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Page 1
Quercetin and its ester derivatives inhibit oxidation of food, LDL and DNA.
Oh WY, Ambigaipalan P, Shahidi F. Oh WY, et al. Food Chem. 2021 Dec 1;364:130394. doi: 10.1016/j.foodchem.2021.130394. Epub 2021 Jun 17. Food Chem. 2021. PMID: 34167006
Quercetin was esterified with fatty acids (FA) in order to expand its application in a wide range of food and biological systems. The antioxidant potential of the esters were examined using hydroxyl radical scavenging activity, antioxidation in oil-in-water emulsion and bu
Quercetin was esterified with fatty acids (FA) in order to expand its application in a wide range of food and biological systems. The
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
Liang X, Zhang J, Yu J, Zhao J, Yang S. Liang X, et al. Eur J Med Res. 2025 May 3;30(1):359. doi: 10.1186/s40001-025-02562-y. Eur J Med Res. 2025. PMID: 40319296 Free PMC article.
METHODS: Oxidized low-density lipoprotein (ox-LDL)-induced human aortic endothelial cells (HAECs) and mouse RAW264.7 macrophages were established, with quercetin treatment or p16, p21 or SERPINE1 siRNA transfection. ...Furthermore, que
METHODS: Oxidized low-density lipoprotein (ox-LDL)-induced human aortic endothelial cells (HAECs) and mou …
Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.
Cao H, Jia Q, Yan L, Chen C, Xing S, Shen D. Cao H, et al. Int J Mol Sci. 2019 Dec 3;20(23):6093. doi: 10.3390/ijms20236093. Int J Mol Sci. 2019. PMID: 31816893 Free PMC article.
METHODS: An in vitro foam cell model was established by culturing RAW264.7 macrophages with oxidized low-density lipoprotein (ox-LDL). The cells were treated with quercetin alone or in combination with the autophagy inhibitor, 3-methylade …
METHODS: An in vitro foam cell model was established by culturing RAW264.7 macrophages with oxidized low-density lip
Red Wine Consumption and Cardiovascular Health.
Castaldo L, Narváez A, Izzo L, Graziani G, Gaspari A, Minno GD, Ritieni A. Castaldo L, et al. Molecules. 2019 Oct 8;24(19):3626. doi: 10.3390/molecules24193626. Molecules. 2019. PMID: 31597344 Free PMC article. Review.
Experimental studies and meta-analyses have mainly attributed this outcome to the presence in red wine of a great variety of polyphenolic compounds such as resveratrol, catechin, epicatechin, quercetin, and anthocyanin. Resveratrol is considered the most effective wine com …
Experimental studies and meta-analyses have mainly attributed this outcome to the presence in red wine of a great variety of polyphenolic co …
Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin.
Janisch KM, Williamson G, Needs P, Plumb GW. Janisch KM, et al. Free Radic Res. 2004 Aug;38(8):877-84. doi: 10.1080/10715760410001728415. Free Radic Res. 2004. PMID: 15493462
In general, the compounds under study prolonged the lag time of copper-induced LDL oxidation in the order: quercetin-7-glucuronide > quercetin > quercetin-3-glucuronide = quercetin-3-glucoside > catechin > quercetin-4'- …
In general, the compounds under study prolonged the lag time of copper-induced LDL oxidation in the order: quercetin-7- …
Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis.
Duan H, Zhang Q, Liu J, Li R, Wang D, Peng W, Wu C. Duan H, et al. Pharmacol Res. 2021 Jun;168:105599. doi: 10.1016/j.phrs.2021.105599. Epub 2021 Apr 7. Pharmacol Res. 2021. PMID: 33838291 Review.
Therefore, this paper reviewed current studies on the inhibitory effect of natural medicines on endothelial cell apoptosis and summarized the risk factors that may induce endothelial cell apoptosis, including oxidized low-density lipoprotein (ox-LDL
Therefore, this paper reviewed current studies on the inhibitory effect of natural medicines on endothelial cell apoptosis and summarized th …
A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis.
Luo X, Weng X, Bao X, Bai X, Lv Y, Zhang S, Chen Y, Zhao C, Zeng M, Huang J, Xu B, Johnson TW, White SJ, Li J, Jia H, Yu B. Luo X, et al. Redox Biol. 2022 Nov;57:102511. doi: 10.1016/j.redox.2022.102511. Epub 2022 Oct 14. Redox Biol. 2022. PMID: 36274522 Free PMC article.
In ApoE(-/-) mice fed with high fat diet, quercetin administration attenuated atherosclerosis progression by reducing oxidative stress level and suppressing macrophage pyroptosis. At the cellular level, quercetin suppressed THP-1 macrophage pyroptosis induced …
In ApoE(-/-) mice fed with high fat diet, quercetin administration attenuated atherosclerosis progression by reducing oxidative
Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels.
Wang YM, Chu TJ, Wan RT, Niu WP, Bian YF, Li J. Wang YM, et al. Phytomedicine. 2024 Sep;132:155865. doi: 10.1016/j.phymed.2024.155865. Epub 2024 Jul 9. Phytomedicine. 2024. PMID: 39004029
BACKGROUND: Natural antioxidants, exemplified by quercetin (Qu), have been shown to exert a protective effect against atherosclerosis (AS). ...Moreover, Qu exhibited a substantial inhibitory effect on inflammatory cytokine expression and reduced the activity of NF-kappaB/N …
BACKGROUND: Natural antioxidants, exemplified by quercetin (Qu), have been shown to exert a protective effect against atherosclerosis …
Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation.
Jiang L, Yi R, Chen H, Wu S. Jiang L, et al. Anim Biotechnol. 2025 Dec;36(1):2442351. doi: 10.1080/10495398.2024.2442351. Epub 2024 Dec 24. Anim Biotechnol. 2025. PMID: 39718035 Free PMC article.
In vivo study attesting to quercetin's protective effect against metabolic-associated fatty liver disease (MAFLD) is inadequate, however. ...The hepatic histological anomalie induced by MAFLD were also mitigated by quercetin. HFD-induced imbalance in serum …
In vivo study attesting to quercetin's protective effect against metabolic-associated fatty liver disease (MAFLD) is inadequat …
Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARgamma, LXRalpha and ABCA1.
Jia Q, Cao H, Shen D, Li S, Yan L, Chen C, Xing S, Dou F. Jia Q, et al. Int J Mol Med. 2019 Sep;44(3):893-902. doi: 10.3892/ijmm.2019.4263. Epub 2019 Jul 3. Int J Mol Med. 2019. PMID: 31524223 Free PMC article.
ELISA was performed to measure the serum levels of lipids including total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and oxidized low-density lipoprotein (oxLDL) …
ELISA was performed to measure the serum levels of lipids including total cholesterol (TC), triglyceride (TG), high-density lipoprotein-chol …
311 results