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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1949 2
1950 1
1951 3
1952 3
1953 3
1954 5
1955 2
1956 5
1958 3
1959 1
1961 1
1962 4
1963 2
1979 1
1984 1
1994 1
1996 3
1997 3
1998 7
1999 9
2000 16
2001 11
2002 14
2003 9
2004 23
2005 15
2006 25
2007 21
2008 25
2009 21
2010 32
2011 20
2012 23
2013 27
2014 29
2015 34
2016 18
2017 23
2018 28
2019 37
2020 17
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473 results
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Page 1
Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis.
Zhang Z, Tong X, Wei YL, Zhao L, Xu JY, Qin LQ. Zhang Z, et al. Iran J Public Health. 2018 Jun;47(6):779-787. Iran J Public Health. 2018. PMID: 30087862 Free PMC article. Review.
RESULTS: We identified nine trials involving 549 participants who received Pycnogenol supplementation ranging from 150 mg/d to 200 mg/d. ...CONCLUSION: This meta-analysis with nine trials provides better evidence that Pycnogenol exerts beneficial effects on BP....
RESULTS: We identified nine trials involving 549 participants who received Pycnogenol supplementation ranging from 150 mg/d to 200 mg …
Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol.
Rohdewald PJ. Rohdewald PJ. J Med Food. 2018 Jan;21(1):1-4. doi: 10.1089/jmf.2017.0015. Epub 2017 Aug 24. J Med Food. 2018. PMID: 28836883 Free PMC article. Review.
This review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol(®)) in mild osteoarthritis (OA), stage 1 and 2. ...Because of its favorable safety profile and sustained anti-inflammatory action, Pycnogenol repr …
This review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol(®)) in mild o …
Postpartum Varicose Veins: Supplementation with Pycnogenol or Elastic Compression-A 12-Month Follow-Up.
Belcaro G, Dugall M, Luzzi R, Ippolito E, Cesarone MR. Belcaro G, et al. Int J Angiol. 2017 Mar;26(1):12-19. doi: 10.1055/s-0033-1363784. Epub 2014 May 29. Int J Angiol. 2017. PMID: 28255210 Free PMC article.
At 3 and 6 months in the Pycnogenol group the number of veins and incompetent sites were lower. At 6 months there were 13.3% of patients with edema in controls versus 3.2% in the Pycnogenol group. Spider veins decreased in Pycnogenol patients. Cramps and othe …
At 3 and 6 months in the Pycnogenol group the number of veins and incompetent sites were lower. At 6 months there were 13.3% of patie …
Pycnogenol supplementation as an adjunct treatment for antidepressant-induced sexual dysfunction.
Smetanka A, Stara V, Farsky I, Tonhajzerova I, Ondrejka I. Smetanka A, et al. Physiol Int. 2019 Mar 1;106(1):59-69. doi: 10.1556/2060.106.2019.02. Epub 2019 Mar 19. Physiol Int. 2019. PMID: 30888217 Clinical Trial.
In this study, we investigated the prospective effect of Pycnogenol (PYC), an antioxidant, anti-inflammatory, and vasodilator agent, on ESC-induced SDys. ...
In this study, we investigated the prospective effect of Pycnogenol (PYC), an antioxidant, anti-inflammatory, and vasodilator agent, …
Toll-Like Receptor-Dependent Immunomodulatory Activity of Pycnogenol(®).
Verlaet A, van der Bolt N, Meijer B, Breynaert A, Naessens T, Konstanti P, Smidt H, Hermans N, Savelkoul HFJ, Teodorowicz M. Verlaet A, et al. Nutrients. 2019 Jan 22;11(2):214. doi: 10.3390/nu11020214. Nutrients. 2019. PMID: 30678156 Free PMC article.
BACKGROUND: Pycnogenol(®) (PYC), an extract of French maritime pine bark, is widely used as a dietary supplement. PYC has been shown to exert anti-inflammatory actions via inhibiting the Toll-like receptor 4 (TLR4) pathway. ...
