Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2019 1
2020 1
2021 2
2023 1
2024 1
2025 2
2026 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

8 results

Results by year

Citations

3 articles found by citation matching
Show all

Search results

Filters applied: . Clear all
Page 1
Multidimensional mechanisms of quercetin in diabetic kidney disease.
Gong Z, Che Q, Wang C, Liu B, Hu M, Zhang H, Liang N, Li H, Zhao G, Yan L, Song T, Chen L, Shi N, Guo J. Gong Z, et al. Front Cell Dev Biol. 2026 Feb 25;13:1705601. doi: 10.3389/fcell.2025.1705601. eCollection 2025. Front Cell Dev Biol. 2026. PMID: 41822029 Free PMC article. Review.
Quercetin is a flavonoid compound that has demonstrated substantial potential in the treatment of diabetic kidney disease (DKD). ...We retrieved the latest research on the pharmacological effects and mechanisms related to quercetin from PubMed a …
Quercetin is a flavonoid compound that has demonstrated substantial potential in the treatment of diabetic kidney di …
Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease.
Bian X, Snow ZK, Zinn CJ, Bratulin AL, Elhusseiny KM, Tchkonia T, Kirkland JL, Zhu Y, Khosla S, Kim SR, Lerman LO, Hickson LJ. Bian X, et al. EBioMedicine. 2026 Feb;124:106124. doi: 10.1016/j.ebiom.2026.106124. Epub 2026 Jan 20. EBioMedicine. 2026. PMID: 41564845 Free PMC article.
BACKGROUND: Maladaptive inflammation and cellular senescence contribute to diabetic kidney disease (DKD) pathogenesis and represent important therapeutic targets. ...However, D + Q senotherapeutic effects on diabetic kidney injury, sen …
BACKGROUND: Maladaptive inflammation and cellular senescence contribute to diabetic kidney disease (DKD) pathoge …
Corrigendum to 'Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease' EBioMedicine 47 (2019) 446-456.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Allison DB, Dickinson SL, Ejima K, Atkinson EJ, Lenburg M, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. EBioMedicine. 2020 Feb;52:102595. doi: 10.1016/j.ebiom.2019.12.004. Epub 2020 Jan 23. EBioMedicine. 2020. PMID: 31982828 Free PMC article. No abstract available.
Strategies for late phase preclinical and early clinical trials of senolytics.
Wissler Gerdes EO, Misra A, Netto JME, Tchkonia T, Kirkland JL. Wissler Gerdes EO, et al. Mech Ageing Dev. 2021 Dec;200:111591. doi: 10.1016/j.mad.2021.111591. Epub 2021 Oct 23. Mech Ageing Dev. 2021. PMID: 34699859 Free PMC article. Review.
Cellular senescence and the hallmarks of aging contribute to age-related disease and dysfunction. ...Early preclinical data using senolytics, agents that target senescent cells, show promising results in several aging and disease models. …
Cellular senescence and the hallmarks of aging contribute to age-related disease and dysfunction. ...Early preclinical …
Potential Clinical Implications of Senotherapies for Cardiovascular Disease.
Suda M, Katsuumi G, Tchkonia T, Kirkland JL, Minamino T. Suda M, et al. Circ J. 2024 Feb 22;88(3):277-284. doi: 10.1253/circj.CJ-23-0657. Epub 2023 Oct 26. Circ J. 2024. PMID: 37880106 Free PMC article.
Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence indicates that biological aging has a significant effect on the onset and progression of CVDs. ...In 2 pilot studies published in 2019 the senolytic combination, dasatinib plus …
Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence indicates that biological aging has …
Dissecting Spatiotemporal Heterogeneity of Senescence Markers p16/p21 Across Tissues During Type 2 Diabetes Progression.
Yan J, Yi Z, Chen S, Zhao R, Shi J, Ding S, Zhu J, Wu J. Yan J, et al. Cell Biochem Funct. 2025 Oct;43(10):e70127. doi: 10.1002/cbf.70127. Cell Biochem Funct. 2025. PMID: 41099311
This study investigates p16/p21 senescence marker heterogeneity in diabetes-related tissues using the p21-3MR mouse model, focusing on p16 and p21 as senescence markers. Type 2 diabetes, a common age-related disease, impacts multiple organs; the study examine …
This study investigates p16/p21 senescence marker heterogeneity in diabetes-related tissues using the p21-3MR mouse model, focusing o …
Protective effects of Quercetin and Resveratrol on aging markers in kidney under high glucose condition: in vivo and in vitro analysis.
Abharzanjani F, Hemmati M. Abharzanjani F, et al. Mol Biol Rep. 2021 Jul;48(7):5435-5442. doi: 10.1007/s11033-021-06550-3. Epub 2021 Jul 17. Mol Biol Rep. 2021. PMID: 34273031
BACKGROUND: Resveratrol and Quercetin as powerful herbal antioxidant reduce kidney complications of diabetes. The purpose of this study was to evaluate the protective effects of Quercetin and Resveratrol on aging markers in high glucose condition. ...C …
BACKGROUND: Resveratrol and Quercetin as powerful herbal antioxidant reduce kidney complications of diabetes. The purpose of t …
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18. EBioMedicine. 2019. PMID: 31542391 Free PMC article.
METHODS: In an open label Phase 1 pilot study, we administered 3 days of oral D 100 mg and Q 1000 mg to subjects with diabetic kidney disease (N = 9; 68.7 3.1 years old; 2 female; BMI:33.9 2.3 kg/m(2); eGFR:27.0 2.1 mL/min/1.73m(2)). ...Senescence …
METHODS: In an open label Phase 1 pilot study, we administered 3 days of oral D 100 mg and Q 1000 mg to subjects with diabetic kid …