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Towards an understanding of psychedelic-induced neuroplasticity.
Calder AE, Hasler G. Calder AE, et al. Neuropsychopharmacology. 2023 Jan;48(1):104-112. doi: 10.1038/s41386-022-01389-z. Epub 2022 Sep 19. Neuropsychopharmacology. 2023. PMID: 36123427 Free PMC article. Review.
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and addiction. ...We then examine where in the brain psychedelics promote neuroplasticity, particularly discussing the prefrontal cor …
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, an …
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning.
Catlow BJ, Song S, Paredes DA, Kirstein CL, Sanchez-Ramos J. Catlow BJ, et al. Exp Brain Res. 2013 Aug;228(4):481-91. doi: 10.1007/s00221-013-3579-0. Epub 2013 Jun 2. Exp Brain Res. 2013. PMID: 23727882
Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and hippocampal (HPC)-dependent learning. The primary objective is to determine the extent to which psilocybin (PSOP) modulates neurogenesis and thereby affects acquisition and e …
Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and hippocampal (HPC)-dependent learning. The primar …
Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity.
Du Y, Li Y, Zhao X, Yao Y, Wang B, Zhang L, Wang G. Du Y, et al. Chin Med J (Engl). 2023 Dec 20;136(24):2983-2992. doi: 10.1097/CM9.0000000000002647. Epub 2023 Mar 30. Chin Med J (Engl). 2023. PMID: 37000971 Free PMC article.
BACKGROUND: Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effects on depression by promoting neuroplasticity. ...In terms of structural neuroplasticity, psilocybin rescued the decrease in hippocamp …
BACKGROUND: Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effect …
Psilocybin promotes neuroplasticity and induces rapid and sustained antidepressant-like effects in mice.
Zhao X, Du Y, Yao Y, Dai W, Yin Y, Wang G, Li Y, Zhang L. Zhao X, et al. J Psychopharmacol. 2024 May;38(5):489-499. doi: 10.1177/02698811241249436. Epub 2024 Apr 28. J Psychopharmacol. 2024. PMID: 38680011
Moreover, psilocybin ameliorated chronic CORT exposure-induced inhibition of neuroplasticity in the PFC and hippocampus, including by increasing neuroplasticity (total number of dendritic branches and dendritic spine density), synaptic protein (p-GluA1, PSD95 and sy …
Moreover, psilocybin ameliorated chronic CORT exposure-induced inhibition of neuroplasticity in the PFC and hippocampus, inclu …
Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases.
Haniff ZR, Bocharova M, Mantingh T, Rucker JJ, Velayudhan L, Taylor DM, Young AH, Aarsland D, Vernon AC, Thuret S. Haniff ZR, et al. Pharmacol Ther. 2024 Jun;258:108641. doi: 10.1016/j.pharmthera.2024.108641. Epub 2024 Apr 6. Pharmacol Ther. 2024. PMID: 38583670 Free article. Review.
Emerging evidence suggests that psychedelics promote neuroplasticity, including neurogenesis, and may also be immunomodulatory. In this context, psilocybin, a serotonergic agonist with rapid-acting antidepressant properties has the potential to ameliorate intersecti …
Emerging evidence suggests that psychedelics promote neuroplasticity, including neurogenesis, and may also be immunomodulatory. In th …
Improving cognitive functioning in major depressive disorder with psychedelics: A dimensional approach.
Magaraggia I, Kuiperes Z, Schreiber R. Magaraggia I, et al. Neurobiol Learn Mem. 2021 Sep;183:107467. doi: 10.1016/j.nlm.2021.107467. Epub 2021 May 26. Neurobiol Learn Mem. 2021. PMID: 34048913 Free article. Review.
Pattern separation is a mnemonic process that relies on adult hippocampal neurogenesis, where similar inputs are made more distinct, which is essential for optimal encoding of contextual information. ...On the (sub) cellular level, psychedelics stimulate hippocampal neu …
Pattern separation is a mnemonic process that relies on adult hippocampal neurogenesis, where similar inputs are made more distinct, …