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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 5
1973 18
1974 16
1975 57
1976 73
1977 88
1978 97
1979 88
1980 104
1981 119
1982 96
1983 119
1984 121
1985 138
1986 110
1987 122
1988 135
1989 175
1990 223
1991 288
1992 343
1993 507
1994 767
1995 837
1996 943
1997 956
1998 992
1999 1001
2000 1109
2001 1022
2002 1174
2003 1162
2004 1244
2005 1161
2006 1245
2007 1159
2008 1168
2009 1083
2010 1096
2011 1117
2012 1151
2013 1131
2014 1122
2015 1063
2016 988
2017 941
2018 849
2019 831
2020 792
2021 731
2022 605
2023 499
2024 183

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30,414 results

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Page 1
Effect of Cyclic Adenosine Monophosphate on Connexin 37 Expression in Sheep Cumulus-Oocyte Complexes.
Zhao M, Subudeng G, Zhao Y, Hao S, Li H. Zhao M, et al. J Dev Biol. 2024 Mar 27;12(2):10. doi: 10.3390/jdb12020010. J Dev Biol. 2024. PMID: 38651455
However, there are no reports on whether cAMP regulates connexin 37 (Cx37) expression, one of the main connexin proteins, in sheep COCs. In this study, the expression of Cx37 protein and gene in immature sheep COC was detected using immunohistochemistry and PCR. ...Followi …
However, there are no reports on whether cAMP regulates connexin 37 (Cx37) expression, one of the main connexin proteins, in sheep COCs. In …
Spilanthes filicaulis (Schumach. & Thonn.) C.D. Adams leaves protects against streptozotocin-induced diabetic nephropathy.
Ojo OA, Ogunlakin AD, Akintayo CO, Olukiran OS, Adetunji JB, Ajayi-Odoko OA, Ogwa TO, Molehin OR, Ojo OO, Mothana RA, Alanzi AR. Ojo OA, et al. PLoS One. 2024 Apr 19;19(4):e0301992. doi: 10.1371/journal.pone.0301992. eCollection 2024. PLoS One. 2024. PMID: 38640098 Free PMC article.
After 15 days, the rats were evaluated for fasting blood glucose (FBG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea, uric acid, serum creatinine, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and lipi …
After 15 days, the rats were evaluated for fasting blood glucose (FBG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), al …
Ghrelin enhances tubular magnesium absorption in the kidney.
Nie M, Zhang J, Bal M, Duran C, An SW, Zigman JM, Baum M, Hiremath C, Marciano DK, Wolf MTF. Nie M, et al. Front Physiol. 2024 Apr 4;15:1363708. doi: 10.3389/fphys.2024.1363708. eCollection 2024. Front Physiol. 2024. PMID: 38638279 Free PMC article.
Applying the Ghrelin-mimetic (D-Trp(7), Ala(8),D-Phe(10))-alpha-MSH (6-11) amide without and with the GHSR antagonist (D-Lys(3))-GHRP6, we confirmed the stimulatory role of Ghrelin towards TRPM6/7. As GHSR initiates downstream signaling via protein kinase A ( …
Applying the Ghrelin-mimetic (D-Trp(7), Ala(8),D-Phe(10))-alpha-MSH (6-11) amide without and with the GHSR antagonist (D-Lys(3))-GHRP6, we c …
Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current.
Constantin S, Quignon C, Pizano K, Shostak DM, Wray S. Constantin S, et al. Front Cell Neurosci. 2024 Apr 3;18:1354095. doi: 10.3389/fncel.2024.1354095. eCollection 2024. Front Cell Neurosci. 2024. PMID: 38633445 Free PMC article.
We found VIP excites GnRH neurons via the VIP receptor, VPAC2. The downstream signaling pathway uses both Gs protein/adenylyl cyclase/protein kinase A (PKA) and phospholipase C/phosphatidylinositol 4,5-bisphosphate (PIP(2)) depletion. Furthermore, we i …
We found VIP excites GnRH neurons via the VIP receptor, VPAC2. The downstream signaling pathway uses both Gs protein/adenylyl cyclase …
The antidiabetic drug ipragliflozin induces vasorelaxation of rabbit femoral artery by activating a Kv channel, the SERCA pump, and the PKA signaling pathway.
