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43 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Racecadotril for acute diarrhoea in children.
Liang Y, Zhang L, Zeng L, Gordon M, Wen J. Liang Y, et al. Cochrane Database Syst Rev. 2019 Dec 19;12(12):CD009359. doi: 10.1002/14651858.CD009359.pub2. Cochrane Database Syst Rev. 2019. PMID: 31858591 Free PMC article.
The trials were carried out on children aged three months to five years, in outpatient and inpatient facilities from France, Spain, Peru, India, Kenya, and Ecuador. The efficacy and safety of racecadotril were compared to placebo or no treatment. Racecadotril may re …
The trials were carried out on children aged three months to five years, in outpatient and inpatient facilities from France, Spain, Peru, In …
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses.
Gordon M, Akobeng A. Gordon M, et al. Arch Dis Child. 2016 Mar;101(3):234-40. doi: 10.1136/archdischild-2015-309676. Epub 2015 Dec 29. Arch Dis Child. 2016. PMID: 26715673 Free PMC article.
RESULTS: Seven RCTs were included, five comparing racecadotril with placebo or no intervention, one with pectin/kaolin and one with loperamide. ...There was no significant difference in efficacy or adverse events between racecadotril and loperamide. A meta-analysis …
RESULTS: Seven RCTs were included, five comparing racecadotril with placebo or no intervention, one with pectin/kaolin and one with l …
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials.
Eberlin M, Chen M, Mueck T, Däbritz J. Eberlin M, et al. BMC Pediatr. 2018 Apr 3;18(1):124. doi: 10.1186/s12887-018-1095-x. BMC Pediatr. 2018. PMID: 29614995 Free PMC article.
BACKGROUND: Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines and previous reviews of the field are based on a small fraction of published evidence. ...These findings support the use of racecadotril …
BACKGROUND: Racecadotril is a guideline-recommended option for the treatment of acute diarrhea in children but existing guidelines an …
Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis.
Lehert P, Chéron G, Calatayud GA, Cézard JP, Castrellón PG, Garcia JM, Santos M, Savitha MR. Lehert P, et al. Dig Liver Dis. 2011 Sep;43(9):707-13. doi: 10.1016/j.dld.2011.03.001. Epub 2011 Apr 22. Dig Liver Dis. 2011. PMID: 21514257
BACKGROUND: Racecadotril is an antidiarrhoeal drug with intestinal antisecretory mechanism of action. ...For inpatient studies, the ratio of mean stool output racecadotril/placebo was 0.59 (0.51; 0.74), p<0.001. For outpatient studies, the ratio of the mean numbe …
BACKGROUND: Racecadotril is an antidiarrhoeal drug with intestinal antisecretory mechanism of action. ...For inpatient studies, the r …
Racecadotril Versus Loperamide in Acute Radiation Enteritis: A Randomized, Double-Masked, Phase 3, Noninferiority Trial.
P B A, Sudha SP, Mohan P, Patil N, Rahman A, Gundapuneedi BS, M H. P B A, et al. Int J Radiat Oncol Biol Phys. 2024 Mar 1;118(3):616-625. doi: 10.1016/j.ijrobp.2023.09.021. Epub 2023 Sep 22. Int J Radiat Oncol Biol Phys. 2024. PMID: 37742773 Clinical Trial.
Since the upper boundary of the 95% CI crossed our non-inferiority margin of 10% (13.4%) we could not prove the non-inferiority of Racecadotril over Loperamide. Rebound constipation was more in the Loperamide arm compared to Racecadotril (17.3% vs 6.2%; P = .028) CO …
Since the upper boundary of the 95% CI crossed our non-inferiority margin of 10% (13.4%) we could not prove the non-inferiority of Raceca …
Is racecadotril effective for acute diarrhea in children? -First update.
Sáez J, Cifuentes L. Sáez J, et al. Medwave. 2016 May 6;16 Suppl 2:e6438. doi: 10.5867/medwave.2016.6438. Medwave. 2016. PMID: 26731112 Review. English, Spanish.
