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Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II).
Nakamura M, Urakawa D, He Z, Akagi I, Hou DX, Sakao K. Nakamura M, et al. Int J Mol Sci. 2023 Dec 14;24(24):17457. doi: 10.3390/ijms242417457. Int J Mol Sci. 2023. PMID: 38139286 Free PMC article.
Thus, synthesizing novel quercetin-zinc complexes with different coordination positions is a significant advance. ...Interestingly, there was a proportional increase in intracellular quercetin absorption in conjunction with zinc (II) uptake. Our resear …
Thus, synthesizing novel quercetin-zinc complexes with different coordination positions is a significant advance. ...Interesti …
Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model.
Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O'Sullivan CK, Fernández-Larrea JB. Dabbagh-Bazarbachi H, et al. J Agric Food Chem. 2014 Aug 13;62(32):8085-93. doi: 10.1021/jf5014633. Epub 2014 Jul 31. J Agric Food Chem. 2014. PMID: 25050823
Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, …
Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that …
Zinc(2+) ion inhibits SARS-CoV-2 main protease and viral replication in vitro.
Panchariya L, Khan WA, Kuila S, Sonkar K, Sahoo S, Ghoshal A, Kumar A, Verma DK, Hasan A, Khan MA, Jain N, Mohapatra AK, Das S, Thakur JK, Maiti S, Nanda RK, Halder R, Sunil S, Arockiasamy A. Panchariya L, et al. Chem Commun (Camb). 2021 Sep 30;57(78):10083-10086. doi: 10.1039/d1cc03563k. Chem Commun (Camb). 2021. PMID: 34514483
Zinc deficiency is linked to poor prognosis in COVID-19 patients while clinical trials with zinc demonstrate better clinical outcomes. The molecular targets and mechanistic details of the anti-coronaviral activity of zinc remain obscure. We show that zinc
Zinc deficiency is linked to poor prognosis in COVID-19 patients while clinical trials with zinc demonstrate better clinical o
Chloroquine inhibits pro-inflammatory effects of heme on macrophages and invivo.
Silva RCMC, Tan L, Rodrigues DA, Prestes EB, Gomes CP, Gama AM, Oliveira PL, Paiva CN, Manoury B, Bozza MT. Silva RCMC, et al. Free Radic Biol Med. 2021 Sep;173:104-116. doi: 10.1016/j.freeradbiomed.2021.07.028. Epub 2021 Jul 22. Free Radic Biol Med. 2021. PMID: 34303829 Free article.
Inhibition of TNF production could be mimicked by zinc ionophore quercetin, but not by primaquine, a chloroquine analog with low affinity for heme. ...
Inhibition of TNF production could be mimicked by zinc ionophore quercetin, but not by primaquine, a chloroquine analog …
Preferential requirement for protein tyrosine phosphatase activity in the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human colon cancer cells.
Kuo ML, Huang TS, Lin JK. Kuo ML, et al. Biochem Pharmacol. 1995 Oct 12;50(8):1217-22. doi: 10.1016/0006-2952(95)00261-w. Biochem Pharmacol. 1995. PMID: 7488237
In addition, two TPA-induced differentiated characteristics, morphological alteration and release of cellular surface proteoglycan, were effectively blocked by PTP inhibitors, such as sodium orthovanadate (50 microM), zinc chloride (100 microM), and iodoacetate (250 microM …
In addition, two TPA-induced differentiated characteristics, morphological alteration and release of cellular surface proteoglycan, were eff …