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Host monitoring of quorum sensing during Pseudomonas aeruginosa infection.
Moura-Alves P, Puyskens A, Stinn A, Klemm M, Guhlich-Bornhof U, Dorhoi A, Furkert J, Kreuchwig A, Protze J, Lozza L, Pei G, Saikali P, Perdomo C, Mollenkopf HJ, Hurwitz R, Kirschhoefer F, Brenner-Weiss G, Weiner J 3rd, Oschkinat H, Kolbe M, Krause G, Kaufmann SHE. Moura-Alves P, et al. Science. 2019 Dec 20;366(6472):eaaw1629. doi: 10.1126/science.aaw1629. Science. 2019. PMID: 31857448
Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses to collectively modify its behavior through the production, release, and detection of signaling molecules. ...This is mirrored upon infection with
Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses to col
Pseudomonas aeruginosa: all roads lead to resistance.
Breidenstein EB, de la Fuente-Núñez C, Hancock RE. Breidenstein EB, et al. Trends Microbiol. 2011 Aug;19(8):419-26. doi: 10.1016/j.tim.2011.04.005. Epub 2011 Jun 12. Trends Microbiol. 2011. PMID: 21664819 Review.
Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has joined the ranks of 'superbugs' due to its enormous capacity to engender resistance. It demonstrates decreased susceptibility to most antibiotics due to low outer membrane permeab
Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has joined the ranks of 'superbugs' due to
A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation.
O'Loughlin CT, Miller LC, Siryaporn A, Drescher K, Semmelhack MF, Bassler BL. O'Loughlin CT, et al. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17981-6. doi: 10.1073/pnas.1316981110. Epub 2013 Oct 18. Proc Natl Acad Sci U S A. 2013. PMID: 24143808 Free PMC article.
Disabling quorum-sensing circuits with small molecules has been proposed as a potential strategy to prevent bacterial pathogenicity. The human pathogen Pseudomonas aeruginosa uses quorum sensing to control virulence and biofilm formation. Here, we analyze synthetic …
Disabling quorum-sensing circuits with small molecules has been proposed as a potential strategy to prevent bacterial pathogenicity. The hum …
Gene expression in Pseudomonas aeruginosa biofilms.
Whiteley M, Bangera MG, Bumgarner RE, Parsek MR, Teitzel GM, Lory S, Greenberg EP. Whiteley M, et al. Nature. 2001 Oct 25;413(6858):860-4. doi: 10.1038/35101627. Nature. 2001. PMID: 11677611
Bacteria often adopt a sessile biofilm lifestyle that is resistant to antimicrobial treatment. Opportunistic pathogenic bacteria like Pseudomonas aeruginosa can develop persistent infections. To gain insights into the differences between free-living P. aeruginosa
Bacteria often adopt a sessile biofilm lifestyle that is resistant to antimicrobial treatment. Opportunistic pathogenic bacteria like Pse
Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin.
Cirz RT, O'Neill BM, Hammond JA, Head SR, Romesberg FE. Cirz RT, et al. J Bacteriol. 2006 Oct;188(20):7101-10. doi: 10.1128/JB.00807-06. J Bacteriol. 2006. PMID: 17015649 Free PMC article.
Pseudomonas aeruginosa infections can be virtually impossible to eradicate, and the evolution of resistance during antibiotic therapy is a significant concern. In this study, we use DNA microarrays to characterize the global transcriptional response of P.
Pseudomonas aeruginosa infections can be virtually impossible to eradicate, and the evolution of resistance during antibiotic
Application of Phenotype Microarray for Profiling Carbon Sources Utilization between Biofilm and Non-Biofilm of Pseudomonas aeruginosa from Clinical Isolates.
Ismail NS, Subbiah SK, Taib NM. Ismail NS, et al. Curr Pharm Biotechnol. 2020;21(14):1539-1550. doi: 10.2174/1389201021666200629145217. Curr Pharm Biotechnol. 2020. PMID: 32598252
BACKGROUND: This is the fastest work in obtaining the metabolic profiles of Pseudomonas aeruginosa in order to combat the infection diseases which leads to high morbidity and mortality rates. Pseudomonas aeruginosa is a high versatility of gram-negativ …
BACKGROUND: This is the fastest work in obtaining the metabolic profiles of Pseudomonas aeruginosa in order to combat the infe …
Transcriptional Responses of Pseudomonas aeruginosa to Potable Water and Freshwater.
English EL, Schutz KC, Willsey GG, Wargo MJ. English EL, et al. Appl Environ Microbiol. 2018 Mar 1;84(6):e02350-17. doi: 10.1128/AEM.02350-17. Print 2018 Mar 15. Appl Environ Microbiol. 2018. PMID: 29305509 Free PMC article.
Many Pseudomonas aeruginosa infections are derived from residential, recreational, or surface water sources; thus, these environments represent an important preinfection niche. To better understand P. aeruginosa biology in these environments, we quantified tr …
Many Pseudomonas aeruginosa infections are derived from residential, recreational, or surface water sources; thus, these envir …
Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates Pyocyanin and Pyoverdine Production.
Little AS, Okkotsu Y, Reinhart AA, Damron FH, Barbier M, Barrett B, Oglesby-Sherrouse AG, Goldberg JB, Cody WL, Schurr MJ, Vasil ML, Schurr MJ. Little AS, et al. mBio. 2018 Jan 30;9(1):e02318-17. doi: 10.1128/mBio.02318-17. mBio. 2018. PMID: 29382736 Free PMC article.
Pseudomonas aeruginosa employs numerous, complex regulatory elements to control expression of its many virulence systems. The P. aeruginosa AlgZR two-component regulatory system controls the expression of several crucial virulence phenotypes. ...
Pseudomonas aeruginosa employs numerous, complex regulatory elements to control expression of its many virulence systems. The
Seawater salt-trapped Pseudomonas aeruginosa survives for years and gets primed for salinity tolerance.
Elabed H, González-Tortuero E, Ibacache-Quiroga C, Bakhrouf A, Johnston P, Gaddour K, Blázquez J, Rodríguez-Rojas A. Elabed H, et al. BMC Microbiol. 2019 Jun 24;19(1):142. doi: 10.1186/s12866-019-1499-2. BMC Microbiol. 2019. PMID: 31234794 Free PMC article.
However, little is known about the evolution of the adaptability of new bacteria to such environments. Pseudomonas aeruginosa, an opportunistic pathogen, after natural evaporation of seawater, was shown to be trapped in laboratory-grown halite crystals and to remain …
However, little is known about the evolution of the adaptability of new bacteria to such environments. Pseudomonas aeruginosa, …
AhR sensing of bacterial pigments regulates antibacterial defence.
Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH. Moura-Alves P, et al. Nature. 2014 Aug 28;512(7515):387-92. doi: 10.1038/nature13684. Epub 2014 Aug 13. Nature. 2014. PMID: 25119038
We characterized bacterial pigmented virulence factors, namely the phenazines from Pseudomonas aeruginosa and the naphthoquinone phthiocol from Mycobacterium tuberculosis, as ligands of AhR. ...The relevance of AhR to host defence is underlined by heightened suscept …
We characterized bacterial pigmented virulence factors, namely the phenazines from Pseudomonas aeruginosa and the naphthoquino …
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