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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
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1968 39
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1971 27
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1974 16
1975 10
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1978 8
1979 13
1980 9
1981 11
1982 10
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1988 3
1989 6
1990 4
1992 5
1993 6
1994 6
1995 1
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1998 13
1999 8
2000 11
2001 9
2002 15
2003 13
2004 12
2005 16
2006 17
2007 13
2008 15
2009 15
2010 16
2011 23
2012 26
2013 31
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3,190 results

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Page 1
The Therapeutic Potential of Psilocybin.
Lowe H, Toyang N, Steele B, Valentine H, Grant J, Ali A, Ngwa W, Gordon L. Lowe H, et al. Molecules. 2021 May 15;26(10):2948. doi: 10.3390/molecules26102948. Molecules. 2021. PMID: 34063505 Free PMC article. Review.
This prohibition on psychedelic drug research significantly delayed advances in medical knowledge on the therapeutic uses of agents such as psilocybin. A 2004 pilot study from the University of California, Los Angeles, exploring the potential of psilocybin treatment …
This prohibition on psychedelic drug research significantly delayed advances in medical knowledge on the therapeutic uses of agents such as …
Trial of Psilocybin versus Escitalopram for Depression.
Carhart-Harris R, Giribaldi B, Watts R, Baker-Jones M, Murphy-Beiner A, Murphy R, Martell J, Blemings A, Erritzoe D, Nutt DJ. Carhart-Harris R, et al. N Engl J Med. 2021 Apr 15;384(15):1402-1411. doi: 10.1056/NEJMoa2032994. N Engl J Med. 2021. PMID: 33852780 Clinical Trial.
BACKGROUND: Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking. ...Patients were assigned in a 1:1 ratio to receive two separate doses of 25 mg of psilocybin 3 weeks a …
BACKGROUND: Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatment …
Psilocybin: from ancient magic to modern medicine.
Nichols DE. Nichols DE. J Antibiot (Tokyo). 2020 Oct;73(10):679-686. doi: 10.1038/s41429-020-0311-8. Epub 2020 May 12. J Antibiot (Tokyo). 2020. PMID: 32398764 Review.
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is an indole-based secondary metabolite produced by numerous species of mushrooms. ...At present, assuming that the early clinical studies can be validated by larger studies, psilocybin is poised to make a signific …
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is an indole-based secondary metabolite produced by numerous species of mushrooms …
Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance.
Dinis-Oliveira RJ. Dinis-Oliveira RJ. Drug Metab Rev. 2017 Feb;49(1):84-91. doi: 10.1080/03602532.2016.1278228. Epub 2017 Jan 31. Drug Metab Rev. 2017. PMID: 28074670 Review.
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)(2A) subtype receptors. ...This review aims to discuss me …
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mu …
Psilocybin for Trauma-Related Disorders.
Khan AJ, Bradley E, O'Donovan A, Woolley J. Khan AJ, et al. Curr Top Behav Neurosci. 2022;56:319-332. doi: 10.1007/7854_2022_366. Curr Top Behav Neurosci. 2022. PMID: 35711024 Review.
We provide an overview of trauma and PTSD and cite literature providing converging evidence of the therapeutic potential of psilocybin for PTSD. No study to date has investigated psilocybin or psilocybin-assisted psychotherapy (PAP) as treatments for PTSD. .. …
We provide an overview of trauma and PTSD and cite literature providing converging evidence of the therapeutic potential of psilocybin …
The pharmacology of psilocybin.
Passie T, Seifert J, Schneider U, Emrich HM. Passie T, et al. Addict Biol. 2002 Oct;7(4):357-64. doi: 10.1080/1355621021000005937. Addict Biol. 2002. PMID: 14578010 Review.
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. ...Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocybin were known until rece …
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed world …
Psilocybin's lasting action requires pyramidal cell types and 5-HT(2A) receptors.
Shao LX, Liao C, Davoudian PA, Savalia NK, Jiang Q, Wojtasiewicz C, Tan D, Nothnagel JD, Liu RJ, Woodburn SC, Bilash OM, Kim H, Che A, Kwan AC. Shao LX, et al. Nature. 2025 Jun;642(8067):411-420. doi: 10.1038/s41586-025-08813-6. Epub 2025 Apr 2. Nature. 2025. PMID: 40175553
Behaviourally, silencing the PT neurons eliminates psilocybin's ability to ameliorate stress-related phenotypes, whereas silencing IT neurons has no detectable effect. ...Targeted knockout of 5-HT(2A) receptors abolishes psilocybin's effects on stress- …
Behaviourally, silencing the PT neurons eliminates psilocybin's ability to ameliorate stress-related phenotypes, whereas silen …
Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study.
Carhart-Harris RL, Bolstridge M, Rucker J, Day CM, Erritzoe D, Kaelen M, Bloomfield M, Rickard JA, Forbes B, Feilding A, Taylor D, Pilling S, Curran VH, Nutt DJ. Carhart-Harris RL, et al. Lancet Psychiatry. 2016 Jul;3(7):619-27. doi: 10.1016/S2215-0366(16)30065-7. Epub 2016 May 17. Lancet Psychiatry. 2016. PMID: 27210031 Free article. Clinical Trial.
The primary outcome measure for feasibility was patient-reported intensity of psilocybin's effects. Patients were monitored for adverse reactions during the dosing sessions and subsequent clinic and remote follow-up. ...This trial is registered with ISRCTN, number I …
The primary outcome measure for feasibility was patient-reported intensity of psilocybin's effects. Patients were monitored fo …
Psilocybin and Other Classic Psychedelics in Depression.
Nutt DJ, Peill JM, Weiss B, Godfrey K, Carhart-Harris RL, Erritzoe D. Nutt DJ, et al. Curr Top Behav Neurosci. 2024;66:149-174. doi: 10.1007/7854_2023_451. Curr Top Behav Neurosci. 2024. PMID: 37955822 Review.
Psychedelic drugs such as psilocybin and ketamine are returning to clinical research and intervention across several disorders including the treatment of depression. This chapter focusses on psychedelics that specifically target the 5-HT(2A) receptor such as psilocybin …
Psychedelic drugs such as psilocybin and ketamine are returning to clinical research and intervention across several disorders includ …
Impact of psilocybin on cognitive function: A systematic review.
Meshkat S, Tello-Gerez TJ, Gholaminezhad F, Dunkley BT, Reichelt AC, Erritzoe D, Vermetten E, Zhang Y, Greenshaw A, Burback L, Winkler O, Jetly R, Mayo LM, Bhat V. Meshkat S, et al. Psychiatry Clin Neurosci. 2024 Dec;78(12):744-764. doi: 10.1111/pcn.13741. Epub 2024 Oct 1. Psychiatry Clin Neurosci. 2024. PMID: 39354706 Free PMC article.
In this systematic review, we assessed psilocybin's effect on cognitive function through a comprehensive search of electronic databases from inception to January 2024, identifying 20 articles involving 2,959 participants. ...The observed mixed findings underscore th …
In this systematic review, we assessed psilocybin's effect on cognitive function through a comprehensive search of electronic …
3,190 results