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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1949 2
1950 1
1951 3
1952 3
1953 3
1954 5
1955 2
1956 5
1958 3
1959 1
1961 1
1962 4
1963 2
1979 1
1984 1
1994 1
1996 3
1997 3
1998 7
1999 9
2000 16
2001 11
2002 14
2003 9
2004 23
2005 15
2006 25
2007 21
2008 25
2009 21
2010 32
2011 20
2012 23
2013 27
2014 29
2015 34
2016 18
2017 23
2018 28
2019 38
2020 25
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481 results
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Pycnogenol(®) for the treatment of chronic disorders.
Schoonees A, Visser J, Musekiwa A, Volmink J. Schoonees A, et al. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD008294. doi: 10.1002/14651858.CD008294.pub3. Cochrane Database Syst Rev. 2012. PMID: 22336841 Updated. Review.
Pycnogenol(®) is marketed as a supplement for preventing or treating a wide range of chronic conditions. OBJECTIVES: To assess the efficacy and safety of Pycnogenol(®) for the treatment of chronic disorders. ...We also contacted the manufacturer of Pycnogenol
Pycnogenol(®) is marketed as a supplement for preventing or treating a wide range of chronic conditions. OBJECTIVES: To assess the ef
Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis.
Zhang Z, Tong X, Wei YL, Zhao L, Xu JY, Qin LQ. Zhang Z, et al. Iran J Public Health. 2018 Jun;47(6):779-787. Iran J Public Health. 2018. PMID: 30087862 Free PMC article. Review.
RESULTS: We identified nine trials involving 549 participants who received Pycnogenol supplementation ranging from 150 mg/d to 200 mg/d. ...CONCLUSION: This meta-analysis with nine trials provides better evidence that Pycnogenol exerts beneficial effects on BP....
RESULTS: We identified nine trials involving 549 participants who received Pycnogenol supplementation ranging from 150 mg/d to 200 mg …
Assessing the Efficacy and Mechanisms of Pycnogenol(®) on Cognitive Aging From In Vitro Animal and Human Studies.
Simpson T, Kure C, Stough C. Simpson T, et al. Front Pharmacol. 2019 Jul 3;10:694. doi: 10.3389/fphar.2019.00694. eCollection 2019. Front Pharmacol. 2019. PMID: 31333448 Free PMC article. Review.
More recently, Pycnogenol has been subjected to more than 100 research trials. In vitro and animal studies using the standardized extract have indicated a multimodal action of Pycnogenol, and several human studies have shown improvements in cognitive function after …
More recently, Pycnogenol has been subjected to more than 100 research trials. In vitro and animal studies using the standardized ext …
Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol.
Rohdewald PJ. Rohdewald PJ. J Med Food. 2018 Jan;21(1):1-4. doi: 10.1089/jmf.2017.0015. Epub 2017 Aug 24. J Med Food. 2018. PMID: 28836883 Free PMC article. Review.
This review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol(®)) in mild osteoarthritis (OA), stage 1 and 2. ...Because of its favorable safety profile and sustained anti-inflammatory action, Pycnogenol repr …
This review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol(®)) in mild o …
Effect of pycnogenol supplementation on blood pressure: A systematic review and meta-analysis of clinical trials.
Pourmasoumi M, Hadi A, Mohammadi H, Rouhani MH. Pourmasoumi M, et al. Phytother Res. 2020 Jan;34(1):67-76. doi: 10.1002/ptr.6515. Epub 2019 Oct 21. Phytother Res. 2020. PMID: 31637782
Several studies investigated the impact of pycnogenol on blood pressure. Nevertheless, the results are inconclusive. The aim of the present systematic review and meta-analysis was to clarify the effect of pycnogenol supplementation on blood pressure. ...Effect of …
Several studies investigated the impact of pycnogenol on blood pressure. Nevertheless, the results are inconclusive. The aim of the p …
Treatment of erectile dysfunction with pycnogenol and L-arginine.
Stanislavov R, Nikolova V. Stanislavov R, et al. J Sex Marital Ther. 2003 May-Jun;29(3):207-13. doi: 10.1080/00926230390155104. J Sex Marital Ther. 2003. PMID: 12851125 Clinical Trial.
During the second month, patients were additionally supplemented with 40 mg Pycnogenol two times per day; during the third month, the daily dosage was increased to three 40-mg Pycnogenol tablets. ...Treatment with a combination of L-arginine and Pycnogenol fo …
During the second month, patients were additionally supplemented with 40 mg Pycnogenol two times per day; during the third month, the …
Treatment of melasma with Pycnogenol.
Ni Z, Mu Y, Gulati O. Ni Z, et al. Phytother Res. 2002 Sep;16(6):567-71. doi: 10.1002/ptr.1085. Phytother Res. 2002. PMID: 12237816 Clinical Trial.
Thirty women with melasma completed a 30-day clinical trial in which they took one 25 mg tablet of Pycnogenol with meals three times daily, i.e. 75 mg Pycnogenol per day. ...To conclude, Pycnogenol was shown to be therapeutically effective and safe in patient …
Thirty women with melasma completed a 30-day clinical trial in which they took one 25 mg tablet of Pycnogenol with meals three times …
The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis.
Nikpayam O, Rouhani MH, Pourmasoumi M, Roshanravan N, Ghaedi E, Mohammadi H. Nikpayam O, et al. Clin Nutr Res. 2018 Apr;7(2):117-125. doi: 10.7762/cnr.2018.7.2.117. Epub 2018 Apr 16. Clin Nutr Res. 2018. PMID: 29713620 Free PMC article.
Pycnogenol is a standardized extract from the bark of the French maritime pine. The aim of the present systematic review and meta-analysis was to clarify the effect of Pycnogenol supplementation on C-reactive protein (CRP) concentration. ...When the meta-analysis wa
Pycnogenol is a standardized extract from the bark of the French maritime pine. The aim of the present systematic review and meta-ana
Effects of pycnogenol on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials.
Malekahmadi M, Moradi Moghaddam O, Firouzi S, Daryabeygi-Khotbehsara R, Shariful Islam SM, Norouzy A, Soltani S. Malekahmadi M, et al. Pharmacol Res. 2019 Dec;150:104472. doi: 10.1016/j.phrs.2019.104472. Epub 2019 Oct 1. Pharmacol Res. 2019. PMID: 31585179
AIM: Clinical trials on the effect of pycnogenol supplementation on cardiometabolic health have been controversial. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the potential effect of pycnogenol supplementati …
AIM: Clinical trials on the effect of pycnogenol supplementation on cardiometabolic health have been controversial. We conducted a sy …
Pycnogenol supplementation as an adjunct treatment for antidepressant-induced sexual dysfunction.
Smetanka A, Stara V, Farsky I, Tonhajzerova I, Ondrejka I. Smetanka A, et al. Physiol Int. 2019 Mar 1;106(1):59-69. doi: 10.1556/2060.106.2019.02. Epub 2019 Mar 19. Physiol Int. 2019. PMID: 30888217 Clinical Trial.
In this study, we investigated the prospective effect of Pycnogenol (PYC), an antioxidant, anti-inflammatory, and vasodilator agent, on ESC-induced SDys. ...
In this study, we investigated the prospective effect of Pycnogenol (PYC), an antioxidant, anti-inflammatory, and vasodilator agent, …
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