Gastroenteritis or acute watery diarrhea is usually a self-limited disease, but it is still associated to substantial healthcare costs and remains a frequent demand for medical care. Racecadotril, an intestinal enkephalinase inhibitor, has been used as treatment because it …
Gastroenteritis or acute watery diarrhea is usually a self-limited disease, but it is still associated to substantial healthcare costs and r …
Racecadotril in the treatment of acute watery diarrhea in children.
Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M. Salazar-Lindo E, et al. N Engl J Med. 2000 Aug 17;343(7):463-7. doi: 10.1056/NEJM200008173430703. N Engl J Med. 2000. PMID: 10944563 Free article. Clinical Trial.
RESULTS: The mean (+/-SE) 48-hour stool output was 92+/-12 g per kilogram in the racecadotril group and 170+/-15 g per kilogram in the placebo group (P<0.001), a 46 percent reduction with racecadotril. ...The intake of oral rehydration solution was significantly …
RESULTS: The mean (+/-SE) 48-hour stool output was 92+/-12 g per kilogram in the racecadotril group and 170+/-15 g per kilogram in th …
[Efficacy of racecadotril vs. smectite, probiotics or zinc as an integral part of treatment of acute diarrhea in children under five years: A meta-analysis of multiple treatments].
Gutiérrez-Castrellón P, Ortíz-Hernández AA, Llamosas-Gallardo B, Acosta-Bastidas MA, Jiménez-Gutiérrez C, Diaz-García L, Anzo-Osorio A, Estevez-Jiménez J, Jiménez-Escobar I, Vidal-Vázquez RP. Gutiérrez-Castrellón P, et al. Gac Med Mex. 2015 May-Jun;151(3):329-37. Gac Med Mex. 2015. PMID: 26089269 Free article. Spanish.
METHODS: A systematic search of multiple databases searching clinical trials related to the use of racecadotril, smectite, Lactobacillus GG, Lactobacillus reuteri, Saccharomyces boulardii and zinc as adjuvants in acute diarrhea was done. ...RESULTS: Network meta-analysis s …
METHODS: A systematic search of multiple databases searching clinical trials related to the use of racecadotril, smectite, Lactobacil …
The efficacy of lactobacillus reuteri in conjunction with racecadotril in managing pediatric rotavirus enteritis and its impact on intestinal mucosa and immune function.
He Z, Lan L, Chen N, Cheng Y, Gong S. He Z, et al. Afr Health Sci. 2025 Jun;25(2):38-45. doi: 10.4314/ahs.v25i2.6. Afr Health Sci. 2025. PMID: 40837632 Free PMC article. Clinical Trial.
BACKGROUND: This study aimed to evaluate the effectiveness of combining Lactobacillus reuteri with racecadotril in treating pediatric rotavirus enteritis, focusing on its impact on intestinal mucosa and immune function. METHODOLOGY: Eighty-five children diagnosed with pedi …
BACKGROUND: This study aimed to evaluate the effectiveness of combining Lactobacillus reuteri with racecadotril in treating pediatric …
Racecadotril versus placebo in the treatment of acute diarrhoea in adults.
Hamza H, Ben Khalifa H, Baumer P, Berard H, Lecomte JM. Hamza H, et al. Aliment Pharmacol Ther. 1999 Dec;13 Suppl 6:15-9. doi: 10.1046/j.1365-2036.1999.00002.x-i1. Aliment Pharmacol Ther. 1999. PMID: 10646047 Clinical Trial.
Fewer patients on racecadotril suffered from abdominal distension following treatment (5.6% vs. 18.2% on placebo). CONCLUSIONS: Racecadotril acts rapidly to resolve acute diarrhoea and has an incidence of adverse events similar to that of placebo....
Fewer patients on racecadotril suffered from abdominal distension following treatment (5.6% vs. 18.2% on placebo). CONCLUSIONS: Ra …
43 results