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382 results

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Page 1
Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells.
Sul OJ, Ra SW. Sul OJ, et al. Molecules. 2021 Nov 17;26(22):6949. doi: 10.3390/molecules26226949. Molecules. 2021. PMID: 34834040 Free PMC article.
We hypothesized that modulation of ROS via quercetin may protect against oxidative stress and inflammation. Thus, this study aimed to investigate the effects of quercetin on oxidative stress and inflammation in lung epithelial A549 cells. ...In additio …
We hypothesized that modulation of ROS via quercetin may protect against oxidative stress and inflammation. Thus, this study a …
Quercetin inhibits TNF-alpha induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro.
Chen T, Zhang X, Zhu G, Liu H, Chen J, Wang Y, He X. Chen T, et al. Medicine (Baltimore). 2020 Sep 18;99(38):e22241. doi: 10.1097/MD.0000000000022241. Medicine (Baltimore). 2020. PMID: 32957369 Free PMC article.
Flow cytometry was used to estimate the apoptosis rates, and the expression of activator protein 1 (AP-1) and nuclear factor kappa B (NF-kappaB) was measured by Western blot. TNF-alpha induced elevated apoptosis rates and upregulation of VCAM-1, ICAM-1, and E …
Flow cytometry was used to estimate the apoptosis rates, and the expression of activator protein 1 (AP-1) and nuclear factor kappa …
Flavonoids as Potential Anti-Inflammatory Molecules: A Review.
Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Al-Khayri JM, et al. Molecules. 2022 May 2;27(9):2901. doi: 10.3390/molecules27092901. Molecules. 2022. PMID: 35566252 Free PMC article. Review.
They possess numerous medicinal properties such as antioxidant, anti-cancer, anti-microbial, neuroprotective, and anti-inflammation. Studies show that flavonoids activate antioxidant pathways that render an anti-inflammatory effect. ...Understanding the anti-inflammatory a …
They possess numerous medicinal properties such as antioxidant, anti-cancer, anti-microbial, neuroprotective, and anti-inflammation. …
Quercetin ameliorates atherosclerosis by inhibiting inflammation of vascular endothelial cells via Piezo1 channels.
Wang YM, Chu TJ, Wan RT, Niu WP, Bian YF, Li J. Wang YM, et al. Phytomedicine. 2024 Sep;132:155865. doi: 10.1016/j.phymed.2024.155865. Epub 2024 Jul 9. Phytomedicine. 2024. PMID: 39004029
BACKGROUND: Natural antioxidants, exemplified by quercetin (Qu), have been shown to exert a protective effect against atherosclerosis (AS). ...METHODS/STUDY DESIGNS: The inflammatory cytokine expression, activity of NLRP3 inflammasome and NF-kappaB, as well as mecha …
BACKGROUND: Natural antioxidants, exemplified by quercetin (Qu), have been shown to exert a protective effect against atherosclerosis …
Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis.
Wang L, He C. Wang L, et al. Front Immunol. 2022 Aug 12;13:967193. doi: 10.3389/fimmu.2022.967193. eCollection 2022. Front Immunol. 2022. PMID: 36032081 Free PMC article. Review.
The activation of Nrf2 can have antioxidant and anti-inflammatory effects, which can also have complex crosstalk with NF-kappaB signaling pathway. The activation of Nrf2 can inhibit the M1 polarization and promote the M2 polarization through potential signaling transductio …
The activation of Nrf2 can have antioxidant and anti-inflammatory effects, which can also have complex crosstalk with NF-kappaB signa …
Quercetin improves the imbalance of Th1/Th2 cells and Treg/Th17 cells to attenuate allergic rhinitis.
Ke X, Chen Z, Wang X, Kang H, Hong S. Ke X, et al. Autoimmunity. 2023 Dec;56(1):2189133. doi: 10.1080/08916934.2023.2189133. Autoimmunity. 2023. PMID: 36938614 Free article.
Allergic rhinitis (AR) is a common inflammation that affects many people globally. Quercetin has anti-allergic biological activity in AR. ...The number of differentiated inflammation cells and goblet cells in tissues that elevated by OVA was reduced by que …
Allergic rhinitis (AR) is a common inflammation that affects many people globally. Quercetin has anti-allergic biological acti …
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARgamma/PGC-1alpha/NF-kappaB axis to improve acute liver failure.
Wu H, Wu L, Luo L, Wu YT, Zhang QX, Li HY, Zhang BF. Wu H, et al. Int Immunopharmacol. 2024 Dec 25;143(Pt 2):113444. doi: 10.1016/j.intimp.2024.113444. Epub 2024 Oct 25. Int Immunopharmacol. 2024. PMID: 39454407 Free article.
BACKGROUND: Reactive oxygen species (ROS) from mitochondrial dysfunction are critical in triggering apoptosis and inflammation in acute liver failure (ALF). Quercetin (QUE), an antioxidant, is renowned for its therapeutic effects onliverdiseases. ...Mechanistically, …
BACKGROUND: Reactive oxygen species (ROS) from mitochondrial dysfunction are critical in triggering apoptosis and inflammation in acu …
Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-kappaB pathway.
Yang SY, Hu Y, Zhao R, Zhou YN, Zhuang Y, Zhu Y, Ge XL, Lu TW, Lin KL, Xu YJ. Yang SY, et al. J Nanobiotechnology. 2024 Mar 6;22(1):94. doi: 10.1186/s12951-024-02352-4. J Nanobiotechnology. 2024. PMID: 38449005 Free PMC article.
Despite its vast spectrum of pharmacological activities, quercetin's clinical application is limited due to its poor water solubility and low bioavailability. ...Furthermore, we also found that the above osteoimmunomodulatory effects of quercetin via macropha …
Despite its vast spectrum of pharmacological activities, quercetin's clinical application is limited due to its poor water sol …
Quercetin inhibits NF-kB and JAK/STAT signaling via modulating TLR in thymocytes and splenocytes during MSG-induced immunotoxicity: an in vitro approach.
Das D, Banerjee A, Mukherjee S, Maji BK. Das D, et al. Mol Biol Rep. 2024 Feb 6;51(1):277. doi: 10.1007/s11033-024-09245-7. Mol Biol Rep. 2024. PMID: 38319443
Q reduced MSG-induced cellular stress and inflammation by acting as an agonist for PPAR-gamma and LXRalpha, preventing NF-kB activation, and lowering MMP-9 production via increasing TIMP-1. ...CONCLUSIONS: MSG exposure is associated with immune cell dysfuncti …
Q reduced MSG-induced cellular stress and inflammation by acting as an agonist for PPAR-gamma and LXRalpha, preventing NF-k …
Quercetin attenuates Pseudomonas aeruginosa-induced acute lung inflammation by inhibiting PI3K/AKT/NF-kappaB signaling pathway.
Jia X, Gu M, Dai J, Wang J, Zhang Y, Pang Z. Jia X, et al. Inflammopharmacology. 2024 Apr;32(2):1059-1076. doi: 10.1007/s10787-023-01416-5. Epub 2024 Feb 3. Inflammopharmacology. 2024. PMID: 38310155
Moreover, the quercetin-treated mice displayed decreased phosphorylation levels of PI3K, AKT, IkappaBalpha, and NF-kappaB p65 in lung tissues compared to non-drug-treated mice. Similarly, the in vitro study showed that the phosphorylation of these regulatory protein …
Moreover, the quercetin-treated mice displayed decreased phosphorylation levels of PI3K, AKT, IkappaBalpha, and NF-kappaB p65 …
382 results