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188 results

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Page 1
Quercetin Attenuates MRGPRX2-Mediated Mast Cell Degranulation via the MyD88/IKK/NF-kappaB and PI3K/AKT/ Rac1/Cdc42 Pathway.
Zhao C, Ding Y, Huang Y, Wang C, Guo B, Zhang T. Zhao C, et al. J Inflamm Res. 2024 Oct 7;17:7099-7110. doi: 10.2147/JIR.S480644. eCollection 2024. J Inflamm Res. 2024. PMID: 39398230 Free PMC article.
OBJECTIVE: This study aims to examine the inhibitory effects of quercetin on MRGPRX2-mediated mast cell degranulation via CLM-1. RESULTS: We found that C48/80 stimulation resulted in significantly increased release of beta-hexosaminidase, histamine and Ca(2+) …
OBJECTIVE: This study aims to examine the inhibitory effects of quercetin on MRGPRX2-mediated mast cell degranulation v …
Quercetin Alleviates Chronic Urticaria by Negatively Regulating IgE-Mediated Mast Cell Activation Through CD300f.
Zhao C, Wang N, Wang C, Yuan Y, Du H, Ding Y, An H. Zhao C, et al. Phytother Res. 2025 Jul;39(7):3033-3045. doi: 10.1002/ptr.8516. Epub 2025 May 1. Phytother Res. 2025. PMID: 40309955
Quercetin targets were examined using mast cell activation experiments with CD300f knockdown. ...Of note, quercetin bound to CD300f to prevent IgE-mediated LAD2 cell beta-hexosaminidase release, histamine release, Ca(2+) influx, mast c …
Quercetin targets were examined using mast cell activation experiments with CD300f knockdown. ...Of note, quercetin …
Mast Cell Activation Syndrome.
Kramer ON, Barkoff MS, Hernandez C. Kramer ON, et al. Skinmed. 2017 Dec 1;15(6):477-479. eCollection 2017. Skinmed. 2017. PMID: 29282192
Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice.
Su P, Li Z, Yan X, Wang B, Bai M, Li Y, Xu E. Su P, et al. Inflamm Res. 2024 Jun;73(6):945-960. doi: 10.1007/s00011-024-01876-7. Epub 2024 Apr 8. Inflamm Res. 2024. PMID: 38587532
OBJECTIVE AND DESIGN: Mast cells (MCs), as the fastest immune responders, play a critical role in the progression of neuroinflammation-related diseases, especially in depression. ...The study aimed to explore the mechanisms of inhibitory effect of Que and Kae on MC …
OBJECTIVE AND DESIGN: Mast cells (MCs), as the fastest immune responders, play a critical role in the progression of neuroinfl …
Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult.
Li J, Sun Z, Luo G, Wang S, Cui H, Yao Z, Xiong H, He Y, Qian Y, Fan C. Li J, et al. Front Immunol. 2021 May 20;12:649285. doi: 10.3389/fimmu.2021.649285. eCollection 2021. Front Immunol. 2021. PMID: 34093537 Free PMC article.
Macrophage depletion by clodronate liposomes and mast cell stabilization by cromolyn sodium significantly impeded HO formation. Therefore, we proposed that the dietary phytochemical quercetin could also suppress immune cell recruitment and related infl …
Macrophage depletion by clodronate liposomes and mast cell stabilization by cromolyn sodium significantly impeded HO formation …
Quercetin-induced expression of rat mast cell protease II and accumulation of secretory granules in rat basophilic leukemia cells.
Trnovsky J, Letourneau R, Haggag E, Boucher W, Theoharides TC. Trnovsky J, et al. Biochem Pharmacol. 1993 Dec 14;46(12):2315-26. doi: 10.1016/0006-2952(93)90623-5. Biochem Pharmacol. 1993. PMID: 7506028
Rat basophilic leukemia (RBL) cells are considered to be similar to bone-marrow derived mast cells and to mucosal mast cells (MMC), the latter of which may be involved in inflammatory bowel diseases. ...Here we show that the flavonoid quercet …
Rat basophilic leukemia (RBL) cells are considered to be similar to bone-marrow derived mast cells and to mucosal ma …
Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans.
Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. Weng Z, et al. PLoS One. 2012;7(3):e33805. doi: 10.1371/journal.pone.0033805. Epub 2012 Mar 28. PLoS One. 2012. PMID: 22470478 Free PMC article.
Contact dermatitis and photosensitivity are skin conditions that involve non-immune triggers such as substance P (SP), and do not respond to conventional treatment. Inhibition of mast cell cytokine release could be effective therapy for such diseases. Unfortunately, …
Contact dermatitis and photosensitivity are skin conditions that involve non-immune triggers such as substance P (SP), and do not respond to …
Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line.
Kempuraj D, Castellani ML, Petrarca C, Frydas S, Conti P, Theoharides TC, Vecchiet J. Kempuraj D, et al. Clin Exp Med. 2006 Dec;6(4):150-6. doi: 10.1007/s10238-006-0114-7. Clin Exp Med. 2006. PMID: 17191106
In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell …
In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a …
Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line.
Castellani ML, Kempuraj D, Frydas S, Theoharides TC, Simeonidou I, Conti P, Vecchiet J. Castellani ML, et al. Neuroimmunomodulation. 2006;13(3):179-86. doi: 10.1159/000098131. Epub 2006 Dec 21. Neuroimmunomodulation. 2006. PMID: 17191019
We used quercetin, a potent antioxidant, cytoprotective and anti-inflammatory compound capable of inhibiting histamine and some cytokines released from several cell types, as an inhibitor of immunological and nonimmunological stimulus for mast cells. . …
We used quercetin, a potent antioxidant, cytoprotective and anti-inflammatory compound capable of inhibiting histamine and some cytok …
Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.
Min YD, Choi CH, Bark H, Son HY, Park HH, Lee S, Park JW, Park EK, Shin HI, Kim SH. Min YD, et al. Inflamm Res. 2007 May;56(5):210-5. doi: 10.1007/s00011-007-6172-9. Inflamm Res. 2007. PMID: 17588137
We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1. ...CONCLUSION: Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic …
We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1. …
188 results