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120 results

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Page 1
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C. Liang H, et al. Cell Death Differ. 2023 Sep;30(9):2135-2150. doi: 10.1038/s41418-023-01210-4. Epub 2023 Aug 21. Cell Death Differ. 2023. PMID: 37605006 Free PMC article.
Protein posttranslational modifications (PTMs) are critical for determining TFEB trafficking and transcriptional activity. Here, we demonstrate that TFEB activity is controlled by protein methylation in degenerated nucleus pulposus cells (NPCs), even though TFEB its …
Protein posttranslational modifications (PTMs) are critical for determining TFEB trafficking and transcriptional activity. Here, we d …
Protein Lysine Methyltransferases Inhibitors.
Li Y, Ding L, Ren S, Zhang W, Rao GW. Li Y, et al. Curr Med Chem. 2023;30(27):3060-3089. doi: 10.2174/0929867329666220829151257. Curr Med Chem. 2023. PMID: 36043747 Review.
Protein lysine methylation is a significant protein post-translational modification (PTMs) and has a key function in epigenetic regulation. Protein lysine methyltransferase (PKMTs) mainly catalyzes the lysine methylation of various core histones and a …
Protein lysine methylation is a significant protein post-translational modification (PTMs) and has a key function in epigeneti …
Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
Bröhm A, Elsawy H, Rathert P, Kudithipudi S, Schoch T, Schuhmacher MK, Weirich S, Jeltsch A. Bröhm A, et al. J Mol Biol. 2019 Aug 9;431(17):3068-3080. doi: 10.1016/j.jmb.2019.06.021. Epub 2019 Jun 27. J Mol Biol. 2019. PMID: 31255706
SUV420H1 is a protein lysine methyltransferase that introduces di- and trimethylation of H4K20 and is frequently mutated in human cancers. ...The third group of mutations (S283L, S304Y) showed enhanced activity with peptide substrates when compared with nucle …
SUV420H1 is a protein lysine methyltransferase that introduces di- and trimethylation of H4K20 and is frequently mutated in hu …
SETDB1-Mediated Silencing of Retroelements.
Fukuda K, Shinkai Y. Fukuda K, et al. Viruses. 2020 May 30;12(6):596. doi: 10.3390/v12060596. Viruses. 2020. PMID: 32486217 Free PMC article. Review.
SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at lysine 9 (H3K9). Among other H3K9 methyltransferases, SETDB1 and SETDB1-mediated H3K9 trimethylation (H3K9me3) play pivotal roles for …
SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone …
Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics.
Olsen JB, Cao XJ, Han B, Chen LH, Horvath A, Richardson TI, Campbell RM, Garcia BA, Nguyen H. Olsen JB, et al. Mol Cell Proteomics. 2016 Mar;15(3):892-905. doi: 10.1074/mcp.M115.053280. Epub 2016 Jan 10. Mol Cell Proteomics. 2016. PMID: 26750096 Free PMC article.
The development of small molecule inhibitors that selectively and potently target enzymes that catalyze the addition of methyl-groups to lysine residues, such as the protein lysine mono-methyltransferase SMYD2, is an active area of drug discovery. Critical to …
The development of small molecule inhibitors that selectively and potently target enzymes that catalyze the addition of methyl-groups to lys …
Insights for the design of protein lysine methyltransferase G9a inhibitors.
Charles MRC, Dhayalan A, Hsieh HP, Coumar MS. Charles MRC, et al. Future Med Chem. 2019 May;11(9):993-1014. doi: 10.4155/fmc-2018-0396. Epub 2019 May 29. Future Med Chem. 2019. PMID: 31141392 Review.
Misregulation of these modifications is associated with altered gene expression, resulting in various disease conditions. G9a belongs to the protein lysine methyltransferases that specifically methylates the K9 residue of histone H3, leading to suppression of severa …
Misregulation of these modifications is associated with altered gene expression, resulting in various disease conditions. G9a belongs to the …
Activity and specificity of the human SUV39H2 protein lysine methyltransferase.
Schuhmacher MK, Kudithipudi S, Kusevic D, Weirich S, Jeltsch A. Schuhmacher MK, et al. Biochim Biophys Acta. 2015 Jan;1849(1):55-63. doi: 10.1016/j.bbagrm.2014.11.005. Epub 2014 Nov 22. Biochim Biophys Acta. 2015. PMID: 25459750
Modification of R8 and phosphorylation of S10 or T11 lead to a reduction or loss of SUV39H2 activity towards H3K9. The specificity of SUV39H2 differs from other H3K9 PKMTs, like Dim-5 or G9a, and these biochemical differences can be explained by the structures of the corre …
Modification of R8 and phosphorylation of S10 or T11 lead to a reduction or loss of SUV39H2 activity towards H3K9. The specificity of …
Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
Yoshioka Y, Suzuki T, Matsuo Y, Tsurita G, Watanabe T, Dohmae N, Nakamura Y, Hamamoto R. Yoshioka Y, et al. Cancer Med. 2017 Jul;6(7):1665-1672. doi: 10.1002/cam4.1099. Epub 2017 Jun 22. Cancer Med. 2017. PMID: 28639750 Free PMC article.
Although its specific ligand(s) has not been detected, HER2 homodimerization, which is critical for its activation, is considered to be dependent on its expression levels. Here, we demonstrate a significant role of HER2 methylation by protein lysine methyltra …
Although its specific ligand(s) has not been detected, HER2 homodimerization, which is critical for its activation, is considered to …
Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues.
Weirich S, Ulu GT, Chandrasekaran TT, Kehl J, Schmid J, Dorscht F, Kublanovsky M, Levy D, Jeltsch A. Weirich S, et al. Protein Sci. 2024 Feb;33(2):e4897. doi: 10.1002/pro.4897. Protein Sci. 2024. PMID: 38284488 Free PMC article.
Based on this, we identified novel HEMK2 K-methylation peptide substrates with sequences taken from human proteins which are methylated with high activity. Since H4K12 methylation by HEMK2 was very low, other protein lysine methyltransferases were examined fo …
Based on this, we identified novel HEMK2 K-methylation peptide substrates with sequences taken from human proteins which are methylated with …
Reduced S-adenosylmethionine:protein-lysine N-methyltransferase activity (protein methylase III) in shiverer mutant mouse brain.
Chanderkar LP, Shanker G, Knobler RL, Lublin FD, Paik WK, Kim S. Chanderkar LP, et al. Neurochem Res. 1987 May;12(5):445-9. doi: 10.1007/BF00972296. Neurochem Res. 1987. PMID: 3035405
Mice with the dysmyelinating mutation shiverer were studied by measuring the activity of two protein methylases and myelin marker enzymes in the brain. It was observed that S-adenosylmethionine:protein-lysine N-methyltransferase (protein methyla …
Mice with the dysmyelinating mutation shiverer were studied by measuring the activity of two protein methylases and myelin marker enz …
120 results