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1953 6
1954 5
1955 6
1956 6
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1958 7
1959 12
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1962 13
1963 23
1964 57
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1966 57
1967 105
1968 118
1969 146
1970 162
1971 201
1972 288
1973 289
1974 350
1975 501
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1977 553
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1981 926
1982 1149
1983 1281
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1986 1839
1987 1834
1988 2118
1989 2384
1990 2669
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1992 3456
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2007 13413
2008 13977
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2010 15633
2011 16501
2012 17277
2013 17895
2014 17963
2015 18226
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410,731 results

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Page 1
Small molecules that target phosphorylation dependent protein-protein interaction.
Watanabe N, Osada H. Watanabe N, et al. Bioorg Med Chem. 2016 Aug 1;24(15):3246-54. doi: 10.1016/j.bmc.2016.03.023. Epub 2016 Mar 14. Bioorg Med Chem. 2016. PMID: 27017542 Review.
When upstream signals are stimulated, protein kinase(s) is/are activated and phosphorylate(s) their substrates, and induce the phosphorylation dependent protein-protein interaction. For this interaction, several domains in proteins are kn …
When upstream signals are stimulated, protein kinase(s) is/are activated and phosphorylate(s) their substrates, and induce the …
Mechanistic insights into G-protein activation via phosphorylation mediated non-canonical pathway.
Shewani K, Madhu MK, Murarka RK. Shewani K, et al. Biophys Chem. 2024 Jun;309:107234. doi: 10.1016/j.bpc.2024.107234. Epub 2024 Apr 5. Biophys Chem. 2024. PMID: 38603989
Activation of heterotrimeric G-proteins (Galphabetagamma) downstream to receptor tyrosine kinases (RTKs) is a well-established crosstalk between the signaling pathways mediated by G-protein coupled receptors (GPCRs) and RTKs. ...Overall, this study provides atomisti …
Activation of heterotrimeric G-proteins (Galphabetagamma) downstream to receptor tyrosine kinases (RTKs) is a well-established crosst …
Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment.
Willet AH, Igarashi MG, Chen JS, Bhattacharjee R, Ren L, Cullati SN, Elmore ZC, Roberts-Galbraith RH, Johnson AE, Beckley JR, Gould KL. Willet AH, et al. J Cell Sci. 2021 Aug 15;134(16):jcs258645. doi: 10.1242/jcs.258645. Epub 2021 Aug 17. J Cell Sci. 2021. PMID: 34402513 Free PMC article.
We found that Imp2 is endogenously phosphorylated on 28 sites within its IDR, with the bulk of phosphorylation being constitutive. ...Mutations that eliminate CK1 phosphorylation sites allow CR sliding, and phosphomimetic substitutions at these sites reduce I …
We found that Imp2 is endogenously phosphorylated on 28 sites within its IDR, with the bulk of phosphorylation being constitut …
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase.
Greiwe JF, Miller TCR, Locke J, Martino F, Howell S, Schreiber A, Nans A, Diffley JFX, Costa A. Greiwe JF, et al. Nat Struct Mol Biol. 2022 Jan;29(1):10-20. doi: 10.1038/s41594-021-00698-z. Epub 2021 Dec 28. Nat Struct Mol Biol. 2022. PMID: 34963704 Free PMC article.
During S phase, helicase activation requires MCM phosphorylation by Dbf4-dependent kinase (DDK), comprising Cdc7 and Dbf4. DDK selectively phosphorylates loaded DHs, but how such fidelity is achieved is unknown. Here, we determine the cryogenic electron microscopy s …
During S phase, helicase activation requires MCM phosphorylation by Dbf4-dependent kinase (DDK), comprising Cdc7 and Dbf4. DDK select …
Phosphorylation-Dependent Regulation of G-Protein Cycle during Nodule Formation in Soybean.
Choudhury SR, Pandey S. Choudhury SR, et al. Plant Cell. 2015 Nov;27(11):3260-76. doi: 10.1105/tpc.15.00517. Epub 2015 Oct 23. Plant Cell. 2015. PMID: 26498905 Free PMC article.
We now demonstrate the role of Nod factor receptor 1 (NFR1)-mediated phosphorylation in regulation of the G-protein cycle during nodulation in soybean. We also show that during nodulation, the G-protein cycle is regulated by the activity of RGS proteins …
We now demonstrate the role of Nod factor receptor 1 (NFR1)-mediated phosphorylation in regulation of the G-protein cycle duri …
Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism.
Sondhi D, Xu W, Songyang Z, Eck MJ, Cole PA. Sondhi D, et al. Biochemistry. 1998 Jan 6;37(1):165-72. doi: 10.1021/bi9722960. Biochemistry. 1998. PMID: 9425036
The high efficiency of purified Csk phosphorylating a pure, unphosphorylated Src family member argues against the importance of an SH2-phosphotyrosine docking interaction or the involvement of extra recruitment proteins in facilitating Csk phosphorylation of …
The high efficiency of purified Csk phosphorylating a pure, unphosphorylated Src family member argues against the importance of an SH …
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases.
Zarkowska T, Mittnacht S. Zarkowska T, et al. J Biol Chem. 1997 May 9;272(19):12738-46. doi: 10.1074/jbc.272.19.12738. J Biol Chem. 1997. PMID: 9139732 Free article.
The retinoblastoma tumor suppressor protein, pRB, is inactivated by phosphorylation. While existing evidence is strong that such phosphorylation is mediated by one or more cyclin-dependent kinases (CDKs) active during G1/S, it remains unclear which of the var …
The retinoblastoma tumor suppressor protein, pRB, is inactivated by phosphorylation. While existing evidence is strong that su …
Phosphorylation of pig epidermal soluble protein by endogenous cAMP-dependent protein kinase.
Yoshikawa K, Takeda J, Nemoto O, Ito T, Halprin KM, Adachi K. Yoshikawa K, et al. J Invest Dermatol. 1983 Feb;80(2):108-11. doi: 10.1111/1523-1747.ep12531722. J Invest Dermatol. 1983. PMID: 6296235 Free article.
The particulate fraction contains protein kinase which is cAMP-independent and phosphorylates particulate-bound proteins as well as histone. ...Among many proteins whose phosphorylation was slightly increased by cAMP, a protein with Mr ap …
The particulate fraction contains protein kinase which is cAMP-independent and phosphorylates particulate-bound proteins …
Screening for protein phosphorylation using nanoscale reactions on microdroplet arrays.
Küster SK, Pabst M, Zenobi R, Dittrich PS. Küster SK, et al. Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1671-5. doi: 10.1002/anie.201409440. Epub 2014 Dec 12. Angew Chem Int Ed Engl. 2015. PMID: 25504774
We present a novel and straightforward screening method to detect protein phosphorylations in complex protein mixtures. A proteolytic digest is separated by a conventional nanoscale liquid chromatography (nano-LC) separation and the eluate is immediately comp …
We present a novel and straightforward screening method to detect protein phosphorylations in complex protein mixtures. …
Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.
Horner TJ, Osawa S, Schaller MD, Weiss ER. Horner TJ, et al. J Biol Chem. 2005 Aug 5;280(31):28241-50. doi: 10.1074/jbc.M505117200. Epub 2005 Jun 9. J Biol Chem. 2005. PMID: 15946941 Free article.
Phosphorylation of G protein-coupled receptors is a critical step in the rapid termination of G protein signaling. ...Although both GRKs also contain putative phosphorylation sites for PKC and Ca(2+)/calmodulin-dependent protein kinase II, neith …
Phosphorylation of G protein-coupled receptors is a critical step in the rapid termination of G protein signaling. ...A …
410,731 results
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