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10,466 results

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Page 1
Single-cell genome sequencing of protozoan parasites.
Dia A, Cheeseman IH. Dia A, et al. Trends Parasitol. 2021 Sep;37(9):803-814. doi: 10.1016/j.pt.2021.05.013. Epub 2021 Jun 22. Trends Parasitol. 2021. PMID: 34172399 Free PMC article. Review.
Despite considerable genetic variation within hosts, most parasite genome sequencing studies focus on bulk samples composed of millions of cells. Analysis of bulk samples is biased toward the dominant genotype, concealing cell-to-cell variation and rare variants. ...
Despite considerable genetic variation within hosts, most parasite genome sequencing studies focus on bulk samples composed of millio …
Species diversity and genome evolution of the pathogenic protozoan parasite, Neospora caninum.
Calarco L, Ellis J. Calarco L, et al. Infect Genet Evol. 2020 Oct;84:104444. doi: 10.1016/j.meegid.2020.104444. Epub 2020 Jun 30. Infect Genet Evol. 2020. PMID: 32619639 Review.
This includes the contribution of sequence variants in both coding and non-coding regions, the presence of genome polymorphic hotspots, and the identification of non-synonymous mutations. The implications of such diversity on important parasite phenotypes such as pathogeni …
This includes the contribution of sequence variants in both coding and non-coding regions, the presence of genome polymorphic hotspot …
What Is a Genome?
Goldman AD, Landweber LF. Goldman AD, et al. PLoS Genet. 2016 Jul 21;12(7):e1006181. doi: 10.1371/journal.pgen.1006181. eCollection 2016 Jul. PLoS Genet. 2016. PMID: 27442251 Free PMC article. Review.
The genome is often described as the information repository of an organism. Whether millions or billions of letters of DNA, its transmission across generations confers the principal medium for inheritance of organismal traits. ...Here, we explore ways in which a deeper und …
The genome is often described as the information repository of an organism. Whether millions or billions of letters of DNA, its trans …
Programmed genome rearrangements in ciliates.
Rzeszutek I, Maurer-Alcalá XX, Nowacki M. Rzeszutek I, et al. Cell Mol Life Sci. 2020 Nov;77(22):4615-4629. doi: 10.1007/s00018-020-03555-2. Epub 2020 May 27. Cell Mol Life Sci. 2020. PMID: 32462406 Free PMC article. Review.
This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex. The transformation from germline to soma genome involves massive DNA eliminat …
This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the developme …
Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution.
Su XZ, Lane KD, Xia L, Sá JM, Wellems TE. Su XZ, et al. Clin Microbiol Rev. 2019 Jul 31;32(4):e00019-19. doi: 10.1128/CMR.00019-19. Print 2019 Sep 18. Clin Microbiol Rev. 2019. PMID: 31366610 Free PMC article. Review.
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that continues to afflict hundreds of millions of people every year. ...
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that continues to afflict hundreds of millions o …
Status of protozoan genome analysis: trypanosomatids.
Blackwell JM, Melville SE. Blackwell JM, et al. Parasitology. 1999;118 Suppl:S11-4. doi: 10.1017/s0031182099004163. Parasitology. 1999. PMID: 10466133 Review.
The three trypanosomatid genome projects have employed common strategies which include: analysis of pulsed-field gel electrophoretic chromosomal karyotypes; physical mapping using big DNA (cosmid, pacmid P1, bacterial artificial chromosome, yeast artificial chromosome) lib …
The three trypanosomatid genome projects have employed common strategies which include: analysis of pulsed-field gel electrophoretic …
Genome evolution in trypanosomatid parasites.
Jackson AP. Jackson AP. Parasitology. 2015 Feb;142 Suppl 1(Suppl 1):S40-56. doi: 10.1017/S0031182014000894. Epub 2014 Jul 28. Parasitology. 2015. PMID: 25068268 Free PMC article. Review.
A decade of genome sequencing has transformed our understanding of how trypanosomatid parasites have evolved and provided fresh impetus to explaining the origins of parasitism in the Kinetoplastida. In this review, I will consider the many ways in which genome seque …
A decade of genome sequencing has transformed our understanding of how trypanosomatid parasites have evolved and provided fresh impet …
Programmed Genome Rearrangements in Tetrahymena.
Yao MC, Chao JL, Cheng CY. Yao MC, et al. Microbiol Spectr. 2014 Dec;2(6). doi: 10.1128/microbiolspec.MDNA3-0012-2014. Microbiol Spectr. 2014. PMID: 26104448 Free article. Review.
Ciliates are champions in programmed genome rearrangements. They carry out extensive restructuring during differentiation to drastically alter the complexity, relative copy number, and arrangement of sequences in the somatic genome. ...The process occurs at thousand …
Ciliates are champions in programmed genome rearrangements. They carry out extensive restructuring during differentiation to drastica …
Nanopore Sequencing Significantly Improves Genome Assembly of the Protozoan Parasite Trypanosoma cruzi.
Díaz-Viraqué F, Pita S, Greif G, de Souza RCM, Iraola G, Robello C. Díaz-Viraqué F, et al. Genome Biol Evol. 2019 Jul 1;11(7):1952-1957. doi: 10.1093/gbe/evz129. Genome Biol Evol. 2019. PMID: 31218350 Free PMC article.
Many T. cruzi sequencing projects based on short reads have demonstrated that genome assembly and downstream comparative analyses are extremely challenging in this species, given that half of its genome is composed of repetitive sequences. ...Finally, this work repr …
Many T. cruzi sequencing projects based on short reads have demonstrated that genome assembly and downstream comparative analyses are …
Choanoflagellates.
King N. King N. Curr Biol. 2005 Feb 22;15(4):R113-4. doi: 10.1016/j.cub.2005.02.004. Curr Biol. 2005. PMID: 15723775 Free article. Review. No abstract available.
10,466 results
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