BACKGROUND: Pycnogenol(®) (PYC), an extract of French maritime pine bark, is widely used as a dietary supplement. PYC has been shown …
The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis.
Nikpayam O, Rouhani MH, Pourmasoumi M, Roshanravan N, Ghaedi E, Mohammadi H. Nikpayam O, et al. Clin Nutr Res. 2018 Apr;7(2):117-125. doi: 10.7762/cnr.2018.7.2.117. Epub 2018 Apr 16. Clin Nutr Res. 2018. PMID: 29713620 Free PMC article.
Pycnogenol is a standardized extract from the bark of the French maritime pine. The aim of the present systematic review and meta-analysis was to clarify the effect of Pycnogenol supplementation on C-reactive protein (CRP) concentration. ...When the meta-analysis wa
Pycnogenol is a standardized extract from the bark of the French maritime pine. The aim of the present systematic review and meta-ana
The Effect of Pycnogenol on Wound Healing in Diabetic Rats.
Dogan E, Yanmaz L, Gedikli S, Ersoz U, Okumus Z. Dogan E, et al. Ostomy Wound Manage. 2017 Apr;63(4):41-47. Ostomy Wound Manage. 2017. PMID: 28448268 Free article.
Pycnogenol (PYC), an extract of pine bark, is known to have photoprotective, antimicrobial, antioxidant, and anti-inflammatory properties. ...
Pycnogenol (PYC), an extract of pine bark, is known to have photoprotective, antimicrobial, antioxidant, and anti-inflammatory proper
Effects of pycnogenol on ischemia/reperfusion-induced inflammatory and oxidative brain injury in rats.
Ozoner B, Yuceli S, Aydin S, Yazici GN, Sunar M, Arslan YK, Coban TA, Suleyman H. Ozoner B, et al. Neurosci Lett. 2019 Jun 21;704:169-175. doi: 10.1016/j.neulet.2019.04.010. Epub 2019 Apr 6. Neurosci Lett. 2019. PMID: 30965107
This study aimed to determine the effects of pycnogenol on I/R injury in rat brain tissues. METHODS: Eighteen albino Wistar rats were divided into three groups: I/R injury (IR, n = 6) group; I/R injury + pycnogenol (IR + P, n = 6) group; and sham group (SG, n = 6). …
This study aimed to determine the effects of pycnogenol on I/R injury in rat brain tissues. METHODS: Eighteen albino Wistar rats were …
The impact of pycnogenol supplementation on plasma lipids in humans: A systematic review and meta-analysis of clinical trials.
Hadi A, Pourmasoumi M, Mohammadi H, Javaheri A, Rouhani MH. Hadi A, et al. Phytother Res. 2019 Feb;33(2):276-287. doi: 10.1002/ptr.6234. Epub 2018 Nov 19. Phytother Res. 2019. PMID: 30456865
The effects of pycnogenol on plasma lipids are controversial. A systematic review and meta-analysis of clinical trials were conducted to obtain a conclusive result in humans. ...The results indicate that pycnogenol supplementation improves levels of HDL-C; however, …
The effects of pycnogenol on plasma lipids are controversial. A systematic review and meta-analysis of clinical trials were conducted …
Effects of a supplement combining Pycnogenol(®) and l-arginine aspartate on lower urinary dysfunction compared with saw palmetto extract.
Yagi H, Sato R, Nishio K, Arai G, Soh S, Okada H. Yagi H, et al. J Tradit Complement Med. 2016 Jun 11;7(1):117-120. doi: 10.1016/j.jtcme.2016.05.008. eCollection 2017 Jan. J Tradit Complement Med. 2016. PMID: 28053897 Free PMC article.
French maritime pine bark extract Pycnogenol(®), which is a potent nitric oxide donor, is reported to be effective for SDys. ...The effects of two supplements, Nokogiriyashi EX(®) containing 160 mg saw palmetto (SP) extract per tablet and Edicare(®) containing 10 mg of …
French maritime pine bark extract Pycnogenol(®), which is a potent nitric oxide donor, is reported to be effective for SDys. ...The e …
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