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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1894 1
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1913 3
1914 2
1915 1
1917 1
1919 2
1920 1
1924 1
1926 1
1927 1
1928 1
1929 2
1932 1
1938 3
1941 1
1942 1
1943 1
1944 1
1945 3
1946 5
1947 8
1948 11
1949 7
1950 18
1951 19
1952 11
1953 19
1954 16
1955 23
1956 27
1957 33
1958 23
1959 33
1960 36
1961 26
1962 34
1963 25
1964 29
1965 27
1966 22
1967 20
1968 31
1969 29
1970 36
1971 29
1972 44
1973 51
1974 58
1975 159
1976 196
1977 194
1978 198
1979 274
1980 331
1981 361
1982 396
1983 555
1984 559
1985 610
1986 610
1987 611
1988 641
1989 731
1990 689
1991 751
1992 734
1993 771
1994 797
1995 918
1996 923
1997 965
1998 1019
1999 1053
2000 1071
2001 1146
2002 1149
2003 1166
2004 1266
2005 1198
2006 1299
2007 1311
2008 1334
2009 1267
2010 1264
2011 1870
2012 3118
2013 3255
2014 3109
2015 3000
2016 3042
2017 3180
2018 2897
2019 2956
2020 3058
2021 2828
2022 1959
2023 1995
2024 2605
2025 3165
2026 2070

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67,147 results

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Page 1
Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies.
Kiyozumi D, Ikawa M. Kiyozumi D, et al. Front Endocrinol (Lausanne). 2022 May 4;13:876370. doi: 10.3389/fendo.2022.876370. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35600599 Free PMC article. Review.
The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription factors, and …
The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in v …
Proteolysis: a key post-translational modification regulating proteoglycans.
Mead TJ, Bhutada S, Martin DR, Apte SS. Mead TJ, et al. Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C651-C665. doi: 10.1152/ajpcell.00215.2022. Epub 2022 Jul 4. Am J Physiol Cell Physiol. 2022. PMID: 35785985 Free PMC article. Review.
As an irreversible post-translational modification, proteolysis has a profound impact on proteoglycan function, abundance, and localization. ...Genetic evidence shows that proteoglycan core protein proteolysis is essential for diverse morphogenetic events during emb …
As an irreversible post-translational modification, proteolysis has a profound impact on proteoglycan function, abundance, and locali …
Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy.
Song Y, Dong QQ, Ni YK, Xu XL, Chen CX, Chen W. Song Y, et al. Int J Nanomedicine. 2024 Jun 12;19:5739-5761. doi: 10.2147/IJN.S448684. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38882545 Free PMC article. Review.
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have the capability to induce specific protein degradation. ...The advent of nanotechnology presents a promising avenue to surmount the challenges associated with conventional PROTACs. The utili …
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have the capability to induce specific protein degrada …
Proteolysis Targeting Chimeras (PROTACs) in Breast Cancer Therapy.
Jin Y, Lee Y. Jin Y, et al. ChemMedChem. 2024 Dec 2;19(23):e202400267. doi: 10.1002/cmdc.202400267. Epub 2024 Oct 15. ChemMedChem. 2024. PMID: 39136599 Free PMC article. Review.
Breast cancer (BC) accounts for 30 % of cancer cases among women cancer patients globally, indicating the urgent need for the development of selective therapies targeting BCs. Recently, proteolysis-targeting chimera (PROTAC) has emerged as a promising strategy to target br …
Breast cancer (BC) accounts for 30 % of cancer cases among women cancer patients globally, indicating the urgent need for the development of …
Proteolysis-targeting chimeras in drug development: A safety perspective.
Moreau K, Coen M, Zhang AX, Pachl F, Castaldi MP, Dahl G, Boyd H, Scott C, Newham P. Moreau K, et al. Br J Pharmacol. 2020 Apr;177(8):1709-1718. doi: 10.1111/bph.15014. Epub 2020 Feb 25. Br J Pharmacol. 2020. PMID: 32022252 Free PMC article. Review.
Proteolysis-targeting chimeras are a new drug modality that exploits the endogenous ubiquitin proteasome system to degrade a protein of interest for therapeutic benefit. As the first-generation of proteolysis-targeting chimeras have now entered clinical trials for o …
Proteolysis-targeting chimeras are a new drug modality that exploits the endogenous ubiquitin proteasome system to degrade a protein …
The Proteolysis of ECM in Intervertebral Disc Degeneration.
Liang H, Luo R, Li G, Zhang W, Song Y, Yang C. Liang H, et al. Int J Mol Sci. 2022 Feb 2;23(3):1715. doi: 10.3390/ijms23031715. Int J Mol Sci. 2022. PMID: 35163637 Free PMC article. Review.
In recent years, extracellular matrix (ECM) homeostasis has received much attention due to its relevance to the mechanical properties of IVDs. ECM proteolysis mediated by a variety of proteases is involved in the pathological process of disc degeneration. Here, we discuss …
In recent years, extracellular matrix (ECM) homeostasis has received much attention due to its relevance to the mechanical properties of IVD …
Natural product-based PROteolysis TArgeting Chimeras (PROTACs).
Liu M, Martyn AP, Quinn RJ. Liu M, et al. Nat Prod Rep. 2022 Dec 14;39(12):2292-2307. doi: 10.1039/d2np00038e. Nat Prod Rep. 2022. PMID: 36196977 Review.
This review highlights the potential of PROteolysis TArgeting Chimeras (PROTACs) in the area of natural products. The approach will complement existing approaches such as the direct use of a bioactive natural product or its analogues, pharmacophore development and drug-ant …
This review highlights the potential of PROteolysis TArgeting Chimeras (PROTACs) in the area of natural products. The approach will c …
Acidosis and proteolysis in the tumor microenvironment.
Ji K, Mayernik L, Moin K, Sloane BF. Ji K, et al. Cancer Metastasis Rev. 2019 Jun;38(1-2):103-112. doi: 10.1007/s10555-019-09796-3. Cancer Metastasis Rev. 2019. PMID: 31069574 Free PMC article. Review.
As a template of an extracellular acidic microenvironment that is linked to proteolysis, we use the resorptive pit formed between osteoclasts and bone. We describe similar changes that have been observed in cancer cells in response to an acidic microenvironment and that ar …
As a template of an extracellular acidic microenvironment that is linked to proteolysis, we use the resorptive pit formed between ost …
Proteolysis, synaptic plasticity and memory.
Hegde AN. Hegde AN. Neurobiol Learn Mem. 2017 Feb;138:98-110. doi: 10.1016/j.nlm.2016.09.003. Epub 2016 Sep 7. Neurobiol Learn Mem. 2017. PMID: 27614141 Free PMC article. Review.
The proteasome also has disparate functions in different parts of the neuron. In addition to the UPP, proteolysis by the lysosome and autophagy play a role in synaptic plasticity and memory. This review details the functions of proteolysis in synaptic plasticity and …
The proteasome also has disparate functions in different parts of the neuron. In addition to the UPP, proteolysis by the lysosome and …
Strategies for designing proteolysis targeting chimaeras (PROTACs).
He S, Dong G, Cheng J, Wu Y, Sheng C. He S, et al. Med Res Rev. 2022 May;42(3):1280-1342. doi: 10.1002/med.21877. Epub 2022 Jan 10. Med Res Rev. 2022. PMID: 35001407 Review.
Proteolysis targeting chimaeras (PROTACs) is a cutting edge and rapidly growing technique for new drug discovery and development. ...
Proteolysis targeting chimaeras (PROTACs) is a cutting edge and rapidly growing technique for new drug discovery and development. ...
67,147 results
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