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15,967 results

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Page 1
Protein targeting to the ER membrane: multiple pathways and shared machinery.
Sánchez WN, Driessen AJM, Wilson CAM. Sánchez WN, et al. Crit Rev Biochem Mol Biol. 2025 Feb-Jun;60(1-3):33-79. doi: 10.1080/10409238.2025.2503746. Epub 2025 May 16. Crit Rev Biochem Mol Biol. 2025. PMID: 40377270 Free article. Review.
Protein targeting to the ER occurs through multiple pathways that operate both during and independent of translation. ...This review focuses on the molecular mechanisms of protein targeting to the ER, from the initial recognition of ta …
Protein targeting to the ER occurs through multiple pathways that operate both during and independent of translation. . …
Identification of two pathways mediating protein targeting from ER to lipid droplets.
Song J, Mizrak A, Lee CW, Cicconet M, Lai ZW, Tang WC, Lu CH, Mohr SE, Farese RV Jr, Walther TC. Song J, et al. Nat Cell Biol. 2022 Sep;24(9):1364-1377. doi: 10.1038/s41556-022-00974-0. Epub 2022 Sep 1. Nat Cell Biol. 2022. PMID: 36050470 Free PMC article.
Pathways localizing proteins to their sites of action are essential for eukaryotic cell organization and function. Although mechanisms of protein targeting to many organelles have been defined, how proteins, such as metabolic enzymes, target from the endoplasmic ret …
Pathways localizing proteins to their sites of action are essential for eukaryotic cell organization and function. Although mechanisms of …
The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria.
Koch C, Lenhard S, Räschle M, Prescianotto-Baschong C, Spang A, Herrmann JM. Koch C, et al. EMBO Rep. 2024 Apr;25(4):2071-2096. doi: 10.1038/s44319-024-00113-w. Epub 2024 Apr 2. EMBO Rep. 2024. PMID: 38565738 Free PMC article.
Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. ...Our observations support an active role of the ER in mitochondrial protein biogenesis....
Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an impo …
Principles of cotranslational mitochondrial protein import.
Zhu Z, Mallik S, Stevens TA, Huang R, Levy ED, Shan SO. Zhu Z, et al. Cell. 2025 Oct 2;188(20):5605-5617.e14. doi: 10.1016/j.cell.2025.07.021. Epub 2025 Aug 11. Cell. 2025. PMID: 40795856 Free PMC article.
In contrast to the early onset of cotranslational protein targeting to the endoplasmic reticulum (ER), the presequence on mitochondrial proteins is inhibited from initiating targeting early during translation until a large globular domain emerges from …
In contrast to the early onset of cotranslational protein targeting to the endoplasmic reticulum (ER), the presequence …
Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E. Jomaa A, et al. Science. 2022 Feb 25;375(6583):839-844. doi: 10.1126/science.abl6459. Epub 2022 Feb 24. Science. 2022. PMID: 35201867 Free PMC article.
The nascent polypeptide-associated complex (NAC) interacts with newly synthesized proteins at the ribosomal tunnel exit and competes with the signal recognition particle (SRP) to prevent mistargeting of cytosolic and mitochondrial polypeptides to the endoplasmic reticulum (ER …
The nascent polypeptide-associated complex (NAC) interacts with newly synthesized proteins at the ribosomal tunnel exit and competes with th …
Fidelity of Cotranslational Protein Targeting to the Endoplasmic Reticulum.
Hsieh HH, Shan SO. Hsieh HH, et al. Int J Mol Sci. 2021 Dec 28;23(1):281. doi: 10.3390/ijms23010281. Int J Mol Sci. 2021. PMID: 35008707 Free PMC article. Review.
Fidelity of protein targeting is essential for the proper biogenesis and functioning of organelles. ...In this chapter, we review recent progress in deciphering the molecular mechanisms and substrate selection of the mammalian SRP pathway, with an emphasis on the ke …
Fidelity of protein targeting is essential for the proper biogenesis and functioning of organelles. ...In this chapter, we rev …
Protein Targeting to the Plastid of Euglena.
Durnford DG, Schwartzbach SD. Durnford DG, et al. Adv Exp Med Biol. 2017;979:183-205. doi: 10.1007/978-3-319-54910-1_10. Adv Exp Med Biol. 2017. PMID: 28429323 Review.
Both have an amino terminal signal peptide followed by a transit peptide for plastid import, but only one of the two classes of presequences has a third domain-the stop transfer sequence. This discovery implied two different transport mechanisms; one where the protein …
Both have an amino terminal signal peptide followed by a transit peptide for plastid import, but only one of the two classes of presequences …
Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.
Kory N, Farese RV Jr, Walther TC. Kory N, et al. Trends Cell Biol. 2016 Jul;26(7):535-546. doi: 10.1016/j.tcb.2016.02.007. Epub 2016 Mar 16. Trends Cell Biol. 2016. PMID: 26995697 Free PMC article. Review.
We review here the major known pathways of protein targeting to LDs and suggest a classification framework based on the localization origin for the protein. ...Other proteins require lipid modifications or protein-protein interactions to bind to …
We review here the major known pathways of protein targeting to LDs and suggest a classification framework based on the locali …
Mechanisms of protein targeting to lipid droplets: A unified cell biological and biophysical perspective.
Dhiman R, Caesar S, Thiam AR, Schrul B. Dhiman R, et al. Semin Cell Dev Biol. 2020 Dec;108:4-13. doi: 10.1016/j.semcdb.2020.03.004. Epub 2020 Mar 20. Semin Cell Dev Biol. 2020. PMID: 32201131 Free article. Review.
These ubiquitous cytoplasmic organelles are derived from the endoplasmic reticulum (ER) and consist of a hydrophobic neutral lipid core - mainly consisting of triglycerides and sterol esters - that is encircled by a phospholipid monolayer. ...We only started very recently …
These ubiquitous cytoplasmic organelles are derived from the endoplasmic reticulum (ER) and consist of a hydrophobic neutral lipid co …
SRP orchestrates protein biogenesis beyond initial ER membrane targeting.
Kotan IE, Sartori S, Bose R, Bukau B, Kramer G. Kotan IE, et al. Nat Commun. 2026 Jun 16;17(1):5316. doi: 10.1038/s41467-026-74404-2. Nat Commun. 2026. PMID: 42303621 Free PMC article.
The Signal Recognition Particle (SRP) targets nascent proteins to the Sec61 translocon for import into the endoplasmic reticulum (ER). However, its range of substrates, point of engagement during targeting, and hence full biological impact remain unclear. ...We show …
The Signal Recognition Particle (SRP) targets nascent proteins to the Sec61 translocon for import into the endoplasmic reticulum (ER) …
15,967 results
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