ubiquitin ligase RNF115 inhibits the post-endoplasmic reticulum (ER) tra …
The subcellular localization and intracellular trafficking of Toll-like receptors (TLRs) critically regulate TLRs-mediated antimicrobial imm …
Ubiquitination in the ERAD Process.
Lopata A, Kniss A, Löhr F, Rogov VV, Dötsch V. Lopata A, et al. Int J Mol Sci. 2020 Jul 28;21(15):5369. doi: 10.3390/ijms21155369. Int J Mol Sci. 2020. PMID: 32731622 Free PMC article. Review.
In this review, we focus on the ubiquitination process within the endoplasmic reticulum associated protein degradation (ERAD) pathway. ...To prevent the accumulation of misfolded protein in the ER, proteins that fail the quality control undergo retrotr …
In this review, we focus on the ubiquitination process within the endoplasmic reticulum associated protein degradation (ERAD) …
USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation.
Shao N, Xi L, Lv Y, Idris M, Zhang L, Cao Y, Xiang J, Xu X, Ong BX, Zhang Q, Peng X, Yue X, Xu F, Liu C. Shao N, et al. Nat Commun. 2025 Feb 3;16(1):1313. doi: 10.1038/s41467-025-56564-9. Nat Commun. 2025. PMID: 39900921 Free PMC article.
The N(6)-methyladenosine binding protein YTHDF1, often upregulated in cancer, promotes tumor growth and hinders immune checkpoint blockade treatment. ...Here, we report that USP5 interacts with YTHDF1, stabilizing it by removing K11-linked polyubiquitination. …
The N(6)-methyladenosine binding protein YTHDF1, often upregulated in cancer, promotes tumor growth and hinders immune checkpoint blo …
Inhibition of UBE2C Promotes Parkin-Mediated K63-Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer.
Yang Y, Li W, Yang H, Xu F, Zhang S, Cao W, Li X, Zhang X, Chi X, Wang H, Du G, Wang Y, Wang J. Yang Y, et al. Adv Sci (Weinh). 2025 Aug;12(32):e17348. doi: 10.1002/advs.202417348. Epub 2025 Jul 29. Adv Sci (Weinh). 2025. PMID: 40729680 Free PMC article.
Therefore, there is an urgent need to discover new targets to overcome doxorubicin resistance in breast cancer. Ubiquitin-conjugating enzyme 2C (UBE2C) is an E2 ubiquitin-conjugating enzyme that catalyzes the assembly of K11-linked ubiquitin cha …
Therefore, there is an urgent need to discover new targets to overcome doxorubicin resistance in breast cancer. Ubiquitin-conjugating …
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways.
He M, Yang Z, Xie L, Chen J, Liu S, Lu L, Li Z, Zheng B, Ye Y, Lin Y, Bu L, Xiao J, Zhong Y, Jia P, Li Q, Liang Y, Guo D, Li CM, Hou P. He M, et al. Nat Commun. 2025 Feb 24;16(1):1920. doi: 10.1038/s41467-025-57245-3. Nat Commun. 2025. PMID: 39994288 Free PMC article.
In contrast, K11-linked polyubiquitination in CTD domains leads to proteasome-dependent degradation of RLRs. Thus, our study clarifies a function of atypical K6- and K11-linked polyubiquitination in the regulation of RLR signaling. We also unveil an el …
In contrast, K11-linked polyubiquitination in CTD domains leads to proteasome-dependent degradation of RLRs. Thus, our study c …
PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14.
Zhang Y, Yang X, Zhong H, Ding C, Xu X, Shao Y, Sun B, Zhang W, Ma J, Feng B, Zheng M, He Z. Zhang Y, et al. Int J Biol Sci. 2026 May 11;22(10):5182-5202. doi: 10.7150/ijbs.130350. eCollection 2026. Int J Biol Sci. 2026. PMID: 42212325 Free PMC article.
Mechanistically, PSMC5 promoted SMURF1-dependent K11-linked ubiquitination of METTL14 at K263, leading to METTL14 destabilization, global m6A remodeling, and activation of EMT-associated malignant phenotypes. ...
Mechanistically, PSMC5 promoted SMURF1-dependent K11-linked ubiquitination of METTL14 at K263, leading to METTL14 desta …
101 results