Park M, Mun SY, Zhuang W, Jeong J, Kim HR, Park H, Han ET, Han JH, Chun W, Li H, Park WS. Park M, et al. Eur J Pharmacol. 2024 Apr 16;972:176589. doi: 10.1016/j.ejphar.2024.176589. Online ahead of print. Eur J Pharmacol. 2024. PMID: 38631503
Specifically, the vasorelaxant response to ipragliflozin was significantly attenuated by pretreatment with the Kv7.X channel inhibitors linopirdine (10 muM) and XE991 (10 muM), the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitors thapsigargin (1 muM) and c …
Specifically, the vasorelaxant response to ipragliflozin was significantly attenuated by pretreatment with the Kv7.X channel inhibitors lino …
Calcium-sensing receptor regulates Kv7 channels via G(i/o) protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like neurons.
Chuinsiri N, Siraboriphantakul N, Kendall L, Yarova P, Nile CJ, Song B, Obara I, Durham J, Telezhkin V. Chuinsiri N, et al. Br J Pharmacol. 2024 Apr 16. doi: 10.1111/bph.16349. Online ahead of print. Br J Pharmacol. 2024. PMID: 38627101
The CaSR-Kv7.2/7.3 channel crosslink was mediated via the G(i/o) protein-adenylate cyclase-cyclicAMP-protein kinase A signalling cascade. ...CONCLUSION AND IMPLICATIONS: This study demonstrates that the CaSR-Kv7.2/7.3 channel crosslink, via a G(i/o) …
The CaSR-Kv7.2/7.3 channel crosslink was mediated via the G(i/o) protein-adenylate cyclase-cyclicAMP-protein kinase …
Erythrocytes membrane fluidity changes induced by adenylyl cyclase cascade activation: study using fluorescence recovery after photobleaching.
Semenov AN, Lugovtsov AE, Rodionov SA, Maksimov EG, Priezzhev AV, Shirshin EA. Semenov AN, et al. Eur Biophys J. 2024 Apr 16. doi: 10.1007/s00249-024-01707-x. Online ahead of print. Eur Biophys J. 2024. PMID: 38625405
Stimulation of adrenergic receptors with epinephrine (adrenaline) or metaproterenol led to the significant acceleration of the FRAP recovery, thus indicating an elevated membrane fluidity. The effect of the stimulation of protein kinase A with membrane-permea …
Stimulation of adrenergic receptors with epinephrine (adrenaline) or metaproterenol led to the significant acceleration of the FRAP recovery …
[Gualou Xiebai Banxia Decoction treats type 2 diabetes mellitus combined with acute myocardial infarction via chemerin/ CMKLR1/PPARα signaling pathway].
Wang L, Guan S, Wu MX, Zhou H, Zhao QT, Xun LY. Wang L, et al. Zhongguo Zhong Yao Za Zhi. 2024 Mar;49(6):1579-1586. doi: 10.19540/j.cnki.cjcmm.20231114.705. Zhongguo Zhong Yao Za Zhi. 2024. PMID: 38621942 Chinese.
Compared with the model group, GXBD down-regulated the expression of chemerin in peripheral blood and up-regulated the expression of cyclic adenosine monophosphate(cAMP) and protein kinase A(PKA) in the liver. After treatment with GXBD, the protein …
Compared with the model group, GXBD down-regulated the expression of chemerin in peripheral blood and up-regulated the expression of cycl …
Role of protein kinase A and A kinase anchoring proteins in buffering and compartmentation of cAMP signalling in human airway smooth muscle cells.
Sherpa RT, Moshal KS, Agarwal SR, Ostrom RS, Harvey RD. Sherpa RT, et al. Br J Pharmacol. 2024 Apr 12. doi: 10.1111/bph.16357. Online ahead of print. Br J Pharmacol. 2024. PMID: 38613158
Phosphodiesterases (PDEs) contribute to compartmentation of many cAMP responses, but PDE activity alone is predicted to be insufficient if cAMP is otherwise freely diffusible. We tested the hypothesis that buffering of cAMP by protein kinase A (PKA) associate …
Phosphodiesterases (PDEs) contribute to compartmentation of many cAMP responses, but PDE activity alone is predicted to be insufficient if c …
Kaempferol as an Alternative Cryosupplement for Bovine Spermatozoa: Cytoprotective and Membrane-Stabilizing Effects.
Baňas Š, Tvrdá E, Benko F, Ďuračka M, Čmiková N, Lukáč N, Kačániová M. Baňas Š, et al. Int J Mol Sci. 2024 Apr 8;25(7):4129. doi: 10.3390/ijms25074129. Int J Mol Sci. 2024. PMID: 38612937 Free PMC article.
Western blot analysis revealed that supplementation with 25 muM KAE in the cryopreservation medium prevented the loss of the protein kinase A (PKA) and protein kinase C (PKC), which are intricately involved in the process of sperm activation. ...
Western blot analysis revealed that supplementation with 25 muM KAE in the cryopreservation medium prevented the loss of the protein …
30,414 results
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