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Psychedelics and ketamine/esketamine in depressive disorders: biological mechanisms and associated neuroimaging and clinical changes.
d'Andrea G, Chiappini S, Ciavoni L, Tucci R, Martino F, Semeraro FM, Di Battista D, Mosca A, Miuli A, Di Carlo F, Russo M, Di Petta G, Fornaro M, Pettorruso M, Sensi SL, Martinotti G. d'Andrea G, et al. Transl Psychiatry. 2025 Oct 31;15(1):453. doi: 10.1038/s41398-025-03654-3. Transl Psychiatry. 2025. PMID: 41173871 Free PMC article.
While these compounds are relatively available for treatment, ketamine and its S(+) enantiomer, esketamine, are increasingly used to manage treatment-resistant depression. ...From the total of 49 studies, 9 were randomized-controlled trials, 25 were open-label studi …
While these compounds are relatively available for treatment, ketamine and its S(+) enantiomer, esketamine, are increasingly used to …
Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors.
Strumila R, Nobile B, Korsakova L, Lengvenyte A, Olie E, Lopez-Castroman J, Guillaume S, Courtet P. Strumila R, et al. Pharmaceuticals (Basel). 2021 Nov 24;14(12):1213. doi: 10.3390/ph14121213. Pharmaceuticals (Basel). 2021. PMID: 34959614 Free PMC article. Review.
Recently, research on new mental health treatments has started to consider psychedelic compounds, particularly psilocybin, a molecule with a few thousand years of history of use in human societies. ...Major pathways related to suicidal behaviors that might be modulated by …
Recently, research on new mental health treatments has started to consider psychedelic compounds, particularly psilocybin, a molecule …
Interventions for deficits in recognition of emotions in facial expressions in major depressive disorder: An updated systematic review of clinical trials.
Reis JAS, Rossi GN, L Osório F, Bouso JC, Hallak JEC, Dos Santos RG. Reis JAS, et al. Neurosci Biobehav Rev. 2023 Oct;153:105367. doi: 10.1016/j.neubiorev.2023.105367. Epub 2023 Aug 22. Neurosci Biobehav Rev. 2023. PMID: 37619644
Some interventions, including drugs (ketamine, bupropion, psylocibin) and non-pharmacological strategies (psychotherapy) seem to be able to reduce pre-existing REFE biases in MDD patients. ...Further studies and more consistent evaluation tools are highly needed to better …
Some interventions, including drugs (ketamine, bupropion, psylocibin) and non-pharmacological strategies (psychotherapy) seem to be a …
The pharmaceuticalisation of 'healthy' ageing: Testosterone enhancement for longevity.
Dunn M, Mulrooney KJ, Forlini C, van de Ven K, Underwood M. Dunn M, et al. Int J Drug Policy. 2021 Sep;95:103159. doi: 10.1016/j.drugpo.2021.103159. Epub 2021 Feb 12. Int J Drug Policy. 2021. PMID: 33583680
At the same time, we are witnessing a shift in how we respond to the health needs of our populations, with global drug policy acknowledging that some substances are contributing to increased morbidity and mortality (e.g. opioids) while others may have beneficial therapeutic effec …
At the same time, we are witnessing a shift in how we respond to the health needs of our populations, with global drug policy acknowledging …
The phenomenology of psilocybin: transformative insights for research and clinical practice.
Metastasio A, Prevete E, Venturini S, Garofalo A, Cecconello B, De Pisapia N, Corazza O. Metastasio A, et al. Front Psychol. 2025 Apr 25;16:1455902. doi: 10.3389/fpsyg.2025.1455902. eCollection 2025. Front Psychol. 2025. PMID: 40351574 Free PMC article.
By employing phenomenological methods, we offer a structured understanding of these states, which could be used in future to provide guidance for their integration into therapy by giving a better insight into psychedelic experience....
By employing phenomenological methods, we offer a structured understanding of these states, which could be used in future to provide guidanc …
Hallucinogen persisting perception disorder after psilocybin consumption: a case study.
Espiard ML, Lecardeur L, Abadie P, Halbecq I, Dollfus S. Espiard ML, et al. Eur Psychiatry. 2005 Aug;20(5-6):458-60. doi: 10.1016/j.eurpsy.2005.04.008. Eur Psychiatry. 2005. PMID: 15963699
We reported here a case of a 18-year-old young man presenting HPPD after a mixed intoxication with psylocibin and cannabis. This report shows symptomatic recurrences persisting more than 8 months. ...
We reported here a case of a 18-year-old young man presenting HPPD after a mixed intoxication with psylocibin and cannabis. This repo …